SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5xhx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S1X_A_NVPA999_1
(REVERSE
TRANSCRIPTASE)		 5xhx HELIX-TURN-HELIX
TRANSCRIPTIONAL
REGULATOR
(Pseudomonas
aeruginosa) 		4 / 8 LEU A 141
GLY A 144
LEU A  34
TYR A 129
 None
 0.92A 1s1xA-5xhxA:
undetectable		 1s1xA-5xhxA:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_C_CHDC3271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE III
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 5xhx HELIX-TURN-HELIX
TRANSCRIPTIONAL
REGULATOR
(Pseudomonas
aeruginosa) 		4 / 7 LEU A 141
GLN A 128
LEU A  30
PHE A  26
 None
 0.94A 1v55C-5xhxA:
undetectable
1v55J-5xhxA:
undetectable		 1v55C-5xhxA:
21.93
1v55J-5xhxA:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5xhx HELIX-TURN-HELIX
TRANSCRIPTIONAL
REGULATOR
(Pseudomonas
aeruginosa) 		4 / 7 LEU A 141
GLN A 128
LEU A  30
PHE A  26
 None
 0.94A 2eijC-5xhxA:
undetectable
2eijJ-5xhxA:
undetectable		 2eijC-5xhxA:
21.93
2eijJ-5xhxA:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5xhx HELIX-TURN-HELIX
TRANSCRIPTIONAL
REGULATOR
(Pseudomonas
aeruginosa) 		4 / 7 LEU A 141
GLN A 128
LEU A  30
PHE A  26
 None
 0.91A 2eikC-5xhxA:
undetectable
2eikJ-5xhxA:
undetectable		 2eikC-5xhxA:
21.93
2eikJ-5xhxA:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5xhx HELIX-TURN-HELIX
TRANSCRIPTIONAL
REGULATOR
(Pseudomonas
aeruginosa) 		4 / 8 LEU A 141
GLN A 128
LEU A  30
PHE A  26
 None
 0.92A 2eikP-5xhxA:
undetectable
2eikW-5xhxA:
undetectable		 2eikP-5xhxA:
21.93
2eikW-5xhxA:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5xhx HELIX-TURN-HELIX
TRANSCRIPTIONAL
REGULATOR
(Pseudomonas
aeruginosa) 		4 / 7 LEU A 141
GLN A 128
LEU A  30
PHE A  26
 None
 0.94A 2eimC-5xhxA:
undetectable
2eimJ-5xhxA:
undetectable		 2eimC-5xhxA:
21.93
2eimJ-5xhxA:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5xhx HELIX-TURN-HELIX
TRANSCRIPTIONAL
REGULATOR
(Pseudomonas
aeruginosa) 		4 / 7 LEU A 141
GLN A 128
LEU A  30
PHE A  26
 None
 0.95A 2einC-5xhxA:
undetectable
2einJ-5xhxA:
undetectable		 2einC-5xhxA:
21.93
2einJ-5xhxA:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5xhx HELIX-TURN-HELIX
TRANSCRIPTIONAL
REGULATOR
(Pseudomonas
aeruginosa) 		4 / 6 LEU A 141
GLN A 128
LEU A  30
PHE A  26
 None
 0.95A 2einP-5xhxA:
undetectable
2einW-5xhxA:
undetectable		 2einP-5xhxA:
21.93
2einW-5xhxA:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5xhx HELIX-TURN-HELIX
TRANSCRIPTIONAL
REGULATOR
(Pseudomonas
aeruginosa) 		4 / 6 LEU A 141
GLN A 128
LEU A  30
PHE A  26
 None
 0.94A 2zxwP-5xhxA:
undetectable
2zxwW-5xhxA:
undetectable		 2zxwP-5xhxA:
21.93
2zxwW-5xhxA:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5xhx HELIX-TURN-HELIX
TRANSCRIPTIONAL
REGULATOR
(Pseudomonas
aeruginosa) 		4 / 8 LEU A 141
GLN A 128
LEU A  30
PHE A  26
 None
 0.90A 3ag4C-5xhxA:
undetectable
3ag4J-5xhxA:
undetectable		 3ag4C-5xhxA:
21.93
3ag4J-5xhxA:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5xhx HELIX-TURN-HELIX
TRANSCRIPTIONAL
REGULATOR
(Pseudomonas
aeruginosa) 		4 / 7 LEU A 141
GLN A 128
LEU A  30
PHE A  26
 None
 0.86A 3ag4P-5xhxA:
undetectable
3ag4W-5xhxA:
undetectable		 3ag4P-5xhxA:
21.93
3ag4W-5xhxA:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_C_CHDC271_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 5xhx HELIX-TURN-HELIX
TRANSCRIPTIONAL
REGULATOR
(Pseudomonas
aeruginosa) 		4 / 7 LEU A 141
GLN A 128
LEU A  30
PHE A  26
 None
 0.96A 3asnC-5xhxA:
undetectable
3asnJ-5xhxA:
undetectable		 3asnC-5xhxA:
21.93
3asnJ-5xhxA:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MEC_A_65BA561_0
(P66 REVERSE
TRANSCRIPTASE)		 5xhx HELIX-TURN-HELIX
TRANSCRIPTIONAL
REGULATOR
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 141
VAL A  40
GLY A 144
LEU A  34
TYR A 129
 None
 1.24A 3mecA-5xhxA:
undetectable		 3mecA-5xhxA:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MED_A_65BA561_0
(P51 REVERSE
TRANSCRIPTASE
P66 REVERSE
TRANSCRIPTASE)		 5xhx HELIX-TURN-HELIX
TRANSCRIPTIONAL
REGULATOR
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 141
VAL A  40
GLY A 144
LEU A  34
TYR A 129
 None
 1.32A 3medA-5xhxA:
undetectable
3medB-5xhxA:
undetectable		 3medA-5xhxA:
16.11
3medB-5xhxA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QIP_A_NVPA561_1
(REVERSE HIV-1
REVERSE
TRANSCRIPTASE P66)		 5xhx HELIX-TURN-HELIX
TRANSCRIPTIONAL
REGULATOR
(Pseudomonas
aeruginosa) 		5 / 10 LEU A 141
VAL A  40
GLY A 144
LEU A  34
TYR A 129
 None
 1.43A 3qipA-5xhxA:
undetectable		 3qipA-5xhxA:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3X2Q_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5xhx HELIX-TURN-HELIX
TRANSCRIPTIONAL
REGULATOR
(Pseudomonas
aeruginosa) 		4 / 7 LEU A 141
GLN A 128
LEU A  30
PHE A  26
 None
 0.95A 3x2qC-5xhxA:
undetectable
3x2qJ-5xhxA:
undetectable		 3x2qC-5xhxA:
21.93
3x2qJ-5xhxA:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5xhx HELIX-TURN-HELIX
TRANSCRIPTIONAL
REGULATOR
(Pseudomonas
aeruginosa) 		4 / 7 LEU A 141
GLN A 128
LEU A  30
PHE A  26
 None
 0.98A 5b1bP-5xhxA:
undetectable
5b1bW-5xhxA:
undetectable		 5b1bP-5xhxA:
21.93
5b1bW-5xhxA:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E8Q_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 5xhx HELIX-TURN-HELIX
TRANSCRIPTIONAL
REGULATOR
(Pseudomonas
aeruginosa) 		3 / 3 ASP A 176
LEU A 133
ARG A 137
 None
 0.76A 5e8qA-5xhxA:
undetectable		 5e8qA-5xhxA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HBM_A_NVPA601_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 5xhx HELIX-TURN-HELIX
TRANSCRIPTIONAL
REGULATOR
(Pseudomonas
aeruginosa) 		5 / 11 LEU A 141
VAL A  40
GLY A 144
LEU A  34
TYR A 129
 None
 1.41A 5hbmA-5xhxA:
undetectable		 5hbmA-5xhxA:
16.85