SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5xfs'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_A_GLYA1292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5xfs PE FAMILY PROTEIN
PE8
PPE FAMILY PROTEIN
PPE15
(Mycobacterium
tuberculosis;
Mycobacterium
tuberculosis) 		4 / 8 SER B  93
HIS B  85
SER B  88
PHE A  55
 None
 1.12A 1eqbA-5xfsB:
undetectable
1eqbB-5xfsB:
undetectable		 1eqbA-5xfsB:
19.90
1eqbB-5xfsB:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_C_GLYC3292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5xfs PE FAMILY PROTEIN
PE8
PPE FAMILY PROTEIN
PPE15
(Mycobacterium
tuberculosis;
Mycobacterium
tuberculosis) 		4 / 8 SER B  93
HIS B  85
SER B  88
PHE A  55
 None
 1.12A 1eqbC-5xfsB:
undetectable
1eqbD-5xfsB:
undetectable		 1eqbC-5xfsB:
19.90
1eqbD-5xfsB:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K5Q_B_PACB559_0
(PENICILLIN G ACYLASE
ALPHA SUBUNIT
PENICILLIN G ACYLASE
BETA SUBUNIT)		 5xfs PPE FAMILY PROTEIN
PPE15
(Mycobacterium
tuberculosis) 		4 / 7 MET B  24
ALA B  86
SER B 158
ALA B  92
 None
 0.96A 1k5qA-5xfsB:
undetectable
1k5qB-5xfsB:
undetectable		 1k5qA-5xfsB:
17.94
1k5qB-5xfsB:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGZ_D_COCD401_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5xfs PE FAMILY PROTEIN
PE8
PPE FAMILY PROTEIN
PPE15
(Mycobacterium
tuberculosis) 		4 / 6 TYR A  62
TRP B  31
TYR A  58
GLN B  89
 None
 1.35A 2pgzD-5xfsA:
undetectable
2pgzE-5xfsA:
undetectable		 2pgzD-5xfsA:
19.05
2pgzE-5xfsA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_Y_BO2Y1403_1
(PROTEASOME COMPONENT
PRE2
PROTEASOME COMPONENT
C5)		 5xfs PE FAMILY PROTEIN
PE8
PPE FAMILY PROTEIN
PPE15
(Mycobacterium
tuberculosis) 		6 / 12 THR A  37
ALA A  34
ALA A  38
ALA B  90
GLY B  28
ALA B  26
 None
 1.37A 3mg0Y-5xfsA:
undetectable
3mg0Z-5xfsA:
undetectable		 3mg0Y-5xfsA:
18.26
3mg0Z-5xfsA:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ENH_A_FVXA602_1
(CHOLESTEROL
24-HYDROXYLASE)		 5xfs PE FAMILY PROTEIN
PE8
PPE FAMILY PROTEIN
PPE15
(Mycobacterium
tuberculosis) 		5 / 12 PHE A  55
ALA B 100
ALA B 157
GLY B 159
ALA B  94
 None
 1.14A 4enhA-5xfsA:
undetectable		 4enhA-5xfsA:
14.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAE_A_CLMA208_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)		 5xfs PPE FAMILY PROTEIN
PPE15
(Mycobacterium
tuberculosis) 		4 / 4 ALA B  92
ALA B  95
ALA B  96
ALA B  99
 None
 0.13A 4oaeA-5xfsB:
undetectable		 4oaeA-5xfsB:
25.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OG9_A_TESA504_1
(-)		 5xfs PE FAMILY PROTEIN
PE8
PPE FAMILY PROTEIN
PPE15
(Mycobacterium
tuberculosis) 		4 / 8 ILE A  21
ILE B  49
LEU B  76
THR B  77
 None
 0.74A 5og9A-5xfsA:
undetectable		 5og9A-5xfsA:
10.99