SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5xi0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7W_A_MTXA301_1
(PTERIDINE REDUCTASE)		 5xi0 ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH]
(Aliivibrio
fischeri) 		5 / 12 PRO A  41
LEU A 316
TYR A 317
LEU A 334
LEU A 270
 None
 1.42A 1e7wA-5xi0A:
17.7		 1e7wA-5xi0A:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHO_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 5xi0 ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH]
(Aliivibrio
fischeri) 		5 / 9 GLY A  87
GLY A  48
PHE A  73
GLU A  75
GLY A  54
 None
 1.30A 1jhoA-5xi0A:
2.4		 1jhoA-5xi0A:
12.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHR_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 5xi0 ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH]
(Aliivibrio
fischeri) 		5 / 9 GLY A  87
GLY A  48
PHE A  73
GLU A  75
GLY A  54
 None
 1.30A 1jhrA-5xi0A:
2.3		 1jhrA-5xi0A:
12.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHY_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 5xi0 ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH]
(Aliivibrio
fischeri) 		5 / 9 GLY A  87
GLY A  48
PHE A  73
GLU A  75
GLY A  54
 None
 1.34A 1jhyA-5xi0A:
2.3		 1jhyA-5xi0A:
12.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AA5_B_STRB302_1
(MINERALOCORTICOID
RECEPTOR)		 5xi0 ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH]
(Aliivibrio
fischeri) 		5 / 12 LEU A 316
LEU A 309
GLN A 305
SER A  56
MET A 134
 None
 1.14A 2aa5B-5xi0A:
undetectable		 2aa5B-5xi0A:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8D_A_BEZA1001_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 5xi0 ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH]
(Aliivibrio
fischeri) 		4 / 6 VAL A  46
ARG A  58
LEU A  55
PHE A  73
 None
 1.32A 2f8dA-5xi0A:
undetectable		 2f8dA-5xi0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RCT_A_RTLA140_1
(RETINOL-BINDING
PROTEIN II, CELLULAR)		 5xi0 ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH]
(Aliivibrio
fischeri) 		3 / 3 GLN A 345
THR A 228
TRP A 351
 None
 0.71A 2rctA-5xi0A:
undetectable		 2rctA-5xi0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_B_DGXB1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		 5xi0 ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH]
(Aliivibrio
fischeri) 		5 / 12 LEU A 129
ALA A  98
VAL A  44
PHE A 312
LEU A 309
 None
 1.08A 3b0wB-5xi0A:
undetectable		 3b0wB-5xi0A:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PFG_A_SAMA264_1
(N-METHYLTRANSFERASE)		 5xi0 ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH]
(Aliivibrio
fischeri) 		3 / 3 TYR A 287
TYR A 225
GLU A 229
 None
 0.66A 3pfgA-5xi0A:
1.2		 3pfgA-5xi0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3THR_A_C2FA1100_0
(GLYCINE
N-METHYLTRANSFERASE)		 5xi0 ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH]
(Aliivibrio
fischeri) 		4 / 6 SER A 105
LEU A 103
THR A  69
ARG A  58
 None
 1.42A 3thrB-5xi0A:
undetectable		 3thrB-5xi0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TNE_A_RITA401_2
(SECRETED ASPARTIC
PROTEASE)		 5xi0 ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH]
(Aliivibrio
fischeri) 		4 / 6 PRO A   5
VAL A 380
THR A  15
THR A  14
 None
 1.03A 3tneA-5xi0A:
undetectable		 3tneA-5xi0A:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TNE_A_RITA401_2
(SECRETED ASPARTIC
PROTEASE)		 5xi0 ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH]
(Aliivibrio
fischeri) 		4 / 6 PRO A   5
VAL A 383
THR A  15
THR A  14
 None
 0.93A 3tneA-5xi0A:
undetectable		 3tneA-5xi0A:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WSJ_A_MK1A201_1
(PROTEASE)		 5xi0 ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH]
(Aliivibrio
fischeri) 		5 / 9 LEU A 124
ASP A 133
VAL A 213
LEU A 214
ILE A 125
 None
 1.42A 3wsjA-5xi0A:
undetectable		 3wsjA-5xi0A:
24.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KIC_A_SAMA401_0
(METHYLTRANSFERASE
MPPJ)		 5xi0 ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH]
(Aliivibrio
fischeri) 		5 / 12 GLY A  54
GLY A  48
ARG A  58
ALA A 140
PHE A  94
 None
 1.23A 4kicA-5xi0A:
5.0		 4kicA-5xi0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_G_377G401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5xi0 ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH]
(Aliivibrio
fischeri) 		4 / 6 TYR A 225
GLU A 338
TYR A 287
LEU A 230
 None
 1.33A 4twdF-5xi0A:
undetectable
4twdG-5xi0A:
undetectable		 4twdF-5xi0A:
11.73
4twdG-5xi0A:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_B_RFPB502_1
(RIFAMPIN
MONOOXYGENASE)		 5xi0 ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH]
(Aliivibrio
fischeri) 		5 / 12 GLY A  71
VAL A  46
THR A  60
GLY A  64
GLY A  65
 None
 0.95A 6brdB-5xi0A:
3.5		 6brdB-5xi0A:
20.69