SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5xgp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K2R_A_H4BA1760_1
(NITRIC-OXIDE
SYNTHASE)		 5xgp SECRETED XWNT8
INHIBITOR SIZZLED
(Xenopus
laevis) 		4 / 7 VAL A 254
TRP A 224
PHE A 180
GLU A 222
 None
 0.94A 1k2rA-5xgpA:
undetectable
1k2rB-5xgpA:
undetectable		 1k2rA-5xgpA:
19.81
1k2rB-5xgpA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K2R_B_H4BB2760_1
(NITRIC-OXIDE
SYNTHASE)		 5xgp SECRETED XWNT8
INHIBITOR SIZZLED
(Xenopus
laevis) 		4 / 7 PHE A 180
GLU A 222
VAL A 254
TRP A 224
 None
 0.92A 1k2rA-5xgpA:
undetectable
1k2rB-5xgpA:
undetectable		 1k2rA-5xgpA:
19.81
1k2rB-5xgpA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K2T_B_H4BB2760_1
(NITRIC-OXIDE
SYNTHASE)		 5xgp SECRETED XWNT8
INHIBITOR SIZZLED
(Xenopus
laevis) 		4 / 7 PHE A 180
GLU A 222
VAL A 254
TRP A 224
 None
 0.87A 1k2tA-5xgpA:
undetectable
1k2tB-5xgpA:
undetectable		 1k2tA-5xgpA:
19.81
1k2tB-5xgpA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K2U_B_H4BB2760_1
(NITRIC-OXIDE
SYNTHASE)		 5xgp SECRETED XWNT8
INHIBITOR SIZZLED
(Xenopus
laevis) 		4 / 6 PHE A 180
GLU A 222
VAL A 254
TRP A 224
 None
 0.91A 1k2uA-5xgpA:
undetectable
1k2uB-5xgpA:
undetectable		 1k2uA-5xgpA:
19.81
1k2uB-5xgpA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LZX_B_H4BB1760_1
(NITRIC-OXIDE
SYNTHASE)		 5xgp SECRETED XWNT8
INHIBITOR SIZZLED
(Xenopus
laevis) 		4 / 7 PHE A 180
GLU A 222
VAL A 254
TRP A 224
 None
 0.91A 1lzxA-5xgpA:
undetectable
1lzxB-5xgpA:
undetectable		 1lzxA-5xgpA:
19.81
1lzxB-5xgpA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LZZ_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE)		 5xgp SECRETED XWNT8
INHIBITOR SIZZLED
(Xenopus
laevis) 		4 / 7 VAL A 254
TRP A 224
PHE A 180
GLU A 222
 None
 0.94A 1lzzA-5xgpA:
undetectable
1lzzB-5xgpA:
undetectable		 1lzzA-5xgpA:
19.81
1lzzB-5xgpA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LZZ_B_H4BB1760_1
(NITRIC-OXIDE
SYNTHASE)		 5xgp SECRETED XWNT8
INHIBITOR SIZZLED
(Xenopus
laevis) 		4 / 7 PHE A 180
GLU A 222
VAL A 254
TRP A 224
 None
 0.94A 1lzzA-5xgpA:
undetectable
1lzzB-5xgpA:
undetectable		 1lzzA-5xgpA:
19.81
1lzzB-5xgpA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M00_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE)		 5xgp SECRETED XWNT8
INHIBITOR SIZZLED
(Xenopus
laevis) 		4 / 7 VAL A 254
TRP A 224
PHE A 180
GLU A 222
 None
 0.93A 1m00A-5xgpA:
undetectable
1m00B-5xgpA:
undetectable		 1m00A-5xgpA:
19.81
1m00B-5xgpA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MMV_B_H4BB2760_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5xgp SECRETED XWNT8
INHIBITOR SIZZLED
(Xenopus
laevis) 		4 / 7 PHE A 180
GLU A 222
VAL A 254
TRP A 224
 None
 0.88A 1mmvA-5xgpA:
undetectable
1mmvB-5xgpA:
undetectable		 1mmvA-5xgpA:
19.81
1mmvB-5xgpA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MMW_A_H4BA1760_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5xgp SECRETED XWNT8
INHIBITOR SIZZLED
(Xenopus
laevis) 		4 / 7 VAL A 254
TRP A 224
PHE A 180
GLU A 222
 None
 0.95A 1mmwA-5xgpA:
undetectable
1mmwB-5xgpA:
undetectable		 1mmwA-5xgpA:
19.81
1mmwB-5xgpA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MMW_B_H4BB2760_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5xgp SECRETED XWNT8
INHIBITOR SIZZLED
(Xenopus
laevis) 		4 / 7 PHE A 180
GLU A 222
VAL A 254
TRP A 224
 None
 0.92A 1mmwA-5xgpA:
undetectable
1mmwB-5xgpA:
undetectable		 1mmwA-5xgpA:
19.81
1mmwB-5xgpA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OM5_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5xgp SECRETED XWNT8
INHIBITOR SIZZLED
(Xenopus
laevis) 		4 / 8 VAL A 254
TRP A 224
PHE A 180
GLU A 222
 None
 0.93A 1om5A-5xgpA:
undetectable
1om5B-5xgpA:
undetectable		 1om5A-5xgpA:
19.72
1om5B-5xgpA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OVF_B_DVAB2_0
(ACTINOMYCIN D)		 5xgp SECRETED XWNT8
INHIBITOR SIZZLED
(Xenopus
laevis) 		3 / 3 THR A 238
PRO A 240
THR A 241
 None
CL  A 305 (-3.7A)
None
 0.86A 1ovfB-5xgpA:
undetectable		 1ovfB-5xgpA:
4.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS6_B_H4BB761_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5xgp SECRETED XWNT8
INHIBITOR SIZZLED
(Xenopus
laevis) 		4 / 8 PHE A 180
GLU A 222
VAL A 254
TRP A 224
 None
 0.90A 1rs6A-5xgpA:
undetectable
1rs6B-5xgpA:
undetectable		 1rs6A-5xgpA:
19.72
1rs6B-5xgpA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G6H_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5xgp SECRETED XWNT8
INHIBITOR SIZZLED
(Xenopus
laevis) 		4 / 8 VAL A 254
TRP A 224
PHE A 180
GLU A 222
 None
 0.94A 2g6hA-5xgpA:
undetectable
2g6hB-5xgpA:
undetectable		 2g6hA-5xgpA:
19.76
2g6hB-5xgpA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G6K_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5xgp SECRETED XWNT8
INHIBITOR SIZZLED
(Xenopus
laevis) 		4 / 7 VAL A 254
TRP A 224
PHE A 180
GLU A 222
 None
 0.92A 2g6kA-5xgpA:
undetectable
2g6kB-5xgpA:
undetectable		 2g6kA-5xgpA:
19.76
2g6kB-5xgpA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B3N_B_H4BB760_1
(NITRIC-OXIDE
SYNTHASE)		 5xgp SECRETED XWNT8
INHIBITOR SIZZLED
(Xenopus
laevis) 		4 / 7 PHE A 180
GLU A 222
VAL A 254
TRP A 224
 None
 0.90A 3b3nA-5xgpA:
undetectable
3b3nB-5xgpA:
undetectable		 3b3nA-5xgpA:
19.67
3b3nB-5xgpA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B3P_B_H4BB760_1
(NITRIC-OXIDE
SYNTHASE)		 5xgp SECRETED XWNT8
INHIBITOR SIZZLED
(Xenopus
laevis) 		4 / 8 PHE A 180
GLU A 222
VAL A 254
TRP A 224
 None
 0.86A 3b3pA-5xgpA:
undetectable
3b3pB-5xgpA:
undetectable		 3b3pA-5xgpA:
19.67
3b3pB-5xgpA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DQR_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5xgp SECRETED XWNT8
INHIBITOR SIZZLED
(Xenopus
laevis) 		4 / 7 VAL A 254
TRP A 224
PHE A 180
GLU A 222
 None
 0.91A 3dqrA-5xgpA:
undetectable
3dqrB-5xgpA:
undetectable		 3dqrA-5xgpA:
20.14
3dqrB-5xgpA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DQR_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5xgp SECRETED XWNT8
INHIBITOR SIZZLED
(Xenopus
laevis) 		4 / 7 PHE A 180
GLU A 222
VAL A 254
TRP A 224
 None
 0.83A 3dqrA-5xgpA:
undetectable
3dqrB-5xgpA:
undetectable		 3dqrA-5xgpA:
20.14
3dqrB-5xgpA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FC5_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5xgp SECRETED XWNT8
INHIBITOR SIZZLED
(Xenopus
laevis) 		4 / 7 VAL A 254
TRP A 224
PHE A 180
GLU A 222
 None
 0.92A 3fc5A-5xgpA:
undetectable
3fc5B-5xgpA:
undetectable		 3fc5A-5xgpA:
19.44
3fc5B-5xgpA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FC5_B_H4BB761_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5xgp SECRETED XWNT8
INHIBITOR SIZZLED
(Xenopus
laevis) 		4 / 7 PHE A 180
GLU A 222
VAL A 254
TRP A 224
 None
 0.93A 3fc5A-5xgpA:
undetectable
3fc5B-5xgpA:
undetectable		 3fc5A-5xgpA:
19.44
3fc5B-5xgpA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HSN_B_H4BB1760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5xgp SECRETED XWNT8
INHIBITOR SIZZLED
(Xenopus
laevis) 		4 / 7 PHE A 180
GLU A 222
VAL A 254
TRP A 224
 None
 0.93A 3hsnA-5xgpA:
undetectable
3hsnB-5xgpA:
undetectable		 3hsnA-5xgpA:
19.67
3hsnB-5xgpA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HSO_B_H4BB1760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5xgp SECRETED XWNT8
INHIBITOR SIZZLED
(Xenopus
laevis) 		4 / 7 PHE A 180
GLU A 222
VAL A 254
TRP A 224
 None
 0.92A 3hsoA-5xgpA:
undetectable
3hsoB-5xgpA:
undetectable		 3hsoA-5xgpA:
19.67
3hsoB-5xgpA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HSP_B_H4BB1760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5xgp SECRETED XWNT8
INHIBITOR SIZZLED
(Xenopus
laevis) 		4 / 7 PHE A 180
GLU A 222
VAL A 254
TRP A 224
 None
 0.89A 3hspA-5xgpA:
undetectable
3hspB-5xgpA:
undetectable		 3hspA-5xgpA:
19.67
3hspB-5xgpA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JT3_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5xgp SECRETED XWNT8
INHIBITOR SIZZLED
(Xenopus
laevis) 		4 / 7 PHE A 180
GLU A 222
VAL A 254
TRP A 224
 None
 0.87A 3jt3A-5xgpA:
undetectable
3jt3B-5xgpA:
undetectable		 3jt3A-5xgpA:
19.67
3jt3B-5xgpA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JT8_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5xgp SECRETED XWNT8
INHIBITOR SIZZLED
(Xenopus
laevis) 		4 / 7 PHE A 180
GLU A 222
VAL A 254
TRP A 224
 None
 0.92A 3jt8A-5xgpA:
undetectable
3jt8B-5xgpA:
undetectable		 3jt8A-5xgpA:
19.67
3jt8B-5xgpA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JTA_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5xgp SECRETED XWNT8
INHIBITOR SIZZLED
(Xenopus
laevis) 		4 / 7 PHE A 180
GLU A 222
VAL A 254
TRP A 224
 None
 0.89A 3jtaA-5xgpA:
undetectable
3jtaB-5xgpA:
undetectable		 3jtaA-5xgpA:
19.67
3jtaB-5xgpA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX2_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5xgp SECRETED XWNT8
INHIBITOR SIZZLED
(Xenopus
laevis) 		4 / 7 PHE A 180
GLU A 222
VAL A 254
TRP A 224
 None
 0.91A 3jx2A-5xgpA:
undetectable
3jx2B-5xgpA:
undetectable		 3jx2A-5xgpA:
20.14
3jx2B-5xgpA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX5_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5xgp SECRETED XWNT8
INHIBITOR SIZZLED
(Xenopus
laevis) 		4 / 7 PHE A 180
GLU A 222
VAL A 254
TRP A 224
 None
 0.92A 3jx5A-5xgpA:
undetectable
3jx5B-5xgpA:
undetectable		 3jx5A-5xgpA:
20.14
3jx5B-5xgpA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX6_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5xgp SECRETED XWNT8
INHIBITOR SIZZLED
(Xenopus
laevis) 		4 / 7 VAL A 254
TRP A 224
PHE A 180
GLU A 222
 None
 0.85A 3jx6A-5xgpA:
undetectable
3jx6B-5xgpA:
undetectable		 3jx6A-5xgpA:
19.91
3jx6B-5xgpA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N5V_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE)		 5xgp SECRETED XWNT8
INHIBITOR SIZZLED
(Xenopus
laevis) 		4 / 7 PHE A 180
GLU A 222
VAL A 254
TRP A 224
 None
 0.85A 3n5vA-5xgpA:
undetectable
3n5vB-5xgpA:
undetectable		 3n5vA-5xgpA:
19.67
3n5vB-5xgpA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N5Z_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE)		 5xgp SECRETED XWNT8
INHIBITOR SIZZLED
(Xenopus
laevis) 		4 / 7 PHE A 180
GLU A 222
VAL A 254
TRP A 224
 None
 0.87A 3n5zA-5xgpA:
undetectable
3n5zB-5xgpA:
undetectable		 3n5zA-5xgpA:
19.67
3n5zB-5xgpA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N61_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE)		 5xgp SECRETED XWNT8
INHIBITOR SIZZLED
(Xenopus
laevis) 		4 / 7 PHE A 180
GLU A 222
VAL A 254
TRP A 224
 None
 0.89A 3n61A-5xgpA:
undetectable
3n61B-5xgpA:
undetectable		 3n61A-5xgpA:
20.14
3n61B-5xgpA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N65_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE)		 5xgp SECRETED XWNT8
INHIBITOR SIZZLED
(Xenopus
laevis) 		4 / 6 VAL A 254
TRP A 224
PHE A 180
GLU A 222
 None
 0.88A 3n65A-5xgpA:
undetectable
3n65B-5xgpA:
undetectable		 3n65A-5xgpA:
19.67
3n65B-5xgpA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLJ_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5xgp SECRETED XWNT8
INHIBITOR SIZZLED
(Xenopus
laevis) 		4 / 7 VAL A 254
TRP A 224
PHE A 180
GLU A 222
 None
 0.89A 3nljA-5xgpA:
undetectable
3nljB-5xgpA:
undetectable		 3nljA-5xgpA:
19.91
3nljB-5xgpA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLJ_B_H4BB761_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5xgp SECRETED XWNT8
INHIBITOR SIZZLED
(Xenopus
laevis) 		4 / 7 PHE A 180
GLU A 222
VAL A 254
TRP A 224
 None
 0.83A 3nljA-5xgpA:
undetectable
3nljB-5xgpA:
undetectable		 3nljA-5xgpA:
19.91
3nljB-5xgpA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLP_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5xgp SECRETED XWNT8
INHIBITOR SIZZLED
(Xenopus
laevis) 		4 / 7 PHE A 180
GLU A 222
VAL A 254
TRP A 224
 None
 0.92A 3nlpA-5xgpA:
undetectable
3nlpB-5xgpA:
undetectable		 3nlpA-5xgpA:
20.14
3nlpB-5xgpA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLQ_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5xgp SECRETED XWNT8
INHIBITOR SIZZLED
(Xenopus
laevis) 		4 / 7 PHE A 180
GLU A 222
VAL A 254
TRP A 224
 None
 0.89A 3nlqA-5xgpA:
undetectable
3nlqB-5xgpA:
undetectable		 3nlqA-5xgpA:
20.14
3nlqB-5xgpA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLR_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5xgp SECRETED XWNT8
INHIBITOR SIZZLED
(Xenopus
laevis) 		4 / 8 PHE A 180
GLU A 222
VAL A 254
TRP A 224
 None
 0.91A 3nlrA-5xgpA:
undetectable
3nlrB-5xgpA:
undetectable		 3nlrA-5xgpA:
20.14
3nlrB-5xgpA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLY_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5xgp SECRETED XWNT8
INHIBITOR SIZZLED
(Xenopus
laevis) 		4 / 8 PHE A 180
GLU A 222
VAL A 254
TRP A 224
 None
 0.89A 3nlyA-5xgpA:
undetectable
3nlyB-5xgpA:
undetectable		 3nlyA-5xgpA:
19.67
3nlyB-5xgpA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQL_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5xgp SECRETED XWNT8
INHIBITOR SIZZLED
(Xenopus
laevis) 		4 / 8 PHE A 180
GLU A 222
VAL A 254
TRP A 224
 None
 0.87A 3rqlA-5xgpA:
undetectable
3rqlB-5xgpA:
undetectable		 3rqlA-5xgpA:
19.67
3rqlB-5xgpA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SVP_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5xgp SECRETED XWNT8
INHIBITOR SIZZLED
(Xenopus
laevis) 		4 / 6 PHE A 180
GLU A 222
VAL A 254
TRP A 224
 None
 0.88A 3svpA-5xgpA:
undetectable
3svpB-5xgpA:
undetectable		 3svpA-5xgpA:
19.67
3svpB-5xgpA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SVQ_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5xgp SECRETED XWNT8
INHIBITOR SIZZLED
(Xenopus
laevis) 		4 / 6 PHE A 180
GLU A 222
VAL A 254
TRP A 224
 None
 0.88A 3svqA-5xgpA:
undetectable
3svqB-5xgpA:
undetectable		 3svqA-5xgpA:
19.67
3svqB-5xgpA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFO_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5xgp SECRETED XWNT8
INHIBITOR SIZZLED
(Xenopus
laevis) 		4 / 7 VAL A 254
TRP A 224
PHE A 180
GLU A 222
 None
 0.86A 3ufoA-5xgpA:
undetectable
3ufoB-5xgpA:
undetectable		 3ufoA-5xgpA:
19.67
3ufoB-5xgpA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFO_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5xgp SECRETED XWNT8
INHIBITOR SIZZLED
(Xenopus
laevis) 		4 / 7 PHE A 180
GLU A 222
VAL A 254
TRP A 224
 None
 0.87A 3ufoA-5xgpA:
undetectable
3ufoB-5xgpA:
undetectable		 3ufoA-5xgpA:
19.67
3ufoB-5xgpA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFP_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5xgp SECRETED XWNT8
INHIBITOR SIZZLED
(Xenopus
laevis) 		4 / 7 VAL A 254
TRP A 224
PHE A 180
GLU A 222
 None
 0.85A 3ufpA-5xgpA:
undetectable
3ufpB-5xgpA:
undetectable		 3ufpA-5xgpA:
19.67
3ufpB-5xgpA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFP_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5xgp SECRETED XWNT8
INHIBITOR SIZZLED
(Xenopus
laevis) 		4 / 7 PHE A 180
GLU A 222
VAL A 254
TRP A 224
 None
 0.85A 3ufpA-5xgpA:
undetectable
3ufpB-5xgpA:
undetectable		 3ufpA-5xgpA:
19.67
3ufpB-5xgpA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFQ_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5xgp SECRETED XWNT8
INHIBITOR SIZZLED
(Xenopus
laevis) 		4 / 7 PHE A 180
GLU A 222
VAL A 254
TRP A 224
 None
 0.90A 3ufqA-5xgpA:
undetectable
3ufqB-5xgpA:
undetectable		 3ufqA-5xgpA:
19.67
3ufqB-5xgpA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFR_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5xgp SECRETED XWNT8
INHIBITOR SIZZLED
(Xenopus
laevis) 		4 / 7 PHE A 180
GLU A 222
VAL A 254
TRP A 224
 None
 0.84A 3ufrA-5xgpA:
undetectable
3ufrB-5xgpA:
undetectable		 3ufrA-5xgpA:
19.67
3ufrB-5xgpA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFT_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5xgp SECRETED XWNT8
INHIBITOR SIZZLED
(Xenopus
laevis) 		4 / 7 PHE A 180
GLU A 222
VAL A 254
TRP A 224
 None
 0.85A 3uftA-5xgpA:
undetectable
3uftB-5xgpA:
undetectable		 3uftA-5xgpA:
19.67
3uftB-5xgpA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFV_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5xgp SECRETED XWNT8
INHIBITOR SIZZLED
(Xenopus
laevis) 		4 / 7 PHE A 180
GLU A 222
VAL A 254
TRP A 224
 None
 0.90A 3ufvA-5xgpA:
undetectable
3ufvB-5xgpA:
undetectable		 3ufvA-5xgpA:
19.67
3ufvB-5xgpA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFW_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5xgp SECRETED XWNT8
INHIBITOR SIZZLED
(Xenopus
laevis) 		4 / 6 PHE A 180
GLU A 222
VAL A 254
TRP A 224
 None
 0.87A 3ufwA-5xgpA:
undetectable
3ufwB-5xgpA:
undetectable		 3ufwA-5xgpA:
19.67
3ufwB-5xgpA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CAO_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5xgp SECRETED XWNT8
INHIBITOR SIZZLED
(Xenopus
laevis) 		4 / 7 PHE A 180
GLU A 222
VAL A 254
TRP A 224
 None
 0.87A 4caoA-5xgpA:
undetectable
4caoB-5xgpA:
undetectable		 4caoA-5xgpA:
19.67
4caoB-5xgpA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CAP_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5xgp SECRETED XWNT8
INHIBITOR SIZZLED
(Xenopus
laevis) 		4 / 8 PHE A 180
GLU A 222
VAL A 254
TRP A 224
 None
 0.89A 4capA-5xgpA:
undetectable
4capB-5xgpA:
undetectable		 4capA-5xgpA:
19.67
4capB-5xgpA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTT_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5xgp SECRETED XWNT8
INHIBITOR SIZZLED
(Xenopus
laevis) 		4 / 7 PHE A 180
GLU A 222
VAL A 254
TRP A 224
 None
 0.89A 4cttA-5xgpA:
undetectable
4cttB-5xgpA:
undetectable		 4cttA-5xgpA:
19.67
4cttB-5xgpA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTU_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5xgp SECRETED XWNT8
INHIBITOR SIZZLED
(Xenopus
laevis) 		4 / 7 PHE A 180
GLU A 222
VAL A 254
TRP A 224
 None
 0.88A 4ctuA-5xgpA:
undetectable
4ctuB-5xgpA:
undetectable		 4ctuA-5xgpA:
19.67
4ctuB-5xgpA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D30_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5xgp SECRETED XWNT8
INHIBITOR SIZZLED
(Xenopus
laevis) 		4 / 7 PHE A 180
GLU A 222
VAL A 254
TRP A 224
 None
 0.88A 4d30A-5xgpA:
undetectable
4d30B-5xgpA:
undetectable		 4d30A-5xgpA:
19.67
4d30B-5xgpA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FVZ_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5xgp SECRETED XWNT8
INHIBITOR SIZZLED
(Xenopus
laevis) 		4 / 7 PHE A 180
GLU A 222
VAL A 254
TRP A 224
 None
 0.91A 4fvzA-5xgpA:
undetectable
4fvzB-5xgpA:
undetectable		 4fvzA-5xgpA:
19.67
4fvzB-5xgpA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IMT_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5xgp SECRETED XWNT8
INHIBITOR SIZZLED
(Xenopus
laevis) 		4 / 7 PHE A 180
GLU A 222
VAL A 254
TRP A 224
 None
 0.94A 4imtA-5xgpA:
undetectable
4imtB-5xgpA:
undetectable		 4imtA-5xgpA:
19.67
4imtB-5xgpA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IMU_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5xgp SECRETED XWNT8
INHIBITOR SIZZLED
(Xenopus
laevis) 		4 / 6 VAL A 254
TRP A 224
PHE A 180
GLU A 222
 None
 0.84A 4imuA-5xgpA:
undetectable
4imuB-5xgpA:
undetectable		 4imuA-5xgpA:
19.67
4imuB-5xgpA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IMU_A_H4BA809_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5xgp SECRETED XWNT8
INHIBITOR SIZZLED
(Xenopus
laevis) 		4 / 6 PHE A 180
GLU A 222
VAL A 254
TRP A 224
 None
 0.87A 4imuA-5xgpA:
undetectable
4imuB-5xgpA:
undetectable		 4imuA-5xgpA:
19.67
4imuB-5xgpA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IMW_A_H4BA805_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5xgp SECRETED XWNT8
INHIBITOR SIZZLED
(Xenopus
laevis) 		4 / 7 PHE A 180
GLU A 222
VAL A 254
TRP A 224
 None
 0.90A 4imwA-5xgpA:
undetectable
4imwB-5xgpA:
undetectable		 4imwA-5xgpA:
19.67
4imwB-5xgpA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCK_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5xgp SECRETED XWNT8
INHIBITOR SIZZLED
(Xenopus
laevis) 		4 / 7 PHE A 180
GLU A 222
VAL A 254
TRP A 224
 None
 0.85A 4kckA-5xgpA:
undetectable
4kckB-5xgpA:
undetectable		 4kckA-5xgpA:
19.67
4kckB-5xgpA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UH5_A_H4BA760_1
(NEURONAL NITRIC
OXIDE SYNTHASE)		 5xgp SECRETED XWNT8
INHIBITOR SIZZLED
(Xenopus
laevis) 		4 / 7 VAL A 254
TRP A 224
PHE A 180
GLU A 222
 None
 0.93A 4uh5A-5xgpA:
undetectable
4uh5B-5xgpA:
undetectable		 4uh5A-5xgpA:
19.48
4uh5B-5xgpA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V3U_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5xgp SECRETED XWNT8
INHIBITOR SIZZLED
(Xenopus
laevis) 		4 / 7 VAL A 254
TRP A 224
PHE A 180
GLU A 222
 None
 0.91A 4v3uA-5xgpA:
undetectable
4v3uB-5xgpA:
undetectable		 4v3uA-5xgpA:
19.53
4v3uB-5xgpA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AD5_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5xgp SECRETED XWNT8
INHIBITOR SIZZLED
(Xenopus
laevis) 		4 / 6 PHE A 180
GLU A 222
VAL A 254
TRP A 224
 None
 0.91A 5ad5A-5xgpA:
undetectable
5ad5B-5xgpA:
undetectable		 5ad5A-5xgpA:
19.67
5ad5B-5xgpA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AGM_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5xgp SECRETED XWNT8
INHIBITOR SIZZLED
(Xenopus
laevis) 		4 / 7 PHE A 180
GLU A 222
VAL A 254
TRP A 224
 None
 0.95A 5agmA-5xgpA:
undetectable
5agmB-5xgpA:
undetectable		 5agmA-5xgpA:
19.67
5agmB-5xgpA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AGN_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5xgp SECRETED XWNT8
INHIBITOR SIZZLED
(Xenopus
laevis) 		4 / 7 PHE A 180
GLU A 222
VAL A 254
TRP A 224
 None
 0.92A 5agnA-5xgpA:
undetectable
5agnB-5xgpA:
undetectable		 5agnA-5xgpA:
19.67
5agnB-5xgpA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVU_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5xgp SECRETED XWNT8
INHIBITOR SIZZLED
(Xenopus
laevis) 		4 / 6 VAL A 254
TRP A 224
PHE A 180
GLU A 222
 None
 0.96A 5fvuA-5xgpA:
undetectable
5fvuB-5xgpA:
undetectable		 5fvuA-5xgpA:
19.48
5fvuB-5xgpA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVU_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5xgp SECRETED XWNT8
INHIBITOR SIZZLED
(Xenopus
laevis) 		4 / 7 PHE A 180
GLU A 222
VAL A 254
TRP A 224
 None
 0.88A 5fvuA-5xgpA:
undetectable
5fvuB-5xgpA:
undetectable		 5fvuA-5xgpA:
19.48
5fvuB-5xgpA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVW_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5xgp SECRETED XWNT8
INHIBITOR SIZZLED
(Xenopus
laevis) 		4 / 7 VAL A 254
TRP A 224
PHE A 180
GLU A 222
 None
 0.93A 5fvwA-5xgpA:
undetectable
5fvwB-5xgpA:
undetectable		 5fvwA-5xgpA:
19.48
5fvwB-5xgpA:
19.48