SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5xhq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4G_B_ZMRB466_2
(NEURAMINIDASE)
5xhq APOLIPOPROTEIN
N-ACYLTRANSFERASE

(Escherichia
coli)
3 / 3 ASP A 230
ARG A 467
ILE A 248
None
0.77A 1a4gB-5xhqA:
undetectable
1a4gB-5xhqA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A7Y_A_DVAA2_0
(ACTINOMYCIN D)
5xhq APOLIPOPROTEIN
N-ACYLTRANSFERASE

(Escherichia
coli)
4 / 4 THR A 477
PRO A 216
THR A 215
PRO A 218
None
1.29A 1a7yA-5xhqA:
undetectable
1a7yC-5xhqA:
undetectable
1a7yA-5xhqA:
1.83
1a7yC-5xhqA:
1.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHY_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)
5xhq APOLIPOPROTEIN
N-ACYLTRANSFERASE

(Escherichia
coli)
5 / 9 GLY A  60
PHE A 108
LEU A  44
ARG A 139
GLY A  64
None
1.32A 1jhyA-5xhqA:
undetectable
1jhyA-5xhqA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L4N_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)
5xhq APOLIPOPROTEIN
N-ACYLTRANSFERASE

(Escherichia
coli)
5 / 9 GLY A  60
PHE A 108
LEU A  44
ARG A 139
GLY A  64
None
1.32A 1l4nA-5xhqA:
undetectable
1l4nA-5xhqA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_A_DIFA701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
5xhq APOLIPOPROTEIN
N-ACYLTRANSFERASE

(Escherichia
coli)
5 / 10 LEU A 149
LEU A  26
ALA A  37
SER A  40
LEU A  41
None
0.98A 1pxxA-5xhqA:
2.0
1pxxA-5xhqA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_C_DIFC2701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
5xhq APOLIPOPROTEIN
N-ACYLTRANSFERASE

(Escherichia
coli)
5 / 12 LEU A 149
LEU A  26
ALA A  37
SER A  40
LEU A  41
None
0.96A 1pxxC-5xhqA:
2.2
1pxxC-5xhqA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V2X_A_SAMA400_0
(TRNA (GM18)
METHYLTRANSFERASE)
5xhq APOLIPOPROTEIN
N-ACYLTRANSFERASE

(Escherichia
coli)
5 / 12 PHE A  65
GLY A  62
GLY A  60
LEU A 101
ALA A  98
None
1.04A 1v2xA-5xhqA:
undetectable
1v2xA-5xhqA:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA6_A_SCKA902_1
(ACETYLCHOLINESTERASE)
5xhq APOLIPOPROTEIN
N-ACYLTRANSFERASE

(Escherichia
coli)
5 / 10 GLU A 267
GLU A 274
LEU A 281
LEU A 319
TYR A 325
None
1.16A 2ha6A-5xhqA:
undetectable
2ha6A-5xhqA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA6_B_SCKB952_1
(ACETYLCHOLINESTERASE)
5xhq APOLIPOPROTEIN
N-ACYLTRANSFERASE

(Escherichia
coli)
5 / 10 GLU A 267
GLU A 274
LEU A 281
LEU A 319
TYR A 325
None
1.16A 2ha6B-5xhqA:
undetectable
2ha6B-5xhqA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BU1_A_HSMA301_1
(LIPOCALIN)
5xhq APOLIPOPROTEIN
N-ACYLTRANSFERASE

(Escherichia
coli)
4 / 7 TYR A 327
TYR A 325
ILE A 317
ASP A 301
None
1.19A 3bu1A-5xhqA:
undetectable
3bu1A-5xhqA:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL5_B_1UNB201_1
(PROTEASE)
5xhq APOLIPOPROTEIN
N-ACYLTRANSFERASE

(Escherichia
coli)
5 / 10 LEU A 208
ALA A 164
ILE A 156
GLY A 152
PRO A 159
None
1.01A 3el5A-5xhqA:
undetectable
3el5A-5xhqA:
12.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_B_30BB500_2
(GENOME POLYPROTEIN)
5xhq APOLIPOPROTEIN
N-ACYLTRANSFERASE

(Escherichia
coli)
3 / 3 PHE A 400
TYR A 406
LEU A 392
None
0.78A 3keeB-5xhqA:
undetectable
3keeB-5xhqA:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGY_A_GLYA510_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)
5xhq APOLIPOPROTEIN
N-ACYLTRANSFERASE

(Escherichia
coli)
4 / 6 ILE A 410
GLU A 267
ALA A 269
ASN A 445
None
1.01A 3pgyA-5xhqA:
undetectable
3pgyB-5xhqA:
undetectable
3pgyA-5xhqA:
20.56
3pgyB-5xhqA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_A_SUEA1201_2
(NS3 PROTEASE, NS4A
PROTEIN)
5xhq APOLIPOPROTEIN
N-ACYLTRANSFERASE

(Escherichia
coli)
4 / 4 PHE A 400
TYR A 406
ILE A 391
LEU A 392
None
1.06A 3sudA-5xhqA:
undetectable
3sudA-5xhqA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_C_SUEC1201_2
(NS3 PROTEASE, NS4A
PROTEIN)
5xhq APOLIPOPROTEIN
N-ACYLTRANSFERASE

(Escherichia
coli)
4 / 5 PHE A 400
TYR A 406
ILE A 391
LEU A 392
None
0.94A 3sueC-5xhqA:
undetectable
3sueC-5xhqA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_B_VIVB301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)
5xhq APOLIPOPROTEIN
N-ACYLTRANSFERASE

(Escherichia
coli)
5 / 12 ILE A 270
SER A 443
ILE A 263
VAL A 224
LEU A 262
None
1.09A 3w67B-5xhqA:
undetectable
3w67B-5xhqA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DR2_A_PARA1609_1
(16S RRNA
30S RIBOSOMAL
PROTEIN S9
30S RIBOSOMAL
PROTEIN S10)
5xhq APOLIPOPROTEIN
N-ACYLTRANSFERASE

(Escherichia
coli)
3 / 3 TYR A 325
ARG A 332
SER A 329
None
1.17A 4dr2I-5xhqA:
undetectable
4dr2J-5xhqA:
undetectable
4dr2I-5xhqA:
14.37
4dr2J-5xhqA:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LF7_A_PARA1817_1
(16S RRNA
RIBOSOMAL PROTEIN S9
RIBOSOMAL PROTEIN
S10)
5xhq APOLIPOPROTEIN
N-ACYLTRANSFERASE

(Escherichia
coli)
3 / 3 TYR A 325
ARG A 332
SER A 329
None
1.01A 4lf7I-5xhqA:
undetectable
4lf7J-5xhqA:
undetectable
4lf7I-5xhqA:
14.37
4lf7J-5xhqA:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LF8_A_PARA1817_1
(16S RRNA
RIBOSOMAL PROTEIN S9
RIBOSOMAL PROTEIN
S10)
5xhq APOLIPOPROTEIN
N-ACYLTRANSFERASE

(Escherichia
coli)
3 / 3 TYR A 325
ARG A 332
SER A 329
None
1.01A 4lf8I-5xhqA:
undetectable
4lf8J-5xhqA:
undetectable
4lf8I-5xhqA:
14.37
4lf8J-5xhqA:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LG1_B_SAMB301_0
(PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21D)
5xhq APOLIPOPROTEIN
N-ACYLTRANSFERASE

(Escherichia
coli)
5 / 12 ALA A  99
GLY A  66
GLY A  62
LEU A  19
ALA A  98
None
1.14A 4lg1B-5xhqA:
undetectable
4lg1B-5xhqA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LG1_C_SAMC301_0
(PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21D)
5xhq APOLIPOPROTEIN
N-ACYLTRANSFERASE

(Escherichia
coli)
5 / 12 ALA A  99
GLY A  66
GLY A  62
LEU A  19
ALA A  98
None
1.14A 4lg1C-5xhqA:
undetectable
4lg1C-5xhqA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNW_A_T3A502_1
(THYROID HORMONE
RECEPTOR ALPHA)
5xhq APOLIPOPROTEIN
N-ACYLTRANSFERASE

(Escherichia
coli)
4 / 8 SER A 411
ASP A 413
MET A 431
ARG A 442
None
1.16A 4lnwA-5xhqA:
undetectable
4lnwA-5xhqA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWJ_B_30ZB201_1
(TRANSTHYRETIN)
5xhq APOLIPOPROTEIN
N-ACYLTRANSFERASE

(Escherichia
coli)
4 / 7 THR A 383
ALA A 385
SER A 411
THR A 409
None
0.95A 4pwjB-5xhqA:
undetectable
4pwjB-5xhqA:
15.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOI_A_ML1A303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])
5xhq APOLIPOPROTEIN
N-ACYLTRANSFERASE

(Escherichia
coli)
4 / 8 PHE A 151
TRP A  63
GLY A  71
ILE A 420
None
0.92A 4qoiA-5xhqA:
undetectable
4qoiB-5xhqA:
undetectable
4qoiA-5xhqA:
17.64
4qoiB-5xhqA:
17.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRW_D_LURD705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
5xhq APOLIPOPROTEIN
N-ACYLTRANSFERASE

(Escherichia
coli)
5 / 12 LEU A 149
LEU A  26
ALA A  37
SER A  40
LEU A  41
None
1.03A 4rrwD-5xhqA:
2.4
4rrwD-5xhqA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRZ_D_LURD705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
5xhq APOLIPOPROTEIN
N-ACYLTRANSFERASE

(Escherichia
coli)
5 / 12 LEU A 149
LEU A  26
ALA A  37
SER A  40
LEU A  41
None
1.03A 4rrzD-5xhqA:
2.4
4rrzD-5xhqA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YBN_A_ACTA303_0
(FLAVIN-NUCLEOTIDE-BI
NDING PROTEIN)
5xhq APOLIPOPROTEIN
N-ACYLTRANSFERASE

(Escherichia
coli)
3 / 3 VAL A 227
TYR A 249
ALA A 252
None
0.46A 4ybnA-5xhqA:
undetectable
4ybnA-5xhqA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_2_BEZ2801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)
5xhq APOLIPOPROTEIN
N-ACYLTRANSFERASE

(Escherichia
coli)
4 / 4 LEU A 235
ARG A 467
ILE A 231
ILE A 248
None
0.94A 5dzk2-5xhqA:
undetectable
5dzkM-5xhqA:
undetectable
5dzkN-5xhqA:
undetectable
5dzk2-5xhqA:
13.33
5dzkM-5xhqA:
18.54
5dzkN-5xhqA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_4_BEZ4801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)
5xhq APOLIPOPROTEIN
N-ACYLTRANSFERASE

(Escherichia
coli)
4 / 5 LEU A 235
ARG A 467
ILE A 231
ILE A 248
None
1.04A 5dzk4-5xhqA:
undetectable
5dzkg-5xhqA:
undetectable
5dzkm-5xhqA:
undetectable
5dzkn-5xhqA:
undetectable
5dzk4-5xhqA:
13.33
5dzkg-5xhqA:
18.40
5dzkm-5xhqA:
18.54
5dzkn-5xhqA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_V_BEZV801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)
5xhq APOLIPOPROTEIN
N-ACYLTRANSFERASE

(Escherichia
coli)
4 / 4 ILE A 231
ILE A 248
ARG A 467
LEU A 235
None
1.07A 5dzkh-5xhqA:
undetectable
5dzkn-5xhqA:
undetectable
5dzkv-5xhqA:
undetectable
5dzkh-5xhqA:
18.54
5dzkn-5xhqA:
18.54
5dzkv-5xhqA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKQ_A_JMSA602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
5xhq APOLIPOPROTEIN
N-ACYLTRANSFERASE

(Escherichia
coli)
5 / 12 LEU A 149
LEU A  26
ALA A  37
SER A  40
LEU A  41
None
1.05A 5ikqA-5xhqA:
1.5
5ikqA-5xhqA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKQ_B_JMSB602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
5xhq APOLIPOPROTEIN
N-ACYLTRANSFERASE

(Escherichia
coli)
5 / 12 LEU A 149
LEU A  26
ALA A  37
SER A  40
LEU A  41
None
1.05A 5ikqB-5xhqA:
1.2
5ikqB-5xhqA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JM4_A_BEZA301_0
(14-3-3 PROTEIN
ZETA/DELTA)
5xhq APOLIPOPROTEIN
N-ACYLTRANSFERASE

(Escherichia
coli)
4 / 5 PHE A 426
ILE A 448
GLN A 427
ARG A 430
None
1.35A 5jm4A-5xhqA:
undetectable
5jm4A-5xhqA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JO9_A_SORA302_0
(RIBITOL
2-DEHYDROGENASE)
5xhq APOLIPOPROTEIN
N-ACYLTRANSFERASE

(Escherichia
coli)
5 / 12 LEU A 288
THR A 253
TRP A 265
GLY A 320
LEU A 284
None
1.16A 5jo9A-5xhqA:
undetectable
5jo9A-5xhqA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JO9_A_SORA302_0
(RIBITOL
2-DEHYDROGENASE)
5xhq APOLIPOPROTEIN
N-ACYLTRANSFERASE

(Escherichia
coli)
5 / 12 SER A 293
LEU A 288
THR A 253
TRP A 265
LEU A 284
None
1.41A 5jo9A-5xhqA:
undetectable
5jo9A-5xhqA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_B_6J3B201_0
(TRANSTHYRETIN)
5xhq APOLIPOPROTEIN
N-ACYLTRANSFERASE

(Escherichia
coli)
4 / 6 LEU A 319
ALA A 323
LEU A 288
SER A 293
None
1.16A 5l4iB-5xhqA:
undetectable
5l4iB-5xhqA:
13.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U6N_A_SALA505_1
(UDP-GLYCOSYLTRANSFER
ASE 74F2)
5xhq APOLIPOPROTEIN
N-ACYLTRANSFERASE

(Escherichia
coli)
4 / 8 SER A  56
PHE A 108
GLN A  45
TRP A 116
None
1.36A 5u6nA-5xhqA:
undetectable
5u6nA-5xhqA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W4Z_A_RBFA502_1
(RIBOFLAVIN LYASE)
5xhq APOLIPOPROTEIN
N-ACYLTRANSFERASE

(Escherichia
coli)
5 / 12 ALA A  22
GLY A  69
GLY A 106
ALA A 109
THR A  48
None
0.83A 5w4zA-5xhqA:
1.5
5w4zA-5xhqA:
10.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W4Z_B_RBFB502_1
(RIBOFLAVIN LYASE)
5xhq APOLIPOPROTEIN
N-ACYLTRANSFERASE

(Escherichia
coli)
5 / 12 ALA A  22
GLY A  69
GLY A 106
ALA A 109
THR A  48
None
0.86A 5w4zB-5xhqA:
undetectable
5w4zB-5xhqA:
10.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM0_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)
5xhq APOLIPOPROTEIN
N-ACYLTRANSFERASE

(Escherichia
coli)
5 / 10 LEU A 262
LEU A 288
ASP A 285
ILE A 380
GLY A 379
None
1.24A 6dm0B-5xhqA:
undetectable
6dm0C-5xhqA:
undetectable
6dm0B-5xhqA:
10.62
6dm0C-5xhqA:
10.62