SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5xei'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZQ_A_PCFA954_0
(CATECHOL
1,2-DIOXYGENASE)		 5xei CHROMOSOME PARTITION
PROTEIN SMC
(Pyrococcus
yayanosii) 		5 / 9 GLU A 210
ALA A 214
TYR A 217
LEU A 218
GLU A 964
 None
 1.15A 2azqA-5xeiA:
undetectable		 2azqA-5xeiA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CBR_A_A80A201_1
(PROTEIN (CRABP-I))		 5xei CHROMOSOME PARTITION
PROTEIN SMC
(Pyrococcus
yayanosii) 		5 / 12 VAL A  82
VAL A  20
THR A  29
VAL A1152
GLY A  43
 None
 1.05A 2cbrA-5xeiA:
undetectable		 2cbrA-5xeiA:
13.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LBD_A_REAA500_1
(RETINOIC ACID
RECEPTOR GAMMA)		 5xei CHROMOSOME PARTITION
PROTEIN SMC
(Pyrococcus
yayanosii) 		5 / 12 PHE A1093
LYS A  26
ILE A  84
PHE A  86
GLY A  43
 None
 1.30A 2lbdA-5xeiA:
undetectable		 2lbdA-5xeiA:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_D_RIMD499_1
(MATRIX PROTEIN 2)		 5xei CHROMOSOME PARTITION
PROTEIN SMC
(Pyrococcus
yayanosii) 		4 / 6 ILE A 163
ARG A 159
LEU A 162
LEU A1039
 None
 1.07A 2rlfA-5xeiA:
undetectable
2rlfD-5xeiA:
undetectable		 2rlfA-5xeiA:
8.52
2rlfD-5xeiA:
8.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3A_A_TOPA1190_1
(DIHYDROFOLATE
REDUCTASE)		 5xei CHROMOSOME PARTITION
PROTEIN SMC
(Pyrococcus
yayanosii) 		5 / 11 ILE A1099
PHE A1124
PHE A1096
VAL A 143
THR A1128
 None
 1.02A 2w3aA-5xeiA:
undetectable		 2w3aA-5xeiA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2N_D_X2ND1479_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 5xei CHROMOSOME PARTITION
PROTEIN SMC
(Pyrococcus
yayanosii) 		5 / 12 ILE A 163
PHE A1093
PHE A  24
ALA A  45
LEU A 144
 None
 1.37A 2x2nD-5xeiA:
2.0		 2x2nD-5xeiA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BUF_A_AEGA394_0
(BETA-SECRETASE 1)		 5xei CHROMOSOME PARTITION
PROTEIN SMC
(Pyrococcus
yayanosii) 		4 / 5 LEU A1095
ILE A1099
ILE A1125
GLY A  43
 None
 0.96A 3bufA-5xeiA:
undetectable		 3bufA-5xeiA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_B_NIMB1701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 5xei CHROMOSOME PARTITION
PROTEIN SMC
(Pyrococcus
yayanosii) 		3 / 3 VAL A  20
VAL A1149
SER A  14
 None
 0.55A 3n8xB-5xeiA:
2.6		 3n8xB-5xeiA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RUK_A_AERA601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 5xei CHROMOSOME PARTITION
PROTEIN SMC
(Pyrococcus
yayanosii) 		5 / 12 ASN A  41
ILE A  42
LEU A   7
VAL A 106
VAL A  82
 None
 1.08A 3rukA-5xeiA:
3.5		 3rukA-5xeiA:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1479_0
(MJ0495-LIKE PROTEIN)		 5xei CHROMOSOME PARTITION
PROTEIN SMC
(Pyrococcus
yayanosii) 		4 / 5 THR A 149
ILE A 152
LYS A 153
GLU A1067
 None
 1.22A 4ac9C-5xeiA:
undetectable		 4ac9C-5xeiA:
24.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1479_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 5xei CHROMOSOME PARTITION
PROTEIN SMC
(Pyrococcus
yayanosii) 		4 / 5 THR A 149
ILE A 152
LYS A 153
GLU A1067
 None
 1.21A 4acaC-5xeiA:
undetectable		 4acaC-5xeiA:
24.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I1R_A_LZUA801_1
(MUCOSA-ASSOCIATED
LYMPHOID TISSUE
LYMPHOMA
TRANSLOCATION
PROTEIN 1)		 5xei CHROMOSOME PARTITION
PROTEIN SMC
(Pyrococcus
yayanosii) 		5 / 12 LEU A 207
ALA A 970
GLU A 972
PHE A 974
ARG A 979
 None
 1.22A 4i1rA-5xeiA:
undetectable		 4i1rA-5xeiA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L3G_F_ACTF401_0
(METHYLAMINE
DEHYDROGENASE HEAVY
CHAIN)		 5xei CHROMOSOME PARTITION
PROTEIN SMC
(Pyrococcus
yayanosii) 		3 / 3 ARG A 980
LEU A 984
GLU A 983
 None
 0.75A 4l3gF-5xeiA:
1.7		 4l3gF-5xeiA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R87_H_SPMH202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 5xei CHROMOSOME PARTITION
PROTEIN SMC
(Pyrococcus
yayanosii) 		4 / 6 MET A 154
TYR A 140
GLU A 138
GLU A 165
 None
 1.40A 4r87H-5xeiA:
undetectable		 4r87H-5xeiA:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R87_I_SPMI202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 5xei CHROMOSOME PARTITION
PROTEIN SMC
(Pyrococcus
yayanosii) 		4 / 7 ASN A  87
GLU A  99
GLU A  97
GLU A  89
 None
 1.25A 4r87I-5xeiA:
undetectable		 4r87I-5xeiA:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_B_032B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 5xei CHROMOSOME PARTITION
PROTEIN SMC
(Pyrococcus
yayanosii) 		4 / 5 ILE A 148
PHE A1093
HIS A1102
ASP A1097
 None
 1.36A 4rzvB-5xeiA:
undetectable		 4rzvB-5xeiA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WQ5_B_ACTB404_0
(TRNA N6-ADENOSINE
THREONYLCARBAMOYLTRA
NSFERASE)		 5xei CHROMOSOME PARTITION
PROTEIN SMC
(Pyrococcus
yayanosii) 		3 / 3 TYR A 981
ARG A 988
LYS A 985
 None
 1.17A 4wq5B-5xeiA:
undetectable		 4wq5B-5xeiA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0Y_A_FOLA201_1
(CONSERVED
HYPOTHETICAL
MEMBRANE PROTEIN)		 5xei CHROMOSOME PARTITION
PROTEIN SMC
(Pyrococcus
yayanosii) 		3 / 3 ARG A 105
LYS A 103
GLU A  81
 None
 0.81A 5d0yA-5xeiA:
undetectable		 5d0yA-5xeiA:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWA_A_GCSA301_1
(CHITOSANASE)		 5xei CHROMOSOME PARTITION
PROTEIN SMC
(Pyrococcus
yayanosii) 		4 / 8 ILE A1127
ASP A1097
GLY A  38
ASN A  35
 None
 1.06A 5hwaA-5xeiA:
undetectable		 5hwaA-5xeiA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5xei CHROMOSOME PARTITION
PROTEIN SMC
(Pyrococcus
yayanosii) 		4 / 5 ARG A1087
LEU A1027
PHE A1028
LEU A1114
 None
 1.21A 5x1fC-5xeiA:
4.5
5x1fJ-5xeiA:
undetectable		 5x1fC-5xeiA:
17.16
5x1fJ-5xeiA:
7.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_C_CHDC308_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT VIIA-HEART)		 5xei CHROMOSOME PARTITION
PROTEIN SMC
(Pyrococcus
yayanosii) 		4 / 5 ARG A1087
LEU A1027
PHE A1028
LEU A1114
 None
 1.27A 5xdxC-5xeiA:
3.8
5xdxJ-5xeiA:
1.5		 5xdxC-5xeiA:
16.97
5xdxJ-5xeiA:
7.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_B_8NUB3001_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 5xei CHROMOSOME PARTITION
PROTEIN SMC
(Pyrococcus
yayanosii) 		4 / 5 ASP A 164
ILE A1085
PHE A1081
ASN A1043
 None
 1.17A 6a93B-5xeiA:
undetectable		 6a93B-5xeiA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6J20_A_GBQA1201_0
(SUBSTANCE-P
RECEPTOR,ENDOLYSIN)		 5xei CHROMOSOME PARTITION
PROTEIN SMC
(Pyrococcus
yayanosii) 		5 / 12 VAL A 143
ILE A 166
PHE A 151
PHE A1081
MET A 154
 None
 1.45A 6j20A-5xeiA:
undetectable		 6j20A-5xeiA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6J21_A_GBQA1201_0
(SUBSTANCE-P
RECEPTOR,ENDOLYSIN)		 5xei CHROMOSOME PARTITION
PROTEIN SMC
(Pyrococcus
yayanosii) 		5 / 12 VAL A 143
ILE A 166
PHE A 151
PHE A1081
MET A 154
 None
 1.45A 6j21A-5xeiA:
undetectable		 6j21A-5xeiA:
20.98