SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5xeo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AEG_A_4APA296_1
(CYTOCHROME C
PEROXIDASE)		 5xeo CYSTEINE SYNTHASE
(Fusobacterium
nucleatum) 		4 / 8 GLY A 179
GLY A 176
MET A 223
LEU A 208
 PLP  A 401 (-4.0A)
PLP  A 401 (-3.7A)
None
None
 0.67A 1aegA-5xeoA:
undetectable		 1aegA-5xeoA:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DTJ_B_THRB402_0
(ASPARTOKINASE)		 5xeo CYSTEINE SYNTHASE
(Fusobacterium
nucleatum) 		5 / 9 ILE A  59
ASP A  60
GLU A  54
ALA A  53
THR A  63
 None
 1.30A 2dtjA-5xeoA:
undetectable
2dtjB-5xeoA:
undetectable		 2dtjA-5xeoA:
undetectable
2dtjB-5xeoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJG_B_ADNB1502_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 5xeo CYSTEINE SYNTHASE
(Fusobacterium
nucleatum) 		4 / 7 GLU A 280
LYS A 284
ASN A  26
ALA A 282
 None
 1.46A 2ejgB-5xeoA:
undetectable		 2ejgB-5xeoA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1499_1
(CYTOCHROME P450 3A4)		 5xeo CYSTEINE SYNTHASE
(Fusobacterium
nucleatum) 		4 / 7 SER A 205
THR A 293
ILE A 213
GLY A 178
 None
PLP  A 401 (-3.4A)
None
PLP  A 401 (-3.3A)
 0.70A 2v0mB-5xeoA:
undetectable		 2v0mB-5xeoA:
10.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPD_B_SAMB1000_1
(UNCHARACTERIZED
PROTEIN MJ0100)		 5xeo CYSTEINE SYNTHASE
(Fusobacterium
nucleatum) 		3 / 3 ASN A 148
ASN A 141
GLU A  67
 PLP  A 401 ( 4.8A)
ACT  A 403 (-3.9A)
None
 0.79A 3kpdC-5xeoA:
undetectable		 3kpdC-5xeoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPD_C_SAMC1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 5xeo CYSTEINE SYNTHASE
(Fusobacterium
nucleatum) 		3 / 3 ASN A  12
ASN A  36
GLU A  33
 None
 0.93A 3kpdB-5xeoA:
undetectable		 3kpdB-5xeoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPD_C_SAMC1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 5xeo CYSTEINE SYNTHASE
(Fusobacterium
nucleatum) 		3 / 3 ASN A 148
ASN A 141
GLU A  67
 PLP  A 401 ( 4.8A)
ACT  A 403 (-3.9A)
None
 0.79A 3kpdB-5xeoA:
undetectable		 3kpdB-5xeoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DJF_B_C2FB300_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 5xeo CYSTEINE SYNTHASE
(Fusobacterium
nucleatum) 		5 / 12 MET A 252
PHE A 249
ASP A 294
ASN A  72
ILE A  75
 None
None
PLP  A 401 (-3.1A)
PLP  A 401 (-3.7A)
None
 1.49A 4djfB-5xeoA:
undetectable		 4djfB-5xeoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEU_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 5xeo CYSTEINE SYNTHASE
(Fusobacterium
nucleatum) 		4 / 8 ASP A 247
ASP A 246
ASP A 276
GLU A 280
 None
None
PEG  A 408 (-3.7A)
None
 1.04A 4feuD-5xeoA:
undetectable		 4feuD-5xeoA:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0U_F_ASWF101_1
(DNA TOPOISOMERASE
2-BETA)		 5xeo CYSTEINE SYNTHASE
(Fusobacterium
nucleatum) 		4 / 6 PRO A 199
GLY A 222
GLU A 201
GLN A 142
 None
 1.01A 4g0uA-5xeoA:
undetectable		 4g0uA-5xeoA:
8.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGF_B_ADNB502_2
(ADENOSYLHOMOCYSTEINA
SE)		 5xeo CYSTEINE SYNTHASE
(Fusobacterium
nucleatum) 		4 / 5 THR A 270
THR A 267
THR A 156
HIS A 152
 None
 1.38A 4pgfB-5xeoA:
2.6		 4pgfB-5xeoA:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YMG_A_SAMA1001_1
(PUTATIVE
SAM-DEPENDENT
O-METHYLTRANFERASE)		 5xeo CYSTEINE SYNTHASE
(Fusobacterium
nucleatum) 		4 / 4 SER A 266
SER A 292
GLU A 297
ASP A 294
 PLP  A 401 (-2.5A)
None
None
PLP  A 401 (-3.1A)
 1.43A 4ymgA-5xeoA:
3.5		 4ymgA-5xeoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JLC_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5xeo CYSTEINE SYNTHASE
(Fusobacterium
nucleatum) 		4 / 5 TYR A 232
GLY A 178
THR A 177
LEU A 241
 None
PLP  A 401 (-3.3A)
PLP  A 401 (-2.8A)
None
 0.75A 5jlcA-5xeoA:
undetectable		 5jlcA-5xeoA:
9.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_A_SUEA1202_0
(NS3 PROTEASE)		 5xeo CYSTEINE SYNTHASE
(Fusobacterium
nucleatum) 		5 / 12 GLY A 174
ARG A  39
ILE A 261
GLY A 268
SER A 266
 None
None
None
None
PLP  A 401 (-2.5A)
 1.13A 6c2mA-5xeoA:
undetectable		 6c2mA-5xeoA:
27.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_B_SUEB1202_0
(NS3 PROTEASE)		 5xeo CYSTEINE SYNTHASE
(Fusobacterium
nucleatum) 		5 / 12 GLY A 174
ARG A  39
ILE A 261
GLY A 268
SER A 266
 None
None
None
None
PLP  A 401 (-2.5A)
 1.07A 6c2mB-5xeoA:
undetectable		 6c2mB-5xeoA:
27.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_A_ACRA602_1
(-)		 5xeo CYSTEINE SYNTHASE
(Fusobacterium
nucleatum) 		5 / 12 GLY A 222
GLY A 176
PRO A 199
CYH A 173
GLY A 174
 None
PLP  A 401 (-3.7A)
None
None
None
 1.02A 6gneA-5xeoA:
3.2		 6gneA-5xeoA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_A_DCFA401_1
(ADENOSINE DEAMINASE)		 5xeo CYSTEINE SYNTHASE
(Fusobacterium
nucleatum) 		4 / 4 HIS A 216
LEU A 208
TYR A 232
GLY A 174
 None
 1.30A 6n91A-5xeoA:
undetectable		 6n91A-5xeoA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_B_DCFB401_1
(ADENOSINE DEAMINASE)		 5xeo CYSTEINE SYNTHASE
(Fusobacterium
nucleatum) 		4 / 4 HIS A 216
LEU A 208
TYR A 232
GLY A 174
 None
 1.30A 6n91B-5xeoA:
undetectable		 6n91B-5xeoA:
24.14