SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5xfl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_A_ACTA1869_0
(FPRA)		 5xfl CATENIN ALPHA-2
(Mus
musculus) 		4 / 4 ASP A 386
HIS A 516
ARG A 324
GLU A 519
 None
 1.49A 1lqtA-5xflA:
undetectable		 1lqtA-5xflA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 5xfl CATENIN ALPHA-2
(Mus
musculus) 		4 / 6 ILE A 517
ARG A 584
MET A 582
LEU A 577
 None
 1.00A 2einN-5xflA:
5.0
2einW-5xflA:
undetectable		 2einN-5xflA:
undetectable
2einW-5xflA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_B_SAMB500_1
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 5xfl CATENIN ALPHA-2
(Mus
musculus) 		4 / 6 THR A 504
ASP A 386
THR A 323
ASP A 326
 None
 1.23A 2okcB-5xflA:
undetectable		 2okcB-5xflA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BUR_B_TESB340_1
(3-OXO-5-BETA-STEROID
4-DEHYDROGENASE)		 5xfl CATENIN ALPHA-2
(Mus
musculus) 		5 / 10 ILE A 553
SER A 439
ASN A 441
VAL A 445
VAL A 448
 None
 1.26A 3burB-5xflA:
undetectable		 3burB-5xflA:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CKZ_A_ZMRA469_2
(NEURAMINIDASE)		 5xfl CATENIN ALPHA-2
(Mus
musculus) 		4 / 6 ASP A 534
ARG A 538
ILE A 593
SER A 597
 None
 1.36A 3ckzA-5xflA:
undetectable		 3ckzA-5xflA:
12.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E9X_A_NIMA1_1
(LACTOTRANSFERRIN')		 5xfl CATENIN ALPHA-2
(Mus
musculus) 		4 / 4 GLU A 562
GLY A 564
THR A 567
GLU A 568
 None
 1.22A 3e9xA-5xflA:
undetectable		 3e9xA-5xflA:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_C_SAMC300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 5xfl CATENIN ALPHA-2
(Mus
musculus) 		5 / 12 LEU A 316
GLY A 313
SER A 312
LEU A 380
ALA A 333
 None
 1.30A 3ou6C-5xflA:
undetectable		 3ou6C-5xflA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_C_SAMC300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 5xfl CATENIN ALPHA-2
(Mus
musculus) 		5 / 12 LEU A 316
GLY A 313
SER A 312
LEU A 380
ALA A 333
 None
 1.31A 3ou7C-5xflA:
undetectable		 3ou7C-5xflA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9T_A_BEZA264_0
(ECHA1_1)		 5xfl CATENIN ALPHA-2
(Mus
musculus) 		4 / 8 ALA A 418
ILE A 463
ALA A 406
ALA A 405
 None
 0.69A 3r9tA-5xflA:
undetectable		 3r9tA-5xflA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VLN_A_ASCA904_0
(GLUTATHIONE
S-TRANSFERASE
OMEGA-1)		 5xfl CATENIN ALPHA-2
(Mus
musculus) 		4 / 6 PHE A 299
ARG A 298
LEU A 303
PRO A 301
 None
 1.41A 3vlnA-5xflA:
undetectable		 3vlnA-5xflA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5xfl CATENIN ALPHA-2
(Mus
musculus) 		4 / 6 ILE A 517
ARG A 584
MET A 582
LEU A 577
 None
 1.03A 3wg7N-5xflA:
undetectable
3wg7W-5xflA:
undetectable		 3wg7N-5xflA:
undetectable
3wg7W-5xflA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZB_E_ACTE403_0
(PROTON-GATED ION
CHANNEL)		 5xfl CATENIN ALPHA-2
(Mus
musculus) 		3 / 3 ARG A 624
TYR A 617
GLU A 514
 None
 0.64A 4zzbE-5xflA:
5.6		 4zzbE-5xflA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODQ_A_ACTA703_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)		 5xfl CATENIN ALPHA-2
(Mus
musculus) 		4 / 6 ARG A 549
ARG A 546
ALA A 547
PHE A 509
 None
 1.13A 5odqA-5xflA:
undetectable		 5odqA-5xflA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OS7_A_ACTA402_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 5xfl CATENIN ALPHA-2
(Mus
musculus) 		3 / 3 HIS A 387
SER A 391
LYS A 427
 None
 1.47A 5os7A-5xflA:
undetectable		 5os7A-5xflA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UH6_C_RFPC1201_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 5xfl CATENIN ALPHA-2
(Mus
musculus) 		5 / 12 ASP A 386
HIS A 387
SER A 437
ILE A 438
HIS A 516
 None
 1.45A 5uh6C-5xflA:
undetectable		 5uh6C-5xflA:
5.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WM2_A_ACTA605_0
(SALICYLATE-AMP
LIGASE)		 5xfl CATENIN ALPHA-2
(Mus
musculus) 		3 / 3 THR A 370
THR A 373
ARG A 377
 None
 1.06A 5wm2A-5xflA:
undetectable		 5wm2A-5xflA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZW2_A_ACTA511_0
(L-PROLYL-[PEPTIDYL-C
ARRIER PROTEIN]
DEHYDROGENASE)		 5xfl CATENIN ALPHA-2
(Mus
musculus) 		3 / 3 ARG A 546
ILE A 517
SER A 513
 None
 0.58A 5zw2A-5xflA:
3.0		 5zw2A-5xflA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FDY_U_DB8U302_1
(-)		 5xfl CATENIN ALPHA-2
(Mus
musculus) 		5 / 9 LEU A 577
PHE A 509
SER A 511
GLU A 514
ILE A 517
 None
 1.16A 6fdyU-5xflA:
1.5		 6fdyU-5xflA:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GMD_B_ACTB402_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 5xfl CATENIN ALPHA-2
(Mus
musculus) 		3 / 3 HIS A 387
SER A 391
LYS A 427
 None
 1.47A 6gmdB-5xflA:
undetectable		 6gmdB-5xflA:
undetectable