SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5xgj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1A28_A_STRA1_1 (PROGESTERONE RECEPTOR)	5xgj	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM (Homo sapiens)	5 / 12	LEU A 911 LEU A 831 MET A 833 CYH A 984 PHE A1039	None	1.49A	1a28A-5xgjA: undetectable	1a28A-5xgjA: 16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1CD2_A_FOLA307_1 (DIHYDROFOLATE REDUCTASE)	5xgj	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM (Homo sapiens)	3 / 3	GLU A 722 ILE A 718 ARG A 38	None	0.82A	1cd2A-5xgjA: undetectable	1cd2A-5xgjA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2CDQ_A_SAMA1500_0 (ASPARTOKINASE)	5xgj	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM (Homo sapiens)	4 / 8	ILE A 393 ASP A 478 SER A 481 LEU A 436	None	0.99A	2cdqA-5xgjA: undetectable	2cdqA-5xgjA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2CIZ_A_ACTA1321_0 (CHLOROPEROXIDASE)	5xgj	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM (Homo sapiens)	4 / 5	LEU A 831 PHE A 980 VAL A 906 ALA A 987	None	1.16A	2cizA-5xgjA: undetectable	2cizA-5xgjA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2HJH_B_NCAB901_0 (NAD-DEPENDENT HISTONE DEACETYLASE SIR2)	5xgj	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM (Homo sapiens)	4 / 5	ILE A 841 PRO A 754 PHE A 668 VAL A 706	None	1.38A	2hjhB-5xgjA: undetectable	2hjhB-5xgjA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2OWC_A_ACRA600_1 (4-ALPHA-GLUCANOTRANS FERASE)	5xgj	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM (Homo sapiens)	5 / 11	GLN A1014 GLN A 637 ASP A 806 HIS A 676 ASN A 677	None	1.49A	2owcA-5xgjA: undetectable	2owcA-5xgjA: 10.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2P16_A_GG2A298_2 (COAGULATION FACTOR X (EC 3.4.21.6) (STUART FACTOR) (STUART-PROWER FACTOR))	5xgj	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM (Homo sapiens)	3 / 3	ARG A 93 GLU A 710 GLN A 75	None	0.98A	2p16A-5xgjA: undetectable	2p16A-5xgjA: 19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2P2F_A_ACTA653_0 (ACETYL-COENZYME A SYNTHETASE)	5xgj	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM (Homo sapiens)	4 / 5	THR A 679 VAL A 461 GLY A 460 TRP A 446	None	1.10A	2p2fA-5xgjA: undetectable	2p2fA-5xgjA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2W3A_B_TOPB1189_1 (DIHYDROFOLATE REDUCTASE)	5xgj	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM (Homo sapiens)	5 / 10	ILE A 964 ALA A 902 PHE A 897 ILE A 857 LEU A 877	None	1.15A	2w3aB-5xgjA: undetectable	2w3aB-5xgjA: 21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2XZ5_B_ACHB1210_0 (SOLUBLE ACETYLCHOLINE RECEPTOR)	5xgj	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM (Homo sapiens)	4 / 7	VAL A 923 TYR A 904 CYH A 901 ILE A 921	None	1.29A	2xz5B-5xgjA: undetectable 2xz5E-5xgjA: undetectable	2xz5B-5xgjA: undetectable 2xz5E-5xgjA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2XZ5_D_ACHD1210_0 (SOLUBLE ACETYLCHOLINE RECEPTOR)	5xgj	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM (Homo sapiens)	4 / 8	ILE A 921 VAL A 923 TYR A 904 CYH A 901	None	1.30A	2xz5C-5xgjA: undetectable 2xz5D-5xgjA: undetectable	2xz5C-5xgjA: undetectable 2xz5D-5xgjA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2XZ5_E_ACHE1210_0 (SOLUBLE ACETYLCHOLINE RECEPTOR)	5xgj	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM (Homo sapiens)	4 / 7	ILE A 921 VAL A 923 TYR A 904 CYH A 901	None	1.30A	2xz5D-5xgjA: undetectable 2xz5E-5xgjA: undetectable	2xz5D-5xgjA: undetectable 2xz5E-5xgjA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2ZZN_A_SAMA401_0 (UNCHARACTERIZED PROTEIN MJ0883)	5xgj	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM (Homo sapiens)	5 / 12	ARG A 577 TYR A 392 ASN A 575 ASP A 608 PHE A 486	None	1.13A	2zznA-5xgjA: undetectable	2zznA-5xgjA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3ADX_A_IMNA2_2 (PEROXISOME PROLIFERATOR-ACTIVAT ED RECEPTOR GAMMA)	5xgj	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM (Homo sapiens)	4 / 7	ILE A 921 LEU A 929 PHE A 930 LEU A 814	None	0.91A	3adxA-5xgjA: undetectable	3adxA-5xgjA: 14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3BJW_C_SVRC505_1 (PHOSPHOLIPASE A2)	5xgj	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM (Homo sapiens)	5 / 10	VAL A 125 GLU A 689 GLY A 118 THR A 74 ARG A 140	None	1.15A	3bjwD-5xgjA: undetectable	3bjwD-5xgjA: 15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3CR5_X_PNTX94_0 (PROTEIN S100-B)	5xgj	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM (Homo sapiens)	3 / 3	PHE A 897 CYH A 901 PHE A 954	None	1.10A	3cr5X-5xgjA: undetectable	3cr5X-5xgjA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3K37_B_BCZB468_1 (NEURAMINIDASE)	5xgj	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM (Homo sapiens)	3 / 3	ARG A1023 GLU A 950 TYR A 988	None	0.79A	3k37B-5xgjA: undetectable	3k37B-5xgjA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3KEE_B_30BB500_2 (GENOME POLYPROTEIN)	5xgj	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM (Homo sapiens)	3 / 3	PHE A 550 TYR A 557 LEU A 570	None	0.78A	3keeB-5xgjA: undetectable	3keeB-5xgjA: 16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3L35_H_DHIH3_0 (GP41 N-PEPTIDE HIV ENTRY INHIBITOR PIE12)	5xgj	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM (Homo sapiens)	3 / 3	LEU A 452 TRP A 424 GLY A 425	None	0.70A	3l35A-5xgjA: undetectable 3l35H-5xgjA: undetectable	3l35A-5xgjA: undetectable 3l35H-5xgjA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3L35_K_DHIK3_0 (GP41 N-PEPTIDE HIV ENTRY INHIBITOR PIE12)	5xgj	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM (Homo sapiens)	3 / 3	LEU A 452 TRP A 424 GLY A 425	None	0.73A	3l35B-5xgjA: undetectable 3l35K-5xgjA: undetectable	3l35B-5xgjA: undetectable 3l35K-5xgjA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3P5N_A_RBFA190_1 (RIBOFLAVIN UPTAKE PROTEIN)	5xgj	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM (Homo sapiens)	5 / 12	THR A 908 ALA A 902 ALA A 987 LEU A 831 LEU A 929	None	1.16A	3p5nA-5xgjA: undetectable	3p5nA-5xgjA: 17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3P5N_B_RBFB190_1 (RIBOFLAVIN UPTAKE PROTEIN)	5xgj	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM (Homo sapiens)	5 / 12	THR A 908 ALA A 902 ALA A 987 LEU A 831 LEU A 929	None	1.16A	3p5nB-5xgjA: undetectable	3p5nB-5xgjA: 17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3QL6_A_NIMA614_1 (LACTOPEROXIDASE)	5xgj	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM (Homo sapiens)	4 / 7	GLN A 630 GLU A 259 PHE A 666 PRO A 757	None	1.35A	3ql6A-5xgjA: undetectable	3ql6A-5xgjA: 8.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3TBG_A_RTZA1_1 (CYTOCHROME P450 2D6)	5xgj	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM (Homo sapiens)	5 / 12	GLY A 451 LEU A 452 GLU A 453 ASP A1017 SER A1015	None	1.24A	3tbgA-5xgjA: undetectable	3tbgA-5xgjA: 11.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4A6D_A_SAMA1350_0 (HYDROXYINDOLE O-METHYLTRANSFERASE)	5xgj	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM (Homo sapiens)	5 / 12	PHE A1016 LEU A 570 TRP A 574 GLY A 363 ASP A 603	None	1.13A	4a6dA-5xgjA: undetectable	4a6dA-5xgjA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4A6D_A_SAMA1350_0 (HYDROXYINDOLE O-METHYLTRANSFERASE)	5xgj	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM (Homo sapiens)	5 / 12	PHE A1016 LEU A 570 TRP A 574 GLY A 364 ASP A 603	None	0.98A	4a6dA-5xgjA: undetectable	4a6dA-5xgjA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4A6E_A_SAMA1349_0 (HYDROXYINDOLE O-METHYLTRANSFERASE)	5xgj	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM (Homo sapiens)	5 / 12	PHE A1016 LEU A 570 TRP A 574 GLY A 364 ASP A 603	None	1.01A	4a6eA-5xgjA: undetectable	4a6eA-5xgjA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4BQT_C_C5EC301_0 (SOLUBLE ACETYLCHOLINE RECEPTOR)	5xgj	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM (Homo sapiens)	4 / 8	VAL A 923 TYR A 904 CYH A 901 ILE A 921	None	1.11A	4bqtC-5xgjA: undetectable 4bqtD-5xgjA: undetectable	4bqtC-5xgjA: undetectable 4bqtD-5xgjA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4FEU_B_KANB301_1 (AMINOGLYCOSIDE 3'-PHOSPHOTRANSFERAS E APHA1-IAB)	5xgj	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM (Homo sapiens)	4 / 7	ASP A 746 ASP A 91 GLU A 39 GLU A 707	None	0.98A	4feuB-5xgjA: undetectable	4feuB-5xgjA: 15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4FEU_F_KANF301_1 (AMINOGLYCOSIDE 3'-PHOSPHOTRANSFERAS E APHA1-IAB)	5xgj	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM (Homo sapiens)	4 / 8	ASP A 746 ASP A 91 GLU A 39 GLU A 707	None	1.01A	4feuF-5xgjA: undetectable	4feuF-5xgjA: 15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4FEV_D_KAND301_1 (AMINOGLYCOSIDE 3'-PHOSPHOTRANSFERAS E APHA1-IAB)	5xgj	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM (Homo sapiens)	4 / 7	ASP A 746 ASP A 91 GLU A 39 GLU A 707	None	0.91A	4fevD-5xgjA: 1.4	4fevD-5xgjA: 15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4FEV_F_KANF301_1 (AMINOGLYCOSIDE 3'-PHOSPHOTRANSFERAS E APHA1-IAB)	5xgj	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM (Homo sapiens)	4 / 7	ASP A 746 ASP A 91 GLU A 39 GLU A 707	None	0.92A	4fevF-5xgjA: 1.1	4fevF-5xgjA: 15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4FEW_D_KAND301_1 (AMINOGLYCOSIDE 3'-PHOSPHOTRANSFERAS E APHA1-IAB)	5xgj	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM (Homo sapiens)	4 / 8	ASP A 746 ASP A 91 GLU A 39 GLU A 707	None	0.87A	4fewD-5xgjA: 5.6	4fewD-5xgjA: 15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4FEW_F_KANF301_1 (AMINOGLYCOSIDE 3'-PHOSPHOTRANSFERAS E APHA1-IAB)	5xgj	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM (Homo sapiens)	4 / 8	ASP A 746 ASP A 91 GLU A 39 GLU A 707	None	0.90A	4fewF-5xgjA: 5.0	4fewF-5xgjA: 15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4FEX_B_KANB301_1 (AMINOGLYCOSIDE 3'-PHOSPHOTRANSFERAS E APHA1-IAB)	5xgj	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM (Homo sapiens)	4 / 7	ASP A 746 ASP A 91 GLU A 39 GLU A 707	None	0.99A	4fexB-5xgjA: 4.9	4fexB-5xgjA: 15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4G1B_A_ECNA403_1 (FLAVOHEMOGLOBIN)	5xgj	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM (Homo sapiens)	5 / 12	ALA A 442 LEU A 443 VAL A 356 LEU A 404 ILE A 336	None	1.11A	4g1bA-5xgjA: undetectable	4g1bA-5xgjA: 12.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4GKH_B_KANB301_1 (AMINOGLYCOSIDE 3'-PHOSPHOTRANSFERAS E APHA1-IAB)	5xgj	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM (Homo sapiens)	4 / 8	ASP A 746 ASP A 91 GLU A 39 GLU A 707	None	1.00A	4gkhB-5xgjA: 5.3	4gkhB-5xgjA: 15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4GKH_F_KANF301_1 (AMINOGLYCOSIDE 3'-PHOSPHOTRANSFERAS E APHA1-IAB)	5xgj	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM (Homo sapiens)	4 / 8	ASP A 746 ASP A 91 GLU A 39 GLU A 707	None	0.87A	4gkhF-5xgjA: 1.1	4gkhF-5xgjA: 15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4GKH_G_KANG301_1 (AMINOGLYCOSIDE 3'-PHOSPHOTRANSFERAS E APHA1-IAB)	5xgj	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM (Homo sapiens)	4 / 7	ASP A 746 ASP A 91 GLU A 39 GLU A 707	None	0.90A	4gkhG-5xgjA: 5.3	4gkhG-5xgjA: 15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4GKH_K_KANK301_1 (AMINOGLYCOSIDE 3'-PHOSPHOTRANSFERAS E APHA1-IAB)	5xgj	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM (Homo sapiens)	4 / 8	ASP A 746 ASP A 91 GLU A 39 GLU A 707	None	0.94A	4gkhC-5xgjA: undetectable 4gkhK-5xgjA: 1.6	4gkhC-5xgjA: 15.44 4gkhK-5xgjA: 15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4GKI_A_KANA301_1 (AMINOGLYCOSIDE 3'-PHOSPHOTRANSFERAS E APHA1-IAB)	5xgj	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM (Homo sapiens)	4 / 8	ASP A 746 ASP A 91 GLU A 39 GLU A 707	None	0.88A	4gkiA-5xgjA: 1.0	4gkiA-5xgjA: 15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4GKI_C_KANC301_1 (AMINOGLYCOSIDE 3'-PHOSPHOTRANSFERAS E APHA1-IAB)	5xgj	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM (Homo sapiens)	4 / 8	ASP A 746 ASP A 91 GLU A 39 GLU A 707	None	1.04A	4gkiC-5xgjA: 5.3	4gkiC-5xgjA: 15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4GKI_G_KANG301_1 (AMINOGLYCOSIDE 3'-PHOSPHOTRANSFERAS E APHA1-IAB)	5xgj	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM (Homo sapiens)	4 / 8	ASP A 746 ASP A 91 GLU A 39 GLU A 707	None	0.92A	4gkiE-5xgjA: 2.5 4gkiG-5xgjA: 1.2	4gkiE-5xgjA: 15.44 4gkiG-5xgjA: 15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4L4C_B_CAMB502_0 (CAMPHOR 5-MONOOXYGENASE)	5xgj	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM (Homo sapiens)	4 / 8	PHE A 139 LEU A 639 VAL A 146 ILE A 143	None	0.93A	4l4cB-5xgjA: undetectable	4l4cB-5xgjA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4M11_C_MXMC606_2 (PROSTAGLANDIN G/H SYNTHASE 2)	5xgj	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM (Homo sapiens)	3 / 3	LEU A 812 ARG A 808 MET A 675	None	0.82A	4m11C-5xgjA: undetectable	4m11C-5xgjA: 11.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4MA8_C_Z80C301_1 (MAJOR PRION PROTEIN)	5xgj	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM (Homo sapiens)	4 / 5	GLY A 8 ILE A 718 LYS A 720 GLN A 721	None	1.05A	4ma8C-5xgjA: undetectable	4ma8C-5xgjA: 22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4XE0_A_40LA1101_0 (PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM)	5xgj	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM (Homo sapiens)	5 / 12	ILE A 848 VAL A 851 THR A 856 MET A 922 ILE A 932	84X A1101 ( 4.3A) 84X A1101 (-3.7A) None 84X A1101 ( 4.3A) 84X A1101 ( 3.8A)	1.13A	4xe0A-5xgjA: 41.1	4xe0A-5xgjA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4XE0_A_40LA1101_0 (PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM)	5xgj	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM (Homo sapiens)	5 / 12	PRO A 778 TRP A 780 ILE A 800 TYR A 836 ILE A 932	84X A1101 (-4.3A) None None 84X A1101 (-4.4A) 84X A1101 ( 3.8A)	0.81A	4xe0A-5xgjA: 41.1	4xe0A-5xgjA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4XE0_A_40LA1101_0 (PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM)	5xgj	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM (Homo sapiens)	7 / 12	TRP A 780 ILE A 800 TYR A 836 VAL A 851 THR A 856 MET A 922 ILE A 932	None None 84X A1101 (-4.4A) 84X A1101 (-3.7A) None 84X A1101 ( 4.3A) 84X A1101 ( 3.8A)	0.63A	4xe0A-5xgjA: 41.1	4xe0A-5xgjA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5AMK_A_EF2A151_1 (CEREBLON ISOFORM 4)	5xgj	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM (Homo sapiens)	4 / 8	ASN A 785 PRO A 786 PHE A 794 TRP A 783	None	1.50A	5amkA-5xgjA: undetectable	5amkA-5xgjA: 21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5MVN_B_PFLB410_1 (PROTON-GATED ION CHANNEL)	5xgj	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM (Homo sapiens)	5 / 9	ILE A 354 ILE A 406 VAL A 376 THR A 373 ILE A 338	None	1.36A	5mvnB-5xgjA: 1.9	5mvnB-5xgjA: 28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5NFP_A_8W5A804_2 (GLUCOCORTICOID RECEPTOR)	5xgj	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM (Homo sapiens)	4 / 4	LEU A1001 MET A 820 ILE A1019 LEU A 911	None	1.28A	5nfpA-5xgjA: undetectable	5nfpA-5xgjA: 15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5YK2_A_ERYA501_0 (PROBABLE CONSERVED ATP-BINDING PROTEIN ABC TRANSPORTER)	5xgj	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM (Homo sapiens)	5 / 11	GLU A 982 ARG A 979 GLY A 903 ALA A 902 ALA A 987	None	1.16A	5yk2A-5xgjA: 5.9	5yk2A-5xgjA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6A5Z_D_9CRD501_0 (RETINOIC ACID RECEPTOR RXR-ALPHA)	5xgj	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM (Homo sapiens)	5 / 12	ILE A 427 ILE A 336 LEU A 443 ALA A 442 ILE A 360	None	1.15A	6a5zD-5xgjA: undetectable	6a5zD-5xgjA: 21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6DJZ_B_GMJB301_0 (SIGMA NON-OPIOID INTRACELLULAR RECEPTOR 1)	5xgj	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM (Homo sapiens)	5 / 12	LEU A 445 ILE A 338 VAL A 376 THR A 358 LEU A 456	None	1.36A	6djzB-5xgjA: undetectable	6djzB-5xgjA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6EW0_B_TA1B501_2 (TUBULIN BETA CHAIN)	5xgj	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM (Homo sapiens)	4 / 5	LEU A 831 THR A 908 ARG A 818 PRO A 835	None	1.35A	6ew0B-5xgjA: undetectable	6ew0B-5xgjA: 19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6EW0_D_TA1D501_2 (TUBULIN BETA CHAIN)	5xgj	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM (Homo sapiens)	4 / 5	LEU A 831 THR A 908 ARG A 818 PRO A 835	None	1.35A	6ew0D-5xgjA: undetectable	6ew0D-5xgjA: 19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6EW0_H_TA1H501_2 (TUBULIN BETA CHAIN)	5xgj	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM (Homo sapiens)	4 / 5	LEU A 831 THR A 908 ARG A 818 PRO A 835	None	1.35A	6ew0H-5xgjA: undetectable	6ew0H-5xgjA: 19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6EW0_I_TA1I501_2 (TUBULIN BETA CHAIN)	5xgj	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM (Homo sapiens)	4 / 5	LEU A 831 THR A 908 ARG A 818 PRO A 835	None	1.35A	6ew0I-5xgjA: undetectable	6ew0I-5xgjA: 19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FGC_A_D95A816_0 (GEPHYRIN)	5xgj	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM (Homo sapiens)	5 / 11	MET A1005 PHE A1002 ILE A1019 LEU A 938 ILE A 819	None	1.32A	6fgcA-5xgjA: undetectable	6fgcA-5xgjA: 21.62

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1A28_A_STRA1_1","PROGESTERONE RECEPTOR","5xgj","PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM","Homo sapiens",5,"LEU A 911;LEU A 831;MET A 833;CYH A 984;PHE A1039","None","1.49A","1a28A-5xgjA:undetectable","1a28A-5xgjA:16.28"],["1CD2_A_FOLA307_1","DIHYDROFOLATE REDUCTASE","5xgj","PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM","Homo sapiens",3,"GLU A 722;ILE A 718;ARG A  38","None","0.82A","1cd2A-5xgjA:undetectable","1cd2A-5xgjA:undetectable"],["2CDQ_A_SAMA1500_0","ASPARTOKINASE","5xgj","PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM","Homo sapiens",4,"ILE A 393;ASP A 478;SER A 481;LEU A 436","None","0.99A","2cdqA-5xgjA:undetectable","2cdqA-5xgjA:undetectable"],["2CIZ_A_ACTA1321_0","CHLOROPEROXIDASE","5xgj","PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM","Homo sapiens",4,"LEU A 831;PHE A 980;VAL A 906;ALA A 987","None","1.16A","2cizA-5xgjA:undetectable","2cizA-5xgjA:undetectable"],["2HJH_B_NCAB901_0","NAD-DEPENDENT HISTONE DEACETYLASE SIR2","5xgj","PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM","Homo sapiens",4,"ILE A 841;PRO A 754;PHE A 668;VAL A 706","None","1.38A","2hjhB-5xgjA:undetectable","2hjhB-5xgjA:undetectable"],["2OWC_A_ACRA600_1","4-ALPHA-GLUCANOTRANSFERASE","5xgj","PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM","Homo sapiens",5,"GLN A1014;GLN A 637;ASP A 806;HIS A 676;ASN A 677","None","1.49A","2owcA-5xgjA:undetectable","2owcA-5xgjA:10.54"],["2P16_A_GG2A298_2","COAGULATION FACTOR X (EC 3.4.21.6) (STUART FACTOR) (STUART-PROWER FACTOR)","5xgj","PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM","Homo sapiens",3,"ARG A  93;GLU A 710;GLN A  75","None","0.98A","2p16A-5xgjA:undetectable","2p16A-5xgjA:19.67"],["2P2F_A_ACTA653_0","ACETYL-COENZYME A SYNTHETASE","5xgj","PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM","Homo sapiens",4,"THR A 679;VAL A 461;GLY A 460;TRP A 446","None","1.10A","2p2fA-5xgjA:undetectable","2p2fA-5xgjA:undetectable"],["2W3A_B_TOPB1189_1","DIHYDROFOLATE REDUCTASE","5xgj","PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM","Homo sapiens",5,"ILE A 964;ALA A 902;PHE A 897;ILE A 857;LEU A 877","None","1.15A","2w3aB-5xgjA:undetectable","2w3aB-5xgjA:21.08"],["2XZ5_B_ACHB1210_0","SOLUBLE ACETYLCHOLINE RECEPTOR","5xgj","PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM","Homo sapiens",4,"VAL A 923;TYR A 904;CYH A 901;ILE A 921","None","1.29A","2xz5B-5xgjA:undetectable;2xz5E-5xgjA:undetectable","2xz5B-5xgjA:undetectable;2xz5E-5xgjA:undetectable"],["2XZ5_D_ACHD1210_0","SOLUBLE ACETYLCHOLINE RECEPTOR","5xgj","PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM","Homo sapiens",4,"ILE A 921;VAL A 923;TYR A 904;CYH A 901","None","1.30A","2xz5C-5xgjA:undetectable;2xz5D-5xgjA:undetectable","2xz5C-5xgjA:undetectable;2xz5D-5xgjA:undetectable"],["2XZ5_E_ACHE1210_0","SOLUBLE ACETYLCHOLINE RECEPTOR","5xgj","PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM","Homo sapiens",4,"ILE A 921;VAL A 923;TYR A 904;CYH A 901","None","1.30A","2xz5D-5xgjA:undetectable;2xz5E-5xgjA:undetectable","2xz5D-5xgjA:undetectable;2xz5E-5xgjA:undetectable"],["2ZZN_A_SAMA401_0","UNCHARACTERIZED PROTEIN MJ0883","5xgj","PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM","Homo sapiens",5,"ARG A 577;TYR A 392;ASN A 575;ASP A 608;PHE A 486","None","1.13A","2zznA-5xgjA:undetectable","2zznA-5xgjA:undetectable"],["3ADX_A_IMNA2_2","PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA","5xgj","PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM","Homo sapiens",4,"ILE A 921;LEU A 929;PHE A 930;LEU A 814","None","0.91A","3adxA-5xgjA:undetectable","3adxA-5xgjA:14.29"],["3BJW_C_SVRC505_1","PHOSPHOLIPASE A2;PHOSPHOLIPASE A2","5xgj","PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM","Homo sapiens",5,"VAL A 125;GLU A 689;GLY A 118;THR A  74;ARG A 140","None","1.15A","3bjwD-5xgjA:undetectable","3bjwD-5xgjA:15.57"],["3CR5_X_PNTX94_0","PROTEIN S100-B","5xgj","PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM","Homo sapiens",3,"PHE A 897;CYH A 901;PHE A 954","None","1.10A","3cr5X-5xgjA:undetectable","3cr5X-5xgjA:undetectable"],["3K37_B_BCZB468_1","NEURAMINIDASE","5xgj","PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM","Homo sapiens",3,"ARG A1023;GLU A 950;TYR A 988","None","0.79A","3k37B-5xgjA:undetectable","3k37B-5xgjA:undetectable"],["3KEE_B_30BB500_2","GENOME POLYPROTEIN","5xgj","PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM","Homo sapiens",3,"PHE A 550;TYR A 557;LEU A 570","None","0.78A","3keeB-5xgjA:undetectable","3keeB-5xgjA:16.57"],["3L35_H_DHIH3_0","GP41 N-PEPTIDE;HIV ENTRY INHIBITOR PIE12","5xgj","PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM","Homo sapiens",3,"LEU A 452;TRP A 424;GLY A 425","None","0.70A","3l35A-5xgjA:undetectable;3l35H-5xgjA:undetectable","3l35A-5xgjA:undetectable;3l35H-5xgjA:undetectable"],["3L35_K_DHIK3_0","GP41 N-PEPTIDE;HIV ENTRY INHIBITOR PIE12","5xgj","PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM","Homo sapiens",3,"LEU A 452;TRP A 424;GLY A 425","None","0.73A","3l35B-5xgjA:undetectable;3l35K-5xgjA:undetectable","3l35B-5xgjA:undetectable;3l35K-5xgjA:undetectable"],["3P5N_A_RBFA190_1","RIBOFLAVIN UPTAKE PROTEIN","5xgj","PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM","Homo sapiens",5,"THR A 908;ALA A 902;ALA A 987;LEU A 831;LEU A 929","None","1.16A","3p5nA-5xgjA:undetectable","3p5nA-5xgjA:17.11"],["3P5N_B_RBFB190_1","RIBOFLAVIN UPTAKE PROTEIN","5xgj","PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM","Homo sapiens",5,"THR A 908;ALA A 902;ALA A 987;LEU A 831;LEU A 929","None","1.16A","3p5nB-5xgjA:undetectable","3p5nB-5xgjA:17.11"],["3QL6_A_NIMA614_1","LACTOPEROXIDASE","5xgj","PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM","Homo sapiens",4,"GLN A 630;GLU A 259;PHE A 666;PRO A 757","None","1.35A","3ql6A-5xgjA:undetectable","3ql6A-5xgjA:8.09"],["3TBG_A_RTZA1_1","CYTOCHROME P450 2D6","5xgj","PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM","Homo sapiens",5,"GLY A 451;LEU A 452;GLU A 453;ASP A1017;SER A1015","None","1.24A","3tbgA-5xgjA:undetectable","3tbgA-5xgjA:11.04"],["4A6D_A_SAMA1350_0","HYDROXYINDOLE O-METHYLTRANSFERASE","5xgj","PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM","Homo sapiens",5,"PHE A1016;LEU A 570;TRP A 574;GLY A 363;ASP A 603","None","1.13A","4a6dA-5xgjA:undetectable","4a6dA-5xgjA:undetectable"],["4A6D_A_SAMA1350_0","HYDROXYINDOLE O-METHYLTRANSFERASE","5xgj","PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM","Homo sapiens",5,"PHE A1016;LEU A 570;TRP A 574;GLY A 364;ASP A 603","None","0.98A","4a6dA-5xgjA:undetectable","4a6dA-5xgjA:undetectable"],["4A6E_A_SAMA1349_0","HYDROXYINDOLE O-METHYLTRANSFERASE","5xgj","PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM","Homo sapiens",5,"PHE A1016;LEU A 570;TRP A 574;GLY A 364;ASP A 603","None","1.01A","4a6eA-5xgjA:undetectable","4a6eA-5xgjA:undetectable"],["4BQT_C_C5EC301_0","SOLUBLE ACETYLCHOLINE RECEPTOR","5xgj","PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM","Homo sapiens",4,"VAL A 923;TYR A 904;CYH A 901;ILE A 921","None","1.11A","4bqtC-5xgjA:undetectable;4bqtD-5xgjA:undetectable","4bqtC-5xgjA:undetectable;4bqtD-5xgjA:undetectable"],["4FEU_B_KANB301_1","AMINOGLYCOSIDE 3'-PHOSPHOTRANSFERASE APHA1-IAB","5xgj","PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM","Homo sapiens",4,"ASP A 746;ASP A  91;GLU A  39;GLU A 707","None","0.98A","4feuB-5xgjA:undetectable","4feuB-5xgjA:15.44"],["4FEU_F_KANF301_1","AMINOGLYCOSIDE 3'-PHOSPHOTRANSFERASE APHA1-IAB","5xgj","PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM","Homo sapiens",4,"ASP A 746;ASP A  91;GLU A  39;GLU A 707","None","1.01A","4feuF-5xgjA:undetectable","4feuF-5xgjA:15.44"],["4FEV_D_KAND301_1","AMINOGLYCOSIDE 3'-PHOSPHOTRANSFERASE APHA1-IAB","5xgj","PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM","Homo sapiens",4,"ASP A 746;ASP A  91;GLU A  39;GLU A 707","None","0.91A","4fevD-5xgjA:1.4","4fevD-5xgjA:15.44"],["4FEV_F_KANF301_1","AMINOGLYCOSIDE 3'-PHOSPHOTRANSFERASE APHA1-IAB","5xgj","PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM","Homo sapiens",4,"ASP A 746;ASP A  91;GLU A  39;GLU A 707","None","0.92A","4fevF-5xgjA:1.1","4fevF-5xgjA:15.44"],["4FEW_D_KAND301_1","AMINOGLYCOSIDE 3'-PHOSPHOTRANSFERASE APHA1-IAB","5xgj","PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM","Homo sapiens",4,"ASP A 746;ASP A  91;GLU A  39;GLU A 707","None","0.87A","4fewD-5xgjA:5.6","4fewD-5xgjA:15.44"],["4FEW_F_KANF301_1","AMINOGLYCOSIDE 3'-PHOSPHOTRANSFERASE APHA1-IAB","5xgj","PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM","Homo sapiens",4,"ASP A 746;ASP A  91;GLU A  39;GLU A 707","None","0.90A","4fewF-5xgjA:5.0","4fewF-5xgjA:15.44"],["4FEX_B_KANB301_1","AMINOGLYCOSIDE 3'-PHOSPHOTRANSFERASE APHA1-IAB","5xgj","PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM","Homo sapiens",4,"ASP A 746;ASP A  91;GLU A  39;GLU A 707","None","0.99A","4fexB-5xgjA:4.9","4fexB-5xgjA:15.44"],["4G1B_A_ECNA403_1","FLAVOHEMOGLOBIN","5xgj","PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM","Homo sapiens",5,"ALA A 442;LEU A 443;VAL A 356;LEU A 404;ILE A 336","None","1.11A","4g1bA-5xgjA:undetectable","4g1bA-5xgjA:12.73"],["4GKH_B_KANB301_1","AMINOGLYCOSIDE 3'-PHOSPHOTRANSFERASE APHA1-IAB","5xgj","PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM","Homo sapiens",4,"ASP A 746;ASP A  91;GLU A  39;GLU A 707","None","1.00A","4gkhB-5xgjA:5.3","4gkhB-5xgjA:15.44"],["4GKH_F_KANF301_1","AMINOGLYCOSIDE 3'-PHOSPHOTRANSFERASE APHA1-IAB","5xgj","PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM","Homo sapiens",4,"ASP A 746;ASP A  91;GLU A  39;GLU A 707","None","0.87A","4gkhF-5xgjA:1.1","4gkhF-5xgjA:15.44"],["4GKH_G_KANG301_1","AMINOGLYCOSIDE 3'-PHOSPHOTRANSFERASE APHA1-IAB","5xgj","PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM","Homo sapiens",4,"ASP A 746;ASP A  91;GLU A  39;GLU A 707","None","0.90A","4gkhG-5xgjA:5.3","4gkhG-5xgjA:15.44"],["4GKH_K_KANK301_1","AMINOGLYCOSIDE 3'-PHOSPHOTRANSFERASE APHA1-IAB;AMINOGLYCOSIDE 3'-PHOSPHOTRANSFERASE APHA1-IAB","5xgj","PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM","Homo sapiens",4,"ASP A 746;ASP A  91;GLU A  39;GLU A 707","None","0.94A","4gkhC-5xgjA:undetectable;4gkhK-5xgjA:1.6","4gkhC-5xgjA:15.44;4gkhK-5xgjA:15.44"],["4GKI_A_KANA301_1","AMINOGLYCOSIDE 3'-PHOSPHOTRANSFERASE APHA1-IAB","5xgj","PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM","Homo sapiens",4,"ASP A 746;ASP A  91;GLU A  39;GLU A 707","None","0.88A","4gkiA-5xgjA:1.0","4gkiA-5xgjA:15.44"],["4GKI_C_KANC301_1","AMINOGLYCOSIDE 3'-PHOSPHOTRANSFERASE APHA1-IAB","5xgj","PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM","Homo sapiens",4,"ASP A 746;ASP A  91;GLU A  39;GLU A 707","None","1.04A","4gkiC-5xgjA:5.3","4gkiC-5xgjA:15.44"],["4GKI_G_KANG301_1","AMINOGLYCOSIDE 3'-PHOSPHOTRANSFERASE APHA1-IAB;AMINOGLYCOSIDE 3'-PHOSPHOTRANSFERASE APHA1-IAB","5xgj","PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM","Homo sapiens",4,"ASP A 746;ASP A  91;GLU A  39;GLU A 707","None","0.92A","4gkiE-5xgjA:2.5;4gkiG-5xgjA:1.2","4gkiE-5xgjA:15.44;4gkiG-5xgjA:15.44"],["4L4C_B_CAMB502_0","CAMPHOR 5-MONOOXYGENASE","5xgj","PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM","Homo sapiens",4,"PHE A 139;LEU A 639;VAL A 146;ILE A 143","None","0.93A","4l4cB-5xgjA:undetectable","4l4cB-5xgjA:undetectable"],["4M11_C_MXMC606_2","PROSTAGLANDIN G\/H SYNTHASE 2","5xgj","PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM","Homo sapiens",3,"LEU A 812;ARG A 808;MET A 675","None","0.82A","4m11C-5xgjA:undetectable","4m11C-5xgjA:11.69"],["4MA8_C_Z80C301_1","MAJOR PRION PROTEIN","5xgj","PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM","Homo sapiens",4,"GLY A   8;ILE A 718;LYS A 720;GLN A 721","None","1.05A","4ma8C-5xgjA:undetectable","4ma8C-5xgjA:22.81"],["4XE0_A_40LA1101_0","PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM","5xgj","PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM","Homo sapiens",5,"ILE A 848;VAL A 851;THR A 856;MET A 922;ILE A 932","84X A1101 ( 4.3A);84X A1101 (-3.7A);None;84X A1101 ( 4.3A);84X A1101 ( 3.8A)","1.13A","4xe0A-5xgjA:41.1","4xe0A-5xgjA:undetectable"],["4XE0_A_40LA1101_0","PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM","5xgj","PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM","Homo sapiens",5,"PRO A 778;TRP A 780;ILE A 800;TYR A 836;ILE A 932","84X A1101 (-4.3A);None;None;84X A1101 (-4.4A);84X A1101 ( 3.8A)","0.81A","4xe0A-5xgjA:41.1","4xe0A-5xgjA:undetectable"],["4XE0_A_40LA1101_0","PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM","5xgj","PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM","Homo sapiens",7,"TRP A 780;ILE A 800;TYR A 836;VAL A 851;THR A 856;MET A 922;ILE A 932","None;None;84X A1101 (-4.4A);84X A1101 (-3.7A);None;84X A1101 ( 4.3A);84X A1101 ( 3.8A)","0.63A","4xe0A-5xgjA:41.1","4xe0A-5xgjA:undetectable"],["5AMK_A_EF2A151_1","CEREBLON ISOFORM 4","5xgj","PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM","Homo sapiens",4,"ASN A 785;PRO A 786;PHE A 794;TRP A 783","None","1.50A","5amkA-5xgjA:undetectable","5amkA-5xgjA:21.60"],["5MVN_B_PFLB410_1","PROTON-GATED ION CHANNEL","5xgj","PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM","Homo sapiens",5,"ILE A 354;ILE A 406;VAL A 376;THR A 373;ILE A 338","None","1.36A","5mvnB-5xgjA:1.9","5mvnB-5xgjA:28.57"],["5NFP_A_8W5A804_2","GLUCOCORTICOID RECEPTOR","5xgj","PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM","Homo sapiens",4,"LEU A1001;MET A 820;ILE A1019;LEU A 911","None","1.28A","5nfpA-5xgjA:undetectable","5nfpA-5xgjA:15.27"],["5YK2_A_ERYA501_0","PROBABLE CONSERVED ATP-BINDING PROTEIN ABC TRANSPORTER","5xgj","PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM","Homo sapiens",5,"GLU A 982;ARG A 979;GLY A 903;ALA A 902;ALA A 987","None","1.16A","5yk2A-5xgjA:5.9","5yk2A-5xgjA:undetectable"],["6A5Z_D_9CRD501_0","RETINOIC ACID RECEPTOR RXR-ALPHA","5xgj","PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM","Homo sapiens",5,"ILE A 427;ILE A 336;LEU A 443;ALA A 442;ILE A 360","None","1.15A","6a5zD-5xgjA:undetectable","6a5zD-5xgjA:21.35"],["6DJZ_B_GMJB301_0","SIGMA NON-OPIOID INTRACELLULAR RECEPTOR 1","5xgj","PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM","Homo sapiens",5,"LEU A 445;ILE A 338;VAL A 376;THR A 358;LEU A 456","None","1.36A","6djzB-5xgjA:undetectable","6djzB-5xgjA:undetectable"],["6EW0_B_TA1B501_2","TUBULIN BETA CHAIN","5xgj","PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM","Homo sapiens",4,"LEU A 831;THR A 908;ARG A 818;PRO A 835","None","1.35A","6ew0B-5xgjA:undetectable","6ew0B-5xgjA:19.32"],["6EW0_D_TA1D501_2","TUBULIN BETA CHAIN","5xgj","PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM","Homo sapiens",4,"LEU A 831;THR A 908;ARG A 818;PRO A 835","None","1.35A","6ew0D-5xgjA:undetectable","6ew0D-5xgjA:19.32"],["6EW0_H_TA1H501_2","TUBULIN BETA CHAIN","5xgj","PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM","Homo sapiens",4,"LEU A 831;THR A 908;ARG A 818;PRO A 835","None","1.35A","6ew0H-5xgjA:undetectable","6ew0H-5xgjA:19.32"],["6EW0_I_TA1I501_2","TUBULIN BETA CHAIN","5xgj","PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM","Homo sapiens",4,"LEU A 831;THR A 908;ARG A 818;PRO A 835","None","1.35A","6ew0I-5xgjA:undetectable","6ew0I-5xgjA:19.32"],["6FGC_A_D95A816_0","GEPHYRIN","5xgj","PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM","Homo sapiens",5,"MET A1005;PHE A1002;ILE A1019;LEU A 938;ILE A 819","None","1.32A","6fgcA-5xgjA:undetectable","6fgcA-5xgjA:21.62"]]