SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5xez'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_U_9CRU502_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5xez GLUCAGON
RECEPTOR,ENDOLYSIN,G
LUCAGON RECEPTOR
(Escherichia
virus
T4;
Homo
sapiens) 		5 / 12 ALA A 397
LEU A 156
ALA A 155
ILE A 235
LEU A 358
 None
 0.78A 1fm6U-5xezA:
undetectable		 1fm6U-5xezA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG4_A_SAMA500_0
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 5xez GLUCAGON
RECEPTOR,ENDOLYSIN,G
LUCAGON RECEPTOR
(Homo
sapiens;
Escherichia
virus
T4) 		5 / 12 GLY A 359
GLY A 246
ALA A 314
VAL A 311
LEU A 243
 None
 1.11A 1jg4A-5xezA:
undetectable		 1jg4A-5xezA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_B_DESB459_2
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 5xez GLUCAGON
RECEPTOR,ENDOLYSIN,G
LUCAGON RECEPTOR
(Escherichia
virus
T4;
Homo
sapiens) 		3 / 3 LEU A 242
HIS A 177
ILE A 176
 None
 0.59A 1s9pB-5xezA:
undetectable		 1s9pB-5xezA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDS_B_SAMB9635_0
(PROTEIN RDMB)		 5xez GLUCAGON
RECEPTOR,ENDOLYSIN,G
LUCAGON RECEPTOR
(Homo
sapiens;
Escherichia
virus
T4) 		5 / 12 GLY A 164
GLY A 165
LEU A 160
SER A 167
ASN A 174
 None
 1.09A 1xdsB-5xezA:
undetectable		 1xdsB-5xezA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACL_A_REAA502_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5xez GLUCAGON
RECEPTOR,ENDOLYSIN,G
LUCAGON RECEPTOR
(Escherichia
virus
T4;
Homo
sapiens) 		5 / 12 ALA A1129
PHE A1153
LEU A1133
ALA A1130
ILE A1078
 None
 1.03A 2aclA-5xezA:
2.8
2aclE-5xezA:
undetectable		 2aclA-5xezA:
17.62
2aclE-5xezA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E1Q_C_SALC4006_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 5xez GLUCAGON
RECEPTOR,ENDOLYSIN,G
LUCAGON RECEPTOR
(Escherichia
virus
T4;
Homo
sapiens) 		4 / 6 PHE A1153
VAL A1087
LEU A1118
ALA A1129
 None
 1.04A 2e1qC-5xezA:
undetectable		 2e1qC-5xezA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CWK_A_REAA300_1
(CELLULAR RETINOIC
ACID-BINDING PROTEIN
2)		 5xez GLUCAGON
RECEPTOR,ENDOLYSIN,G
LUCAGON RECEPTOR
(Escherichia
virus
T4;
Homo
sapiens) 		5 / 12 PHE A 181
LEU A 395
ALA A 397
ALA A 159
VAL A 407
 None
 1.10A 3cwkA-5xezA:
undetectable		 3cwkA-5xezA:
12.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DL9_A_V2HA602_1
(CYTOCHROME P450 2R1)		 5xez GLUCAGON
RECEPTOR,ENDOLYSIN,G
LUCAGON RECEPTOR
(Homo
sapiens;
Escherichia
virus
T4) 		4 / 5 ASN A 404
ALA A 178
LEU A 156
THR A 353
 97V  A1208 (-2.9A)
None
None
97V  A1208 (-3.3A)
 0.77A 3dl9A-5xezA:
undetectable		 3dl9A-5xezA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_B_715B801_2
(DIPEPTIDYL PEPTIDASE
4)		 5xez GLUCAGON
RECEPTOR,ENDOLYSIN,G
LUCAGON RECEPTOR
(Escherichia
virus
T4;
Homo
sapiens) 		3 / 3 ARG A 413
TYR A 343
ASN A 174
 None
 0.87A 4ffwB-5xezA:
undetectable		 4ffwB-5xezA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NQA_H_9CRH501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5xez GLUCAGON
RECEPTOR,ENDOLYSIN,G
LUCAGON RECEPTOR
(Escherichia
virus
T4;
Homo
sapiens) 		5 / 12 ALA A 397
LEU A 156
ALA A 155
ILE A 235
LEU A 358
 None
 0.98A 4nqaH-5xezA:
undetectable		 4nqaH-5xezA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1Z_A_MXMA807_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 5xez GLUCAGON
RECEPTOR,ENDOLYSIN,G
LUCAGON RECEPTOR
(Escherichia
virus
T4;
Homo
sapiens) 		4 / 6 VAL A 396
LEU A 395
LEU A 358
MET A 231
 None
 1.03A 4o1zA-5xezA:
undetectable		 4o1zA-5xezA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_B_SUEB1202_1
(NS3 PROTEASE)		 5xez GLUCAGON
RECEPTOR,ENDOLYSIN,G
LUCAGON RECEPTOR
(Homo
sapiens;
Escherichia
virus
T4) 		5 / 9 VAL A 396
LEU A 153
ALA A 188
VAL A 191
SER A 190
 None
 1.36A 6c2mB-5xezA:
undetectable		 6c2mB-5xezA:
9.66