SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5xi8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_A_AG2A672_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 5xi8 BETA-BARREL
ASSEMBLY-ENHANCING
PROTEASE
(Escherichia
coli) 		4 / 7 LEU A 423
LEU A 416
ILE A 398
GLN A 393
 None
 1.05A 2qqcA-5xi8A:
undetectable
2qqcF-5xi8A:
undetectable		 2qqcA-5xi8A:
16.36
2qqcF-5xi8A:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_E_ACTE503_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 5xi8 BETA-BARREL
ASSEMBLY-ENHANCING
PROTEASE
(Escherichia
coli) 		3 / 3 GLN A 388
THR A 350
ASN A 384
 None
 0.81A 3v4tE-5xi8A:
undetectable		 3v4tE-5xi8A:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_C_ADNC401_2
(ADENOSINE KINASE)		 5xi8 BETA-BARREL
ASSEMBLY-ENHANCING
PROTEASE
(Escherichia
coli) 		4 / 5 ASN A 384
LEU A 380
LEU A 416
ASN A 400
 None
 1.31A 4n09C-5xi8A:
undetectable		 4n09C-5xi8A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_B_SVRB207_2
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 5xi8 BETA-BARREL
ASSEMBLY-ENHANCING
PROTEASE
(Escherichia
coli) 		4 / 7 ASN A 357
LYS A 358
TYR A 386
LEU A 387
 None
 1.24A 4yv5B-5xi8A:
undetectable		 4yv5B-5xi8A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_A_AM2A301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 5xi8 BETA-BARREL
ASSEMBLY-ENHANCING
PROTEASE
(Escherichia
coli) 		4 / 8 ASP A 326
ARG A 329
ASP A 353
GLU A 361
 None
 1.22A 6mn4A-5xi8A:
undetectable		 6mn4A-5xi8A:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MXT_A_K5YA1401_1
(ENDOLYSIN, BETA-2
ADRENERGIC RECEPTOR
CHIMERA)		 5xi8 BETA-BARREL
ASSEMBLY-ENHANCING
PROTEASE
(Escherichia
coli) 		3 / 3 ASP A 472
SER A 451
SER A 454
 None
 0.83A 6mxtA-5xi8A:
2.1		 6mxtA-5xi8A:
17.86