SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5xga'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O76_B_CAMB1420_0
(CYTOCHROME P450-CAM)		 5xga OSMOLARITY SENSOR
PROTEIN ENVZ
(Escherichia
coli) 		4 / 8 TYR A  48
LEU A  55
VAL A 112
THR A 104
 CPS  A 202 (-3.4A)
CPS  A 201 ( 4.6A)
None
CPS  A 201 (-2.7A)
 1.01A 1o76B-5xgaA:
undetectable		 1o76B-5xgaA:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UYU_B_CAMB1416_0
(CYTOCHROME P450-CAM)		 5xga OSMOLARITY SENSOR
PROTEIN ENVZ
(Escherichia
coli) 		4 / 8 TYR A  48
LEU A  55
VAL A 112
THR A 104
 CPS  A 202 (-3.4A)
CPS  A 201 ( 4.6A)
None
CPS  A 201 (-2.7A)
 1.17A 1uyuB-5xgaA:
undetectable		 1uyuB-5xgaA:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_A_CRNA401_1
(CREATININE
AMIDOHYDROLASE)		 5xga OSMOLARITY SENSOR
PROTEIN ENVZ
(Escherichia
coli) 		4 / 8 GLU A  73
HIS A  71
HIS A  77
GLU A  88
 None
 0.91A 1v7zA-5xgaA:
undetectable		 1v7zA-5xgaA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_B_CRNB3401_1
(CREATININE
AMIDOHYDROLASE)		 5xga OSMOLARITY SENSOR
PROTEIN ENVZ
(Escherichia
coli) 		4 / 8 GLU A  73
HIS A  71
HIS A  77
GLU A  88
 None
 0.89A 1v7zB-5xgaA:
undetectable		 1v7zB-5xgaA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_C_CRNC4401_1
(CREATININE
AMIDOHYDROLASE)		 5xga OSMOLARITY SENSOR
PROTEIN ENVZ
(Escherichia
coli) 		4 / 8 GLU A  73
HIS A  71
HIS A  77
GLU A  88
 None
 0.90A 1v7zC-5xgaA:
undetectable		 1v7zC-5xgaA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_D_CRND5401_1
(CREATININE
AMIDOHYDROLASE)		 5xga OSMOLARITY SENSOR
PROTEIN ENVZ
(Escherichia
coli) 		4 / 8 GLU A  73
HIS A  71
HIS A  77
GLU A  88
 None
 0.90A 1v7zD-5xgaA:
undetectable		 1v7zD-5xgaA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_E_CRNE6401_1
(CREATININE
AMIDOHYDROLASE)		 5xga OSMOLARITY SENSOR
PROTEIN ENVZ
(Escherichia
coli) 		4 / 8 GLU A  73
HIS A  71
HIS A  77
GLU A  88
 None
 0.91A 1v7zE-5xgaA:
undetectable		 1v7zE-5xgaA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_F_CRNF7401_1
(CREATININE
AMIDOHYDROLASE)		 5xga OSMOLARITY SENSOR
PROTEIN ENVZ
(Escherichia
coli) 		4 / 8 GLU A  73
HIS A  71
HIS A  77
GLU A  88
 None
 0.89A 1v7zF-5xgaA:
undetectable		 1v7zF-5xgaA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FN1_A_SALA506_1
(SALICYLATE
SYNTHETASE, IRP9)		 5xga OSMOLARITY SENSOR
PROTEIN ENVZ
(Escherichia
coli) 		5 / 11 ILE A  53
GLU A  20
THR A 117
LEU A  17
GLY A  52
 None
ACY  A 203 ( 4.1A)
None
None
None
 1.38A 2fn1A-5xgaA:
undetectable		 2fn1A-5xgaA:
14.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y05_A_RALA801_1
(PROSTAGLANDIN
REDUCTASE 1)		 5xga OSMOLARITY SENSOR
PROTEIN ENVZ
(Escherichia
coli) 		4 / 8 TYR A  48
ARG A 113
VAL A  21
VAL A 112
 CPS  A 202 (-3.4A)
None
None
None
 1.12A 2y05A-5xgaA:
undetectable
2y05B-5xgaA:
undetectable		 2y05A-5xgaA:
17.53
2y05B-5xgaA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_A_CRNA303_1
(CREATININE
AMIDOHYDROLASE)		 5xga OSMOLARITY SENSOR
PROTEIN ENVZ
(Escherichia
coli) 		4 / 8 GLU A  73
HIS A  71
HIS A  77
GLU A  88
 None
 0.93A 3a6jA-5xgaA:
undetectable		 3a6jA-5xgaA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_C_CRNC305_1
(CREATININE
AMIDOHYDROLASE)		 5xga OSMOLARITY SENSOR
PROTEIN ENVZ
(Escherichia
coli) 		4 / 8 GLU A  73
HIS A  71
HIS A  77
GLU A  88
 None
 0.92A 3a6jC-5xgaA:
undetectable		 3a6jC-5xgaA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_E_CRNE306_1
(CREATININE
AMIDOHYDROLASE)		 5xga OSMOLARITY SENSOR
PROTEIN ENVZ
(Escherichia
coli) 		4 / 8 GLU A  73
HIS A  71
HIS A  77
GLU A  88
 None
 0.96A 3a6jE-5xgaA:
undetectable		 3a6jE-5xgaA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_F_CRNF307_1
(CREATININE
AMIDOHYDROLASE)		 5xga OSMOLARITY SENSOR
PROTEIN ENVZ
(Escherichia
coli) 		4 / 8 GLU A  73
HIS A  71
HIS A  77
GLU A  88
 None
 0.91A 3a6jF-5xgaA:
undetectable		 3a6jF-5xgaA:
20.93