SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5xfm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_A_CHDA130_1
(FATTY ACID-BINDING
PROTEIN)		 5xfm ALPHA-GLUCOSIDASE
(Bacteroides
thetaiotaomicron) 		3 / 3 TYR A 450
ARG A 419
GLN A 415
 None
 0.99A 1tw4A-5xfmA:
2.3		 1tw4A-5xfmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA501_1
(CYTOCHROME P450 2B4)		 5xfm ALPHA-GLUCOSIDASE
(Bacteroides
thetaiotaomicron) 		4 / 7 LEU A 108
PHE A  69
GLY A  61
THR A 149
 None
 0.94A 2bdmA-5xfmA:
undetectable		 2bdmA-5xfmA:
10.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FJ1_A_CTCA222_0
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 5xfm ALPHA-GLUCOSIDASE
(Bacteroides
thetaiotaomicron) 		5 / 12 PHE A 494
ARG A 513
LEU A 308
ILE A 307
SER A 462
 None
 1.33A 2fj1A-5xfmA:
undetectable		 2fj1A-5xfmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2M2O_B_DHIB24_0
(INSULIN B CHAIN)		 5xfm ALPHA-GLUCOSIDASE
(Bacteroides
thetaiotaomicron) 		4 / 6 GLY A 439
PRO A 176
LYS A 175
THR A 174
 CA  A 701 ( 4.6A)
None
None
None
 1.31A 2m2oB-5xfmA:
undetectable		 2m2oB-5xfmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P16_A_GG2A298_2
(COAGULATION FACTOR X
(EC 3.4.21.6)
(STUART FACTOR)
(STUART-PROWER
FACTOR))		 5xfm ALPHA-GLUCOSIDASE
(Bacteroides
thetaiotaomicron) 		3 / 3 ARG A 419
GLU A 416
GLN A 415
 None
 1.07A 2p16A-5xfmA:
undetectable		 2p16A-5xfmA:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_2
(RENIN)		 5xfm ALPHA-GLUCOSIDASE
(Bacteroides
thetaiotaomicron) 		4 / 8 TYR A 333
THR A 524
LEU A 536
THR A 562
 None
 1.19A 2v0zO-5xfmA:
undetectable		 2v0zO-5xfmA:
11.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WA2_B_SAMB1267_1
(NON-STRUCTURAL
PROTEIN 5)		 5xfm ALPHA-GLUCOSIDASE
(Bacteroides
thetaiotaomicron) 		3 / 3 SER A 288
HIS A  98
ASP A 124
 None
 0.75A 2wa2B-5xfmA:
undetectable		 2wa2B-5xfmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X8O_A_OINA1314_1
(CHOLINE-BINDING
PROTEIN F)		 5xfm ALPHA-GLUCOSIDASE
(Bacteroides
thetaiotaomicron) 		4 / 5 ASP A 341
ARG A 383
TYR A 367
GLU A 393
 None
 1.25A 2x8oA-5xfmA:
undetectable		 2x8oA-5xfmA:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XTK_B_AZMB1339_1
(CLASS III CHITINASE
CHIA1)		 5xfm ALPHA-GLUCOSIDASE
(Bacteroides
thetaiotaomicron) 		5 / 10 TYR A 178
GLY A 412
ASP A 413
GLU A 246
GLN A 164
 None
 1.36A 2xtkB-5xfmA:
5.1		 2xtkB-5xfmA:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZD1_A_T27A557_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 5xfm ALPHA-GLUCOSIDASE
(Bacteroides
thetaiotaomicron) 		5 / 12 VAL A 214
VAL A 239
TYR A 237
PHE A 153
TYR A  45
 None
 1.25A 2zd1A-5xfmA:
undetectable		 2zd1A-5xfmA:
8.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZM_A_SAMA401_1
(UNCHARACTERIZED
PROTEIN MJ0883)		 5xfm ALPHA-GLUCOSIDASE
(Bacteroides
thetaiotaomicron) 		3 / 3 ARG A 392
ASP A 427
ASN A 386
 None
 0.86A 2zzmA-5xfmA:
undetectable		 2zzmA-5xfmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CO4_A_GCSA401_1
(CHITINASE)		 5xfm ALPHA-GLUCOSIDASE
(Bacteroides
thetaiotaomicron) 		3 / 3 GLU A 103
HIS A  78
HIS A 107
 None
 0.89A 3co4A-5xfmA:
10.2		 3co4A-5xfmA:
12.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DH0_A_SAMA220_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 5xfm ALPHA-GLUCOSIDASE
(Bacteroides
thetaiotaomicron) 		4 / 8 ARG A 266
TYR A 223
GLN A 164
GLU A 245
 None
 1.40A 3dh0A-5xfmA:
undetectable		 3dh0A-5xfmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HP1_A_LLTA401_1
(DEOXYCYTIDINE KINASE)		 5xfm ALPHA-GLUCOSIDASE
(Bacteroides
thetaiotaomicron) 		5 / 12 GLU A 147
VAL A 239
PHE A 129
MET A  62
GLU A 216
 None
 1.42A 3hp1A-5xfmA:
undetectable		 3hp1A-5xfmA:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TNE_B_RITB401_2
(SECRETED ASPARTIC
PROTEASE)		 5xfm ALPHA-GLUCOSIDASE
(Bacteroides
thetaiotaomicron) 		4 / 7 TYR A 182
ILE A 485
THR A 159
THR A 158
 None
 0.69A 3tneB-5xfmA:
undetectable		 3tneB-5xfmA:
12.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ASD_A_BAXA1500_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 5xfm ALPHA-GLUCOSIDASE
(Bacteroides
thetaiotaomicron) 		4 / 6 VAL A 609
LEU A 611
ILE A 646
CYH A 645
 None
 0.83A 4asdA-5xfmA:
undetectable		 4asdA-5xfmA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZT_A_SAMA1472_1
(METHYLTRANSFERASE
WBDD)		 5xfm ALPHA-GLUCOSIDASE
(Bacteroides
thetaiotaomicron) 		3 / 3 GLN A 640
ASP A 473
GLN A 469
 None
 0.91A 4aztA-5xfmA:
undetectable		 4aztA-5xfmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ID5_A_T27A601_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 5xfm ALPHA-GLUCOSIDASE
(Bacteroides
thetaiotaomicron) 		5 / 12 VAL A 214
VAL A 239
TYR A 237
PHE A 153
TYR A  45
 None
 1.24A 4id5A-5xfmA:
undetectable		 4id5A-5xfmA:
8.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IDK_A_T27A601_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 5xfm ALPHA-GLUCOSIDASE
(Bacteroides
thetaiotaomicron) 		5 / 12 VAL A 214
VAL A 239
TYR A 237
PHE A 153
TYR A  45
 None
 1.27A 4idkA-5xfmA:
undetectable		 4idkA-5xfmA:
8.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IFV_A_T27A601_1
(EXORIBONUCLEASE H,
P66 RT)		 5xfm ALPHA-GLUCOSIDASE
(Bacteroides
thetaiotaomicron) 		5 / 12 VAL A 214
VAL A 239
TYR A 237
PHE A 153
TYR A  45
 None
 1.26A 4ifvA-5xfmA:
undetectable		 4ifvA-5xfmA:
8.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IFY_A_T27A601_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 5xfm ALPHA-GLUCOSIDASE
(Bacteroides
thetaiotaomicron) 		5 / 12 VAL A 214
VAL A 239
TYR A 237
PHE A 153
TYR A  45
 None
 1.24A 4ifyA-5xfmA:
undetectable		 4ifyA-5xfmA:
8.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IG3_A_T27A601_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 5xfm ALPHA-GLUCOSIDASE
(Bacteroides
thetaiotaomicron) 		5 / 12 VAL A 214
VAL A 239
TYR A 237
PHE A 153
TYR A  45
 None
 1.30A 4ig3A-5xfmA:
undetectable		 4ig3A-5xfmA:
8.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IP7_D_ADND604_1
(PYRUVATE KINASE
ISOZYMES L)		 5xfm ALPHA-GLUCOSIDASE
(Bacteroides
thetaiotaomicron) 		3 / 3 ARG A 152
GLU A 233
ASN A 235
 None
 0.88A 4ip7D-5xfmA:
undetectable		 4ip7D-5xfmA:
8.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KFB_A_T27A607_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H,
EXORIBONUCLEA P66 RT)		 5xfm ALPHA-GLUCOSIDASE
(Bacteroides
thetaiotaomicron) 		5 / 12 VAL A 214
VAL A 239
TYR A 237
PHE A 153
TYR A  45
 None
 1.25A 4kfbA-5xfmA:
undetectable		 4kfbA-5xfmA:
8.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NDN_A_SAMA407_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 5xfm ALPHA-GLUCOSIDASE
(Bacteroides
thetaiotaomicron) 		4 / 8 ALA A 356
ASP A 337
ILE A 336
ILE A 344
 None
 0.94A 4ndnB-5xfmA:
undetectable		 4ndnB-5xfmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKX_A_198A1002_2
(ANDROGEN RECEPTOR)		 5xfm ALPHA-GLUCOSIDASE
(Bacteroides
thetaiotaomicron) 		4 / 6 ASN A 533
MET A 349
LEU A 365
ILE A 436
 None
 1.04A 4okxA-5xfmA:
undetectable		 4okxA-5xfmA:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B2O_A_ACTA1728_0
(CRISPR-ASSOCIATED
ENDONUCLEASE CAS9)		 5xfm ALPHA-GLUCOSIDASE
(Bacteroides
thetaiotaomicron) 		4 / 5 GLN A 378
THR A 174
TRP A 171
ASN A 374
 None
 1.37A 5b2oA-5xfmA:
0.1		 5b2oA-5xfmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B2P_A_ACTA1728_0
(CRISPR-ASSOCIATED
ENDONUCLEASE CAS9)		 5xfm ALPHA-GLUCOSIDASE
(Bacteroides
thetaiotaomicron) 		4 / 5 GLN A 378
THR A 174
TRP A 171
ASN A 374
 None
 1.36A 5b2pA-5xfmA:
2.3		 5b2pA-5xfmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B2Q_A_ACTA1729_0
(CRISPR-ASSOCIATED
ENDONUCLEASE CAS9)		 5xfm ALPHA-GLUCOSIDASE
(Bacteroides
thetaiotaomicron) 		4 / 5 GLN A 378
THR A 174
TRP A 171
ASN A 374
 None
 1.37A 5b2qA-5xfmA:
0.0		 5b2qA-5xfmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I71_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 5xfm ALPHA-GLUCOSIDASE
(Bacteroides
thetaiotaomicron) 		5 / 12 GLY A 302
GLY A 404
LEU A 433
GLY A 360
VAL A 361
 None
 1.33A 5i71A-5xfmA:
undetectable		 5i71A-5xfmA:
9.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V5Z_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5xfm ALPHA-GLUCOSIDASE
(Bacteroides
thetaiotaomicron) 		3 / 3 GLY A 251
THR A 199
PRO A 242
 None
 0.53A 5v5zA-5xfmA:
undetectable		 5v5zA-5xfmA:
9.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIP_C_HFGC1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 5xfm ALPHA-GLUCOSIDASE
(Bacteroides
thetaiotaomicron) 		5 / 12 GLU A 147
VAL A 144
PRO A 255
THR A 441
GLY A 412
 None
 1.26A 5xipC-5xfmA:
undetectable		 5xipC-5xfmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_A_RFPA502_1
(RIFAMPIN
MONOOXYGENASE)		 5xfm ALPHA-GLUCOSIDASE
(Bacteroides
thetaiotaomicron) 		5 / 12 PHE A 120
LEU A 228
VAL A 239
PHE A 200
THR A 267
 None
 1.45A 6brdA-5xfmA:
undetectable		 6brdA-5xfmA:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_A_RFPA502_1
(RIFAMPIN
MONOOXYGENASE)		 5xfm ALPHA-GLUCOSIDASE
(Bacteroides
thetaiotaomicron) 		5 / 12 VAL A  35
PHE A 120
VAL A 239
PHE A 200
THR A 267
 None
 1.44A 6brdA-5xfmA:
undetectable		 6brdA-5xfmA:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_A_AQ4A602_1
(CYTOCHROME P450 1A1)		 5xfm ALPHA-GLUCOSIDASE
(Bacteroides
thetaiotaomicron) 		4 / 5 ILE A 314
SER A 313
ALA A 334
LEU A 365
 None
 0.94A 6dwnA-5xfmA:
undetectable		 6dwnA-5xfmA:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ELI_A_T27A701_1
(REVERSE
TRANSCRIPTASE)		 5xfm ALPHA-GLUCOSIDASE
(Bacteroides
thetaiotaomicron) 		5 / 12 VAL A 214
VAL A 239
TYR A 237
PHE A 153
TYR A  45
 None
 1.27A 6eliA-5xfmA:
undetectable		 6eliA-5xfmA:
28.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBN_B_SAMB401_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 5xfm ALPHA-GLUCOSIDASE
(Bacteroides
thetaiotaomicron) 		4 / 7 ALA A 356
ASP A 337
ILE A 336
ILE A 344
 None
 0.91A 6fbnA-5xfmA:
undetectable		 6fbnA-5xfmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_1
(-)		 5xfm ALPHA-GLUCOSIDASE
(Bacteroides
thetaiotaomicron) 		5 / 12 THR A  64
TYR A 131
PRO A  43
VAL A 286
GLY A 218
 None
 1.48A 6gngB-5xfmA:
2.1		 6gngB-5xfmA:
9.67