SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5xgl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2PGZ_A_COCA401_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5xgl SOLUBLE
ACETYLCHOLINE
RECEPTOR
(Aplysia
californica) 		5 / 11 THR A  34
TYR A  53
GLN A  55
MET A 114
ILE A 116
 None
 0.51A 2pgzA-5xglA:
29.9
2pgzB-5xglA:
30.5		 2pgzA-5xglA:
98.75
2pgzB-5xglA:
98.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2PH9_A_GNTA301_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5xgl SOLUBLE
ACETYLCHOLINE
RECEPTOR
(Aplysia
californica) 		4 / 7 TRP A 145
GLN A 184
TYR A 186
TYR A 193
 None
 1.06A 2ph9A-5xglA:
31.0
2ph9B-5xglA:
31.2		 2ph9A-5xglA:
98.75
2ph9B-5xglA:
98.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2PH9_A_GNTA301_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5xgl SOLUBLE
ACETYLCHOLINE
RECEPTOR
(Aplysia
californica) 		4 / 7 TYR A  91
TRP A 145
TYR A 186
TYR A 193
 None
 0.39A 2ph9A-5xglA:
31.0
2ph9B-5xglA:
31.2		 2ph9A-5xglA:
98.75
2ph9B-5xglA:
98.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2XYT_D_TC9D1206_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5xgl SOLUBLE
ACETYLCHOLINE
RECEPTOR
(Aplysia
californica) 		4 / 7 TYR A  91
TRP A 145
GLU A 191
TYR A 193
 None
 0.45A 2xytD-5xglA:
31.7		 2xytD-5xglA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2XYT_D_TC9D1206_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5xgl SOLUBLE
ACETYLCHOLINE
RECEPTOR
(Aplysia
californica) 		5 / 8 THR A  34
GLN A  55
ILE A 116
ASP A 162
SER A 164
 None
 1.19A 2xytE-5xglA:
31.8		 2xytE-5xglA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2XYT_D_TC9D1206_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5xgl SOLUBLE
ACETYLCHOLINE
RECEPTOR
(Aplysia
californica) 		5 / 8 THR A  34
MET A 114
ILE A 116
ASP A 162
SER A 164
 None
 1.07A 2xytE-5xglA:
31.8		 2xytE-5xglA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2XYT_D_TC9D1206_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5xgl SOLUBLE
ACETYLCHOLINE
RECEPTOR
(Aplysia
californica) 		6 / 8 THR A  34
TYR A  53
GLN A  55
ILE A 116
ASP A 162
SER A 165
 None
 0.44A 2xytE-5xglA:
31.8		 2xytE-5xglA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2XYT_D_TC9D1206_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5xgl SOLUBLE
ACETYLCHOLINE
RECEPTOR
(Aplysia
californica) 		6 / 8 THR A  34
TYR A  53
MET A 114
ILE A 116
ASP A 162
SER A 165
 None
 0.46A 2xytE-5xglA:
31.8		 2xytE-5xglA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2XYT_F_TC9F1206_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5xgl SOLUBLE
ACETYLCHOLINE
RECEPTOR
(Aplysia
californica) 		6 / 12 TYR A  91
LYS A 141
TRP A 145
TYR A 186
GLU A 191
TYR A 193
 None
 0.74A 2xytF-5xglA:
31.7
2xytG-5xglA:
31.4		 2xytF-5xglA:
100.00
2xytG-5xglA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2XYT_G_TC9G1206_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5xgl SOLUBLE
ACETYLCHOLINE
RECEPTOR
(Aplysia
californica) 		4 / 7 TYR A  91
TRP A 145
GLU A 191
TYR A 193
 None
 0.40A 2xytG-5xglA:
31.4		 2xytG-5xglA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2XYT_G_TC9G1206_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5xgl SOLUBLE
ACETYLCHOLINE
RECEPTOR
(Aplysia
californica) 		5 / 8 THR A  34
GLN A  55
MET A 114
ILE A 116
SER A 164
 None
 1.00A 2xytH-5xglA:
31.7		 2xytH-5xglA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2XYT_G_TC9G1206_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5xgl SOLUBLE
ACETYLCHOLINE
RECEPTOR
(Aplysia
californica) 		7 / 8 THR A  34
TYR A  53
GLN A  55
MET A 114
ILE A 116
ASP A 162
SER A 165
 None
 0.55A 2xytH-5xglA:
31.7		 2xytH-5xglA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2XYT_H_TC9H1206_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5xgl SOLUBLE
ACETYLCHOLINE
RECEPTOR
(Aplysia
californica) 		4 / 7 TYR A  91
TRP A 145
GLU A 191
TYR A 193
 None
 0.35A 2xytH-5xglA:
31.7		 2xytH-5xglA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2XYT_H_TC9H1206_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5xgl SOLUBLE
ACETYLCHOLINE
RECEPTOR
(Aplysia
californica) 		5 / 7 THR A  34
GLN A  55
MET A 114
ILE A 116
SER A 164
 None
 0.97A 2xytI-5xglA:
31.9		 2xytI-5xglA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2XYT_H_TC9H1206_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5xgl SOLUBLE
ACETYLCHOLINE
RECEPTOR
(Aplysia
californica) 		7 / 7 THR A  34
TYR A  53
GLN A  55
MET A 114
ILE A 116
ASP A 162
SER A 165
 None
 0.44A 2xytI-5xglA:
31.9		 2xytI-5xglA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_B_ACHB1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5xgl SOLUBLE
ACETYLCHOLINE
RECEPTOR
(Aplysia
californica) 		4 / 8 GLN A  36
GLN A  55
ILE A 116
SER A 165
 None
 0.48A 2xz5B-5xglA:
30.8
2xz5E-5xglA:
30.9		 2xz5B-5xglA:
undetectable
2xz5E-5xglA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_C_ACHC1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5xgl SOLUBLE
ACETYLCHOLINE
RECEPTOR
(Aplysia
californica) 		4 / 8 THR A  34
GLN A  36
ASP A 162
SER A 165
 None
 0.33A 2xz5A-5xglA:
30.7
2xz5C-5xglA:
30.8		 2xz5A-5xglA:
undetectable
2xz5C-5xglA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_D_ACHD1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5xgl SOLUBLE
ACETYLCHOLINE
RECEPTOR
(Aplysia
californica) 		5 / 8 THR A  34
GLN A  36
GLN A  55
ASP A 162
SER A 165
 None
 0.39A 2xz5C-5xglA:
30.8
2xz5D-5xglA:
30.8		 2xz5C-5xglA:
undetectable
2xz5D-5xglA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D9L_A_ACTA501_0
(CTD-PEPTIDE
RNA-BINDING PROTEIN
16)		 5xgl SOLUBLE
ACETYLCHOLINE
RECEPTOR
(Aplysia
californica) 		4 / 5 PRO A 190
PRO A 192
TYR A 193
TYR A 186
 None
 1.05A 3d9lA-5xglA:
undetectable
3d9lY-5xglA:
undetectable		 3d9lA-5xglA:
undetectable
3d9lY-5xglA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_D_SAMD300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 5xgl SOLUBLE
ACETYLCHOLINE
RECEPTOR
(Aplysia
californica) 		5 / 12 TYR A 186
GLY A 149
SER A 148
ASP A 153
LEU A 154
 None
 1.40A 3ou6D-5xglA:
undetectable		 3ou6D-5xglA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3PEO_B_CU9B301_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5xgl SOLUBLE
ACETYLCHOLINE
RECEPTOR
(Aplysia
californica) 		5 / 12 THR A  34
GLN A  36
TYR A  53
GLN A  55
SER A 165
 None
 0.61A 3peoA-5xglA:
30.5
3peoB-5xglA:
30.9		 3peoA-5xglA:
98.75
3peoB-5xglA:
98.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3PEO_C_CU9C301_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5xgl SOLUBLE
ACETYLCHOLINE
RECEPTOR
(Aplysia
californica) 		5 / 12 THR A  34
GLN A  36
TYR A  53
GLN A  55
SER A 165
 None
 0.70A 3peoC-5xglA:
30.6
3peoD-5xglA:
30.6		 3peoC-5xglA:
98.75
3peoD-5xglA:
98.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3PEO_D_CU9D301_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5xgl SOLUBLE
ACETYLCHOLINE
RECEPTOR
(Aplysia
californica) 		5 / 10 THR A  34
TYR A  53
GLN A  55
SER A 164
SER A 165
 None
 0.26A 3peoD-5xglA:
30.6
3peoE-5xglA:
31.2		 3peoD-5xglA:
98.75
3peoE-5xglA:
98.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3PEO_F_CU9F301_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5xgl SOLUBLE
ACETYLCHOLINE
RECEPTOR
(Aplysia
californica) 		6 / 6 THR A  34
GLN A  36
TYR A  53
GLN A  55
ILE A 116
SER A 165
 None
 0.62A 3peoG-5xglA:
30.8		 3peoG-5xglA:
98.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3PEO_F_CU9F301_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5xgl SOLUBLE
ACETYLCHOLINE
RECEPTOR
(Aplysia
californica) 		4 / 6 THR A  34
GLN A  55
ILE A 116
SER A 164
 None
 0.82A 3peoG-5xglA:
30.8		 3peoG-5xglA:
98.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3PEO_H_CU9H301_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5xgl SOLUBLE
ACETYLCHOLINE
RECEPTOR
(Aplysia
californica) 		5 / 12 THR A  34
GLN A  36
TYR A  53
GLN A  55
SER A 165
 None
 0.68A 3peoH-5xglA:
30.6
3peoI-5xglA:
30.6		 3peoH-5xglA:
98.75
3peoI-5xglA:
98.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3PEO_J_CU9J301_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5xgl SOLUBLE
ACETYLCHOLINE
RECEPTOR
(Aplysia
californica) 		7 / 11 THR A  34
GLN A  36
TYR A  53
GLN A  55
ILE A 116
SER A 164
SER A 165
 None
 0.34A 3peoI-5xglA:
30.6
3peoJ-5xglA:
31.5		 3peoI-5xglA:
98.75
3peoJ-5xglA:
98.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3PMZ_E_TUBE220_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5xgl SOLUBLE
ACETYLCHOLINE
RECEPTOR
(Aplysia
californica) 		4 / 6 GLN A  55
MET A 114
ILE A 116
SER A 164
 None
 1.04A 3pmzD-5xglA:
30.9		 3pmzD-5xglA:
98.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3PMZ_E_TUBE220_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5xgl SOLUBLE
ACETYLCHOLINE
RECEPTOR
(Aplysia
californica) 		6 / 6 TYR A  53
GLN A  55
MET A 114
ILE A 116
SER A 164
SER A 165
 None
 0.83A 3pmzD-5xglA:
30.9		 3pmzD-5xglA:
98.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_B_RFPB502_2
(RIFAMPIN
MONOOXYGENASE)		 5xgl SOLUBLE
ACETYLCHOLINE
RECEPTOR
(Aplysia
californica) 		4 / 6 VAL A  97
LEU A 154
ARG A  57
PRO A  86
 None
 1.26A 6brdB-5xglA:
undetectable		 6brdB-5xglA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_B_RFPB502_2
(RIFAMPIN
MONOOXYGENASE)		 5xgl SOLUBLE
ACETYLCHOLINE
RECEPTOR
(Aplysia
californica) 		4 / 6 VAL A  99
LEU A 154
ARG A  57
PRO A  86
 None
 1.17A 6brdB-5xglA:
undetectable		 6brdB-5xglA:
18.39