SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5xfr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AX9_A_EDRA999_1
(ACETYLCHOLINESTERASE)		 5xfr METAL-RESPONSE
ELEMENT-BINDING
TRANSCRIPTION FACTOR
2
(Homo
sapiens) 		4 / 8 GLY A 207
TYR A 184
PHE A 226
HIS A 227
 None
None
None
ZN  A 404 (-3.2A)
 1.00A 1ax9A-5xfrA:
undetectable		 1ax9A-5xfrA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NP1_B_HSMB304_1
(NITROPHORIN 1)		 5xfr METAL-RESPONSE
ELEMENT-BINDING
TRANSCRIPTION FACTOR
2
(Homo
sapiens) 		3 / 3 ASP A 268
LEU A 262
LEU A 264
 None
 0.72A 1np1B-5xfrA:
undetectable		 1np1B-5xfrA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VOU_A_ACTA1397_0
(2,6-DIHYDROXYPYRIDIN
E HYDROXYLASE)		 5xfr METAL-RESPONSE
ELEMENT-BINDING
TRANSCRIPTION FACTOR
2
(Homo
sapiens) 		3 / 3 PRO A 183
GLY A 207
TYR A 184
 None
 0.70A 2vouA-5xfrA:
undetectable		 2vouA-5xfrA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1479_0
(MJ0495-LIKE PROTEIN)		 5xfr METAL-RESPONSE
ELEMENT-BINDING
TRANSCRIPTION FACTOR
2
(Homo
sapiens) 		4 / 5 THR A  65
ILE A  66
LYS A  67
GLU A  48
 None
 1.31A 4ac9C-5xfrA:
undetectable		 4ac9C-5xfrA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1479_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 5xfr METAL-RESPONSE
ELEMENT-BINDING
TRANSCRIPTION FACTOR
2
(Homo
sapiens) 		4 / 5 THR A  65
ILE A  66
LYS A  67
GLU A  48
 None
 1.34A 4acaC-5xfrA:
undetectable		 4acaC-5xfrA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1479_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 5xfr METAL-RESPONSE
ELEMENT-BINDING
TRANSCRIPTION FACTOR
2
(Homo
sapiens) 		4 / 5 THR A  65
ILE A  66
LYS A  67
GLU A  48
 None
 1.34A 4acbC-5xfrA:
undetectable		 4acbC-5xfrA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5INZ_D_DVAD15_0
(THETA DEFENSIN-2,
D-PEPTIDE
THETA DEFENSIN-2,
L-PEPTIDE)		 5xfr METAL-RESPONSE
ELEMENT-BINDING
TRANSCRIPTION FACTOR
2
(Homo
sapiens) 		3 / 3 GLY A 208
CYH A 206
CYH A 204
 None
ZN  A 404 (-2.4A)
ZN  A 404 (-2.4A)
 0.92A 5inzB-5xfrA:
undetectable		 5inzB-5xfrA:
6.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KXI_A_NCTA402_1
(NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-4
NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
BETA-2)		 5xfr METAL-RESPONSE
ELEMENT-BINDING
TRANSCRIPTION FACTOR
2
(Homo
sapiens) 		4 / 8 TYR A 184
CYH A 252
CYH A 249
TYR A 205
 None
ZN  A 403 (-2.4A)
ZN  A 403 (-2.3A)
None
 1.39A 5kxiA-5xfrA:
undetectable
5kxiB-5xfrA:
undetectable		 5kxiA-5xfrA:
21.25
5kxiB-5xfrA:
18.87