SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5xea'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_C_DVAC6_0
(GRAMICIDIN A)		 5xea ENVELOPE
GLYCOPROTEIN
(Thogoto
thogotovirus) 		3 / 3 ALA A 297
VAL A 295
TRP A 292
 None
 0.85A 1av2C-5xeaA:
undetectable
1av2D-5xeaA:
undetectable		 1av2C-5xeaA:
4.35
1av2D-5xeaA:
4.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_C_DVAC6_0
(GRAMICIDIN D)		 5xea ENVELOPE
GLYCOPROTEIN
(Thogoto
thogotovirus) 		3 / 3 ALA A 297
VAL A 295
TRP A 292
 None
 0.81A 1w5uC-5xeaA:
undetectable
1w5uD-5xeaA:
undetectable		 1w5uC-5xeaA:
4.35
1w5uD-5xeaA:
4.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_B_DVAB6_0
(GRAMICIDIN D)		 5xea ENVELOPE
GLYCOPROTEIN
(Thogoto
thogotovirus) 		3 / 3 TRP A 292
ALA A 297
VAL A 295
 None
 0.70A 2izqA-5xeaA:
undetectable
2izqB-5xeaA:
undetectable		 2izqA-5xeaA:
4.35
2izqB-5xeaA:
4.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_A_DVAA6_0
(GRAMICIDIN D)		 5xea ENVELOPE
GLYCOPROTEIN
(Thogoto
thogotovirus) 		3 / 3 ALA A 297
VAL A 295
TRP A 292
 None
 0.67A 3l8lA-5xeaA:
undetectable
3l8lB-5xeaA:
undetectable		 3l8lA-5xeaA:
4.35
3l8lB-5xeaA:
4.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_C_DVAC6_0
(GRAMICIDIN D)		 5xea ENVELOPE
GLYCOPROTEIN
(Thogoto
thogotovirus) 		3 / 3 ALA A 297
VAL A 295
TRP A 292
 None
 0.76A 3l8lC-5xeaA:
undetectable
3l8lD-5xeaA:
undetectable		 3l8lC-5xeaA:
4.35
3l8lD-5xeaA:
4.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_J_ZPCJ1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5xea ENVELOPE
GLYCOPROTEIN
(Thogoto
thogotovirus) 		4 / 5 GLU A  57
PHE A 212
TYR A 259
HIS A 257
 None
 1.47A 4a97J-5xeaA:
undetectable		 4a97J-5xeaA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G1B_A_ECNA403_1
(FLAVOHEMOGLOBIN)		 5xea ENVELOPE
GLYCOPROTEIN
(Thogoto
thogotovirus) 		5 / 12 TYR A  63
ALA A 449
LEU A 450
THR A 453
LEU A  87
 None
 1.11A 4g1bA-5xeaA:
undetectable		 4g1bA-5xeaA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z2D_F_LFXF102_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
SYMMETRIZED E-SITE
DNA)		 5xea ENVELOPE
GLYCOPROTEIN
(Thogoto
thogotovirus) 		3 / 4 ARG A 317
GLY A 315
GLU A 314
 None
 0.55A 4z2dB-5xeaA:
undetectable
4z2dC-5xeaA:
undetectable		 4z2dB-5xeaA:
22.01
4z2dC-5xeaA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KPC_A_SAMA401_1
(PAVINE
N-METHYLTRANSFERASE)		 5xea ENVELOPE
GLYCOPROTEIN
(Thogoto
thogotovirus) 		4 / 5 SER A 180
ASN A 246
GLN A 258
ASP A 243
 None
 1.27A 5kpcA-5xeaA:
undetectable		 5kpcA-5xeaA:
22.24