SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5xgc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A28_A_STRA1_1
(PROGESTERONE
RECEPTOR)		 5xgc RAP1 GTPASE-GDP
DISSOCIATION
STIMULATOR 1
(Homo
sapiens) 		5 / 12 LEU A 421
ASN A 418
LEU A 420
LEU A 465
THR A 448
 None
 1.43A 1a28A-5xgcA:
undetectable		 1a28A-5xgcA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DVX_B_DIFB125_1
(TRANSTHYRETIN)		 5xgc RAP1 GTPASE-GDP
DISSOCIATION
STIMULATOR 1
(Homo
sapiens) 		4 / 7 LEU A 471
ALA A 469
LEU A 467
SER A 422
 None
 1.02A 1dvxA-5xgcA:
undetectable		 1dvxA-5xgcA:
11.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_A_VIBA501_1
(YKOF)		 5xgc RAP1 GTPASE-GDP
DISSOCIATION
STIMULATOR 1
(Homo
sapiens) 		4 / 8 SER A 244
LEU A 221
ILE A 224
THR A 242
 None
 0.93A 1sbrA-5xgcA:
undetectable		 1sbrA-5xgcA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U70_A_MTXA187_2
(DIHYDROFOLATE
REDUCTASE)		 5xgc RAP1 GTPASE-GDP
DISSOCIATION
STIMULATOR 1
(Homo
sapiens) 		4 / 4 SER A 422
ILE A 425
VAL A 398
THR A 355
 None
 1.24A 1u70A-5xgcA:
undetectable		 1u70A-5xgcA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_F_SC2F1291_1
(FICOLIN-2)		 5xgc RAP1 GTPASE-GDP
DISSOCIATION
STIMULATOR 1
(Homo
sapiens) 		4 / 6 SER A 256
LEU A 250
ASP A 206
ASP A 254
 None
 1.14A 2j2pE-5xgcA:
undetectable
2j2pF-5xgcA:
undetectable		 2j2pE-5xgcA:
18.79
2j2pF-5xgcA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_A_RIMA199_1
(MATRIX PROTEIN 2)		 5xgc RAP1 GTPASE-GDP
DISSOCIATION
STIMULATOR 1
(Homo
sapiens) 		4 / 6 LEU A 424
LEU A 421
ILE A 381
ARG A 378
 None
 1.03A 2rlfA-5xgcA:
undetectable
2rlfB-5xgcA:
undetectable		 2rlfA-5xgcA:
6.70
2rlfB-5xgcA:
6.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CKK_A_SAMA301_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 5xgc RAP1 GTPASE-GDP
DISSOCIATION
STIMULATOR 1
(Homo
sapiens) 		5 / 12 GLY A 110
ASN A 159
ALA A 156
LEU A 106
GLU A 104
 None
 0.95A 3ckkA-5xgcA:
undetectable		 3ckkA-5xgcA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_D_SAMD300_0
(PUTATIVE RRNA
METHYLASE)		 5xgc RAP1 GTPASE-GDP
DISSOCIATION
STIMULATOR 1
(Homo
sapiens) 		5 / 12 THR A 436
GLY A 392
ASP A 432
GLY A 441
LEU A 397
 None
 1.19A 3eeyD-5xgcA:
undetectable		 3eeyD-5xgcA:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_B_SAMB6735_0
(16S RRNA METHYLASE)		 5xgc RAP1 GTPASE-GDP
DISSOCIATION
STIMULATOR 1
(Homo
sapiens) 		5 / 12 GLY A 287
ASN A 280
VAL A 268
ALA A 292
LEU A 289
 None
 1.12A 3p2kB-5xgcA:
undetectable		 3p2kB-5xgcA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UAY_A_ADNA236_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 5xgc RAP1 GTPASE-GDP
DISSOCIATION
STIMULATOR 1
(Homo
sapiens) 		5 / 10 GLY A 158
VAL A 198
GLU A 197
MET A 194
ASN A 159
 None
 1.28A 3uayA-5xgcA:
undetectable		 3uayA-5xgcA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRK_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 5xgc RAP1 GTPASE-GDP
DISSOCIATION
STIMULATOR 1
(Homo
sapiens) 		4 / 5 PHE A 170
GLY A 114
ILE A 133
VAL A 132
 None
 0.85A 3wrkA-5xgcA:
undetectable		 3wrkA-5xgcA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FN9_A_STRA301_1
(STEROID RECEPTOR 2)		 5xgc RAP1 GTPASE-GDP
DISSOCIATION
STIMULATOR 1
(Homo
sapiens) 		5 / 12 LEU A 333
LEU A 336
LEU A 339
ALA A 340
ALA A 352
 None
 1.03A 4fn9A-5xgcA:
undetectable		 4fn9A-5xgcA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_J_CHDJ103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 5xgc RAP1 GTPASE-GDP
DISSOCIATION
STIMULATOR 1
(Homo
sapiens) 		5 / 11 LEU A 221
LEU A 217
LEU A 246
GLU A 197
LEU A 199
 None
 1.08A 4wg0J-5xgcA:
undetectable
4wg0K-5xgcA:
undetectable
4wg0L-5xgcA:
undetectable		 4wg0J-5xgcA:
2.91
4wg0K-5xgcA:
2.91
4wg0L-5xgcA:
2.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_K_CHDK103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 5xgc RAP1 GTPASE-GDP
DISSOCIATION
STIMULATOR 1
(Homo
sapiens) 		5 / 11 GLU A 197
LEU A 199
LEU A 246
LEU A 221
LEU A 217
 None
 1.08A 4wg0I-5xgcA:
undetectable
4wg0J-5xgcA:
undetectable
4wg0K-5xgcA:
undetectable		 4wg0I-5xgcA:
2.91
4wg0J-5xgcA:
2.91
4wg0K-5xgcA:
2.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GTR_A_ESTA601_1
(ESTROGEN RECEPTOR)		 5xgc RAP1 GTPASE-GDP
DISSOCIATION
STIMULATOR 1
(Homo
sapiens) 		5 / 12 LEU A 149
LEU A 136
LEU A 140
MET A 194
GLY A 158
 None
 1.13A 5gtrA-5xgcA:
undetectable		 5gtrA-5xgcA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_A_ADNA501_2
(ADENOSYLHOMOCYSTEINA
SE)		 5xgc RAP1 GTPASE-GDP
DISSOCIATION
STIMULATOR 1
(Homo
sapiens) 		4 / 5 GLU A 239
THR A 242
GLU A 197
LEU A 179
 None
 1.08A 5hm8A-5xgcA:
undetectable		 5hm8A-5xgcA:
24.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_B_ADNB501_2
(ADENOSYLHOMOCYSTEINA
SE)		 5xgc RAP1 GTPASE-GDP
DISSOCIATION
STIMULATOR 1
(Homo
sapiens) 		4 / 5 GLU A 239
THR A 242
GLU A 197
LEU A 179
 None
 1.08A 5hm8B-5xgcA:
undetectable		 5hm8B-5xgcA:
24.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_C_ADNC501_2
(ADENOSYLHOMOCYSTEINA
SE)		 5xgc RAP1 GTPASE-GDP
DISSOCIATION
STIMULATOR 1
(Homo
sapiens) 		4 / 5 GLU A 239
THR A 242
GLU A 197
LEU A 179
 None
 1.08A 5hm8C-5xgcA:
undetectable		 5hm8C-5xgcA:
24.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_D_ADND501_2
(ADENOSYLHOMOCYSTEINA
SE)		 5xgc RAP1 GTPASE-GDP
DISSOCIATION
STIMULATOR 1
(Homo
sapiens) 		4 / 5 GLU A 239
THR A 242
GLU A 197
LEU A 179
 None
 1.08A 5hm8D-5xgcA:
undetectable		 5hm8D-5xgcA:
24.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_E_ADNE501_2
(ADENOSYLHOMOCYSTEINA
SE)		 5xgc RAP1 GTPASE-GDP
DISSOCIATION
STIMULATOR 1
(Homo
sapiens) 		4 / 5 GLU A 239
THR A 242
GLU A 197
LEU A 179
 None
 1.08A 5hm8E-5xgcA:
undetectable		 5hm8E-5xgcA:
24.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_F_ADNF501_2
(ADENOSYLHOMOCYSTEINA
SE)		 5xgc RAP1 GTPASE-GDP
DISSOCIATION
STIMULATOR 1
(Homo
sapiens) 		4 / 5 GLU A 239
THR A 242
GLU A 197
LEU A 179
 None
 1.08A 5hm8F-5xgcA:
undetectable		 5hm8F-5xgcA:
24.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_G_ADNG501_2
(ADENOSYLHOMOCYSTEINA
SE)		 5xgc RAP1 GTPASE-GDP
DISSOCIATION
STIMULATOR 1
(Homo
sapiens) 		4 / 5 GLU A 239
THR A 242
GLU A 197
LEU A 179
 None
 1.07A 5hm8G-5xgcA:
undetectable		 5hm8G-5xgcA:
24.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_H_ADNH501_2
(ADENOSYLHOMOCYSTEINA
SE)		 5xgc RAP1 GTPASE-GDP
DISSOCIATION
STIMULATOR 1
(Homo
sapiens) 		4 / 5 GLU A 239
THR A 242
GLU A 197
LEU A 179
 None
 1.08A 5hm8H-5xgcA:
undetectable		 5hm8H-5xgcA:
24.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N9X_A_THRA601_0
(ADENYLATION DOMAIN)		 5xgc RAP1 GTPASE-GDP
DISSOCIATION
STIMULATOR 1
(Homo
sapiens) 		5 / 7 PHE A 294
PHE A 269
GLY A 266
GLY A 263
HIS A 303
 None
 1.32A 5n9xA-5xgcA:
undetectable		 5n9xA-5xgcA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZWR_A_9KLA402_0
(EST-Y29)		 5xgc RAP1 GTPASE-GDP
DISSOCIATION
STIMULATOR 1
(Homo
sapiens) 		5 / 12 ILE A 425
LEU A 446
GLY A 474
ALA A 476
LEU A 480
 None
 1.07A 5zwrA-5xgcA:
undetectable		 5zwrA-5xgcA:
21.25