SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5xe7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_A_CHDA131_0
(FATTY ACID-BINDING
PROTEIN)		 5xe7 ECF RNA POLYMERASE
SIGMA FACTOR SIGJ
(Mycobacterium
tuberculosis) 		5 / 11 LEU A 236
ILE A 272
THR A 270
LEU A 282
VAL A 174
 None
 1.38A 1tw4A-5xe7A:
undetectable		 1tw4A-5xe7A:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB1283_1
(CES1 PROTEIN)		 5xe7 ECF RNA POLYMERASE
SIGMA FACTOR SIGJ
(Mycobacterium
tuberculosis) 		4 / 7 LEU A 242
GLY A 250
LEU A  87
PRO A 295
 None
 0.91A 1ya4B-5xe7A:
2.0		 1ya4B-5xe7A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C12_C_SPMC1434_1
(NITROALKANE OXIDASE)		 5xe7 ECF RNA POLYMERASE
SIGMA FACTOR SIGJ
(Mycobacterium
tuberculosis) 		5 / 12 LEU A  64
ALA A 120
LEU A 123
SER A  57
LEU A  61
 None
 1.14A 2c12C-5xe7A:
undetectable		 2c12C-5xe7A:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C12_F_SPMF1433_1
(NITROALKANE OXIDASE)		 5xe7 ECF RNA POLYMERASE
SIGMA FACTOR SIGJ
(Mycobacterium
tuberculosis) 		5 / 11 LEU A  64
ALA A 120
LEU A 123
SER A  57
LEU A  61
 None
 1.12A 2c12F-5xe7A:
undetectable		 2c12F-5xe7A:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KL3_A_DHIA403_0
(GLUCURONOXYLANASE
XYNC)		 5xe7 ECF RNA POLYMERASE
SIGMA FACTOR SIGJ
(Mycobacterium
tuberculosis) 		4 / 4 GLY A 258
TYR A 262
GLY A 261
ASP A 260
 None
 1.32A 3kl3A-5xe7A:
undetectable		 3kl3A-5xe7A:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0Y_A_FOLA201_0
(CONSERVED
HYPOTHETICAL
MEMBRANE PROTEIN)		 5xe7 ECF RNA POLYMERASE
SIGMA FACTOR SIGJ
(Mycobacterium
tuberculosis) 		5 / 12 GLY A 250
ASP A  88
THR A  90
VAL A  96
HIS A 171
 None
 1.39A 5d0yA-5xe7A:
undetectable		 5d0yA-5xe7A:
23.10