SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5xgz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_C_ADNC603_2
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 5xgz BETA-GLYCOSIDASE
(uncultured
microorganism) 		4 / 5 THR A 355
THR A 291
HIS A 205
LEU A 226
 None
 1.38A 1d4fC-5xgzA:
undetectable		 1d4fC-5xgzA:
9.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TUV_A_VK3A4558_1
(PROTEIN YGIN)		 5xgz BETA-GLYCOSIDASE
(uncultured
microorganism) 		4 / 7 TYR A 379
HIS A 383
LEU A 336
TYR A 299
 None
None
None
GOL  A 501 (-4.3A)
 1.18A 1tuvA-5xgzA:
undetectable		 1tuvA-5xgzA:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3C_B_PNXB2434_1
(CHITINASE)		 5xgz BETA-GLYCOSIDASE
(uncultured
microorganism) 		4 / 6 TYR A  80
GLY A 437
PHE A 440
SER A 441
 None
 1.33A 2a3cB-5xgzA:
5.4		 2a3cB-5xgzA:
9.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A7Q_A_CFBA328_2
(DEOXYCYTIDINE KINASE)		 5xgz BETA-GLYCOSIDASE
(uncultured
microorganism) 		4 / 4 ILE A 432
ASP A  68
LEU A  75
ARG A 418
 None
 1.04A 2a7qA-5xgzA:
1.1		 2a7qA-5xgzA:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CC8_A_RBFA1067_1
(VNG1446H)		 5xgz BETA-GLYCOSIDASE
(uncultured
microorganism) 		3 / 3 PHE A 384
VAL A 443
TRP A 439
 None
 0.62A 2cc8A-5xgzA:
undetectable		 2cc8A-5xgzA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CCB_A_RBFA1067_1
(VNG1446H)		 5xgz BETA-GLYCOSIDASE
(uncultured
microorganism) 		3 / 3 PHE A 384
VAL A 443
TRP A 439
 None
 0.62A 2ccbA-5xgzA:
undetectable		 2ccbA-5xgzA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYU_B_SAMB201_1
(PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2)		 5xgz BETA-GLYCOSIDASE
(uncultured
microorganism) 		4 / 5 ALA A 359
ASP A 407
ASP A 425
ASP A 373
 None
 1.09A 2nyuB-5xgzA:
undetectable		 2nyuB-5xgzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V3D_B_NBVB1504_1
(GLUCOSYLCERAMIDASE)		 5xgz BETA-GLYCOSIDASE
(uncultured
microorganism) 		5 / 11 ASN A 169
GLU A 170
TYR A 299
GLU A 356
TRP A 403
 None
GOL  A 502 ( 2.8A)
GOL  A 501 (-4.3A)
GOL  A 501 (-3.9A)
GOL  A 501 (-3.5A)
 0.86A 2v3dB-5xgzA:
2.8		 2v3dB-5xgzA:
10.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VX9_A_RBFA1064_1
(DODECIN)		 5xgz BETA-GLYCOSIDASE
(uncultured
microorganism) 		3 / 3 PHE A 384
VAL A 443
TRP A 439
 None
 0.61A 2vx9A-5xgzA:
undetectable		 2vx9A-5xgzA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF509_2
(PHOSPHOLIPASE A2)		 5xgz BETA-GLYCOSIDASE
(uncultured
microorganism) 		4 / 8 TYR A 124
ASN A 169
PHE A 419
TRP A 403
 None
None
GOL  A 501 (-4.3A)
GOL  A 501 (-3.5A)
 1.42A 3bjwD-5xgzA:
undetectable		 3bjwD-5xgzA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_E_SAME300_0
(PUTATIVE RRNA
METHYLASE)		 5xgz BETA-GLYCOSIDASE
(uncultured
microorganism) 		5 / 12 ASP A 152
GLY A 223
ASN A 215
LEU A 158
THR A 220
 None
 0.99A 3eeyE-5xgzA:
undetectable		 3eeyE-5xgzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_H_SAMH300_0
(PUTATIVE RRNA
METHYLASE)		 5xgz BETA-GLYCOSIDASE
(uncultured
microorganism) 		5 / 12 ASP A 152
GLY A 223
ASN A 215
LEU A 158
THR A 220
 None
 1.14A 3eeyH-5xgzA:
undetectable		 3eeyH-5xgzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_I_SAMI300_0
(PUTATIVE RRNA
METHYLASE)		 5xgz BETA-GLYCOSIDASE
(uncultured
microorganism) 		5 / 12 ASP A 152
GLY A 223
ASN A 215
LEU A 158
THR A 220
 None
 1.08A 3eeyI-5xgzA:
undetectable		 3eeyI-5xgzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_J_SAMJ300_0
(PUTATIVE RRNA
METHYLASE)		 5xgz BETA-GLYCOSIDASE
(uncultured
microorganism) 		5 / 12 ASP A 152
GLY A 223
ASN A 215
LEU A 158
THR A 220
 None
 1.06A 3eeyJ-5xgzA:
undetectable		 3eeyJ-5xgzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL5_B_1UNB201_2
(PROTEASE)		 5xgz BETA-GLYCOSIDASE
(uncultured
microorganism) 		5 / 12 GLY A  76
VAL A 402
GLY A 437
ILE A 433
VAL A  18
 None
 0.77A 3el5B-5xgzA:
undetectable		 3el5B-5xgzA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N23_C_OBNC1_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 5xgz BETA-GLYCOSIDASE
(uncultured
microorganism) 		5 / 11 ASN A 169
LEU A 168
VAL A 201
ALA A 198
PHE A 251
 None
None
None
None
GOL  A 502 (-4.8A)
 1.18A 3n23C-5xgzA:
undetectable		 3n23C-5xgzA:
6.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOF_B_HQEB200_1
(FLAVOREDOXIN)		 5xgz BETA-GLYCOSIDASE
(uncultured
microorganism) 		4 / 5 TYR A 264
VAL A 277
ARG A 141
HIS A 200
 None
 1.33A 3zofB-5xgzA:
undetectable		 3zofB-5xgzA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_H_ZPCH1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5xgz BETA-GLYCOSIDASE
(uncultured
microorganism) 		4 / 7 GLU A 410
HIS A  61
VAL A  29
PHE A 415
 GOL  A 501 ( 2.7A)
None
None
GOL  A 506 (-3.7A)
 0.98A 4a97H-5xgzA:
undetectable		 4a97H-5xgzA:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_B_FOLB301_1
(FOLATE RECEPTOR
ALPHA)		 5xgz BETA-GLYCOSIDASE
(uncultured
microorganism) 		3 / 3 ASP A 127
TRP A 403
SER A  83
 None
GOL  A 501 (-3.5A)
None
 1.08A 4lrhB-5xgzA:
undetectable		 4lrhB-5xgzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_B_ADNB501_1
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 5xgz BETA-GLYCOSIDASE
(uncultured
microorganism) 		5 / 12 VAL A  18
SER A 436
ASP A 407
GLY A 437
ASP A 373
 None
 1.39A 4pevB-5xgzA:
undetectable		 4pevB-5xgzA:
10.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_C_ADNC501_1
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 5xgz BETA-GLYCOSIDASE
(uncultured
microorganism) 		5 / 12 VAL A  18
SER A 436
ASP A 407
GLY A 437
ASP A 373
 None
 1.34A 4pevC-5xgzA:
undetectable		 4pevC-5xgzA:
10.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTP_A_SAMA301_0
(DNA ADENINE
METHYLASE)		 5xgz BETA-GLYCOSIDASE
(uncultured
microorganism) 		5 / 12 GLY A 101
ALA A 100
ILE A  84
SER A  83
PRO A  87
 None
 1.29A 4rtpA-5xgzA:
undetectable		 4rtpA-5xgzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1I_B_LOCB502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 5xgz BETA-GLYCOSIDASE
(uncultured
microorganism) 		3 / 3 SER A  21
ALA A  19
VAL A  18
 None
 0.50A 4x1iA-5xgzA:
3.3		 4x1iA-5xgzA:
12.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YOA_A_017A100_1
(HIV-1 PROTEASE)		 5xgz BETA-GLYCOSIDASE
(uncultured
microorganism) 		4 / 6 ASN A 261
ASP A 346
PRO A 290
THR A 288
 None
 1.12A 4yoaA-5xgzA:
undetectable		 4yoaA-5xgzA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EYP_B_LOCB502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 5xgz BETA-GLYCOSIDASE
(uncultured
microorganism) 		3 / 3 SER A  21
ALA A  19
VAL A  18
 None
 0.52A 5eypA-5xgzA:
undetectable		 5eypA-5xgzA:
12.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6APH_A_ADNA501_2
(ADENOSYLHOMOCYSTEINA
SE)		 5xgz BETA-GLYCOSIDASE
(uncultured
microorganism) 		4 / 5 THR A 355
THR A 291
HIS A 205
LEU A 226
 None
 1.35A 6aphA-5xgzA:
undetectable		 6aphA-5xgzA:
10.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA609_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 5xgz BETA-GLYCOSIDASE
(uncultured
microorganism) 		3 / 3 HIS A 199
HIS A 200
ARG A 196
 None
None
NI  A 508 (-3.6A)
 1.08A 6b58A-5xgzA:
undetectable		 6b58A-5xgzA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6ESM_A_PZEA307_1
(MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9)		 5xgz BETA-GLYCOSIDASE
(uncultured
microorganism) 		3 / 3 TYR A  65
HIS A  61
PHE A 104
 None
 0.94A 6esmA-5xgzA:
undetectable		 6esmA-5xgzA:
30.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_B_ADNB501_2
(-)		 5xgz BETA-GLYCOSIDASE
(uncultured
microorganism) 		4 / 5 THR A 355
THR A 291
HIS A 205
LEU A 226
 None
 1.35A 6gbnB-5xgzA:
2.0		 6gbnB-5xgzA:
11.52