SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5xft'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZWP_A_NIMA401_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 5xft DEHYDROASCORBATE
REDUCTASE
(Chlamydomonas
reinhardtii) 		4 / 5 LEU A  19
GLY A 210
TRP A 211
LYS A  10
 None
 1.37A 1zwpA-5xftA:
undetectable		 1zwpA-5xftA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DXR_A_SORA1002_0
(LACTOTRANSFERRIN)		 5xft DEHYDROASCORBATE
REDUCTASE
(Chlamydomonas
reinhardtii) 		3 / 3 THR A 154
PRO A  96
TYR A 135
 None
 0.75A 2dxrA-5xftA:
undetectable		 2dxrA-5xftA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AFG_D_QMRD1214_1
(CAPITELLA TELETA
ACHBP)		 5xft DEHYDROASCORBATE
REDUCTASE
(Chlamydomonas
reinhardtii) 		5 / 9 VAL A  62
CYH A  21
CYH A  24
ILE A  78
PHE A  45
 None
 1.48A 4afgC-5xftA:
undetectable
4afgD-5xftA:
undetectable		 4afgC-5xftA:
17.53
4afgD-5xftA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AFG_E_QMRE1214_1
(CAPITELLA TELETA
ACHBP)		 5xft DEHYDROASCORBATE
REDUCTASE
(Chlamydomonas
reinhardtii) 		5 / 9 VAL A  62
CYH A  21
CYH A  24
ILE A  78
PHE A  45
 None
 1.41A 4afgB-5xftA:
0.0
4afgC-5xftA:
0.0		 4afgB-5xftA:
17.53
4afgC-5xftA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_B_CHDB102_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 5xft DEHYDROASCORBATE
REDUCTASE
(Chlamydomonas
reinhardtii) 		5 / 11 LEU A 162
LEU A 177
ALA A 189
LEU A 188
TYR A 187
 None
 1.15A 4wg0B-5xftA:
undetectable
4wg0C-5xftA:
undetectable
4wg0D-5xftA:
undetectable		 4wg0B-5xftA:
undetectable
4wg0C-5xftA:
undetectable
4wg0D-5xftA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_D_CHDD102_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 5xft DEHYDROASCORBATE
REDUCTASE
(Chlamydomonas
reinhardtii) 		5 / 11 LEU A 162
LEU A 177
ALA A 189
LEU A 188
TYR A 187
 None
 1.13A 4wg0D-5xftA:
undetectable
4wg0E-5xftA:
undetectable
4wg0F-5xftA:
undetectable		 4wg0D-5xftA:
undetectable
4wg0E-5xftA:
undetectable
4wg0F-5xftA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_F_CHDF103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 5xft DEHYDROASCORBATE
REDUCTASE
(Chlamydomonas
reinhardtii) 		5 / 11 LEU A 162
LEU A 177
ALA A 189
LEU A 188
TYR A 187
 None
 1.15A 4wg0F-5xftA:
undetectable
4wg0G-5xftA:
undetectable
4wg0H-5xftA:
undetectable		 4wg0F-5xftA:
undetectable
4wg0G-5xftA:
undetectable
4wg0H-5xftA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_I_CHDI103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 5xft DEHYDROASCORBATE
REDUCTASE
(Chlamydomonas
reinhardtii) 		5 / 11 ALA A 189
LEU A 188
TYR A 187
LEU A 177
LEU A 162
 None
 1.16A 4wg0G-5xftA:
undetectable
4wg0H-5xftA:
undetectable
4wg0I-5xftA:
undetectable		 4wg0G-5xftA:
undetectable
4wg0H-5xftA:
undetectable
4wg0I-5xftA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_M_CHDM103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 5xft DEHYDROASCORBATE
REDUCTASE
(Chlamydomonas
reinhardtii) 		5 / 11 ALA A 189
LEU A 188
TYR A 187
LEU A 177
LEU A 162
 None
 1.16A 4wg0K-5xftA:
undetectable
4wg0L-5xftA:
undetectable
4wg0M-5xftA:
undetectable		 4wg0K-5xftA:
undetectable
4wg0L-5xftA:
undetectable
4wg0M-5xftA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D9W_A_ASCA301_0
(DEHYDROASCORBATE
REDUCTASE)		 5xft DEHYDROASCORBATE
REDUCTASE
(Chlamydomonas
reinhardtii) 		7 / 9 LYS A  10
ASP A  20
PRO A  22
PHE A 104
HIS A 164
GLY A 210
TRP A 211
 None
 0.69A 5d9wA-5xftA:
17.3		 5d9wA-5xftA:
undetectable