SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5xdr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FXV_B_PNNB1001_0
(PENICILLIN ACYLASE)		 5xdr PRE-MRNA-SPLICING
FACTOR ATP-DEPENDENT
RNA HELICASE DHX15
(Homo
sapiens) 		4 / 7 PHE A 565
SER A 560
PHE A 671
ALA A 563
 None
 1.21A 1fxvA-5xdrA:
undetectable
1fxvB-5xdrA:
undetectable		 1fxvA-5xdrA:
15.70
1fxvB-5xdrA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_E_DVAE2_0
(ACTINOMYCIN D)		 5xdr PRE-MRNA-SPLICING
FACTOR ATP-DEPENDENT
RNA HELICASE DHX15
(Homo
sapiens) 		3 / 3 THR A 237
PRO A 193
THR A 191
 None
 0.85A 1i3wE-5xdrA:
undetectable		 1i3wE-5xdrA:
3.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J3J_A_CP6A609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5xdr PRE-MRNA-SPLICING
FACTOR ATP-DEPENDENT
RNA HELICASE DHX15
(Homo
sapiens) 		5 / 10 ILE A 258
SER A 164
ILE A 312
ILE A 170
THR A 191
 None
ADP  A 801 (-3.3A)
None
None
None
 1.28A 1j3jA-5xdrA:
undetectable		 1j3jA-5xdrA:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QFI_B_DVAB8_0
(ACTINOMYCIN X2)		 5xdr PRE-MRNA-SPLICING
FACTOR ATP-DEPENDENT
RNA HELICASE DHX15
(Homo
sapiens) 		3 / 3 THR A 191
THR A 237
PRO A 193
 None
 0.86A 1qfiB-5xdrA:
undetectable		 1qfiB-5xdrA:
3.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1O_B_CAMB2422_0
(CYTOCHROME P450-CAM)		 5xdr PRE-MRNA-SPLICING
FACTOR ATP-DEPENDENT
RNA HELICASE DHX15
(Homo
sapiens) 		5 / 9 THR A 269
VAL A 275
GLY A 274
VAL A 288
ILE A 257
 None
 1.24A 2a1oB-5xdrA:
undetectable		 2a1oB-5xdrA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_A_SAMA1001_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 5xdr PRE-MRNA-SPLICING
FACTOR ATP-DEPENDENT
RNA HELICASE DHX15
(Homo
sapiens) 		3 / 3 ASP A 238
ASP A 270
ASP A 260
 None
None
MG  A 804 (-3.5A)
 0.74A 2igtA-5xdrA:
2.6		 2igtA-5xdrA:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_A_SNLA1001_1
(MINERALOCORTICOID
RECEPTOR)		 5xdr PRE-MRNA-SPLICING
FACTOR ATP-DEPENDENT
RNA HELICASE DHX15
(Homo
sapiens) 		5 / 12 LEU A 627
MET A 574
LEU A 664
LEU A 571
THR A 749
 None
 1.49A 2oaxA-5xdrA:
undetectable		 2oaxA-5xdrA:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6H_A_CXXA801_1
(TRANSPORTER)		 5xdr PRE-MRNA-SPLICING
FACTOR ATP-DEPENDENT
RNA HELICASE DHX15
(Homo
sapiens) 		5 / 11 LEU A 259
LEU A 272
ILE A 257
PHE A 304
LEU A 286
 None
 1.18A 2q6hA-5xdrA:
undetectable		 2q6hA-5xdrA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6O_A_SAMA500_0
(HYPOTHETICAL PROTEIN)		 5xdr PRE-MRNA-SPLICING
FACTOR ATP-DEPENDENT
RNA HELICASE DHX15
(Homo
sapiens) 		4 / 7 VAL A 719
ALA A 702
PRO A 723
THR A 725
 None
 0.92A 2q6oA-5xdrA:
undetectable		 2q6oA-5xdrA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q72_A_IXXA801_1
(TRANSPORTER)		 5xdr PRE-MRNA-SPLICING
FACTOR ATP-DEPENDENT
RNA HELICASE DHX15
(Homo
sapiens) 		5 / 11 LEU A 259
LEU A 272
ILE A 257
PHE A 304
LEU A 286
 None
 1.19A 2q72A-5xdrA:
undetectable		 2q72A-5xdrA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEI_A_CXXA801_1
(TRANSPORTER)		 5xdr PRE-MRNA-SPLICING
FACTOR ATP-DEPENDENT
RNA HELICASE DHX15
(Homo
sapiens) 		5 / 11 LEU A 259
LEU A 272
ILE A 257
PHE A 304
LEU A 286
 None
 1.21A 2qeiA-5xdrA:
undetectable		 2qeiA-5xdrA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QJU_A_DSMA801_1
(TRANSPORTER)		 5xdr PRE-MRNA-SPLICING
FACTOR ATP-DEPENDENT
RNA HELICASE DHX15
(Homo
sapiens) 		5 / 11 LEU A 259
LEU A 272
ILE A 257
PHE A 304
LEU A 286
 None
 1.17A 2qjuA-5xdrA:
undetectable		 2qjuA-5xdrA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9H_A_TOPA1160_1
(DIHYDROFOLATE
REDUCTASE)		 5xdr PRE-MRNA-SPLICING
FACTOR ATP-DEPENDENT
RNA HELICASE DHX15
(Homo
sapiens) 		5 / 10 LEU A 250
ALA A 245
LEU A 241
LEU A 276
VAL A 279
 None
 0.87A 2w9hA-5xdrA:
undetectable		 2w9hA-5xdrA:
13.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YJA_B_ESTB1550_1
(ESTROGEN RECEPTOR)		 5xdr PRE-MRNA-SPLICING
FACTOR ATP-DEPENDENT
RNA HELICASE DHX15
(Homo
sapiens) 		5 / 12 ALA A 563
LEU A 242
ILE A 519
GLY A 518
LEU A 555
 None
 1.06A 2yjaB-5xdrA:
undetectable		 2yjaB-5xdrA:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HGI_A_BEZA284_0
(CATECHOL
1,2-DIOXYGENASE)		 5xdr PRE-MRNA-SPLICING
FACTOR ATP-DEPENDENT
RNA HELICASE DHX15
(Homo
sapiens) 		5 / 12 LEU A 356
ILE A 461
GLY A 440
PRO A 439
TYR A 331
 None
 1.40A 3hgiA-5xdrA:
undetectable		 3hgiA-5xdrA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q95_A_ESLA700_1
(ESTROGEN RECEPTOR)		 5xdr PRE-MRNA-SPLICING
FACTOR ATP-DEPENDENT
RNA HELICASE DHX15
(Homo
sapiens) 		5 / 12 ALA A 563
LEU A 242
ILE A 519
GLY A 518
LEU A 555
 None
 1.12A 3q95A-5xdrA:
undetectable		 3q95A-5xdrA:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UM5_A_CP6A609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5xdr PRE-MRNA-SPLICING
FACTOR ATP-DEPENDENT
RNA HELICASE DHX15
(Homo
sapiens) 		5 / 10 ILE A 258
SER A 164
ILE A 312
ILE A 170
THR A 191
 None
ADP  A 801 (-3.3A)
None
None
None
 1.26A 3um5A-5xdrA:
undetectable		 3um5A-5xdrA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KUK_A_RBFA201_2
(BLUE-LIGHT
PHOTORECEPTOR)		 5xdr PRE-MRNA-SPLICING
FACTOR ATP-DEPENDENT
RNA HELICASE DHX15
(Homo
sapiens) 		5 / 9 LEU A 353
VAL A 339
ILE A 342
ILE A 437
GLY A 479
 None
 0.83A 4kukA-5xdrA:
undetectable		 4kukA-5xdrA:
12.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB2_A_DM5A601_1
(SERUM ALBUMIN)		 5xdr PRE-MRNA-SPLICING
FACTOR ATP-DEPENDENT
RNA HELICASE DHX15
(Homo
sapiens) 		4 / 7 LEU A 158
VAL A 157
PRO A 308
TYR A 142
 None
 1.07A 4lb2A-5xdrA:
undetectable		 4lb2A-5xdrA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB2_B_DM5B601_1
(SERUM ALBUMIN)		 5xdr PRE-MRNA-SPLICING
FACTOR ATP-DEPENDENT
RNA HELICASE DHX15
(Homo
sapiens) 		5 / 9 LEU A 158
VAL A 157
PRO A 308
TYR A 142
ILE A 312
 None
 1.24A 4lb2B-5xdrA:
0.8		 4lb2B-5xdrA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OT2_A_NPSA601_1
(SERUM ALBUMIN)		 5xdr PRE-MRNA-SPLICING
FACTOR ATP-DEPENDENT
RNA HELICASE DHX15
(Homo
sapiens) 		5 / 12 LEU A 267
PHE A 525
VAL A 275
GLY A 274
LEU A 242
 None
 0.97A 4ot2A-5xdrA:
2.0		 4ot2A-5xdrA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBR_A_NPSA602_1
(SERUM ALBUMIN)		 5xdr PRE-MRNA-SPLICING
FACTOR ATP-DEPENDENT
RNA HELICASE DHX15
(Homo
sapiens) 		5 / 12 LEU A 267
PHE A 525
LEU A 514
GLY A 274
LEU A 242
 None
 0.90A 4zbrA-5xdrA:
undetectable		 4zbrA-5xdrA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJ8_A_SUVA2001_2
(HUMAN OX1R FUSION
PROTEIN TO P.ABYSII
GLYCOGEN SYNTHASE)		 5xdr PRE-MRNA-SPLICING
FACTOR ATP-DEPENDENT
RNA HELICASE DHX15
(Homo
sapiens) 		4 / 6 ILE A 386
PRO A 387
ILE A 336
VAL A 339
 None
 0.87A 4zj8A-5xdrA:
2.4		 4zj8A-5xdrA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXB_B_ESTB601_1
(ESTROGEN RECEPTOR)		 5xdr PRE-MRNA-SPLICING
FACTOR ATP-DEPENDENT
RNA HELICASE DHX15
(Homo
sapiens) 		5 / 11 ALA A 563
LEU A 242
ILE A 519
GLY A 518
LEU A 555
 None
 1.09A 5dxbB-5xdrA:
undetectable		 5dxbB-5xdrA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GS4_A_ESTA603_1
(ESTROGEN RECEPTOR)		 5xdr PRE-MRNA-SPLICING
FACTOR ATP-DEPENDENT
RNA HELICASE DHX15
(Homo
sapiens) 		5 / 12 ALA A 563
LEU A 242
ILE A 519
GLY A 518
LEU A 555
 None
 1.09A 5gs4A-5xdrA:
undetectable		 5gs4A-5xdrA:
16.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GS4_A_ESTA603_1
(ESTROGEN RECEPTOR)		 5xdr PRE-MRNA-SPLICING
FACTOR ATP-DEPENDENT
RNA HELICASE DHX15
(Homo
sapiens) 		5 / 12 MET A 273
THR A 269
LEU A 267
LEU A 503
GLY A 298
 None
 1.10A 5gs4A-5xdrA:
undetectable		 5gs4A-5xdrA:
16.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND4_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 5xdr PRE-MRNA-SPLICING
FACTOR ATP-DEPENDENT
RNA HELICASE DHX15
(Homo
sapiens) 		5 / 12 VAL A 701
LEU A 693
ARG A 748
PRO A 731
LEU A 727
 None
 1.09A 5nd4B-5xdrA:
undetectable		 5nd4B-5xdrA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NUJ_A_Z80A201_1
(BETA-LACTOGLOBULIN)		 5xdr PRE-MRNA-SPLICING
FACTOR ATP-DEPENDENT
RNA HELICASE DHX15
(Homo
sapiens) 		4 / 8 ALA A 202
VAL A 205
ILE A 258
VAL A 188
 None
 0.60A 5nujA-5xdrA:
undetectable		 5nujA-5xdrA:
7.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X66_A_MTXA402_1
(THYMIDYLATE SYNTHASE)		 5xdr PRE-MRNA-SPLICING
FACTOR ATP-DEPENDENT
RNA HELICASE DHX15
(Homo
sapiens) 		5 / 12 ILE A 649
LEU A 627
PHE A 617
MET A 593
ALA A 592
 None
 0.90A 5x66A-5xdrA:
undetectable
5x66B-5xdrA:
undetectable		 5x66A-5xdrA:
19.05
5x66B-5xdrA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X66_C_MTXC402_1
(THYMIDYLATE SYNTHASE)		 5xdr PRE-MRNA-SPLICING
FACTOR ATP-DEPENDENT
RNA HELICASE DHX15
(Homo
sapiens) 		5 / 9 ILE A 649
LEU A 627
PHE A 617
MET A 593
ALA A 592
 None
 0.94A 5x66C-5xdrA:
undetectable		 5x66C-5xdrA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X66_F_MTXF402_1
(THYMIDYLATE SYNTHASE)		 5xdr PRE-MRNA-SPLICING
FACTOR ATP-DEPENDENT
RNA HELICASE DHX15
(Homo
sapiens) 		5 / 12 ILE A 649
LEU A 627
PHE A 617
MET A 593
ALA A 592
 None
 1.10A 5x66F-5xdrA:
undetectable		 5x66F-5xdrA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXM_A_SAMA402_0
(DIPHTHAMIDE
BIOSYNTHESIS ENZYME
DPH2)		 5xdr PRE-MRNA-SPLICING
FACTOR ATP-DEPENDENT
RNA HELICASE DHX15
(Homo
sapiens) 		5 / 12 GLY A 163
SER A 420
VAL A 418
ILE A 430
ASP A 431
 ADP  A 801 (-3.7A)
None
None
None
ADP  A 801 (-2.5A)
 1.19A 6bxmA-5xdrA:
2.8		 6bxmA-5xdrA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_F_TA1F502_2
(TUBULIN BETA CHAIN)		 5xdr PRE-MRNA-SPLICING
FACTOR ATP-DEPENDENT
RNA HELICASE DHX15
(Homo
sapiens) 		4 / 5 LEU A 594
LEU A 693
THR A 626
PRO A 731
 None
 0.77A 6ew0F-5xdrA:
undetectable		 6ew0F-5xdrA:
6.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA812_0
(GEPHYRIN)		 5xdr PRE-MRNA-SPLICING
FACTOR ATP-DEPENDENT
RNA HELICASE DHX15
(Homo
sapiens) 		4 / 6 GLU A 224
ARG A 195
VAL A 596
PRO A 597
 None
 1.39A 6fgdA-5xdrA:
undetectable		 6fgdA-5xdrA:
22.49