SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5xey'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J36_A_LPRA801_1
(ANGIOTENSIN
CONVERTING ENZYME)		 5xey PHLORETIN HYDROLASE
(Mycobacteroides
abscessus) 		5 / 12 HIS A 133
GLU A 164
HIS A 269
GLU A 273
HIS A 217
 None
 1.44A 1j36A-5xeyA:
undetectable		 1j36A-5xeyA:
7.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J36_B_LPRB802_1
(ANGIOTENSIN
CONVERTING ENZYME)		 5xey PHLORETIN HYDROLASE
(Mycobacteroides
abscessus) 		5 / 12 HIS A 133
GLU A 164
HIS A 269
GLU A 273
HIS A 217
 None
 1.43A 1j36B-5xeyA:
undetectable		 1j36B-5xeyA:
7.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J37_A_X8ZA801_1
(ANGIOTENSIN
CONVERTING ENZYME)		 5xey PHLORETIN HYDROLASE
(Mycobacteroides
abscessus) 		5 / 11 HIS A 133
GLU A 164
HIS A 269
GLU A 273
HIS A 217
 None
 1.42A 1j37A-5xeyA:
undetectable		 1j37A-5xeyA:
7.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J37_A_X8ZA801_1
(ANGIOTENSIN
CONVERTING ENZYME)		 5xey PHLORETIN HYDROLASE
(Mycobacteroides
abscessus) 		5 / 11 HIS A 217
HIS A 269
GLU A 273
HIS A 133
GLU A 164
 None
 1.26A 1j37A-5xeyA:
undetectable		 1j37A-5xeyA:
7.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J37_B_X8ZB802_1
(ANGIOTENSIN
CONVERTING ENZYME)		 5xey PHLORETIN HYDROLASE
(Mycobacteroides
abscessus) 		5 / 11 HIS A 133
GLU A 164
HIS A 269
GLU A 273
HIS A 217
 None
 1.42A 1j37B-5xeyA:
undetectable		 1j37B-5xeyA:
7.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J37_B_X8ZB802_1
(ANGIOTENSIN
CONVERTING ENZYME)		 5xey PHLORETIN HYDROLASE
(Mycobacteroides
abscessus) 		5 / 11 HIS A 217
HIS A 269
GLU A 273
HIS A 133
GLU A 164
 None
 1.25A 1j37B-5xeyA:
undetectable		 1j37B-5xeyA:
7.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O86_A_LPRA702_1
(ANGIOTENSIN
CONVERTING ENZYME)		 5xey PHLORETIN HYDROLASE
(Mycobacteroides
abscessus) 		5 / 12 HIS A 133
GLU A 164
HIS A 269
GLU A 273
HIS A 217
 None
 1.47A 1o86A-5xeyA:
undetectable		 1o86A-5xeyA:
9.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O86_A_LPRA702_1
(ANGIOTENSIN
CONVERTING ENZYME)		 5xey PHLORETIN HYDROLASE
(Mycobacteroides
abscessus) 		5 / 12 HIS A 217
HIS A 269
GLU A 273
HIS A 133
GLU A 164
 None
 1.14A 1o86A-5xeyA:
undetectable		 1o86A-5xeyA:
9.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XIH_A_SORA389_0
(D-XYLOSE ISOMERASE)		 5xey PHLORETIN HYDROLASE
(Mycobacteroides
abscessus) 		5 / 12 HIS A 217
PHE A 115
TRP A 128
GLU A 164
HIS A 133
 None
 1.20A 1xihA-5xeyA:
undetectable		 1xihA-5xeyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_A_LPRA705_1
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		 5xey PHLORETIN HYDROLASE
(Mycobacteroides
abscessus) 		6 / 12 HIS A 217
GLN A 271
HIS A 269
GLU A 273
HIS A 133
GLU A 164
 None
 1.27A 2c6nA-5xeyA:
undetectable		 2c6nA-5xeyA:
10.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_B_LPRB705_1
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		 5xey PHLORETIN HYDROLASE
(Mycobacteroides
abscessus) 		5 / 12 HIS A 217
HIS A 269
GLU A 273
HIS A 133
GLU A 164
 None
 1.21A 2c6nB-5xeyA:
undetectable		 2c6nB-5xeyA:
10.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X8Z_A_X8ZA1615_1
(ANGIOTENSIN
CONVERTING ENZYME)		 5xey PHLORETIN HYDROLASE
(Mycobacteroides
abscessus) 		5 / 11 HIS A 133
GLU A 164
HIS A 269
GLU A 273
HIS A 217
 None
 1.41A 2x8zA-5xeyA:
undetectable		 2x8zA-5xeyA:
7.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X8Z_A_X8ZA1615_1
(ANGIOTENSIN
CONVERTING ENZYME)		 5xey PHLORETIN HYDROLASE
(Mycobacteroides
abscessus) 		5 / 11 HIS A 217
HIS A 269
GLU A 273
HIS A 133
GLU A 164
 None
 1.21A 2x8zA-5xeyA:
undetectable		 2x8zA-5xeyA:
7.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGN_A_ACTA1181_0
(WNT INHIBITORY
FACTOR 1)		 5xey PHLORETIN HYDROLASE
(Mycobacteroides
abscessus) 		3 / 3 TYR A  17
VAL A  45
THR A  15
 None
 0.61A 2ygnA-5xeyA:
undetectable		 2ygnA-5xeyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 5xey PHLORETIN HYDROLASE
(Mycobacteroides
abscessus) 		4 / 5 ILE A 166
TYR A 232
MET A 215
THR A 214
 None
 1.45A 3abkN-5xeyA:
undetectable
3abkW-5xeyA:
undetectable		 3abkN-5xeyA:
undetectable
3abkW-5xeyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TOP_A_ACRA1_1
(MALTASE-GLUCOAMYLASE
, INTESTINAL)		 5xey PHLORETIN HYDROLASE
(Mycobacteroides
abscessus) 		5 / 12 ASP A 270
ILE A 162
PHE A 115
PHE A 111
HIS A 118
 None
 1.16A 3topA-5xeyA:
undetectable		 3topA-5xeyA:
7.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C2P_A_X8ZA709_1
(ANGIOTENSIN-CONVERTI
NG ENZYME)		 5xey PHLORETIN HYDROLASE
(Mycobacteroides
abscessus) 		5 / 11 HIS A 133
GLU A 164
HIS A 269
GLU A 273
HIS A 217
 None
 1.42A 4c2pA-5xeyA:
undetectable		 4c2pA-5xeyA:
9.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C2P_A_X8ZA709_1
(ANGIOTENSIN-CONVERTI
NG ENZYME)		 5xey PHLORETIN HYDROLASE
(Mycobacteroides
abscessus) 		5 / 11 HIS A 217
HIS A 269
GLU A 273
HIS A 133
GLU A 164
 None
 1.23A 4c2pA-5xeyA:
undetectable		 4c2pA-5xeyA:
9.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZDY_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5xey PHLORETIN HYDROLASE
(Mycobacteroides
abscessus) 		5 / 12 GLY A 225
PHE A 177
ILE A 175
LEU A 277
THR A 107
 None
 1.08A 4zdyA-5xeyA:
undetectable		 4zdyA-5xeyA:
10.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_G_ADNG501_2
(ADENOSYLHOMOCYSTEINA
SE)		 5xey PHLORETIN HYDROLASE
(Mycobacteroides
abscessus) 		4 / 5 GLU A  62
GLU A  71
THR A  67
LEU A  90
 None
 1.23A 5hm8G-5xeyA:
undetectable		 5hm8G-5xeyA:
11.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M10_A_NCAA603_0
(CYCLOHEXANONE
MONOOXYGENASE FROM
THERMOCRISPUM
MUNICIPALE)		 5xey PHLORETIN HYDROLASE
(Mycobacteroides
abscessus) 		4 / 5 LEU A  72
ARG A 231
LEU A 218
TRP A 233
 None
 1.46A 5m10A-5xeyA:
undetectable		 5m10A-5xeyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_A_ERMA2001_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 5xey PHLORETIN HYDROLASE
(Mycobacteroides
abscessus) 		5 / 12 ASP A 270
SER A 230
ALA A 199
PHE A 103
PHE A 111
 None
 1.14A 5tudA-5xeyA:
undetectable		 5tudA-5xeyA:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_ACTA813_0
(GEPHYRIN)		 5xey PHLORETIN HYDROLASE
(Mycobacteroides
abscessus) 		3 / 3 THR A  85
ALA A  54
LYS A  56
 None
 0.77A 6fgcA-5xeyA:
undetectable		 6fgcA-5xeyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA817_0
(GEPHYRIN)		 5xey PHLORETIN HYDROLASE
(Mycobacteroides
abscessus) 		3 / 3 THR A  85
ALA A  54
LYS A  56
 None
 0.74A 6fgdA-5xeyA:
undetectable		 6fgdA-5xeyA:
undetectable