SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5xhu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
11GS_B_EAAB211_1
(GLUTATHIONE
S-TRANSFERASE)		 5xhu FERREDOXIN--NADP
REDUCTASE
(Bacillus
subtilis) 		4 / 7 PHE A 302
GLY A 305
ILE A  12
GLY A 286
 None
None
None
FAD  A1000 (-3.2A)
 0.85A 11gsB-5xhuA:
undetectable		 11gsB-5xhuA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX4_A_ML1A233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5xhu FERREDOXIN--NADP
REDUCTASE
(Bacillus
subtilis) 		4 / 8 ILE A 298
PHE A  50
GLY A  43
GLY A  44
 FAD  A1000 (-3.7A)
FAD  A1000 (-3.6A)
None
FAD  A1000 (-3.3A)
 0.81A 2qx4A-5xhuA:
undetectable
2qx4B-5xhuA:
undetectable		 2qx4A-5xhuA:
14.41
2qx4B-5xhuA:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WD9_C_IBPC1570_1
(ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL)		 5xhu FERREDOXIN--NADP
REDUCTASE
(Bacillus
subtilis) 		5 / 10 THR A 124
ILE A  13
GLY A 105
GLY A  92
ARG A  89
 FAD  A1000 (-4.2A)
FAD  A1000 (-4.7A)
None
None
None
 1.04A 2wd9C-5xhuA:
2.6		 2wd9C-5xhuA:
9.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM4_V_DR7V100_2
(PROTEASE)		 5xhu FERREDOXIN--NADP
REDUCTASE
(Bacillus
subtilis) 		6 / 10 ARG A 206
ASP A 169
GLY A 164
GLY A 163
VAL A 159
ILE A 160
 None
 1.36A 3em4V-5xhuA:
undetectable		 3em4V-5xhuA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SEL_X_DXCX75_0
(CYTOCHROME C7)		 5xhu FERREDOXIN--NADP
REDUCTASE
(Bacillus
subtilis) 		4 / 8 ILE A  84
LEU A  86
LYS A  45
GLY A  44
 None
None
FAD  A1000 (-2.8A)
FAD  A1000 (-3.3A)
 0.85A 3selX-5xhuA:
undetectable		 3selX-5xhuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5xhu FERREDOXIN--NADP
REDUCTASE
(Bacillus
subtilis) 		4 / 6 ILE A 223
LEU A 216
ARG A 157
THR A 182
 None
 1.09A 3wg7A-5xhuA:
undetectable
3wg7J-5xhuA:
undetectable		 3wg7A-5xhuA:
undetectable
3wg7J-5xhuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9K_A_TYLA2200_1
(CREB-BINDING PROTEIN)		 5xhu FERREDOXIN--NADP
REDUCTASE
(Bacillus
subtilis) 		4 / 6 VAL A 159
LEU A 244
ILE A 223
VAL A 228
 None
 0.92A 4a9kA-5xhuA:
undetectable		 4a9kA-5xhuA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BWL_C_MN9C1297_0
(N-ACETYLNEURAMINATE
LYASE)		 5xhu FERREDOXIN--NADP
REDUCTASE
(Bacillus
subtilis) 		5 / 10 ILE A  70
LEU A  69
GLY A  15
GLY A  19
PHE A 302
 None
 1.07A 4bwlC-5xhuA:
undetectable		 4bwlC-5xhuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FE1_A_PQNA846_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 5xhu FERREDOXIN--NADP
REDUCTASE
(Bacillus
subtilis) 		5 / 10 PHE A  50
LEU A  69
GLY A  66
ALA A 308
MET A 275
 FAD  A1000 (-3.6A)
None
None
None
None
 1.21A 4fe1A-5xhuA:
undetectable
4fe1J-5xhuA:
undetectable		 4fe1A-5xhuA:
7.49
4fe1J-5xhuA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HBF_A_DXCA75_0
(PPCA)		 5xhu FERREDOXIN--NADP
REDUCTASE
(Bacillus
subtilis) 		4 / 7 ILE A  84
LEU A  86
LYS A  45
GLY A  44
 None
None
FAD  A1000 (-2.8A)
FAD  A1000 (-3.3A)
 0.92A 4hbfA-5xhuA:
undetectable		 4hbfA-5xhuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HC3_A_DXCA75_0
(PPCA)		 5xhu FERREDOXIN--NADP
REDUCTASE
(Bacillus
subtilis) 		4 / 7 ILE A  84
LEU A  86
LYS A  45
GLY A  44
 None
None
FAD  A1000 (-2.8A)
FAD  A1000 (-3.3A)
 0.82A 4hc3A-5xhuA:
undetectable		 4hc3A-5xhuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_B_SAMB301_0
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 5xhu FERREDOXIN--NADP
REDUCTASE
(Bacillus
subtilis) 		5 / 12 GLY A  14
GLY A  15
LEU A  86
ILE A  18
ILE A  36
 FAD  A1000 (-3.3A)
None
None
FAD  A1000 (-3.9A)
None
 1.10A 4qtuB-5xhuA:
3.0		 4qtuB-5xhuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5xhu FERREDOXIN--NADP
REDUCTASE
(Bacillus
subtilis) 		4 / 6 ILE A 223
LEU A 216
ARG A 157
THR A 182
 None
 1.07A 5b1aN-5xhuA:
undetectable
5b1aW-5xhuA:
undetectable		 5b1aN-5xhuA:
undetectable
5b1aW-5xhuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERG_B_SAMB401_1
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRM61)		 5xhu FERREDOXIN--NADP
REDUCTASE
(Bacillus
subtilis) 		4 / 7 GLY A  14
GLY A  16
GLU A  37
PHE A  38
 FAD  A1000 (-3.3A)
FAD  A1000 (-3.4A)
FAD  A1000 (-2.7A)
None
 0.72A 5ergB-5xhuA:
4.0		 5ergB-5xhuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMF_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5xhu FERREDOXIN--NADP
REDUCTASE
(Bacillus
subtilis) 		4 / 6 ILE A 223
LEU A 216
ARG A 157
THR A 182
 None
 1.13A 6nmfN-5xhuA:
undetectable
6nmfW-5xhuA:
undetectable		 6nmfN-5xhuA:
undetectable
6nmfW-5xhuA:
undetectable