SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5xgs'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_C_ADNC603_1
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 5xgs RCC1-LIKE G
EXCHANGING
FACTOR-LIKE PROTEIN
(Homo
sapiens) 		5 / 12 LEU A 187
HIS A 185
GLY A 255
HIS A 241
PHE A 244
 None
 1.31A 1d4fC-5xgsA:
undetectable		 1d4fC-5xgsA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_B_CHDB2503_0
(FERROCHELATASE)		 5xgs RCC1-LIKE G
EXCHANGING
FACTOR-LIKE PROTEIN
(Homo
sapiens) 		4 / 4 LEU A 415
PRO A 446
LEU A 409
ARG A 400
 None
 1.33A 1hrkB-5xgsA:
undetectable		 1hrkB-5xgsA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J96_A_TESA903_1
(3ALPHA-HYDROXYSTEROI
D DEHYDROGENASE TYPE
3)		 5xgs RCC1-LIKE G
EXCHANGING
FACTOR-LIKE PROTEIN
(Homo
sapiens) 		4 / 6 VAL A 350
ILE A 399
TRP A 418
LEU A 384
 None
 1.16A 1j96A-5xgsA:
undetectable		 1j96A-5xgsA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_B_FUAB703_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5xgs RCC1-LIKE G
EXCHANGING
FACTOR-LIKE PROTEIN
(Homo
sapiens) 		5 / 12 SER A 110
LEU A 166
VAL A 164
VAL A 188
THR A 190
 None
 1.21A 1q23B-5xgsA:
undetectable		 1q23B-5xgsA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_F_FUAF704_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5xgs RCC1-LIKE G
EXCHANGING
FACTOR-LIKE PROTEIN
(Homo
sapiens) 		5 / 11 SER A 110
LEU A 166
VAL A 164
VAL A 188
THR A 190
 None
 1.21A 1q23F-5xgsA:
undetectable		 1q23F-5xgsA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQP_B_SAMB500_1
(5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE)		 5xgs RCC1-LIKE G
EXCHANGING
FACTOR-LIKE PROTEIN
(Homo
sapiens) 		4 / 8 ASN A 200
SER A 219
ARG A 221
ALA A 184
 None
 1.18A 1rqpC-5xgsA:
undetectable		 1rqpC-5xgsA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5xgs RCC1-LIKE G
EXCHANGING
FACTOR-LIKE PROTEIN
(Homo
sapiens) 		5 / 12 LEU A 187
HIS A 185
GLY A 255
HIS A 241
PHE A 244
 None
 1.36A 1v8bA-5xgsA:
undetectable		 1v8bA-5xgsA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_B_ADNB1502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5xgs RCC1-LIKE G
EXCHANGING
FACTOR-LIKE PROTEIN
(Homo
sapiens) 		5 / 12 LEU A 187
HIS A 185
GLY A 255
HIS A 241
PHE A 244
 None
 1.37A 1v8bB-5xgsA:
undetectable		 1v8bB-5xgsA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_C_ADNC2502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5xgs RCC1-LIKE G
EXCHANGING
FACTOR-LIKE PROTEIN
(Homo
sapiens) 		5 / 12 LEU A 187
HIS A 185
GLY A 255
HIS A 241
PHE A 244
 None
 1.37A 1v8bC-5xgsA:
undetectable		 1v8bC-5xgsA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_D_ADND3502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5xgs RCC1-LIKE G
EXCHANGING
FACTOR-LIKE PROTEIN
(Homo
sapiens) 		5 / 12 LEU A 187
HIS A 185
GLY A 255
HIS A 241
PHE A 244
 None
 1.37A 1v8bD-5xgsA:
undetectable		 1v8bD-5xgsA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZGY_A_BRLA503_1
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 5xgs RCC1-LIKE G
EXCHANGING
FACTOR-LIKE PROTEIN
(Homo
sapiens) 		5 / 12 GLY A 255
CYH A 254
LEU A 187
MET A 225
LEU A 276
 None
 1.15A 1zgyA-5xgsA:
undetectable		 1zgyA-5xgsA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_B_CHDB1604_0
(FERROCHELATASE)		 5xgs RCC1-LIKE G
EXCHANGING
FACTOR-LIKE PROTEIN
(Homo
sapiens) 		4 / 4 LEU A 415
PRO A 446
LEU A 409
ARG A 400
 None
 1.36A 2hrcB-5xgsA:
undetectable		 2hrcB-5xgsA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5xgs RCC1-LIKE G
EXCHANGING
FACTOR-LIKE PROTEIN
(Homo
sapiens) 		4 / 4 LEU A 415
PRO A 446
LEU A 409
ARG A 400
 None
 1.39A 2pnjB-5xgsA:
undetectable		 2pnjB-5xgsA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXO_B_TACB1211_1
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		 5xgs RCC1-LIKE G
EXCHANGING
FACTOR-LIKE PROTEIN
(Homo
sapiens) 		5 / 11 ASN A 421
LEU A 431
MET A 442
VAL A 440
ILE A 428
 None
 1.16A 2uxoB-5xgsA:
undetectable		 2uxoB-5xgsA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_D_KLND1498_1
(CYTOCHROME P450 3A4)		 5xgs RCC1-LIKE G
EXCHANGING
FACTOR-LIKE PROTEIN
(Homo
sapiens) 		5 / 11 LEU A 159
ALA A  71
THR A 119
MET A 198
LEU A 142
 None
 1.25A 2v0mD-5xgsA:
undetectable		 2v0mD-5xgsA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7U_A_SAMA1299_0
(5'-FLUORO-5'-DEOXY
ADENOSINE SYNTHETASE)		 5xgs RCC1-LIKE G
EXCHANGING
FACTOR-LIKE PROTEIN
(Homo
sapiens) 		4 / 8 ASN A 200
SER A 219
ARG A 221
ALA A 184
 None
 1.15A 2v7uA-5xgsA:
undetectable		 2v7uA-5xgsA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_A_2FAA500_1
(ADENOSYLHOMOCYSTEINA
SE)		 5xgs RCC1-LIKE G
EXCHANGING
FACTOR-LIKE PROTEIN
(Homo
sapiens) 		5 / 12 LEU A 187
HIS A 185
GLY A 255
HIS A 241
PHE A 244
 None
 1.41A 2zj0A-5xgsA:
undetectable		 2zj0A-5xgsA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_A_ADNA500_1
(ADENOSYLHOMOCYSTEINA
SE)		 5xgs RCC1-LIKE G
EXCHANGING
FACTOR-LIKE PROTEIN
(Homo
sapiens) 		5 / 12 LEU A 187
HIS A 185
GLY A 255
HIS A 241
PHE A 244
 None
 1.44A 3ce6A-5xgsA:
undetectable		 3ce6A-5xgsA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_C_ADNC500_1
(ADENOSYLHOMOCYSTEINA
SE)		 5xgs RCC1-LIKE G
EXCHANGING
FACTOR-LIKE PROTEIN
(Homo
sapiens) 		5 / 12 LEU A 187
HIS A 185
GLY A 255
HIS A 241
PHE A 244
 None
 1.43A 3ce6C-5xgsA:
undetectable		 3ce6C-5xgsA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_A_ADNA438_1
(ADENOSYLHOMOCYSTEINA
SE)		 5xgs RCC1-LIKE G
EXCHANGING
FACTOR-LIKE PROTEIN
(Homo
sapiens) 		5 / 12 LEU A 187
HIS A 185
GLY A 255
HIS A 241
PHE A 244
 None
 1.40A 3g1uA-5xgsA:
undetectable		 3g1uA-5xgsA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GLQ_A_RABA602_1
(ADENOSYLHOMOCYSTEINA
SE)		 5xgs RCC1-LIKE G
EXCHANGING
FACTOR-LIKE PROTEIN
(Homo
sapiens) 		5 / 12 LEU A 187
HIS A 185
GLY A 255
HIS A 241
PHE A 244
 None
 1.41A 3glqA-5xgsA:
undetectable		 3glqA-5xgsA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GLQ_B_RABB602_1
(ADENOSYLHOMOCYSTEINA
SE)		 5xgs RCC1-LIKE G
EXCHANGING
FACTOR-LIKE PROTEIN
(Homo
sapiens) 		5 / 12 LEU A 187
HIS A 185
GLY A 255
HIS A 241
PHE A 244
 None
 1.43A 3glqB-5xgsA:
undetectable		 3glqB-5xgsA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H9U_A_ADNA439_1
(ADENOSYLHOMOCYSTEINA
SE)		 5xgs RCC1-LIKE G
EXCHANGING
FACTOR-LIKE PROTEIN
(Homo
sapiens) 		5 / 10 LEU A 187
HIS A 185
GLY A 255
HIS A 241
PHE A 244
 None
 1.38A 3h9uA-5xgsA:
undetectable		 3h9uA-5xgsA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H9U_C_ADNC438_1
(ADENOSYLHOMOCYSTEINA
SE)		 5xgs RCC1-LIKE G
EXCHANGING
FACTOR-LIKE PROTEIN
(Homo
sapiens) 		5 / 10 LEU A 187
HIS A 185
GLY A 255
HIS A 241
PHE A 244
 None
 1.39A 3h9uC-5xgsA:
undetectable		 3h9uC-5xgsA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H9U_D_ADND438_1
(ADENOSYLHOMOCYSTEINA
SE)		 5xgs RCC1-LIKE G
EXCHANGING
FACTOR-LIKE PROTEIN
(Homo
sapiens) 		5 / 10 LEU A 187
HIS A 185
GLY A 255
HIS A 241
PHE A 244
 None
 1.39A 3h9uD-5xgsA:
undetectable		 3h9uD-5xgsA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IHT_A_SAMA200_0
(S-ADENOSYL-L-METHION
INE METHYL
TRANSFERASE)		 5xgs RCC1-LIKE G
EXCHANGING
FACTOR-LIKE PROTEIN
(Homo
sapiens) 		5 / 12 GLY A 263
GLY A 260
GLY A 257
ARG A 328
ASP A 279
 None
 1.07A 3ihtA-5xgsA:
undetectable		 3ihtA-5xgsA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZU_A_X89A411_1
(FLAVOHEMOPROTEIN)		 5xgs RCC1-LIKE G
EXCHANGING
FACTOR-LIKE PROTEIN
(Homo
sapiens) 		5 / 12 ALA A 281
LEU A 280
VAL A 285
HIS A 331
ALA A 341
 None
 1.23A 3ozuA-5xgsA:
undetectable		 3ozuA-5xgsA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SOA_A_DB8A445_1
(CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II
SUBUNIT ALPHA WITH A
BETA 7 LINKER)		 5xgs RCC1-LIKE G
EXCHANGING
FACTOR-LIKE PROTEIN
(Homo
sapiens) 		4 / 6 LEU A 189
VAL A 195
MET A 225
PHE A 228
 None
 0.92A 3soaA-5xgsA:
undetectable		 3soaA-5xgsA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BLV_B_SAMB1281_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 5xgs RCC1-LIKE G
EXCHANGING
FACTOR-LIKE PROTEIN
(Homo
sapiens) 		5 / 12 HIS A 185
GLY A 292
TYR A 116
GLY A 182
GLY A 308
 None
 0.98A 4blvB-5xgsA:
undetectable		 4blvB-5xgsA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EMA_A_BRLA601_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5xgs RCC1-LIKE G
EXCHANGING
FACTOR-LIKE PROTEIN
(Homo
sapiens) 		5 / 12 GLY A 255
CYH A 254
LEU A 187
MET A 225
LEU A 276
 None
 1.12A 4emaA-5xgsA:
undetectable		 4emaA-5xgsA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FR0_A_SAMA401_0
(ARSENIC
METHYLTRANSFERASE)		 5xgs RCC1-LIKE G
EXCHANGING
FACTOR-LIKE PROTEIN
(Homo
sapiens) 		5 / 12 GLY A 302
LEU A 304
ASN A 284
VAL A 283
LEU A 280
 None
 1.12A 4fr0A-5xgsA:
undetectable		 4fr0A-5xgsA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I41_A_MIXA500_2
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 5xgs RCC1-LIKE G
EXCHANGING
FACTOR-LIKE PROTEIN
(Homo
sapiens) 		4 / 4 LEU A 304
LEU A 351
GLN A 314
GLU A 378
 None
 1.07A 4i41A-5xgsA:
undetectable		 4i41A-5xgsA:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KF9_A_ACTA408_0
(GLUTATHIONE
S-TRANSFERASE
PROTEIN)		 5xgs RCC1-LIKE G
EXCHANGING
FACTOR-LIKE PROTEIN
(Homo
sapiens) 		4 / 6 THR A 174
PRO A 171
PHE A 196
ARG A 224
 None
 1.48A 4kf9A-5xgsA:
undetectable		 4kf9A-5xgsA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LVC_A_ADNA501_1
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE))		 5xgs RCC1-LIKE G
EXCHANGING
FACTOR-LIKE PROTEIN
(Homo
sapiens) 		5 / 12 LEU A 187
HIS A 185
GLY A 255
HIS A 241
PHE A 244
 None
 1.35A 4lvcA-5xgsA:
undetectable		 4lvcA-5xgsA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LVC_B_ADNB501_1
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE))		 5xgs RCC1-LIKE G
EXCHANGING
FACTOR-LIKE PROTEIN
(Homo
sapiens) 		5 / 12 LEU A 187
HIS A 185
GLY A 255
HIS A 241
PHE A 244
 None
 1.37A 4lvcB-5xgsA:
undetectable		 4lvcB-5xgsA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LVC_C_ADNC501_1
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE))		 5xgs RCC1-LIKE G
EXCHANGING
FACTOR-LIKE PROTEIN
(Homo
sapiens) 		5 / 12 LEU A 187
HIS A 185
GLY A 255
HIS A 241
PHE A 244
 None
 1.38A 4lvcC-5xgsA:
undetectable		 4lvcC-5xgsA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_A_SAMA601_0
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 5xgs RCC1-LIKE G
EXCHANGING
FACTOR-LIKE PROTEIN
(Homo
sapiens) 		5 / 12 CYH A 294
GLY A 292
GLY A 238
GLY A 308
LEU A 315
 None
 1.24A 4n48A-5xgsA:
undetectable		 4n48A-5xgsA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_B_SAMB601_0
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 5xgs RCC1-LIKE G
EXCHANGING
FACTOR-LIKE PROTEIN
(Homo
sapiens) 		5 / 12 CYH A 294
GLY A 292
GLY A 238
GLY A 308
LEU A 315
 None
 1.21A 4n48B-5xgsA:
undetectable		 4n48B-5xgsA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PFJ_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5xgs RCC1-LIKE G
EXCHANGING
FACTOR-LIKE PROTEIN
(Homo
sapiens) 		5 / 12 LEU A 187
HIS A 185
GLY A 255
HIS A 241
PHE A 244
 None
 1.36A 4pfjA-5xgsA:
undetectable		 4pfjA-5xgsA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGF_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5xgs RCC1-LIKE G
EXCHANGING
FACTOR-LIKE PROTEIN
(Homo
sapiens) 		5 / 12 LEU A 187
HIS A 185
GLY A 255
HIS A 241
PHE A 244
 None
 1.42A 4pgfA-5xgsA:
undetectable		 4pgfA-5xgsA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XLD_A_BRLA502_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5xgs RCC1-LIKE G
EXCHANGING
FACTOR-LIKE PROTEIN
(Homo
sapiens) 		5 / 12 GLY A 255
CYH A 254
LEU A 187
MET A 225
LEU A 276
 None
 1.07A 4xldA-5xgsA:
undetectable		 4xldA-5xgsA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_A_SVRA205_2
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 5xgs RCC1-LIKE G
EXCHANGING
FACTOR-LIKE PROTEIN
(Homo
sapiens) 		4 / 6 PHE A  77
LEU A 103
PRO A 161
ARG A  93
 None
 1.35A 4yv5B-5xgsA:
undetectable		 4yv5B-5xgsA:
12.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_B_SVRB207_1
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 5xgs RCC1-LIKE G
EXCHANGING
FACTOR-LIKE PROTEIN
(Homo
sapiens) 		4 / 6 PHE A  77
LEU A 103
PRO A 161
ARG A  93
 None
 1.33A 4yv5A-5xgsA:
undetectable		 4yv5A-5xgsA:
12.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXA_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5xgs RCC1-LIKE G
EXCHANGING
FACTOR-LIKE PROTEIN
(Homo
sapiens) 		5 / 12 LEU A 187
HIS A 185
GLY A 255
HIS A 241
PHE A 244
 None
 1.39A 5axaA-5xgsA:
undetectable		 5axaA-5xgsA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXA_C_ADNC502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5xgs RCC1-LIKE G
EXCHANGING
FACTOR-LIKE PROTEIN
(Homo
sapiens) 		5 / 12 LEU A 187
HIS A 185
GLY A 255
HIS A 241
PHE A 244
 None
 1.40A 5axaC-5xgsA:
undetectable		 5axaC-5xgsA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_B_BEZB202_0
(HYDROXYNITRILE LYASE)		 5xgs RCC1-LIKE G
EXCHANGING
FACTOR-LIKE PROTEIN
(Homo
sapiens) 		4 / 7 VAL A 449
THR A 458
MET A 442
VAL A 440
 None
 0.86A 5e4dA-5xgsA:
undetectable
5e4dB-5xgsA:
undetectable		 5e4dA-5xgsA:
18.29
5e4dB-5xgsA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_A_ADNA501_1
(ADENOSYLHOMOCYSTEINA
SE)		 5xgs RCC1-LIKE G
EXCHANGING
FACTOR-LIKE PROTEIN
(Homo
sapiens) 		5 / 12 LEU A 187
HIS A 185
GLY A 255
HIS A 241
PHE A 244
 None
 1.40A 5hm8A-5xgsA:
undetectable		 5hm8A-5xgsA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_B_ADNB501_1
(ADENOSYLHOMOCYSTEINA
SE)		 5xgs RCC1-LIKE G
EXCHANGING
FACTOR-LIKE PROTEIN
(Homo
sapiens) 		5 / 12 LEU A 187
HIS A 185
GLY A 255
HIS A 241
PHE A 244
 None
 1.40A 5hm8B-5xgsA:
undetectable		 5hm8B-5xgsA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_C_ADNC501_1
(ADENOSYLHOMOCYSTEINA
SE)		 5xgs RCC1-LIKE G
EXCHANGING
FACTOR-LIKE PROTEIN
(Homo
sapiens) 		5 / 12 LEU A 187
HIS A 185
GLY A 255
HIS A 241
PHE A 244
 None
 1.40A 5hm8C-5xgsA:
undetectable		 5hm8C-5xgsA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_D_ADND501_1
(ADENOSYLHOMOCYSTEINA
SE)		 5xgs RCC1-LIKE G
EXCHANGING
FACTOR-LIKE PROTEIN
(Homo
sapiens) 		5 / 12 LEU A 187
HIS A 185
GLY A 255
HIS A 241
PHE A 244
 None
 1.40A 5hm8D-5xgsA:
undetectable		 5hm8D-5xgsA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_E_ADNE501_1
(ADENOSYLHOMOCYSTEINA
SE)		 5xgs RCC1-LIKE G
EXCHANGING
FACTOR-LIKE PROTEIN
(Homo
sapiens) 		5 / 12 LEU A 187
HIS A 185
GLY A 255
HIS A 241
PHE A 244
 None
 1.40A 5hm8E-5xgsA:
undetectable		 5hm8E-5xgsA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_F_ADNF501_1
(ADENOSYLHOMOCYSTEINA
SE)		 5xgs RCC1-LIKE G
EXCHANGING
FACTOR-LIKE PROTEIN
(Homo
sapiens) 		5 / 12 LEU A 187
HIS A 185
GLY A 255
HIS A 241
PHE A 244
 None
 1.40A 5hm8F-5xgsA:
undetectable		 5hm8F-5xgsA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_G_ADNG501_1
(ADENOSYLHOMOCYSTEINA
SE)		 5xgs RCC1-LIKE G
EXCHANGING
FACTOR-LIKE PROTEIN
(Homo
sapiens) 		5 / 12 LEU A 187
HIS A 185
GLY A 255
HIS A 241
PHE A 244
 None
 1.40A 5hm8G-5xgsA:
undetectable		 5hm8G-5xgsA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_H_ADNH501_1
(ADENOSYLHOMOCYSTEINA
SE)		 5xgs RCC1-LIKE G
EXCHANGING
FACTOR-LIKE PROTEIN
(Homo
sapiens) 		5 / 12 LEU A 187
HIS A 185
GLY A 255
HIS A 241
PHE A 244
 None
 1.40A 5hm8H-5xgsA:
undetectable		 5hm8H-5xgsA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5K_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5xgs RCC1-LIKE G
EXCHANGING
FACTOR-LIKE PROTEIN
(Homo
sapiens) 		5 / 12 LEU A 187
HIS A 185
GLY A 255
HIS A 241
PHE A 244
 None
 1.40A 5m5kA-5xgsA:
undetectable		 5m5kA-5xgsA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5K_B_ADNB502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5xgs RCC1-LIKE G
EXCHANGING
FACTOR-LIKE PROTEIN
(Homo
sapiens) 		5 / 12 LEU A 187
HIS A 185
GLY A 255
HIS A 241
PHE A 244
 None
 1.39A 5m5kB-5xgsA:
undetectable		 5m5kB-5xgsA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5K_C_ADNC502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5xgs RCC1-LIKE G
EXCHANGING
FACTOR-LIKE PROTEIN
(Homo
sapiens) 		5 / 12 LEU A 187
HIS A 185
GLY A 255
HIS A 241
PHE A 244
 None
 1.41A 5m5kC-5xgsA:
undetectable		 5m5kC-5xgsA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M66_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5xgs RCC1-LIKE G
EXCHANGING
FACTOR-LIKE PROTEIN
(Homo
sapiens) 		5 / 12 LEU A 187
HIS A 185
GLY A 255
HIS A 241
PHE A 244
 None
 1.37A 5m66A-5xgsA:
undetectable		 5m66A-5xgsA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M66_B_ADNB502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5xgs RCC1-LIKE G
EXCHANGING
FACTOR-LIKE PROTEIN
(Homo
sapiens) 		5 / 12 LEU A 187
HIS A 185
GLY A 255
HIS A 241
PHE A 244
 None
 1.33A 5m66B-5xgsA:
undetectable		 5m66B-5xgsA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UTU_F_ADNF503_1
(ADENOSYLHOMOCYSTEINA
SE)		 5xgs RCC1-LIKE G
EXCHANGING
FACTOR-LIKE PROTEIN
(Homo
sapiens) 		5 / 12 LEU A 187
HIS A 185
GLY A 255
HIS A 241
PHE A 244
 None
 1.36A 5utuF-5xgsA:
undetectable		 5utuF-5xgsA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UTU_H_ADNH503_1
(ADENOSYLHOMOCYSTEINA
SE)		 5xgs RCC1-LIKE G
EXCHANGING
FACTOR-LIKE PROTEIN
(Homo
sapiens) 		5 / 12 LEU A 187
HIS A 185
GLY A 255
HIS A 241
PHE A 244
 None
 1.37A 5utuH-5xgsA:
undetectable		 5utuH-5xgsA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V96_A_ADNA502_1
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE)		 5xgs RCC1-LIKE G
EXCHANGING
FACTOR-LIKE PROTEIN
(Homo
sapiens) 		5 / 12 LEU A 187
HIS A 185
GLY A 255
HIS A 241
PHE A 244
 None
 1.35A 5v96A-5xgsA:
undetectable		 5v96A-5xgsA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V96_B_ADNB502_1
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE)		 5xgs RCC1-LIKE G
EXCHANGING
FACTOR-LIKE PROTEIN
(Homo
sapiens) 		5 / 12 LEU A 187
HIS A 185
GLY A 255
HIS A 241
PHE A 244
 None
 1.35A 5v96B-5xgsA:
undetectable		 5v96B-5xgsA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V96_C_ADNC502_1
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE)		 5xgs RCC1-LIKE G
EXCHANGING
FACTOR-LIKE PROTEIN
(Homo
sapiens) 		5 / 12 LEU A 187
HIS A 185
GLY A 255
HIS A 241
PHE A 244
 None
 1.35A 5v96C-5xgsA:
undetectable		 5v96C-5xgsA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V96_D_ADND502_1
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE)		 5xgs RCC1-LIKE G
EXCHANGING
FACTOR-LIKE PROTEIN
(Homo
sapiens) 		5 / 12 LEU A 187
HIS A 185
GLY A 255
HIS A 241
PHE A 244
 None
 1.35A 5v96D-5xgsA:
undetectable		 5v96D-5xgsA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDH_C_DAHC60_1
(PUTATIVE CYTOCHROME
C)		 5xgs RCC1-LIKE G
EXCHANGING
FACTOR-LIKE PROTEIN
(Homo
sapiens) 		4 / 6 GLN A 178
HIS A 185
VAL A 235
LEU A 243
 None
 1.33A 5xdhA-5xgsA:
undetectable
5xdhC-5xgsA:
undetectable		 5xdhA-5xgsA:
11.41
5xdhC-5xgsA:
11.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YOD_D_BEZD201_0
(NS3 PROTEASE)		 5xgs RCC1-LIKE G
EXCHANGING
FACTOR-LIKE PROTEIN
(Homo
sapiens) 		4 / 5 HIS A 455
ALA A 113
GLY A 452
TYR A 291
 None
 1.20A 5yodD-5xgsA:
undetectable		 5yodD-5xgsA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YOD_H_BEZH201_0
(NS3 PROTEASE)		 5xgs RCC1-LIKE G
EXCHANGING
FACTOR-LIKE PROTEIN
(Homo
sapiens) 		4 / 5 HIS A 455
TYR A 116
GLY A 115
TYR A 291
 None
 1.27A 5yodH-5xgsA:
undetectable		 5yodH-5xgsA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6APH_A_ADNA501_1
(ADENOSYLHOMOCYSTEINA
SE)		 5xgs RCC1-LIKE G
EXCHANGING
FACTOR-LIKE PROTEIN
(Homo
sapiens) 		5 / 12 LEU A 187
HIS A 185
GLY A 255
HIS A 241
PHE A 244
 None
 1.42A 6aphA-5xgsA:
undetectable		 6aphA-5xgsA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_A_ADNA501_1
(-)		 5xgs RCC1-LIKE G
EXCHANGING
FACTOR-LIKE PROTEIN
(Homo
sapiens) 		5 / 12 LEU A 187
HIS A 185
GLY A 255
HIS A 241
PHE A 244
 None
 1.38A 6gbnA-5xgsA:
undetectable		 6gbnA-5xgsA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_B_ADNB501_1
(-)		 5xgs RCC1-LIKE G
EXCHANGING
FACTOR-LIKE PROTEIN
(Homo
sapiens) 		5 / 12 LEU A 187
HIS A 185
GLY A 255
HIS A 241
PHE A 244
 None
 1.38A 6gbnB-5xgsA:
undetectable		 6gbnB-5xgsA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_D_ADND501_1
(-)		 5xgs RCC1-LIKE G
EXCHANGING
FACTOR-LIKE PROTEIN
(Homo
sapiens) 		5 / 12 LEU A 187
HIS A 185
GLY A 255
HIS A 241
PHE A 244
 None
 1.40A 6gbnD-5xgsA:
undetectable		 6gbnD-5xgsA:
21.09