SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5xfo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AX9_A_EDRA999_1
(ACETYLCHOLINESTERASE)		 5xfo PHD FINGER PROTEIN 1
(Homo
sapiens) 		4 / 8 GLY A 192
TYR A 169
PHE A 211
HIS A 212
 None
None
None
ZN  A 403 (-3.2A)
 0.96A 1ax9A-5xfoA:
2.0		 1ax9A-5xfoA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DFO_A_FFOA1002_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5xfo PHD FINGER PROTEIN 1
(Homo
sapiens) 		5 / 12 LEU A 171
GLY A 173
LEU A 167
VAL A 236
ASN A 183
 None
 1.06A 1dfoA-5xfoA:
undetectable		 1dfoA-5xfoA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DFO_B_FFOB2002_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5xfo PHD FINGER PROTEIN 1
(Homo
sapiens) 		5 / 12 LEU A 171
GLY A 173
LEU A 167
VAL A 236
ASN A 183
 None
 1.07A 1dfoB-5xfoA:
undetectable		 1dfoB-5xfoA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DFO_C_FFOC3002_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5xfo PHD FINGER PROTEIN 1
(Homo
sapiens) 		5 / 12 LEU A 171
GLY A 173
LEU A 167
VAL A 236
ASN A 183
 None
 1.06A 1dfoC-5xfoA:
undetectable		 1dfoC-5xfoA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DFO_D_FFOD4002_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5xfo PHD FINGER PROTEIN 1
(Homo
sapiens) 		5 / 12 LEU A 171
GLY A 173
LEU A 167
VAL A 236
ASN A 183
 None
 1.06A 1dfoD-5xfoA:
undetectable		 1dfoD-5xfoA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_A_FFOA1293_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5xfo PHD FINGER PROTEIN 1
(Homo
sapiens) 		5 / 12 LEU A 171
GLY A 173
LEU A 167
VAL A 236
ASN A 183
 None
 1.04A 1eqbA-5xfoA:
undetectable		 1eqbA-5xfoA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_B_FFOB2293_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5xfo PHD FINGER PROTEIN 1
(Homo
sapiens) 		5 / 12 LEU A 171
GLY A 173
LEU A 167
VAL A 236
ASN A 183
 None
 1.04A 1eqbB-5xfoA:
undetectable		 1eqbB-5xfoA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_C_FFOC3293_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5xfo PHD FINGER PROTEIN 1
(Homo
sapiens) 		5 / 12 LEU A 171
GLY A 173
LEU A 167
VAL A 236
ASN A 183
 None
 1.03A 1eqbC-5xfoA:
undetectable		 1eqbC-5xfoA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_D_FFOD4293_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5xfo PHD FINGER PROTEIN 1
(Homo
sapiens) 		5 / 12 LEU A 171
GLY A 173
LEU A 167
VAL A 236
ASN A 183
 None
 1.04A 1eqbD-5xfoA:
undetectable		 1eqbD-5xfoA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKE_A_HSMA190_1
(NITROPHORIN 4)		 5xfo PHD FINGER PROTEIN 1
(Homo
sapiens) 		3 / 3 ASP A 253
LEU A 247
LEU A 249
 None
 0.77A 1ikeA-5xfoA:
undetectable		 1ikeA-5xfoA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NP1_B_HSMB304_1
(NITROPHORIN 1)		 5xfo PHD FINGER PROTEIN 1
(Homo
sapiens) 		3 / 3 ASP A 253
LEU A 247
LEU A 249
 None
 0.69A 1np1B-5xfoA:
undetectable		 1np1B-5xfoA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_NCAA493_0
(CHORISMATE SYNTHASE)		 5xfo PHD FINGER PROTEIN 1
(Homo
sapiens) 		5 / 11 THR A 281
ILE A 277
ALA A 308
ALA A 255
VAL A 258
 None
 1.19A 2qhfA-5xfoA:
undetectable		 2qhfA-5xfoA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VOU_A_ACTA1397_0
(2,6-DIHYDROXYPYRIDIN
E HYDROXYLASE)		 5xfo PHD FINGER PROTEIN 1
(Homo
sapiens) 		3 / 3 PRO A 168
GLY A 192
TYR A 169
 None
 0.69A 2vouA-5xfoA:
undetectable		 2vouA-5xfoA:
25.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VOU_B_ACTB1391_0
(2,6-DIHYDROXYPYRIDIN
E HYDROXYLASE)		 5xfo PHD FINGER PROTEIN 1
(Homo
sapiens) 		3 / 3 PRO A 168
GLY A 192
TYR A 169
 None
 0.73A 2vouB-5xfoA:
undetectable		 2vouB-5xfoA:
25.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VOU_C_ACTC1391_0
(2,6-DIHYDROXYPYRIDIN
E HYDROXYLASE)		 5xfo PHD FINGER PROTEIN 1
(Homo
sapiens) 		3 / 3 PRO A 168
GLY A 192
TYR A 169
 None
 0.73A 2vouC-5xfoA:
undetectable		 2vouC-5xfoA:
25.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A301_1
(THIOPURINE
S-METHYLTRANSFERASE)		 5xfo PHD FINGER PROTEIN 1
(Homo
sapiens) 		4 / 6 PHE A 141
ARG A  40
GLY A  44
ALA A 214
 None
None
ZN  A 403 ( 4.1A)
None
 0.98A 3bgdA-5xfoA:
undetectable		 3bgdA-5xfoA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LCV_B_SAMB301_1
(SISOMICIN-GENTAMICIN
RESISTANCE METHYLASE
SGM)		 5xfo PHD FINGER PROTEIN 1
(Homo
sapiens) 		3 / 3 ARG A 334
ASP A 177
GLN A 203
 None
 0.87A 3lcvB-5xfoA:
undetectable		 3lcvB-5xfoA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1479_0
(MJ0495-LIKE PROTEIN)		 5xfo PHD FINGER PROTEIN 1
(Homo
sapiens) 		4 / 5 THR A  50
ILE A  51
LYS A  52
GLU A  33
 None
 1.16A 4ac9C-5xfoA:
2.4		 4ac9C-5xfoA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1479_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 5xfo PHD FINGER PROTEIN 1
(Homo
sapiens) 		4 / 5 THR A  50
ILE A  51
LYS A  52
GLU A  33
 None
 1.18A 4acaC-5xfoA:
undetectable		 4acaC-5xfoA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1479_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 5xfo PHD FINGER PROTEIN 1
(Homo
sapiens) 		4 / 5 THR A  50
ILE A  51
LYS A  52
GLU A  33
 None
 1.23A 4acbC-5xfoA:
undetectable		 4acbC-5xfoA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_C_ADNC401_2
(ADENOSINE KINASE)		 5xfo PHD FINGER PROTEIN 1
(Homo
sapiens) 		4 / 5 ASN A 284
LEU A 288
SER A 282
LEU A 305
 None
 1.26A 4n09C-5xfoA:
undetectable		 4n09C-5xfoA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4USW_A_ACTA1470_0
(ADENYLATE CYCLASE
TYPE 10)		 5xfo PHD FINGER PROTEIN 1
(Homo
sapiens) 		4 / 6 LEU A 305
LEU A 259
VAL A 258
PHE A 329
 None
 1.00A 4uswA-5xfoA:
undetectable		 4uswA-5xfoA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XK8_A_PQNA845_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 5xfo PHD FINGER PROTEIN 1
(Homo
sapiens) 		4 / 8 PHE A 316
ALA A 333
LEU A 331
GLY A 330
 None
 0.85A 4xk8a-5xfoA:
undetectable		 4xk8a-5xfoA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_D_SORD1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 5xfo PHD FINGER PROTEIN 1
(Homo
sapiens) 		4 / 6 LYS A 164
GLU A 242
GLY A 240
GLY A 239
 None
 0.99A 5a06D-5xfoA:
undetectable		 5a06D-5xfoA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5INZ_D_DVAD15_0
(THETA DEFENSIN-2,
D-PEPTIDE
THETA DEFENSIN-2,
L-PEPTIDE)		 5xfo PHD FINGER PROTEIN 1
(Homo
sapiens) 		3 / 3 GLY A 193
CYH A 191
CYH A 189
 None
ZN  A 403 (-2.3A)
ZN  A 403 (-2.3A)
 0.91A 5inzB-5xfoA:
undetectable		 5inzB-5xfoA:
7.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KB5_A_ADNA401_2
(ADENOSINE KINASE)		 5xfo PHD FINGER PROTEIN 1
(Homo
sapiens) 		4 / 4 ASN A 284
LEU A 288
SER A 282
LEU A 305
 None
 1.21A 5kb5A-5xfoA:
undetectable		 5kb5A-5xfoA:
18.95