SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5xgr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_E_ACTE503_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 5xgr SPIKE PROTEIN S1
(Pipistrellus
bat
coronavirus
HKU5) 		3 / 3 GLN A 186
THR A  97
ASN A  95
 None
 0.83A 3v4tE-5xgrA:
undetectable		 3v4tE-5xgrA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_1
(SEPIAPTERIN
REDUCTASE)		 5xgr SPIKE PROTEIN S1
(Pipistrellus
bat
coronavirus
HKU5) 		5 / 12 LEU A   9
PHE A  38
TYR A  65
ALA A  67
LEU A 177
 None
 1.26A 4j7xB-5xgrA:
undetectable		 4j7xB-5xgrA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJW_B_ACTB603_0
(CHOLINE OXIDASE)		 5xgr SPIKE PROTEIN S1
(Pipistrellus
bat
coronavirus
HKU5) 		3 / 3 SER A 149
ARG A 150
HIS A 159
 None
 1.01A 4mjwA-5xgrA:
undetectable
4mjwB-5xgrA:
undetectable		 4mjwA-5xgrA:
16.12
4mjwB-5xgrA:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWA_A_GCSA302_1
(CHITOSANASE)		 5xgr SPIKE PROTEIN S1
(Pipistrellus
bat
coronavirus
HKU5) 		4 / 7 THR A  62
ASP A  64
TYR A  89
GLY A 139
 None
 1.09A 5hwaA-5xgrA:
undetectable		 5hwaA-5xgrA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0R_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 5xgr SPIKE PROTEIN S1
(Pipistrellus
bat
coronavirus
HKU5) 		4 / 4 SER A 149
ALA A 148
GLN A 157
THR A 166
 None
 1.24A 5n0rA-5xgrA:
undetectable		 5n0rA-5xgrA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0S_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 5xgr SPIKE PROTEIN S1
(Pipistrellus
bat
coronavirus
HKU5) 		4 / 4 SER A 149
ALA A 148
GLN A 157
THR A 166
 None
 1.22A 5n0sA-5xgrA:
undetectable		 5n0sA-5xgrA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0T_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 5xgr SPIKE PROTEIN S1
(Pipistrellus
bat
coronavirus
HKU5) 		4 / 5 SER A 149
ALA A 148
GLN A 157
THR A 166
 None
 1.27A 5n0tA-5xgrA:
undetectable		 5n0tA-5xgrA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0W_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 5xgr SPIKE PROTEIN S1
(Pipistrellus
bat
coronavirus
HKU5) 		4 / 4 SER A 149
ALA A 148
GLN A 157
THR A 166
 None
 1.22A 5n0wA-5xgrA:
undetectable		 5n0wA-5xgrA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0W_B_SAMB501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 5xgr SPIKE PROTEIN S1
(Pipistrellus
bat
coronavirus
HKU5) 		4 / 5 SER A 149
ALA A 148
GLN A 157
THR A 166
 None
 1.22A 5n0wB-5xgrA:
undetectable		 5n0wB-5xgrA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0X_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 5xgr SPIKE PROTEIN S1
(Pipistrellus
bat
coronavirus
HKU5) 		4 / 4 SER A 149
ALA A 148
GLN A 157
THR A 166
 None
 1.22A 5n0xA-5xgrA:
undetectable		 5n0xA-5xgrA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N4I_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 5xgr SPIKE PROTEIN S1
(Pipistrellus
bat
coronavirus
HKU5) 		4 / 5 SER A 149
ALA A 148
GLN A 157
THR A 166
 None
 1.16A 5n4iA-5xgrA:
undetectable		 5n4iA-5xgrA:
19.17