SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5xex'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X7P_B_SAMB302_0
(RRNA
METHYLTRANSFERASE)		 5xex POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE
(Staphylococcus
aureus) 		5 / 10 GLY A 501
GLY A 467
ILE A 461
MET A 455
ALA A 463
 None
 1.13A 1x7pA-5xexA:
undetectable
1x7pB-5xexA:
undetectable		 1x7pA-5xexA:
18.25
1x7pB-5xexA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z35_A_2FAA300_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 5xex POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE
(Staphylococcus
aureus) 		5 / 10 GLY A 345
THR A 544
VAL A 335
GLU A 334
SER A 356
 None
 1.49A 1z35A-5xexA:
undetectable		 1z35A-5xexA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVS_B_MK1B902_3
(POL POLYPROTEIN)		 5xex POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE
(Staphylococcus
aureus) 		5 / 12 GLY A 192
ALA A 193
GLY A 155
VAL A 154
ILE A 196
 None
 0.91A 2avsB-5xexA:
undetectable		 2avsB-5xexA:
10.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8G_B_017B401_1
(POL POLYPROTEIN)		 5xex POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE
(Staphylococcus
aureus) 		5 / 12 GLY A 192
ALA A 193
GLY A 155
VAL A 154
ILE A 196
 None
 0.88A 2f8gA-5xexA:
undetectable		 2f8gA-5xexA:
10.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R2V_D_ACTD36_0
(GCN4 LEUCINE ZIPPER)		 5xex POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE
(Staphylococcus
aureus) 		3 / 3 SER A 433
TYR A 384
HIS A 383
 None
 0.74A 2r2vD-5xexA:
undetectable		 2r2vD-5xexA:
6.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_G_BEZG1222_0
(PEROXIREDOXIN 6.)		 5xex POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE
(Staphylococcus
aureus) 		4 / 8 VAL A  40
GLU A  65
ALA A  69
PRO A 126
 None
 1.10A 2v41G-5xexA:
undetectable
2v41H-5xexA:
undetectable		 2v41G-5xexA:
18.72
2v41H-5xexA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYX_A_ROCA201_3
(HIV-1 PROTEASE)		 5xex POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE
(Staphylococcus
aureus) 		5 / 12 GLY A 192
ALA A 193
GLY A 155
VAL A 154
ILE A 196
 None
 0.83A 3cyxB-5xexA:
undetectable		 3cyxB-5xexA:
10.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZU_A_9CRA7223_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5xex POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE
(Staphylococcus
aureus) 		5 / 12 ILE A 132
ALA A 150
ILE A 222
PHE A 218
LEU A 215
 None
 1.07A 3dzuA-5xexA:
undetectable		 3dzuA-5xexA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_A_TOPA200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 5xex POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE
(Staphylococcus
aureus) 		5 / 10 MET A 511
LEU A 177
ALA A 193
ILE A 506
LEU A 527
 None
 1.20A 3fl9A-5xexA:
undetectable		 3fl9A-5xexA:
14.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_F_TOPF200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 5xex POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE
(Staphylococcus
aureus) 		5 / 10 MET A 511
LEU A 177
ALA A 193
ILE A 506
LEU A 527
 None
 1.18A 3fl9F-5xexA:
undetectable		 3fl9F-5xexA:
14.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK6_B_HCZB800_1
(GLUTAMATE RECEPTOR 2)		 5xex POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE
(Staphylococcus
aureus) 		5 / 10 SER A 441
LEU A 331
ILE A 537
SER A 446
GLY A 467
 PPV  A 603 (-2.7A)
None
None
None
None
 1.11A 3ik6B-5xexA:
undetectable
3ik6E-5xexA:
undetectable		 3ik6B-5xexA:
17.67
3ik6E-5xexA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Y_B_SALB900_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 5xex POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE
(Staphylococcus
aureus) 		4 / 5 LEU A  59
TYR A 107
ILE A 143
ALA A  47
 None
 1.01A 3n8yB-5xexA:
undetectable		 3n8yB-5xexA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU5_B_478B401_2
(PROTEASE)		 5xex POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE
(Staphylococcus
aureus) 		5 / 12 GLY A 192
ALA A 193
GLY A 155
VAL A 154
ILE A 196
 None
 0.76A 3nu5B-5xexA:
undetectable		 3nu5B-5xexA:
10.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXV_B_478B200_1
(HIV-1 PROTEASE)		 5xex POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE
(Staphylococcus
aureus) 		5 / 9 GLY A 192
ALA A 193
GLY A 155
VAL A 154
ILE A 196
 None
 0.79A 3oxvA-5xexA:
undetectable		 3oxvA-5xexA:
10.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXV_C_478C200_1
(HIV-1 PROTEASE)		 5xex POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE
(Staphylococcus
aureus) 		5 / 9 GLY A 192
ALA A 193
GLY A 155
VAL A 154
ILE A 196
 None
 0.75A 3oxvC-5xexA:
undetectable		 3oxvC-5xexA:
10.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXX_A_DR7A100_1
(HIV-1 PROTEASE)		 5xex POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE
(Staphylococcus
aureus) 		5 / 12 GLY A 192
ALA A 193
GLY A 155
VAL A 154
ILE A 196
 None
 0.91A 3oxxA-5xexA:
undetectable		 3oxxA-5xexA:
10.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XJE_A_TOYA202_1
(AADB)		 5xex POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE
(Staphylococcus
aureus) 		4 / 8 ASP A 121
ASP A 123
GLU A 169
ILE A 162
 None
 0.98A 4xjeA-5xexA:
undetectable		 4xjeA-5xexA:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CFS_A_TOYA203_1
(AAD(2''),GENTAMICIN
2''-NUCLEOTIDYLTRANS
FERASE,GENTAMICIN
RESISTANCE PROTEIN)		 5xex POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE
(Staphylococcus
aureus) 		4 / 8 ASP A 121
ASP A 123
GLU A 169
ILE A 162
 None
 0.96A 5cfsA-5xexA:
undetectable		 5cfsA-5xexA:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FPD_A_PZAA1385_0
(HEAT SHOCK-RELATED
70KDA PROTEIN 2)		 5xex POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE
(Staphylococcus
aureus) 		4 / 7 VAL A 140
SER A 139
GLY A 133
VAL A  32
 None
 0.81A 5fpdA-5xexA:
undetectable		 5fpdA-5xexA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_A_ADNA501_2
(ADENOSYLHOMOCYSTEINA
SE)		 5xex POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE
(Staphylococcus
aureus) 		4 / 5 GLU A 504
THR A 502
GLU A 198
LEU A 175
 None
 1.25A 5hm8A-5xexA:
undetectable		 5hm8A-5xexA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_B_ADNB501_2
(ADENOSYLHOMOCYSTEINA
SE)		 5xex POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE
(Staphylococcus
aureus) 		4 / 5 GLU A 504
THR A 502
GLU A 198
LEU A 175
 None
 1.25A 5hm8B-5xexA:
undetectable		 5hm8B-5xexA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_C_ADNC501_2
(ADENOSYLHOMOCYSTEINA
SE)		 5xex POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE
(Staphylococcus
aureus) 		4 / 5 GLU A 504
THR A 502
GLU A 198
LEU A 175
 None
 1.25A 5hm8C-5xexA:
undetectable		 5hm8C-5xexA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_D_ADND501_2
(ADENOSYLHOMOCYSTEINA
SE)		 5xex POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE
(Staphylococcus
aureus) 		4 / 5 GLU A 504
THR A 502
GLU A 198
LEU A 175
 None
 1.25A 5hm8D-5xexA:
undetectable		 5hm8D-5xexA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_E_ADNE501_2
(ADENOSYLHOMOCYSTEINA
SE)		 5xex POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE
(Staphylococcus
aureus) 		4 / 5 GLU A 504
THR A 502
GLU A 198
LEU A 175
 None
 1.25A 5hm8E-5xexA:
undetectable		 5hm8E-5xexA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_F_ADNF501_2
(ADENOSYLHOMOCYSTEINA
SE)		 5xex POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE
(Staphylococcus
aureus) 		4 / 5 GLU A 504
THR A 502
GLU A 198
LEU A 175
 None
 1.25A 5hm8F-5xexA:
undetectable		 5hm8F-5xexA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_G_ADNG501_2
(ADENOSYLHOMOCYSTEINA
SE)		 5xex POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE
(Staphylococcus
aureus) 		4 / 5 GLU A 504
THR A 502
GLU A 198
LEU A 175
 None
 1.27A 5hm8G-5xexA:
2.5		 5hm8G-5xexA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_H_ADNH501_2
(ADENOSYLHOMOCYSTEINA
SE)		 5xex POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE
(Staphylococcus
aureus) 		4 / 5 GLU A 504
THR A 502
GLU A 198
LEU A 175
 None
 1.25A 5hm8H-5xexA:
undetectable		 5hm8H-5xexA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J4N_A_AG2A501_1
(ARGININE/AGMATINE
ANTIPORTER)		 5xex POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE
(Staphylococcus
aureus) 		4 / 6 SER A 125
GLY A 151
MET A 128
ILE A 163
 None
 1.15A 5j4nA-5xexA:
undetectable		 5j4nA-5xexA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MSD_A_BEZA1202_0
(CARBOXYLIC ACID
REDUCTASE)		 5xex POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE
(Staphylococcus
aureus) 		4 / 5 HIS A 382
ILE A 431
SER A 446
ALA A 453
 None
 0.93A 5msdA-5xexA:
undetectable		 5msdA-5xexA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NM5_B_LOCB502_2
(TUBULIN BETA-2B
CHAIN)		 5xex POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE
(Staphylococcus
aureus) 		5 / 12 LEU A 202
LEU A 177
ALA A 204
ILE A 509
ALA A 191
 None
 1.34A 5nm5B-5xexA:
undetectable		 5nm5B-5xexA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OM2_B_DXTB501_1
(ALPHA-1-ANTICHYMOTRY
PSIN)		 5xex POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE
(Staphylococcus
aureus) 		5 / 9 VAL A 246
ALA A 299
ASP A  55
VAL A 279
ILE A 278
 None
 1.11A 5om2A-5xexA:
0.1
5om2B-5xexA:
undetectable		 5om2A-5xexA:
9.12
5om2B-5xexA:
6.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V02_R_657R201_0
(CALMODULIN-1
SMALL CONDUCTANCE
CALCIUM-ACTIVATED
POTASSIUM CHANNEL
PROTEIN 2)		 5xex POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE
(Staphylococcus
aureus) 		5 / 10 ALA A 150
LEU A 215
VAL A 216
LEU A  17
ILE A  19
 None
 1.11A 5v02B-5xexA:
undetectable
5v02R-5xexA:
undetectable		 5v02B-5xexA:
10.38
5v02R-5xexA:
14.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5xex POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE
(Staphylococcus
aureus) 		4 / 5 ILE A 523
PHE A 497
ARG A 531
THR A 197
 None
 1.23A 5z84N-5xexA:
undetectable
5z84W-5xexA:
undetectable		 5z84N-5xexA:
21.93
5z84W-5xexA:
6.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH6_A_017A104_0
(PROTEASE)		 5xex POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE
(Staphylococcus
aureus) 		5 / 12 GLY A 192
ALA A 193
GLY A 155
VAL A 154
ILE A 196
 None
 0.85A 6dh6A-5xexA:
undetectable		 6dh6A-5xexA:
9.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MA7_A_TPFA602_0
(CYTOCHROME P450 3A4)		 5xex POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE
(Staphylococcus
aureus) 		4 / 7 ALA A 466
THR A 451
ILE A 461
ALA A 463
 None
 0.83A 6ma7A-5xexA:
undetectable		 6ma7A-5xexA:
10.67