SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5xeq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG4_A_SAMA500_0
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 5xeq NEUROLIGIN-2
(Homo
sapiens) 		5 / 12 VAL A 507
GLY A 509
GLY A  64
ALA A 202
VAL A 209
 None
 1.12A 1jg4A-5xeqA:
undetectable		 1jg4A-5xeqA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RMT_A_ADNA1501_1
(CLASS B ACID
PHOSPHATASE)		 5xeq NEUROLIGIN-2
(Homo
sapiens) 		5 / 10 PHE A 196
LEU A 504
TRP A 122
GLY A 186
THR A 211
 None
 1.45A 1rmtA-5xeqA:
undetectable		 1rmtA-5xeqA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS7_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5xeq NEUROLIGIN-2
MAM
DOMAIN-CONTAINING
GLYCOSYLPHOSPHATIDYL
INOSITOL ANCHOR
PROTEIN 1
(Homo
sapiens;
Homo
sapiens) 		4 / 8 GLN A 343
PHE B 147
ASN A 109
ASP A 341
 None
 1.30A 1rs7B-5xeqA:
undetectable		 1rs7B-5xeqA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_A_IMNA379_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 5xeq MAM
DOMAIN-CONTAINING
GLYCOSYLPHOSPHATIDYL
INOSITOL ANCHOR
PROTEIN 1
(Homo
sapiens) 		5 / 12 THR B 237
PRO B 239
VAL B 153
VAL B 314
LEU B 155
 None
 1.37A 1z9hA-5xeqB:
undetectable		 1z9hA-5xeqB:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_B_IMNB381_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 5xeq MAM
DOMAIN-CONTAINING
GLYCOSYLPHOSPHATIDYL
INOSITOL ANCHOR
PROTEIN 1
(Homo
sapiens) 		5 / 12 THR B 237
PRO B 239
VAL B 153
VAL B 314
LEU B 155
 None
 1.36A 1z9hB-5xeqB:
undetectable		 1z9hB-5xeqB:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_C_IMNC379_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 5xeq MAM
DOMAIN-CONTAINING
GLYCOSYLPHOSPHATIDYL
INOSITOL ANCHOR
PROTEIN 1
(Homo
sapiens) 		5 / 12 THR B 237
PRO B 239
VAL B 153
VAL B 314
LEU B 155
 None
 1.37A 1z9hC-5xeqB:
undetectable		 1z9hC-5xeqB:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1O_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 5xeq MAM
DOMAIN-CONTAINING
GLYCOSYLPHOSPHATIDYL
INOSITOL ANCHOR
PROTEIN 1
(Homo
sapiens) 		4 / 8 TYR B 212
LEU B 201
VAL B 184
GLY B 183
 None
 0.93A 2a1oA-5xeqB:
undetectable		 2a1oA-5xeqB:
24.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B82_A_ADNA1001_1
(CLASS B ACID
PHOSPHATASE)		 5xeq NEUROLIGIN-2
(Homo
sapiens) 		5 / 10 PHE A 196
LEU A 504
TRP A 122
GLY A 186
THR A 211
 None
 1.46A 2b82A-5xeqA:
undetectable		 2b82A-5xeqA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_C_SAMC1003_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 5xeq NEUROLIGIN-2
(Homo
sapiens) 		4 / 4 ASP A 502
ASP A 497
ASP A 125
GLY A 387
 None
 1.38A 2igtC-5xeqA:
undetectable		 2igtC-5xeqA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_D_DVAD6_0
(GRAMICIDIN D)		 5xeq NEUROLIGIN-2
(Homo
sapiens) 		3 / 3 TRP A 460
ALA A 289
VAL A 382
 None
 0.88A 3l8lC-5xeqA:
undetectable
3l8lD-5xeqA:
undetectable		 3l8lC-5xeqA:
2.30
3l8lD-5xeqA:
5.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TF1_A_ACTA191_0
(METHYL-ACCEPTING
CHEMOTAXIS PROTEIN)		 5xeq NEUROLIGIN-2
(Homo
sapiens) 		4 / 5 THR A 430
ILE A 431
PHE A 600
LEU A 608
 None
 1.28A 3tf1A-5xeqA:
1.2		 3tf1A-5xeqA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_A_VIVA301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 5xeq MAM
DOMAIN-CONTAINING
GLYCOSYLPHOSPHATIDYL
INOSITOL ANCHOR
PROTEIN 1
(Homo
sapiens) 		5 / 12 VAL B 326
LEU B 250
ILE B 295
VAL B 260
LEU B 293
 None
 1.05A 3w68A-5xeqB:
undetectable		 3w68A-5xeqB:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_D_VIVD301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 5xeq MAM
DOMAIN-CONTAINING
GLYCOSYLPHOSPHATIDYL
INOSITOL ANCHOR
PROTEIN 1
(Homo
sapiens) 		5 / 12 VAL B 326
LEU B 250
ILE B 295
VAL B 260
LEU B 293
 None
 1.02A 3w68D-5xeqB:
undetectable		 3w68D-5xeqB:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1G_B_LNLB701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5xeq NEUROLIGIN-2
(Homo
sapiens) 		5 / 12 ILE A 380
GLY A 265
ALA A 266
SER A 269
LEU A 273
 None
 1.02A 4e1gB-5xeqA:
undetectable		 4e1gB-5xeqA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K0B_B_SAMB504_1
(S-ADENOSYLMETHIONINE
SYNTHASE)		 5xeq MAM
DOMAIN-CONTAINING
GLYCOSYLPHOSPHATIDYL
INOSITOL ANCHOR
PROTEIN 1
(Homo
sapiens) 		4 / 8 ASP B 208
ALA B 210
TYR B 212
ASP B 181
 None
 1.03A 4k0bB-5xeqB:
undetectable		 4k0bB-5xeqB:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L7I_B_SAMB501_1
(S-ADENOSYLMETHIONINE
SYNTHASE)		 5xeq MAM
DOMAIN-CONTAINING
GLYCOSYLPHOSPHATIDYL
INOSITOL ANCHOR
PROTEIN 1
(Homo
sapiens) 		4 / 8 ASP B 208
ALA B 210
TYR B 212
ASP B 181
 None
 1.03A 4l7iB-5xeqB:
undetectable		 4l7iB-5xeqB:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_A_IPHA101_0
(INSULIN)		 5xeq NEUROLIGIN-2
(Homo
sapiens) 		5 / 10 LEU A 245
LEU A 242
ALA A 241
LEU A 183
LEU A 144
 None
 1.24A 4p65A-5xeqA:
undetectable
4p65B-5xeqA:
undetectable
4p65F-5xeqA:
undetectable
4p65H-5xeqA:
undetectable		 4p65A-5xeqA:
3.38
4p65B-5xeqA:
5.02
4p65F-5xeqA:
5.02
4p65H-5xeqA:
5.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_G_IPHG101_0
(INSULIN)		 5xeq NEUROLIGIN-2
(Homo
sapiens) 		5 / 11 LEU A 144
LEU A 183
LEU A 245
LEU A 242
ALA A 241
 None
 1.09A 4p65B-5xeqA:
undetectable
4p65D-5xeqA:
undetectable
4p65G-5xeqA:
undetectable
4p65H-5xeqA:
undetectable		 4p65B-5xeqA:
5.02
4p65D-5xeqA:
5.02
4p65G-5xeqA:
3.38
4p65H-5xeqA:
5.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QKN_A_JMSA602_1
(ALPHA-KETOGLUTARATE-
DEPENDENT
DIOXYGENASE FTO)		 5xeq NEUROLIGIN-2
(Homo
sapiens) 		4 / 8 PRO A 364
LEU A 235
VAL A 300
SER A 299
 None
 1.22A 4qknA-5xeqA:
undetectable		 4qknA-5xeqA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_B_032B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 5xeq MAM
DOMAIN-CONTAINING
GLYCOSYLPHOSPHATIDYL
INOSITOL ANCHOR
PROTEIN 1
(Homo
sapiens) 		4 / 5 PHE B 231
SER B 177
HIS B 178
ASP B 208
 None
 1.33A 4rzvB-5xeqB:
undetectable		 4rzvB-5xeqB:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WQ5_B_ACTB404_0
(TRNA N6-ADENOSINE
THREONYLCARBAMOYLTRA
NSFERASE)		 5xeq NEUROLIGIN-2
(Homo
sapiens) 		3 / 3 TYR A 435
ARG A 594
LYS A 597
 None
 1.38A 4wq5B-5xeqA:
undetectable		 4wq5B-5xeqA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_F_SAMF301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 5xeq NEUROLIGIN-2
(Homo
sapiens) 		6 / 12 GLY A 234
GLY A 220
GLY A 217
LEU A 216
ALA A 241
LEU A 183
 None
 1.49A 5c0oF-5xeqA:
undetectable		 5c0oF-5xeqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E26_D_PAUD601_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)		 5xeq NEUROLIGIN-2
(Homo
sapiens) 		4 / 8 VAL A 507
GLY A 501
SER A 291
GLY A 265
 None
 0.85A 5e26C-5xeqA:
undetectable
5e26D-5xeqA:
undetectable		 5e26C-5xeqA:
20.86
5e26D-5xeqA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JMN_C_FUAC1101_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 5xeq NEUROLIGIN-2
(Homo
sapiens) 		3 / 3 VAL A 148
HIS A 251
VAL A  44
 None
 0.67A 5jmnC-5xeqA:
undetectable		 5jmnC-5xeqA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V4V_A_NCAA402_0
(NADPH DEHYDROGENASE
3)		 5xeq NEUROLIGIN-2
(Homo
sapiens) 		4 / 8 HIS A 184
ASN A 213
PRO A 103
TYR A 147
 None
 1.06A 5v4vA-5xeqA:
2.1		 5v4vA-5xeqA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V4V_B_NCAB402_0
(NADPH DEHYDROGENASE
3)		 5xeq NEUROLIGIN-2
(Homo
sapiens) 		4 / 8 HIS A 184
ASN A 213
PRO A 103
TYR A 147
 None
 1.05A 5v4vB-5xeqA:
2.2		 5v4vB-5xeqA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_A_SAMA902_1
(MRNA CAPPING ENZYME
P5)		 5xeq NEUROLIGIN-2
(Homo
sapiens) 		3 / 3 TYR A 479
ASP A 377
ASP A 546
 None
 0.79A 5x6yA-5xeqA:
undetectable		 5x6yA-5xeqA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G2P_B_TRPB502_0
(FLAVIN-DEPENDENT
L-TRYPTOPHAN OXIDASE
VIOA)		 5xeq MAM
DOMAIN-CONTAINING
GLYCOSYLPHOSPHATIDYL
INOSITOL ANCHOR
PROTEIN 1
(Homo
sapiens) 		5 / 10 LEU B 201
LEU B 204
TYR B 209
ASP B 208
VAL B 153
 None
 1.42A 6g2pB-5xeqB:
undetectable		 6g2pB-5xeqB:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_C_FK5C201_0
(PEPTIDYLPROLYL
ISOMERASE)		 5xeq MAM
DOMAIN-CONTAINING
GLYCOSYLPHOSPHATIDYL
INOSITOL ANCHOR
PROTEIN 1
(Homo
sapiens) 		4 / 4 ASP B 130
ILE B 224
PRO B 225
LEU B 129
 None
 1.33A 6mkeB-5xeqB:
undetectable		 6mkeB-5xeqB:
9.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_D_FK5D201_0
(PEPTIDYLPROLYL
ISOMERASE)		 5xeq MAM
DOMAIN-CONTAINING
GLYCOSYLPHOSPHATIDYL
INOSITOL ANCHOR
PROTEIN 1
(Homo
sapiens) 		4 / 4 ASP B 130
ILE B 224
PRO B 225
LEU B 129
 None
 1.33A 6mkeA-5xeqB:
undetectable		 6mkeA-5xeqB:
9.72