SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5xdy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KAW_A_SUZA91_1
(SEGMENT POLARITY
PROTEIN DISHEVELLED
HOMOLOG DVL-1)		 5xdy HEAT SHOCK PROTEIN
HTRA
(Mycobacterium
tuberculosis) 		5 / 11 LEU A 442
GLY A 443
ILE A 444
SER A 445
VAL A 497
 None
 0.44A 2kawA-5xdyA:
7.1		 2kawA-5xdyA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_B_SAMB300_0
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 5xdy HEAT SHOCK PROTEIN
HTRA
(Mycobacterium
tuberculosis) 		6 / 12 GLY A 343
GLY A 389
GLY A 339
GLY A 385
ILE A 401
VAL A 257
 GOL  A 601 (-3.4A)
None
GOL  A 601 ( 4.9A)
GOL  A 601 ( 3.7A)
None
None
 1.48A 2oxtB-5xdyA:
undetectable		 2oxtB-5xdyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YY8_B_SAMB500_0
(UPF0106 PROTEIN
PH0461)		 5xdy HEAT SHOCK PROTEIN
HTRA
(Mycobacterium
tuberculosis) 		5 / 11 HIS A 270
LEU A 391
GLY A 389
VAL A 257
ALA A 418
 None
 1.12A 2yy8A-5xdyA:
undetectable
2yy8B-5xdyA:
undetectable		 2yy8A-5xdyA:
undetectable
2yy8B-5xdyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YY8_B_SAMB500_0
(UPF0106 PROTEIN
PH0461)		 5xdy HEAT SHOCK PROTEIN
HTRA
(Mycobacterium
tuberculosis) 		5 / 11 LEU A 391
GLY A 389
VAL A 257
ILE A 376
ALA A 418
 None
 0.98A 2yy8A-5xdyA:
undetectable
2yy8B-5xdyA:
undetectable		 2yy8A-5xdyA:
undetectable
2yy8B-5xdyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_D_TMQD614_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5xdy HEAT SHOCK PROTEIN
HTRA
(Mycobacterium
tuberculosis) 		5 / 10 VAL A 353
ALA A 380
ILE A 382
ILE A 419
ILE A 376
 None
 1.25A 3hbbD-5xdyA:
undetectable		 3hbbD-5xdyA:
9.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P97_A_SAMA263_0
(NON-STRUCTURAL
PROTEIN 5)		 5xdy HEAT SHOCK PROTEIN
HTRA
(Mycobacterium
tuberculosis) 		5 / 12 GLY A 400
GLY A 256
GLY A 388
VAL A 286
ILE A 265
 None
 0.85A 3p97A-5xdyA:
undetectable		 3p97A-5xdyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ6_A_SAMA300_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 5xdy HEAT SHOCK PROTEIN
HTRA
(Mycobacterium
tuberculosis) 		4 / 4 SER A 450
ASP A 491
ASP A 374
ALA A 488
 None
 1.36A 3uj6A-5xdyA:
undetectable		 3uj6A-5xdyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UT5_D_LOCD502_1
(TUBULIN BETA CHAIN)		 5xdy HEAT SHOCK PROTEIN
HTRA
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 310
ASN A 297
LYS A 283
ALA A 275
ILE A 243
 None
 1.20A 3ut5D-5xdyA:
undetectable		 3ut5D-5xdyA:
11.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTK_A_SAMA1263_0
(POLYPROTEIN)		 5xdy HEAT SHOCK PROTEIN
HTRA
(Mycobacterium
tuberculosis) 		5 / 12 GLY A 400
GLY A 256
GLY A 388
VAL A 286
ILE A 265
 None
 0.86A 4ctkA-5xdyA:
undetectable		 4ctkA-5xdyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJG_D_NCTD501_1
(CYTOCHROME P450 2A13)		 5xdy HEAT SHOCK PROTEIN
HTRA
(Mycobacterium
tuberculosis) 		4 / 6 ASN A 277
ALA A 275
THR A 284
LEU A 310
 None
 0.97A 4ejgD-5xdyA:
undetectable		 4ejgD-5xdyA:
10.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q5M_A_ROCA1101_2
(PROTEASE)		 5xdy HEAT SHOCK PROTEIN
HTRA
(Mycobacterium
tuberculosis) 		5 / 12 ALA A 308
GLY A 256
ILE A 272
ILE A 243
VAL A 259
 None
 0.95A 4q5mA-5xdyA:
undetectable		 4q5mA-5xdyA:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R21_B_STRB601_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 5xdy HEAT SHOCK PROTEIN
HTRA
(Mycobacterium
tuberculosis) 		5 / 9 ALA A 308
ILE A 258
GLY A 256
SER A 245
VAL A 286
 None
 1.06A 4r21B-5xdyA:
undetectable		 4r21B-5xdyA:
12.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E9Q_A_SAMA301_0
(GENOME POLYPROTEIN)		 5xdy HEAT SHOCK PROTEIN
HTRA
(Mycobacterium
tuberculosis) 		5 / 12 GLY A 400
GLY A 256
GLY A 388
VAL A 286
ILE A 265
 None
 0.84A 5e9qA-5xdyA:
undetectable		 5e9qA-5xdyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EC8_A_SAMA301_0
(GENOME POLYPROTEIN)		 5xdy HEAT SHOCK PROTEIN
HTRA
(Mycobacterium
tuberculosis) 		5 / 12 GLY A 400
GLY A 256
GLY A 388
VAL A 286
ILE A 265
 None
 0.79A 5ec8A-5xdyA:
undetectable		 5ec8A-5xdyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EHG_A_SAMA301_0
(RNA-DIRECTED RNA
POLYMERASE NS5)		 5xdy HEAT SHOCK PROTEIN
HTRA
(Mycobacterium
tuberculosis) 		5 / 12 GLY A 400
GLY A 256
GLY A 388
VAL A 286
ILE A 265
 None
 0.83A 5ehgA-5xdyA:
undetectable		 5ehgA-5xdyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EIF_A_SAMA301_0
(GENOME POLYPROTEIN)		 5xdy HEAT SHOCK PROTEIN
HTRA
(Mycobacterium
tuberculosis) 		5 / 12 GLY A 400
GLY A 256
GLY A 388
VAL A 286
ILE A 265
 None
 0.88A 5eifA-5xdyA:
undetectable		 5eifA-5xdyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKM_A_SAMA311_0
(NS5 METHYL
TRANSFERASE)		 5xdy HEAT SHOCK PROTEIN
HTRA
(Mycobacterium
tuberculosis) 		5 / 12 GLY A 400
GLY A 256
GLY A 388
VAL A 286
ILE A 265
 None
 0.92A 5ikmA-5xdyA:
undetectable		 5ikmA-5xdyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQS_A_SAMA307_0
(GENOME POLYPROTEIN)		 5xdy HEAT SHOCK PROTEIN
HTRA
(Mycobacterium
tuberculosis) 		5 / 12 GLY A 400
GLY A 256
GLY A 388
VAL A 286
ILE A 265
 None
 0.91A 5kqsA-5xdyA:
undetectable		 5kqsA-5xdyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NJV_C_SAMC301_0
(NS5)		 5xdy HEAT SHOCK PROTEIN
HTRA
(Mycobacterium
tuberculosis) 		5 / 12 GLY A 400
GLY A 256
GLY A 388
VAL A 286
ILE A 265
 None
 0.87A 5njvC-5xdyA:
undetectable		 5njvC-5xdyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ2_A_SAMA601_0
(NS5 MTASE)		 5xdy HEAT SHOCK PROTEIN
HTRA
(Mycobacterium
tuberculosis) 		5 / 12 GLY A 400
GLY A 256
GLY A 388
VAL A 286
ILE A 265
 None
 0.88A 5wz2A-5xdyA:
undetectable		 5wz2A-5xdyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ2_B_SAMB601_0
(NS5 MTASE)		 5xdy HEAT SHOCK PROTEIN
HTRA
(Mycobacterium
tuberculosis) 		5 / 12 GLY A 400
GLY A 256
GLY A 388
VAL A 286
ILE A 265
 None
 0.85A 5wz2B-5xdyA:
undetectable		 5wz2B-5xdyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ2_C_SAMC601_0
(NS5 MTASE)		 5xdy HEAT SHOCK PROTEIN
HTRA
(Mycobacterium
tuberculosis) 		5 / 12 GLY A 400
GLY A 256
GLY A 388
VAL A 286
ILE A 265
 None
 0.85A 5wz2C-5xdyA:
undetectable		 5wz2C-5xdyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIW_D_LOCD503_2
(TUBULIN BETA CHAIN)		 5xdy HEAT SHOCK PROTEIN
HTRA
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 310
ASN A 297
LYS A 283
ALA A 275
ILE A 243
 None
 1.26A 5xiwD-5xdyA:
undetectable		 5xiwD-5xdyA:
20.24