SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5xil'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

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	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1MRG_A_ADNA300_1 (ALPHA-MOMORCHARIN)	5xil	PUTATIVE PROLYL-TRNA SYNTHETASE (Leishmania major)	5 / 9	TYR A 267 GLY A 519 TYR A 756 ILE A 467 ALA A 469	ACT A1003 (-4.1A) None ACT A1003 (-4.5A) None None	1.23A	1mrgA-5xilA: undetectable	1mrgA-5xilA: 15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1QHY_A_CLMA888_0 (CHLORAMPHENICOL PHOSPHOTRANSFERASE)	5xil	PUTATIVE PROLYL-TRNA SYNTHETASE (Leishmania major)	4 / 6	PRO A 506 ALA A 417 GLU A 418 GLU A 419	None	1.33A	1qhyA-5xilA: undetectable	1qhyA-5xilA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XOQ_A_ROFA502_1 (CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4D)	5xil	PUTATIVE PROLYL-TRNA SYNTHETASE (Leishmania major)	3 / 3	ASN A 509 TRP A 511 GLN A 508	None	1.42A	1xoqA-5xilA: undetectable	1xoqA-5xilA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2WD9_C_IBPC1570_1 (ACYL-COENZYME A SYNTHETASE ACSM2A, MITOCHONDRIAL)	5xil	PUTATIVE PROLYL-TRNA SYNTHETASE (Leishmania major)	5 / 10	ILE A 682 LEU A 681 GLY A 471 THR A 675 ARG A 678	None	1.11A	2wd9C-5xilA: 2.1	2wd9C-5xilA: 9.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3BPX_B_SALB258_1 (TRANSCRIPTIONAL REGULATOR)	5xil	PUTATIVE PROLYL-TRNA SYNTHETASE (Leishmania major)	5 / 11	ALA A 369 ARG A 493 ILE A 505 PRO A 506 GLY A 487	None	0.73A	3bpxA-5xilA: 1.2 3bpxB-5xilA: 0.9	3bpxA-5xilA: 18.79 3bpxB-5xilA: 18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3LN1_C_CELC682_1 (PROSTAGLANDIN G/H SYNTHASE 2)	5xil	PUTATIVE PROLYL-TRNA SYNTHETASE (Leishmania major)	5 / 12	VAL A 434 LEU A 303 VAL A 463 GLY A 476 ALA A 477	None	1.08A	3ln1C-5xilA: undetectable	3ln1C-5xilA: 8.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3LN1_D_CELD682_1 (PROSTAGLANDIN G/H SYNTHASE 2)	5xil	PUTATIVE PROLYL-TRNA SYNTHETASE (Leishmania major)	5 / 12	VAL A 434 LEU A 303 VAL A 463 GLY A 476 ALA A 477	None	1.08A	3ln1D-5xilA: undetectable	3ln1D-5xilA: 8.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3OXC_A_ROCA401_2 (PROTEASE)	5xil	PUTATIVE PROLYL-TRNA SYNTHETASE (Leishmania major)	3 / 3	ARG A 663 LEU A 751 THR A 462	None	0.87A	3oxcA-5xilA: undetectable	3oxcA-5xilA: 13.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3PGH_B_FLPB701_1 (CYCLOOXYGENASE-2)	5xil	PUTATIVE PROLYL-TRNA SYNTHETASE (Leishmania major)	5 / 11	VAL A 434 LEU A 303 VAL A 463 GLY A 476 ALA A 477	None	1.09A	3pghB-5xilA: undetectable	3pghB-5xilA: 8.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3RR3_A_FLRA700_1 (PROSTAGLANDIN G/H SYNTHASE 2)	5xil	PUTATIVE PROLYL-TRNA SYNTHETASE (Leishmania major)	5 / 12	VAL A 434 LEU A 303 VAL A 463 GLY A 476 ALA A 477	None	1.02A	3rr3A-5xilA: undetectable	3rr3A-5xilA: 8.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3RR3_B_FLRB700_1 (PROSTAGLANDIN G/H SYNTHASE 2)	5xil	PUTATIVE PROLYL-TRNA SYNTHETASE (Leishmania major)	5 / 12	VAL A 434 LEU A 303 VAL A 463 GLY A 476 ALA A 477	None	1.03A	3rr3B-5xilA: undetectable	3rr3B-5xilA: 8.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3RR3_C_FLRC700_1 (PROSTAGLANDIN G/H SYNTHASE 2)	5xil	PUTATIVE PROLYL-TRNA SYNTHETASE (Leishmania major)	5 / 12	VAL A 434 LEU A 303 VAL A 463 GLY A 476 ALA A 477	None	1.03A	3rr3C-5xilA: undetectable	3rr3C-5xilA: 8.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3RR3_D_FLRD700_1 (PROSTAGLANDIN G/H SYNTHASE 2)	5xil	PUTATIVE PROLYL-TRNA SYNTHETASE (Leishmania major)	5 / 12	VAL A 434 LEU A 303 VAL A 463 GLY A 476 ALA A 477	None	1.02A	3rr3D-5xilA: undetectable	3rr3D-5xilA: 8.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4E3H_A_HQEA303_1 (CARBONIC ANHYDRASE 2)	5xil	PUTATIVE PROLYL-TRNA SYNTHETASE (Leishmania major)	5 / 10	VAL A 619 LEU A 603 VAL A 605 THR A 636 VAL A 542	None	0.91A	4e3hA-5xilA: undetectable	4e3hA-5xilA: 13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HVC_A_HFGA1602_0 (BIFUNCTIONAL GLUTAMATE/PROLINE--T RNA LIGASE)	5xil	PUTATIVE PROLYL-TRNA SYNTHETASE (Leishmania major)	7 / 12	TRP A 407 GLU A 409 HIS A 411 PHE A 454 THR A 478 SER A 510 GLY A 512	None	0.39A	4hvcA-5xilA: 46.7	4hvcA-5xilA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HVC_B_HFGB1602_0 (BIFUNCTIONAL GLUTAMATE/PROLINE--T RNA LIGASE)	5xil	PUTATIVE PROLYL-TRNA SYNTHETASE (Leishmania major)	7 / 12	TRP A 407 GLU A 409 HIS A 411 PHE A 454 THR A 478 SER A 510 GLY A 512	None	0.40A	4hvcB-5xilA: 46.7	4hvcB-5xilA: undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4K87_A_ADNA602_1 (PROLINE--TRNA LIGASE)	5xil	PUTATIVE PROLYL-TRNA SYNTHETASE (Leishmania major)	5 / 8	ARG A 401 PHE A 405 GLN A 475 THR A 478 ARG A 516	None	0.80A	4k87A-5xilA: 46.6	4k87A-5xilA: 56.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4K88_A_HFGA602_0 (PROLINE--TRNA LIGASE)	5xil	PUTATIVE PROLYL-TRNA SYNTHETASE (Leishmania major)	6 / 12	GLU A 361 TRP A 407 GLU A 409 PHE A 454 HIS A 480 SER A 510	None	0.59A	4k88A-5xilA: 46.6	4k88A-5xilA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4OLF_A_HFGA802_0 (PROLINE--TRNA LIGASE)	5xil	PUTATIVE PROLYL-TRNA SYNTHETASE (Leishmania major)	8 / 12	TRP A 407 GLU A 409 HIS A 411 PHE A 454 THR A 478 SER A 510 TRP A 511 GLY A 512	None	0.42A	4olfA-5xilA: 46.1	4olfA-5xilA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4Q15_A_HFGA803_0 (PROLINE--TRNA LIGASE)	5xil	PUTATIVE PROLYL-TRNA SYNTHETASE (Leishmania major)	5 / 12	TRP A 407 HIS A 411 PHE A 454 SER A 510 GLY A 512	None	0.33A	4q15A-5xilA: 48.4	4q15A-5xilA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4Q15_B_HFGB803_0 (PROLINE--TRNA LIGASE)	5xil	PUTATIVE PROLYL-TRNA SYNTHETASE (Leishmania major)	5 / 12	TRP A 407 GLU A 409 PHE A 454 SER A 510 GLY A 512	None	0.40A	4q15B-5xilA: 45.4	4q15B-5xilA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RRW_A_LURA705_1 (PROSTAGLANDIN G/H SYNTHASE 2)	5xil	PUTATIVE PROLYL-TRNA SYNTHETASE (Leishmania major)	5 / 12	VAL A 434 SER A 433 VAL A 463 GLY A 476 ALA A 477	None	1.17A	4rrwA-5xilA: undetectable	4rrwA-5xilA: 8.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RRZ_A_LURA705_1 (PROSTAGLANDIN G/H SYNTHASE 2)	5xil	PUTATIVE PROLYL-TRNA SYNTHETASE (Leishmania major)	5 / 12	VAL A 434 SER A 433 VAL A 463 GLY A 476 ALA A 477	None	1.17A	4rrzA-5xilA: undetectable	4rrzA-5xilA: 8.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4YDQ_A_HFGA802_0 (PROLINE--TRNA LIGASE)	5xil	PUTATIVE PROLYL-TRNA SYNTHETASE (Leishmania major)	6 / 12	TRP A 407 GLU A 409 HIS A 411 PHE A 454 SER A 510 GLY A 512	None	0.78A	4ydqA-5xilA: 46.3	4ydqA-5xilA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4YDQ_B_HFGB802_0 (PROLINE--TRNA LIGASE)	5xil	PUTATIVE PROLYL-TRNA SYNTHETASE (Leishmania major)	6 / 12	TRP A 407 GLU A 409 HIS A 411 PHE A 454 SER A 510 GLY A 512	None	0.80A	4ydqB-5xilA: 46.6	4ydqB-5xilA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5F9Z_A_HFGA702_0 (AMINOACYL-TRNA SYNTHETASE)	5xil	PUTATIVE PROLYL-TRNA SYNTHETASE (Leishmania major)	5 / 12	TRP A 407 GLU A 409 PHE A 454 SER A 510 GLY A 512	None	0.43A	5f9zA-5xilA: 45.4	5f9zA-5xilA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5F9Z_B_HFGB703_0 (AMINOACYL-TRNA SYNTHETASE)	5xil	PUTATIVE PROLYL-TRNA SYNTHETASE (Leishmania major)	5 / 12	TRP A 407 GLU A 409 PHE A 454 SER A 510 GLY A 512	None	0.43A	5f9zB-5xilA: 46.7	5f9zB-5xilA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5H5F_A_SAMA301_1 (PROTEIN ARGININE N-METHYLTRANSFERASE SFM1)	5xil	PUTATIVE PROLYL-TRNA SYNTHETASE (Leishmania major)	4 / 5	GLY A 688 PRO A 724 GLN A 727 THR A 747	None	1.28A	5h5fA-5xilA: undetectable	5h5fA-5xilA: undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5IFU_A_GBMA801_1 (PROLINE--TRNA LIGASE)	5xil	PUTATIVE PROLYL-TRNA SYNTHETASE (Leishmania major)	9 / 12	PHE A 263 TYR A 267 THR A 515 ARG A 516 ILE A 518 GLY A 519 ILE A 522 MET A 523 TYR A 756	ACT A1003 (-4.3A) ACT A1003 (-4.1A) None None None None None ACT A1003 (-4.3A) ACT A1003 (-4.5A)	0.35A	5ifuA-5xilA: 48.0	5ifuA-5xilA: 53.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5IFU_B_GBMB801_1 (PROLINE--TRNA LIGASE)	5xil	PUTATIVE PROLYL-TRNA SYNTHETASE (Leishmania major)	6 / 9	TYR A 267 ILE A 277 THR A 515 ARG A 516 ILE A 518 GLY A 519	ACT A1003 (-4.1A) None None None None None	0.41A	5ifuB-5xilA: 46.7	5ifuB-5xilA: 53.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5IKR_A_ID8A601_1 (PROSTAGLANDIN G/H SYNTHASE 2)	5xil	PUTATIVE PROLYL-TRNA SYNTHETASE (Leishmania major)	5 / 12	VAL A 434 SER A 433 VAL A 463 GLY A 476 ALA A 477	None	1.14A	5ikrA-5xilA: undetectable	5ikrA-5xilA: 9.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5JVZ_A_FLPA601_1 (PROSTAGLANDIN G/H SYNTHASE 2)	5xil	PUTATIVE PROLYL-TRNA SYNTHETASE (Leishmania major)	5 / 12	VAL A 434 LEU A 303 VAL A 463 GLY A 476 ALA A 477	None	1.08A	5jvzA-5xilA: undetectable	5jvzA-5xilA: 8.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5JW1_A_CELA602_1 (PROSTAGLANDIN G/H SYNTHASE 2)	5xil	PUTATIVE PROLYL-TRNA SYNTHETASE (Leishmania major)	5 / 12	VAL A 434 LEU A 303 VAL A 463 GLY A 476 ALA A 477	None	1.07A	5jw1A-5xilA: undetectable	5jw1A-5xilA: 8.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5MLM_A_STRA401_1 (-)	5xil	PUTATIVE PROLYL-TRNA SYNTHETASE (Leishmania major)	5 / 12	PHE A 593 ALA A 579 VAL A 605 ILE A 543 CYH A 581	None	1.18A	5mlmA-5xilA: undetectable	5mlmA-5xilA: 12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5XIO_A_HFGA801_0 (PROLINE-TRNA SYNTHETASE CLASS II AARS (YBAK RNA BINDING DOMAIN PLUS TRNA SYNTHETASE))	5xil	PUTATIVE PROLYL-TRNA SYNTHETASE (Leishmania major)	7 / 12	TRP A 407 GLU A 409 HIS A 411 PHE A 454 THR A 478 SER A 510 GLY A 512	None	0.41A	5xioA-5xilA: 46.0	5xioA-5xilA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5XIO_B_HFGB802_0 (PROLINE-TRNA SYNTHETASE CLASS II AARS (YBAK RNA BINDING DOMAIN PLUS TRNA SYNTHETASE))	5xil	PUTATIVE PROLYL-TRNA SYNTHETASE (Leishmania major)	6 / 12	TRP A 407 GLU A 409 HIS A 411 PHE A 454 THR A 478 HIS A 480	None	0.50A	5xioB-5xilA: 46.1	5xioB-5xilA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5XIP_A_HFGA1003_0 (PROLYL-TRNA SYNTHETASE, PUTATIVE)	5xil	PUTATIVE PROLYL-TRNA SYNTHETASE (Leishmania major)	5 / 12	HIS A 411 PHE A 454 THR A 478 SER A 510 GLY A 512	None	0.40A	5xipA-5xilA: 49.8	5xipA-5xilA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5XIP_A_HFGA1003_1 (PROLYL-TRNA SYNTHETASE, PUTATIVE)	5xil	PUTATIVE PROLYL-TRNA SYNTHETASE (Leishmania major)	3 / 3	GLU A 361 TRP A 407 HIS A 480	None	0.83A	5xipA-5xilA: 49.8	5xipA-5xilA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5XIP_B_HFGB1003_0 (PROLYL-TRNA SYNTHETASE, PUTATIVE)	5xil	PUTATIVE PROLYL-TRNA SYNTHETASE (Leishmania major)	5 / 12	GLU A 361 TRP A 407 HIS A 411 PHE A 454 HIS A 480	None	0.67A	5xipB-5xilA: 46.8	5xipB-5xilA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5XIP_B_HFGB1003_0 (PROLYL-TRNA SYNTHETASE, PUTATIVE)	5xil	PUTATIVE PROLYL-TRNA SYNTHETASE (Leishmania major)	5 / 12	TRP A 407 HIS A 411 PHE A 454 THR A 478 HIS A 480	None	0.45A	5xipB-5xilA: 46.8	5xipB-5xilA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5XIP_C_HFGC1003_0 (PROLYL-TRNA SYNTHETASE, PUTATIVE)	5xil	PUTATIVE PROLYL-TRNA SYNTHETASE (Leishmania major)	7 / 12	GLU A 361 TRP A 407 GLU A 409 HIS A 411 PHE A 454 THR A 478 GLY A 512	None	0.58A	5xipC-5xilA: 46.2	5xipC-5xilA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5XIP_D_HFGD1003_0 (PROLYL-TRNA SYNTHETASE, PUTATIVE)	5xil	PUTATIVE PROLYL-TRNA SYNTHETASE (Leishmania major)	6 / 12	GLU A 361 TRP A 407 GLU A 409 PHE A 454 THR A 478 TRP A 511	None	0.61A	5xipD-5xilA: 46.3	5xipD-5xilA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5XIQ_A_HFGA1002_0 (PROLYL-TRNA SYNTHETASE (PRORS))	5xil	PUTATIVE PROLYL-TRNA SYNTHETASE (Leishmania major)	7 / 12	TRP A 407 GLU A 409 HIS A 411 PHE A 454 THR A 478 SER A 510 GLY A 512	None	0.50A	5xiqA-5xilA: 47.6	5xiqA-5xilA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5XIQ_B_HFGB1002_0 (PROLYL-TRNA SYNTHETASE (PRORS))	5xil	PUTATIVE PROLYL-TRNA SYNTHETASE (Leishmania major)	6 / 12	TRP A 407 GLU A 409 HIS A 411 PHE A 454 THR A 478 SER A 510	None	0.46A	5xiqB-5xilA: 47.1	5xiqB-5xilA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5XIQ_C_HFGC1002_0 (PROLYL-TRNA SYNTHETASE (PRORS))	5xil	PUTATIVE PROLYL-TRNA SYNTHETASE (Leishmania major)	6 / 12	TRP A 407 GLU A 409 HIS A 411 PHE A 454 THR A 478 SER A 510	None	0.50A	5xiqC-5xilA: 47.0	5xiqC-5xilA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5XIQ_D_HFGD1002_0 (PROLYL-TRNA SYNTHETASE (PRORS))	5xil	PUTATIVE PROLYL-TRNA SYNTHETASE (Leishmania major)	6 / 12	TRP A 407 GLU A 409 HIS A 411 PHE A 454 THR A 478 GLY A 512	None	0.52A	5xiqD-5xilA: 47.3	5xiqD-5xilA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6F3M_D_ADND502_2 (-)	5xil	PUTATIVE PROLYL-TRNA SYNTHETASE (Leishmania major)	4 / 5	ILE A 543 GLN A 541 THR A 540 LEU A 568	None	1.09A	6f3mD-5xilA: undetectable	6f3mD-5xilA: 10.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6MN8_A_HFGA603_0 (UNCHARACTERIZED PROTEIN)	5xil	PUTATIVE PROLYL-TRNA SYNTHETASE (Leishmania major)	7 / 12	TRP A 407 GLU A 409 HIS A 411 THR A 478 SER A 510 TRP A 511 GLY A 512	None	0.38A	6mn8A-5xilA: 19.5	6mn8A-5xilA: undetectable

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1MRG_A_ADNA300_1","ALPHA-MOMORCHARIN","5xil","PUTATIVE PROLYL-TRNA SYNTHETASE","Leishmania major",5,"TYR A 267;GLY A 519;TYR A 756;ILE A 467;ALA A 469","ACT A1003 (-4.1A);None;ACT A1003 (-4.5A);None;None","1.23A","1mrgA-5xilA:undetectable","1mrgA-5xilA:15.67"],["1QHY_A_CLMA888_0","CHLORAMPHENICOL PHOSPHOTRANSFERASE","5xil","PUTATIVE PROLYL-TRNA SYNTHETASE","Leishmania major",4,"PRO A 506;ALA A 417;GLU A 418;GLU A 419","None","1.33A","1qhyA-5xilA:undetectable","1qhyA-5xilA:undetectable"],["1XOQ_A_ROFA502_1","CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4D","5xil","PUTATIVE PROLYL-TRNA SYNTHETASE","Leishmania major",3,"ASN A 509;TRP A 511;GLN A 508","None","1.42A","1xoqA-5xilA:undetectable","1xoqA-5xilA:undetectable"],["2WD9_C_IBPC1570_1","ACYL-COENZYME A SYNTHETASE ACSM2A, MITOCHONDRIAL","5xil","PUTATIVE PROLYL-TRNA SYNTHETASE","Leishmania major",5,"ILE A 682;LEU A 681;GLY A 471;THR A 675;ARG A 678","None","1.11A","2wd9C-5xilA:2.1","2wd9C-5xilA:9.48"],["3BPX_B_SALB258_1","TRANSCRIPTIONAL REGULATOR;TRANSCRIPTIONAL REGULATOR","5xil","PUTATIVE PROLYL-TRNA SYNTHETASE","Leishmania major",5,"ALA A 369;ARG A 493;ILE A 505;PRO A 506;GLY A 487","None","0.73A","3bpxA-5xilA:1.2;3bpxB-5xilA:0.9","3bpxA-5xilA:18.79;3bpxB-5xilA:18.79"],["3LN1_C_CELC682_1","PROSTAGLANDIN G\/H SYNTHASE 2","5xil","PUTATIVE PROLYL-TRNA SYNTHETASE","Leishmania major",5,"VAL A 434;LEU A 303;VAL A 463;GLY A 476;ALA A 477","None","1.08A","3ln1C-5xilA:undetectable","3ln1C-5xilA:8.80"],["3LN1_D_CELD682_1","PROSTAGLANDIN G\/H SYNTHASE 2","5xil","PUTATIVE PROLYL-TRNA SYNTHETASE","Leishmania major",5,"VAL A 434;LEU A 303;VAL A 463;GLY A 476;ALA A 477","None","1.08A","3ln1D-5xilA:undetectable","3ln1D-5xilA:8.80"],["3OXC_A_ROCA401_2","PROTEASE","5xil","PUTATIVE PROLYL-TRNA SYNTHETASE","Leishmania major",3,"ARG A 663;LEU A 751;THR A 462","None","0.87A","3oxcA-5xilA:undetectable","3oxcA-5xilA:13.83"],["3PGH_B_FLPB701_1","CYCLOOXYGENASE-2","5xil","PUTATIVE PROLYL-TRNA SYNTHETASE","Leishmania major",5,"VAL A 434;LEU A 303;VAL A 463;GLY A 476;ALA A 477","None","1.09A","3pghB-5xilA:undetectable","3pghB-5xilA:8.80"],["3RR3_A_FLRA700_1","PROSTAGLANDIN G\/H SYNTHASE 2","5xil","PUTATIVE PROLYL-TRNA SYNTHETASE","Leishmania major",5,"VAL A 434;LEU A 303;VAL A 463;GLY A 476;ALA A 477","None","1.02A","3rr3A-5xilA:undetectable","3rr3A-5xilA:8.30"],["3RR3_B_FLRB700_1","PROSTAGLANDIN G\/H SYNTHASE 2","5xil","PUTATIVE PROLYL-TRNA SYNTHETASE","Leishmania major",5,"VAL A 434;LEU A 303;VAL A 463;GLY A 476;ALA A 477","None","1.03A","3rr3B-5xilA:undetectable","3rr3B-5xilA:8.30"],["3RR3_C_FLRC700_1","PROSTAGLANDIN G\/H SYNTHASE 2","5xil","PUTATIVE PROLYL-TRNA SYNTHETASE","Leishmania major",5,"VAL A 434;LEU A 303;VAL A 463;GLY A 476;ALA A 477","None","1.03A","3rr3C-5xilA:undetectable","3rr3C-5xilA:8.30"],["3RR3_D_FLRD700_1","PROSTAGLANDIN G\/H SYNTHASE 2","5xil","PUTATIVE PROLYL-TRNA SYNTHETASE","Leishmania major",5,"VAL A 434;LEU A 303;VAL A 463;GLY A 476;ALA A 477","None","1.02A","3rr3D-5xilA:undetectable","3rr3D-5xilA:8.30"],["4E3H_A_HQEA303_1","CARBONIC ANHYDRASE 2","5xil","PUTATIVE PROLYL-TRNA SYNTHETASE","Leishmania major",5,"VAL A 619;LEU A 603;VAL A 605;THR A 636;VAL A 542","None","0.91A","4e3hA-5xilA:undetectable","4e3hA-5xilA:13.46"],["4HVC_A_HFGA1602_0","BIFUNCTIONAL GLUTAMATE\/PROLINE--TRNA LIGASE","5xil","PUTATIVE PROLYL-TRNA SYNTHETASE","Leishmania major",7,"TRP A 407;GLU A 409;HIS A 411;PHE A 454;THR A 478;SER A 510;GLY A 512","None","0.39A","4hvcA-5xilA:46.7","4hvcA-5xilA:undetectable"],["4HVC_B_HFGB1602_0","BIFUNCTIONAL GLUTAMATE\/PROLINE--TRNA LIGASE","5xil","PUTATIVE PROLYL-TRNA SYNTHETASE","Leishmania major",7,"TRP A 407;GLU A 409;HIS A 411;PHE A 454;THR A 478;SER A 510;GLY A 512","None","0.40A","4hvcB-5xilA:46.7","4hvcB-5xilA:undetectable"],["4K87_A_ADNA602_1","PROLINE--TRNA LIGASE","5xil","PUTATIVE PROLYL-TRNA SYNTHETASE","Leishmania major",5,"ARG A 401;PHE A 405;GLN A 475;THR A 478;ARG A 516","None","0.80A","4k87A-5xilA:46.6","4k87A-5xilA:56.04"],["4K88_A_HFGA602_0","PROLINE--TRNA LIGASE","5xil","PUTATIVE PROLYL-TRNA SYNTHETASE","Leishmania major",6,"GLU A 361;TRP A 407;GLU A 409;PHE A 454;HIS A 480;SER A 510","None","0.59A","4k88A-5xilA:46.6","4k88A-5xilA:undetectable"],["4OLF_A_HFGA802_0","PROLINE--TRNA LIGASE","5xil","PUTATIVE PROLYL-TRNA SYNTHETASE","Leishmania major",8,"TRP A 407;GLU A 409;HIS A 411;PHE A 454;THR A 478;SER A 510;TRP A 511;GLY A 512","None","0.42A","4olfA-5xilA:46.1","4olfA-5xilA:undetectable"],["4Q15_A_HFGA803_0","PROLINE--TRNA LIGASE","5xil","PUTATIVE PROLYL-TRNA SYNTHETASE","Leishmania major",5,"TRP A 407;HIS A 411;PHE A 454;SER A 510;GLY A 512","None","0.33A","4q15A-5xilA:48.4","4q15A-5xilA:undetectable"],["4Q15_B_HFGB803_0","PROLINE--TRNA LIGASE","5xil","PUTATIVE PROLYL-TRNA SYNTHETASE","Leishmania major",5,"TRP A 407;GLU A 409;PHE A 454;SER A 510;GLY A 512","None","0.40A","4q15B-5xilA:45.4","4q15B-5xilA:undetectable"],["4RRW_A_LURA705_1","PROSTAGLANDIN G\/H SYNTHASE 2","5xil","PUTATIVE PROLYL-TRNA SYNTHETASE","Leishmania major",5,"VAL A 434;SER A 433;VAL A 463;GLY A 476;ALA A 477","None","1.17A","4rrwA-5xilA:undetectable","4rrwA-5xilA:8.80"],["4RRZ_A_LURA705_1","PROSTAGLANDIN G\/H SYNTHASE 2","5xil","PUTATIVE PROLYL-TRNA SYNTHETASE","Leishmania major",5,"VAL A 434;SER A 433;VAL A 463;GLY A 476;ALA A 477","None","1.17A","4rrzA-5xilA:undetectable","4rrzA-5xilA:8.80"],["4YDQ_A_HFGA802_0","PROLINE--TRNA LIGASE","5xil","PUTATIVE PROLYL-TRNA SYNTHETASE","Leishmania major",6,"TRP A 407;GLU A 409;HIS A 411;PHE A 454;SER A 510;GLY A 512","None","0.78A","4ydqA-5xilA:46.3","4ydqA-5xilA:undetectable"],["4YDQ_B_HFGB802_0","PROLINE--TRNA LIGASE","5xil","PUTATIVE PROLYL-TRNA SYNTHETASE","Leishmania major",6,"TRP A 407;GLU A 409;HIS A 411;PHE A 454;SER A 510;GLY A 512","None","0.80A","4ydqB-5xilA:46.6","4ydqB-5xilA:undetectable"],["5F9Z_A_HFGA702_0","AMINOACYL-TRNA SYNTHETASE","5xil","PUTATIVE PROLYL-TRNA SYNTHETASE","Leishmania major",5,"TRP A 407;GLU A 409;PHE A 454;SER A 510;GLY A 512","None","0.43A","5f9zA-5xilA:45.4","5f9zA-5xilA:undetectable"],["5F9Z_B_HFGB703_0","AMINOACYL-TRNA SYNTHETASE","5xil","PUTATIVE PROLYL-TRNA SYNTHETASE","Leishmania major",5,"TRP A 407;GLU A 409;PHE A 454;SER A 510;GLY A 512","None","0.43A","5f9zB-5xilA:46.7","5f9zB-5xilA:undetectable"],["5H5F_A_SAMA301_1","PROTEIN ARGININE N-METHYLTRANSFERASE SFM1","5xil","PUTATIVE PROLYL-TRNA SYNTHETASE","Leishmania major",4,"GLY A 688;PRO A 724;GLN A 727;THR A 747","None","1.28A","5h5fA-5xilA:undetectable","5h5fA-5xilA:undetectable"],["5IFU_A_GBMA801_1","PROLINE--TRNA LIGASE","5xil","PUTATIVE PROLYL-TRNA SYNTHETASE","Leishmania major",9,"PHE A 263;TYR A 267;THR A 515;ARG A 516;ILE A 518;GLY A 519;ILE A 522;MET A 523;TYR A 756","ACT A1003 (-4.3A);ACT A1003 (-4.1A);None;None;None;None;None;ACT A1003 (-4.3A);ACT A1003 (-4.5A)","0.35A","5ifuA-5xilA:48.0","5ifuA-5xilA:53.93"],["5IFU_B_GBMB801_1","PROLINE--TRNA LIGASE","5xil","PUTATIVE PROLYL-TRNA SYNTHETASE","Leishmania major",6,"TYR A 267;ILE A 277;THR A 515;ARG A 516;ILE A 518;GLY A 519","ACT A1003 (-4.1A);None;None;None;None;None","0.41A","5ifuB-5xilA:46.7","5ifuB-5xilA:53.93"],["5IKR_A_ID8A601_1","PROSTAGLANDIN G\/H SYNTHASE 2","5xil","PUTATIVE PROLYL-TRNA SYNTHETASE","Leishmania major",5,"VAL A 434;SER A 433;VAL A 463;GLY A 476;ALA A 477","None","1.14A","5ikrA-5xilA:undetectable","5ikrA-5xilA:9.38"],["5JVZ_A_FLPA601_1","PROSTAGLANDIN G\/H SYNTHASE 2","5xil","PUTATIVE PROLYL-TRNA SYNTHETASE","Leishmania major",5,"VAL A 434;LEU A 303;VAL A 463;GLY A 476;ALA A 477","None","1.08A","5jvzA-5xilA:undetectable","5jvzA-5xilA:8.87"],["5JW1_A_CELA602_1","PROSTAGLANDIN G\/H SYNTHASE 2","5xil","PUTATIVE PROLYL-TRNA SYNTHETASE","Leishmania major",5,"VAL A 434;LEU A 303;VAL A 463;GLY A 476;ALA A 477","None","1.07A","5jw1A-5xilA:undetectable","5jw1A-5xilA:8.87"],["5MLM_A_STRA401_1","-","5xil","PUTATIVE PROLYL-TRNA SYNTHETASE","Leishmania major",5,"PHE A 593;ALA A 579;VAL A 605;ILE A 543;CYH A 581","None","1.18A","5mlmA-5xilA:undetectable","5mlmA-5xilA:12.18"],["5XIO_A_HFGA801_0","PROLINE-TRNA SYNTHETASE CLASS II AARS (YBAK RNA BINDING DOMAIN PLUS TRNA SYNTHETASE)","5xil","PUTATIVE PROLYL-TRNA SYNTHETASE","Leishmania major",7,"TRP A 407;GLU A 409;HIS A 411;PHE A 454;THR A 478;SER A 510;GLY A 512","None","0.41A","5xioA-5xilA:46.0","5xioA-5xilA:undetectable"],["5XIO_B_HFGB802_0","PROLINE-TRNA SYNTHETASE CLASS II AARS (YBAK RNA BINDING DOMAIN PLUS TRNA SYNTHETASE)","5xil","PUTATIVE PROLYL-TRNA SYNTHETASE","Leishmania major",6,"TRP A 407;GLU A 409;HIS A 411;PHE A 454;THR A 478;HIS A 480","None","0.50A","5xioB-5xilA:46.1","5xioB-5xilA:undetectable"],["5XIP_A_HFGA1003_0","PROLYL-TRNA SYNTHETASE, PUTATIVE","5xil","PUTATIVE PROLYL-TRNA SYNTHETASE","Leishmania major",5,"HIS A 411;PHE A 454;THR A 478;SER A 510;GLY A 512","None","0.40A","5xipA-5xilA:49.8","5xipA-5xilA:undetectable"],["5XIP_A_HFGA1003_1","PROLYL-TRNA SYNTHETASE, PUTATIVE","5xil","PUTATIVE PROLYL-TRNA SYNTHETASE","Leishmania major",3,"GLU A 361;TRP A 407;HIS A 480","None","0.83A","5xipA-5xilA:49.8","5xipA-5xilA:undetectable"],["5XIP_B_HFGB1003_0","PROLYL-TRNA SYNTHETASE, PUTATIVE","5xil","PUTATIVE PROLYL-TRNA SYNTHETASE","Leishmania major",5,"GLU A 361;TRP A 407;HIS A 411;PHE A 454;HIS A 480","None","0.67A","5xipB-5xilA:46.8","5xipB-5xilA:undetectable"],["5XIP_B_HFGB1003_0","PROLYL-TRNA SYNTHETASE, PUTATIVE","5xil","PUTATIVE PROLYL-TRNA SYNTHETASE","Leishmania major",5,"TRP A 407;HIS A 411;PHE A 454;THR A 478;HIS A 480","None","0.45A","5xipB-5xilA:46.8","5xipB-5xilA:undetectable"],["5XIP_C_HFGC1003_0","PROLYL-TRNA SYNTHETASE, PUTATIVE","5xil","PUTATIVE PROLYL-TRNA SYNTHETASE","Leishmania major",7,"GLU A 361;TRP A 407;GLU A 409;HIS A 411;PHE A 454;THR A 478;GLY A 512","None","0.58A","5xipC-5xilA:46.2","5xipC-5xilA:undetectable"],["5XIP_D_HFGD1003_0","PROLYL-TRNA SYNTHETASE, PUTATIVE","5xil","PUTATIVE PROLYL-TRNA SYNTHETASE","Leishmania major",6,"GLU A 361;TRP A 407;GLU A 409;PHE A 454;THR A 478;TRP A 511","None","0.61A","5xipD-5xilA:46.3","5xipD-5xilA:undetectable"],["5XIQ_A_HFGA1002_0","PROLYL-TRNA SYNTHETASE (PRORS)","5xil","PUTATIVE PROLYL-TRNA SYNTHETASE","Leishmania major",7,"TRP A 407;GLU A 409;HIS A 411;PHE A 454;THR A 478;SER A 510;GLY A 512","None","0.50A","5xiqA-5xilA:47.6","5xiqA-5xilA:undetectable"],["5XIQ_B_HFGB1002_0","PROLYL-TRNA SYNTHETASE (PRORS)","5xil","PUTATIVE PROLYL-TRNA SYNTHETASE","Leishmania major",6,"TRP A 407;GLU A 409;HIS A 411;PHE A 454;THR A 478;SER A 510","None","0.46A","5xiqB-5xilA:47.1","5xiqB-5xilA:undetectable"],["5XIQ_C_HFGC1002_0","PROLYL-TRNA SYNTHETASE (PRORS)","5xil","PUTATIVE PROLYL-TRNA SYNTHETASE","Leishmania major",6,"TRP A 407;GLU A 409;HIS A 411;PHE A 454;THR A 478;SER A 510","None","0.50A","5xiqC-5xilA:47.0","5xiqC-5xilA:undetectable"],["5XIQ_D_HFGD1002_0","PROLYL-TRNA SYNTHETASE (PRORS)","5xil","PUTATIVE PROLYL-TRNA SYNTHETASE","Leishmania major",6,"TRP A 407;GLU A 409;HIS A 411;PHE A 454;THR A 478;GLY A 512","None","0.52A","5xiqD-5xilA:47.3","5xiqD-5xilA:undetectable"],["6F3M_D_ADND502_2","-","5xil","PUTATIVE PROLYL-TRNA SYNTHETASE","Leishmania major",4,"ILE A 543;GLN A 541;THR A 540;LEU A 568","None","1.09A","6f3mD-5xilA:undetectable","6f3mD-5xilA:10.51"],["6MN8_A_HFGA603_0","UNCHARACTERIZED PROTEIN","5xil","PUTATIVE PROLYL-TRNA SYNTHETASE","Leishmania major",7,"TRP A 407;GLU A 409;HIS A 411;THR A 478;SER A 510;TRP A 511;GLY A 512","None","0.38A","6mn8A-5xilA:19.5","6mn8A-5xilA:undetectable"]]