SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5xio'

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)	View	Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1JHO_A_NIOA991_1 (NICOTINATE MONONUCLEOTIDE:5,6-D IMETHYLBENZIMIDAZOLE PHOSPHORIBOSYLTRANSF ERASE)	5xio	PROLINE-TRNA SYNTHETASE CLASS II AARS (YBAK RNA BINDING DOMAIN PLUS TRNA SYNTHETASE) (Cryptosporidium parvum)	5 / 9	THR A 331 GLY A 382 SER A 480 GLU A 333 GLY A 482	HFG  A 801 (-3.4A) None HFG  A 801 ( 3.8A) HFG  A 801 (-3.0A) HFG  A 801 (-3.9A)	0.98A	1jhoA-5xioA: undetectable	1jhoA-5xioA: 10.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1JHR_A_NIOA991_1 (NICOTINATE MONONUCLEOTIDE:5,6-D IMETHYLBENZIMIDAZOLE PHOSPHORIBOSYLTRANSF ERASE)	5xio	PROLINE-TRNA SYNTHETASE CLASS II AARS (YBAK RNA BINDING DOMAIN PLUS TRNA SYNTHETASE) (Cryptosporidium parvum)	5 / 9	THR A 331 GLY A 382 SER A 480 GLU A 333 GLY A 482	HFG  A 801 (-3.4A) None HFG  A 801 ( 3.8A) HFG  A 801 (-3.0A) HFG  A 801 (-3.9A)	1.00A	1jhrA-5xioA: undetectable	1jhrA-5xioA: 10.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1JHY_A_NIOA991_1 (NICOTINATE MONONUCLEOTIDE:5,6-D IMETHYLBENZIMIDAZOLE PHOSPHORIBOSYLTRANSF ERASE)	5xio	PROLINE-TRNA SYNTHETASE CLASS II AARS (YBAK RNA BINDING DOMAIN PLUS TRNA SYNTHETASE) (Cryptosporidium parvum)	5 / 9	THR A 331 GLY A 382 SER A 480 GLU A 333 GLY A 482	HFG  A 801 (-3.4A) None HFG  A 801 ( 3.8A) HFG  A 801 (-3.0A) HFG  A 801 (-3.9A)	1.00A	1jhyA-5xioA: undetectable	1jhyA-5xioA: 10.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1L4N_A_NIOA991_1 (NICOTINATE-NUCLEOTID E--DIMETHYLBENZIMIDA ZOLE PHOSPHORIBOSYLTRANSF ERASE)	5xio	PROLINE-TRNA SYNTHETASE CLASS II AARS (YBAK RNA BINDING DOMAIN PLUS TRNA SYNTHETASE) (Cryptosporidium parvum)	5 / 9	THR A 331 GLY A 382 SER A 480 GLU A 333 GLY A 482	HFG  A 801 (-3.4A) None HFG  A 801 ( 3.8A) HFG  A 801 (-3.0A) HFG  A 801 (-3.9A)	1.00A	1l4nA-5xioA: undetectable	1l4nA-5xioA: 10.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1L5K_A_NIOA991_1 (NICOTINATE-NUCLEOTID E--DIMETHYLBENZIMIDA ZOLE PHOSPHORIBOSYLTRANSF ERASE)	5xio	PROLINE-TRNA SYNTHETASE CLASS II AARS (YBAK RNA BINDING DOMAIN PLUS TRNA SYNTHETASE) (Cryptosporidium parvum)	5 / 9	THR A 331 GLY A 382 SER A 480 GLU A 333 GLY A 482	HFG  A 801 (-3.4A) None HFG  A 801 ( 3.8A) HFG  A 801 (-3.0A) HFG  A 801 (-3.9A)	0.98A	1l5kA-5xioA: undetectable	1l5kA-5xioA: 10.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1L5L_A_NIOA991_1 (NICOTINATE-NUCLEOTID E--DIMETHYLBENZIMIDA ZOLE PHOSPHORIBOSYLTRANSF ERASE)	5xio	PROLINE-TRNA SYNTHETASE CLASS II AARS (YBAK RNA BINDING DOMAIN PLUS TRNA SYNTHETASE) (Cryptosporidium parvum)	5 / 9	THR A 331 GLY A 382 SER A 480 GLU A 333 GLY A 482	HFG  A 801 (-3.4A) None HFG  A 801 ( 3.8A) HFG  A 801 (-3.0A) HFG  A 801 (-3.9A)	0.98A	1l5lA-5xioA: undetectable	1l5lA-5xioA: 10.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1L5M_A_NIOA991_1 (NICOTINATE-NUCLEOTID E--DIMETHYLBENZIMIDA ZOLE PHOSPHORIBOSYLTRANSF ERASE)	5xio	PROLINE-TRNA SYNTHETASE CLASS II AARS (YBAK RNA BINDING DOMAIN PLUS TRNA SYNTHETASE) (Cryptosporidium parvum)	5 / 9	THR A 331 GLY A 382 SER A 480 GLU A 333 GLY A 482	HFG  A 801 (-3.4A) None HFG  A 801 ( 3.8A) HFG  A 801 (-3.0A) HFG  A 801 (-3.9A)	0.98A	1l5mA-5xioA: undetectable	1l5mA-5xioA: 10.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1U70_A_MTXA187_2 (DIHYDROFOLATE REDUCTASE)	5xio	PROLINE-TRNA SYNTHETASE CLASS II AARS (YBAK RNA BINDING DOMAIN PLUS TRNA SYNTHETASE) (Cryptosporidium parvum)	4 / 4	SER A 254 ILE A 253 VAL A 361 THR A 485	None	1.09A	1u70A-5xioA: undetectable	1u70A-5xioA: 19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2RHM_D_BEZD194_0 (PUTATIVE KINASE)	5xio	PROLINE-TRNA SYNTHETASE CLASS II AARS (YBAK RNA BINDING DOMAIN PLUS TRNA SYNTHETASE) (Cryptosporidium parvum)	4 / 5	PRO A 555 ILE A 515 ARG A 570 ASP A 548	None	1.46A	2rhmD-5xioA: undetectable	2rhmD-5xioA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2V0M_B_KLNB1499_1 (CYTOCHROME P450 3A4)	5xio	PROLINE-TRNA SYNTHETASE CLASS II AARS (YBAK RNA BINDING DOMAIN PLUS TRNA SYNTHETASE) (Cryptosporidium parvum)	4 / 7	PHE A 458 SER A 434 THR A 331 GLY A 428	None None HFG  A 801 (-3.4A) None	0.83A	2v0mB-5xioA: undetectable	2v0mB-5xioA: 10.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2ZLC_A_VDXA500_1 (VITAMIN D3 RECEPTOR)	5xio	PROLINE-TRNA SYNTHETASE CLASS II AARS (YBAK RNA BINDING DOMAIN PLUS TRNA SYNTHETASE) (Cryptosporidium parvum)	5 / 12	TYR A 238 LEU A 501 VAL A 502 VAL A 507 LEU A 609	None	1.27A	2zlcA-5xioA: undetectable	2zlcA-5xioA: 21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3AF0_A_PAUA314_0 (PANTOTHENATE KINASE)	5xio	PROLINE-TRNA SYNTHETASE CLASS II AARS (YBAK RNA BINDING DOMAIN PLUS TRNA SYNTHETASE) (Cryptosporidium parvum)	4 / 8	ASP A 397 LEU A 400 LYS A 417 GLY A 418	None	1.04A	3af0A-5xioA: undetectable	3af0A-5xioA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3GWX_A_EPAA1_2 (PROTEIN (PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR (PPAR-DELTA)))	5xio	PROLINE-TRNA SYNTHETASE CLASS II AARS (YBAK RNA BINDING DOMAIN PLUS TRNA SYNTHETASE) (Cryptosporidium parvum)	5 / 12	THR A 369 THR A 374 HIS A 367 ILE A 442 ILE A 439	None ANP  A 803 (-4.3A) None None None	1.30A	3gwxA-5xioA: undetectable	3gwxA-5xioA: 16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HVC_A_HFGA1602_0 (BIFUNCTIONAL GLUTAMATE/PROLINE--T RNA LIGASE)	5xio	PROLINE-TRNA SYNTHETASE CLASS II AARS (YBAK RNA BINDING DOMAIN PLUS TRNA SYNTHETASE) (Cryptosporidium parvum)	7 / 12	GLU A 364 TRP A 379 GLU A 381 HIS A 383 THR A 450 SER A 480 GLY A 482	ANP  A 803 (-3.7A) None HFG  A 801 ( 4.9A) HFG  A 801 ( 4.7A) ANP  A 803 (-3.9A) HFG  A 801 ( 3.8A) HFG  A 801 (-3.9A)	1.10A	4hvcA-5xioA: 50.6	4hvcA-5xioA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HVC_A_HFGA1602_0 (BIFUNCTIONAL GLUTAMATE/PROLINE--T RNA LIGASE)	5xio	PROLINE-TRNA SYNTHETASE CLASS II AARS (YBAK RNA BINDING DOMAIN PLUS TRNA SYNTHETASE) (Cryptosporidium parvum)	7 / 12	PHE A 307 GLU A 310 VAL A 311 PRO A 330 GLU A 381 PHE A 426 GLY A 482	HFG  A 801 (-3.7A) None HFG  A 801 (-4.3A) HFG  A 801 ( 4.8A) HFG  A 801 ( 4.9A) HFG  A 801 (-3.7A) HFG  A 801 (-3.9A)	0.69A	4hvcA-5xioA: 50.6	4hvcA-5xioA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HVC_A_HFGA1602_0 (BIFUNCTIONAL GLUTAMATE/PROLINE--T RNA LIGASE)	5xio	PROLINE-TRNA SYNTHETASE CLASS II AARS (YBAK RNA BINDING DOMAIN PLUS TRNA SYNTHETASE) (Cryptosporidium parvum)	10 / 12	PHE A 307 VAL A 311 PRO A 330 TRP A 379 GLU A 381 HIS A 383 PHE A 426 THR A 450 SER A 480 GLY A 482	HFG  A 801 (-3.7A) HFG  A 801 (-4.3A) HFG  A 801 ( 4.8A) None HFG  A 801 ( 4.9A) HFG  A 801 ( 4.7A) HFG  A 801 (-3.7A) ANP  A 803 (-3.9A) HFG  A 801 ( 3.8A) HFG  A 801 (-3.9A)	0.42A	4hvcA-5xioA: 50.6	4hvcA-5xioA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HVC_A_HFGA1602_1 (BIFUNCTIONAL GLUTAMATE/PROLINE--T RNA LIGASE)	5xio	PROLINE-TRNA SYNTHETASE CLASS II AARS (YBAK RNA BINDING DOMAIN PLUS TRNA SYNTHETASE) (Cryptosporidium parvum)	4 / 4	THR A 331 GLU A 333 ARG A 362 HIS A 452	HFG  A 801 (-3.4A) HFG  A 801 (-3.0A) ANP  A 803 ( 3.1A) HFG  A 801 (-4.2A)	0.26A	4hvcA-5xioA: 50.6	4hvcA-5xioA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HVC_B_HFGB1602_0 (BIFUNCTIONAL GLUTAMATE/PROLINE--T RNA LIGASE)	5xio	PROLINE-TRNA SYNTHETASE CLASS II AARS (YBAK RNA BINDING DOMAIN PLUS TRNA SYNTHETASE) (Cryptosporidium parvum)	7 / 12	GLU A 364 TRP A 379 GLU A 381 HIS A 383 THR A 450 SER A 480 GLY A 482	ANP  A 803 (-3.7A) None HFG  A 801 ( 4.9A) HFG  A 801 ( 4.7A) ANP  A 803 (-3.9A) HFG  A 801 ( 3.8A) HFG  A 801 (-3.9A)	1.12A	4hvcB-5xioA: 49.4	4hvcB-5xioA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HVC_B_HFGB1602_0 (BIFUNCTIONAL GLUTAMATE/PROLINE--T RNA LIGASE)	5xio	PROLINE-TRNA SYNTHETASE CLASS II AARS (YBAK RNA BINDING DOMAIN PLUS TRNA SYNTHETASE) (Cryptosporidium parvum)	9 / 12	LEU A 297 PHE A 307 GLU A 310 VAL A 311 PRO A 330 GLU A 381 PHE A 426 THR A 450 GLY A 482	None HFG  A 801 (-3.7A) None HFG  A 801 (-4.3A) HFG  A 801 ( 4.8A) HFG  A 801 ( 4.9A) HFG  A 801 (-3.7A) ANP  A 803 (-3.9A) HFG  A 801 (-3.9A)	0.64A	4hvcB-5xioA: 49.4	4hvcB-5xioA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HVC_B_HFGB1602_0 (BIFUNCTIONAL GLUTAMATE/PROLINE--T RNA LIGASE)	5xio	PROLINE-TRNA SYNTHETASE CLASS II AARS (YBAK RNA BINDING DOMAIN PLUS TRNA SYNTHETASE) (Cryptosporidium parvum)	11 / 12	LEU A 297 PHE A 307 VAL A 311 PRO A 330 TRP A 379 GLU A 381 HIS A 383 PHE A 426 THR A 450 SER A 480 GLY A 482	None HFG  A 801 (-3.7A) HFG  A 801 (-4.3A) HFG  A 801 ( 4.8A) None HFG  A 801 ( 4.9A) HFG  A 801 ( 4.7A) HFG  A 801 (-3.7A) ANP  A 803 (-3.9A) HFG  A 801 ( 3.8A) HFG  A 801 (-3.9A)	0.38A	4hvcB-5xioA: 49.4	4hvcB-5xioA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HVC_B_HFGB1602_1 (BIFUNCTIONAL GLUTAMATE/PROLINE--T RNA LIGASE)	5xio	PROLINE-TRNA SYNTHETASE CLASS II AARS (YBAK RNA BINDING DOMAIN PLUS TRNA SYNTHETASE) (Cryptosporidium parvum)	4 / 5	THR A 331 GLU A 333 ARG A 362 HIS A 452	HFG  A 801 (-3.4A) HFG  A 801 (-3.0A) ANP  A 803 ( 3.1A) HFG  A 801 (-4.2A)	0.27A	4hvcB-5xioA: 49.4	4hvcB-5xioA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4K87_A_ADNA602_1 (PROLINE--TRNA LIGASE)	5xio	PROLINE-TRNA SYNTHETASE CLASS II AARS (YBAK RNA BINDING DOMAIN PLUS TRNA SYNTHETASE) (Cryptosporidium parvum)	6 / 8	ARG A 362 PHE A 377 GLN A 447 THR A 450 THR A 484 ARG A 486	ANP  A 803 ( 3.1A) ANP  A 803 (-4.1A) ANP  A 803 (-3.5A) ANP  A 803 (-3.9A) ANP  A 803 (-3.3A) ANP  A 803 (-3.5A)	0.52A	4k87A-5xioA: 51.4	4k87A-5xioA: 24.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4K88_A_HFGA602_0 (PROLINE--TRNA LIGASE)	5xio	PROLINE-TRNA SYNTHETASE CLASS II AARS (YBAK RNA BINDING DOMAIN PLUS TRNA SYNTHETASE) (Cryptosporidium parvum)	8 / 12	GLU A 364 THR A 331 GLU A 333 ARG A 362 GLU A 381 PHE A 426 HIS A 452 SER A 480	ANP  A 803 (-3.7A) HFG  A 801 (-3.4A) HFG  A 801 (-3.0A) ANP  A 803 ( 3.1A) HFG  A 801 ( 4.9A) HFG  A 801 (-3.7A) HFG  A 801 (-4.2A) HFG  A 801 ( 3.8A)	1.45A	4k88A-5xioA: 51.1	4k88A-5xioA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4K88_A_HFGA602_0 (PROLINE--TRNA LIGASE)	5xio	PROLINE-TRNA SYNTHETASE CLASS II AARS (YBAK RNA BINDING DOMAIN PLUS TRNA SYNTHETASE) (Cryptosporidium parvum)	12 / 12	PHE A 307 GLU A 310 VAL A 311 PRO A 330 THR A 331 GLU A 333 ARG A 362 TRP A 379 GLU A 381 PHE A 426 HIS A 452 SER A 480	HFG  A 801 (-3.7A) None HFG  A 801 (-4.3A) HFG  A 801 ( 4.8A) HFG  A 801 (-3.4A) HFG  A 801 (-3.0A) ANP  A 803 ( 3.1A) None HFG  A 801 ( 4.9A) HFG  A 801 (-3.7A) HFG  A 801 (-4.2A) HFG  A 801 ( 3.8A)	0.52A	4k88A-5xioA: 51.1	4k88A-5xioA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4KQI_A_NIOA403_1 (NICOTINATE-NUCLEOTID E--DIMETHYLBENZIMIDA ZOLE PHOSPHORIBOSYLTRANSF ERASE)	5xio	PROLINE-TRNA SYNTHETASE CLASS II AARS (YBAK RNA BINDING DOMAIN PLUS TRNA SYNTHETASE) (Cryptosporidium parvum)	5 / 9	THR A 331 GLY A 382 SER A 480 GLU A 333 GLY A 482	HFG  A 801 (-3.4A) None HFG  A 801 ( 3.8A) HFG  A 801 (-3.0A) HFG  A 801 (-3.9A)	1.03A	4kqiA-5xioA: undetectable	4kqiA-5xioA: 11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4LB2_A_DM5A601_1 (SERUM ALBUMIN)	5xio	PROLINE-TRNA SYNTHETASE CLASS II AARS (YBAK RNA BINDING DOMAIN PLUS TRNA SYNTHETASE) (Cryptosporidium parvum)	4 / 7	VAL A 311 PRO A 309 LYS A 366 GLU A 364	HFG  A 801 (-4.3A) None None ANP  A 803 (-3.7A)	1.02A	4lb2A-5xioA: undetectable	4lb2A-5xioA: 7.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4OLF_A_HFGA802_0 (PROLINE--TRNA LIGASE)	5xio	PROLINE-TRNA SYNTHETASE CLASS II AARS (YBAK RNA BINDING DOMAIN PLUS TRNA SYNTHETASE) (Cryptosporidium parvum)	8 / 12	GLU A 364 TRP A 379 GLU A 381 HIS A 383 THR A 450 SER A 480 TRP A 481 GLY A 482	ANP  A 803 (-3.7A) None HFG  A 801 ( 4.9A) HFG  A 801 ( 4.7A) ANP  A 803 (-3.9A) HFG  A 801 ( 3.8A) None HFG  A 801 (-3.9A)	1.21A	4olfA-5xioA: 52.7	4olfA-5xioA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4OLF_A_HFGA802_0 (PROLINE--TRNA LIGASE)	5xio	PROLINE-TRNA SYNTHETASE CLASS II AARS (YBAK RNA BINDING DOMAIN PLUS TRNA SYNTHETASE) (Cryptosporidium parvum)	9 / 12	PHE A 307 GLU A 310 VAL A 311 PRO A 330 TRP A 379 GLU A 381 PHE A 426 THR A 450 GLY A 482	HFG  A 801 (-3.7A) None HFG  A 801 (-4.3A) HFG  A 801 ( 4.8A) None HFG  A 801 ( 4.9A) HFG  A 801 (-3.7A) ANP  A 803 (-3.9A) HFG  A 801 (-3.9A)	0.59A	4olfA-5xioA: 52.7	4olfA-5xioA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4OLF_A_HFGA802_0 (PROLINE--TRNA LIGASE)	5xio	PROLINE-TRNA SYNTHETASE CLASS II AARS (YBAK RNA BINDING DOMAIN PLUS TRNA SYNTHETASE) (Cryptosporidium parvum)	11 / 12	PHE A 307 VAL A 311 PRO A 330 TRP A 379 GLU A 381 HIS A 383 PHE A 426 THR A 450 SER A 480 TRP A 481 GLY A 482	HFG  A 801 (-3.7A) HFG  A 801 (-4.3A) HFG  A 801 ( 4.8A) None HFG  A 801 ( 4.9A) HFG  A 801 ( 4.7A) HFG  A 801 (-3.7A) ANP  A 803 (-3.9A) HFG  A 801 ( 3.8A) None HFG  A 801 (-3.9A)	0.38A	4olfA-5xioA: 52.7	4olfA-5xioA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4OLF_A_HFGA802_1 (PROLINE--TRNA LIGASE)	5xio	PROLINE-TRNA SYNTHETASE CLASS II AARS (YBAK RNA BINDING DOMAIN PLUS TRNA SYNTHETASE) (Cryptosporidium parvum)	4 / 4	THR A 331 GLU A 333 ARG A 362 HIS A 452	HFG  A 801 (-3.4A) HFG  A 801 (-3.0A) ANP  A 803 ( 3.1A) HFG  A 801 (-4.2A)	0.34A	4olfA-5xioA: 52.7	4olfA-5xioA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4Q15_A_HFGA803_0 (PROLINE--TRNA LIGASE)	5xio	PROLINE-TRNA SYNTHETASE CLASS II AARS (YBAK RNA BINDING DOMAIN PLUS TRNA SYNTHETASE) (Cryptosporidium parvum)	6 / 12	GLU A 364 ARG A 362 TRP A 379 HIS A 383 SER A 480 GLY A 482	ANP  A 803 (-3.7A) ANP  A 803 ( 3.1A) None HFG  A 801 ( 4.7A) HFG  A 801 ( 3.8A) HFG  A 801 (-3.9A)	1.45A	4q15A-5xioA: 49.3	4q15A-5xioA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4Q15_A_HFGA803_0 (PROLINE--TRNA LIGASE)	5xio	PROLINE-TRNA SYNTHETASE CLASS II AARS (YBAK RNA BINDING DOMAIN PLUS TRNA SYNTHETASE) (Cryptosporidium parvum)	9 / 12	LEU A 297 PHE A 307 GLU A 310 VAL A 311 THR A 331 ARG A 362 PHE A 426 SER A 480 GLY A 482	None HFG  A 801 (-3.7A) None HFG  A 801 (-4.3A) HFG  A 801 (-3.4A) ANP  A 803 ( 3.1A) HFG  A 801 (-3.7A) HFG  A 801 ( 3.8A) HFG  A 801 (-3.9A)	0.60A	4q15A-5xioA: 49.3	4q15A-5xioA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4Q15_A_HFGA803_0 (PROLINE--TRNA LIGASE)	5xio	PROLINE-TRNA SYNTHETASE CLASS II AARS (YBAK RNA BINDING DOMAIN PLUS TRNA SYNTHETASE) (Cryptosporidium parvum)	11 / 12	LEU A 297 PHE A 307 VAL A 311 PRO A 330 THR A 331 ARG A 362 TRP A 379 HIS A 383 PHE A 426 SER A 480 GLY A 482	None HFG  A 801 (-3.7A) HFG  A 801 (-4.3A) HFG  A 801 ( 4.8A) HFG  A 801 (-3.4A) ANP  A 803 ( 3.1A) None HFG  A 801 ( 4.7A) HFG  A 801 (-3.7A) HFG  A 801 ( 3.8A) HFG  A 801 (-3.9A)	0.38A	4q15A-5xioA: 49.3	4q15A-5xioA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4Q15_A_HFGA803_1 (PROLINE--TRNA LIGASE)	5xio	PROLINE-TRNA SYNTHETASE CLASS II AARS (YBAK RNA BINDING DOMAIN PLUS TRNA SYNTHETASE) (Cryptosporidium parvum)	3 / 3	GLU A 333 THR A 450 HIS A 452	HFG  A 801 (-3.0A) ANP  A 803 (-3.9A) HFG  A 801 (-4.2A)	0.58A	4q15A-5xioA: 31.6	4q15A-5xioA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4Q15_B_HFGB803_0 (PROLINE--TRNA LIGASE)	5xio	PROLINE-TRNA SYNTHETASE CLASS II AARS (YBAK RNA BINDING DOMAIN PLUS TRNA SYNTHETASE) (Cryptosporidium parvum)	6 / 12	GLU A 364 ARG A 362 TRP A 379 GLU A 381 SER A 480 GLY A 482	ANP  A 803 (-3.7A) ANP  A 803 ( 3.1A) None HFG  A 801 ( 4.9A) HFG  A 801 ( 3.8A) HFG  A 801 (-3.9A)	1.35A	4q15B-5xioA: 48.8	4q15B-5xioA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4Q15_B_HFGB803_0 (PROLINE--TRNA LIGASE)	5xio	PROLINE-TRNA SYNTHETASE CLASS II AARS (YBAK RNA BINDING DOMAIN PLUS TRNA SYNTHETASE) (Cryptosporidium parvum)	12 / 12	LEU A 297 PHE A 307 GLU A 310 VAL A 311 PRO A 330 THR A 331 ARG A 362 TRP A 379 GLU A 381 PHE A 426 SER A 480 GLY A 482	None HFG  A 801 (-3.7A) None HFG  A 801 (-4.3A) HFG  A 801 ( 4.8A) HFG  A 801 (-3.4A) ANP  A 803 ( 3.1A) None HFG  A 801 ( 4.9A) HFG  A 801 (-3.7A) HFG  A 801 ( 3.8A) HFG  A 801 (-3.9A)	0.54A	4q15B-5xioA: 48.8	4q15B-5xioA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4Q15_B_HFGB803_1 (PROLINE--TRNA LIGASE)	5xio	PROLINE-TRNA SYNTHETASE CLASS II AARS (YBAK RNA BINDING DOMAIN PLUS TRNA SYNTHETASE) (Cryptosporidium parvum)	3 / 3	GLU A 333 THR A 450 HIS A 452	HFG  A 801 (-3.0A) ANP  A 803 (-3.9A) HFG  A 801 (-4.2A)	0.61A	4q15B-5xioA: 48.8	4q15B-5xioA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RUJ_A_VDXA501_1 (VITAMIN D3 RECEPTOR A)	5xio	PROLINE-TRNA SYNTHETASE CLASS II AARS (YBAK RNA BINDING DOMAIN PLUS TRNA SYNTHETASE) (Cryptosporidium parvum)	5 / 12	TYR A 287 VAL A 292 ILE A 335 SER A 359 VAL A 311	None None None None HFG  A 801 (-4.3A)	1.30A	4rujA-5xioA: undetectable	4rujA-5xioA: 14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4TXN_A_URFA302_1 (URIDINE PHOSPHORYLASE)	5xio	PROLINE-TRNA SYNTHETASE CLASS II AARS (YBAK RNA BINDING DOMAIN PLUS TRNA SYNTHETASE) (Cryptosporidium parvum)	4 / 7	GLY A 437 GLN A 624 ALA A 448 ILE A 435	None	0.94A	4txnA-5xioA: 3.2	4txnA-5xioA: 12.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4TXN_B_URFB302_1 (URIDINE PHOSPHORYLASE)	5xio	PROLINE-TRNA SYNTHETASE CLASS II AARS (YBAK RNA BINDING DOMAIN PLUS TRNA SYNTHETASE) (Cryptosporidium parvum)	4 / 7	GLY A 437 GLN A 624 ALA A 448 ILE A 435	None	0.94A	4txnB-5xioA: undetectable	4txnB-5xioA: 12.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4TXN_C_URFC302_1 (URIDINE PHOSPHORYLASE)	5xio	PROLINE-TRNA SYNTHETASE CLASS II AARS (YBAK RNA BINDING DOMAIN PLUS TRNA SYNTHETASE) (Cryptosporidium parvum)	4 / 7	GLY A 437 GLN A 624 ALA A 448 ILE A 435	None	0.94A	4txnC-5xioA: 2.5	4txnC-5xioA: 12.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4TXN_D_URFD302_1 (URIDINE PHOSPHORYLASE)	5xio	PROLINE-TRNA SYNTHETASE CLASS II AARS (YBAK RNA BINDING DOMAIN PLUS TRNA SYNTHETASE) (Cryptosporidium parvum)	4 / 7	GLY A 437 GLN A 624 ALA A 448 ILE A 435	None	0.95A	4txnD-5xioA: undetectable	4txnD-5xioA: 12.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4Y1D_D_DVAD5_0 (CYCLIC HEXAPEPTIDE CYC[NDPOPPKID] INTEGRASE)	5xio	PROLINE-TRNA SYNTHETASE CLASS II AARS (YBAK RNA BINDING DOMAIN PLUS TRNA SYNTHETASE) (Cryptosporidium parvum)	3 / 3	GLU A 424 LYS A 420 ASN A 423	None	0.99A	4y1dA-5xioA: undetectable 4y1dD-5xioA: undetectable	4y1dA-5xioA: undetectable 4y1dD-5xioA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4YDQ_A_HFGA802_0 (PROLINE--TRNA LIGASE)	5xio	PROLINE-TRNA SYNTHETASE CLASS II AARS (YBAK RNA BINDING DOMAIN PLUS TRNA SYNTHETASE) (Cryptosporidium parvum)	6 / 12	GLU A 364 ARG A 362 GLU A 381 HIS A 383 SER A 480 GLY A 482	ANP  A 803 (-3.7A) ANP  A 803 ( 3.1A) HFG  A 801 ( 4.9A) HFG  A 801 ( 4.7A) HFG  A 801 ( 3.8A) HFG  A 801 (-3.9A)	1.39A	4ydqA-5xioA: 50.6	4ydqA-5xioA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4YDQ_A_HFGA802_0 (PROLINE--TRNA LIGASE)	5xio	PROLINE-TRNA SYNTHETASE CLASS II AARS (YBAK RNA BINDING DOMAIN PLUS TRNA SYNTHETASE) (Cryptosporidium parvum)	11 / 12	LEU A 297 PHE A 307 GLU A 310 VAL A 311 PRO A 330 ARG A 362 GLU A 381 HIS A 383 PHE A 426 SER A 480 GLY A 482	None HFG  A 801 (-3.7A) None HFG  A 801 (-4.3A) HFG  A 801 ( 4.8A) ANP  A 803 ( 3.1A) HFG  A 801 ( 4.9A) HFG  A 801 ( 4.7A) HFG  A 801 (-3.7A) HFG  A 801 ( 3.8A) HFG  A 801 (-3.9A)	0.51A	4ydqA-5xioA: 50.6	4ydqA-5xioA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4YDQ_A_HFGA802_0 (PROLINE--TRNA LIGASE)	5xio	PROLINE-TRNA SYNTHETASE CLASS II AARS (YBAK RNA BINDING DOMAIN PLUS TRNA SYNTHETASE) (Cryptosporidium parvum)	10 / 12	LEU A 297 PHE A 307 GLU A 310 VAL A 311 PRO A 330 ARG A 362 TRP A 379 PHE A 426 SER A 480 GLY A 482	None HFG  A 801 (-3.7A) None HFG  A 801 (-4.3A) HFG  A 801 ( 4.8A) ANP  A 803 ( 3.1A) None HFG  A 801 (-3.7A) HFG  A 801 ( 3.8A) HFG  A 801 (-3.9A)	0.77A	4ydqA-5xioA: 50.6	4ydqA-5xioA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4YDQ_A_HFGA802_1 (PROLINE--TRNA LIGASE)	5xio	PROLINE-TRNA SYNTHETASE CLASS II AARS (YBAK RNA BINDING DOMAIN PLUS TRNA SYNTHETASE) (Cryptosporidium parvum)	4 / 4	THR A 331 GLU A 333 THR A 450 HIS A 452	HFG  A 801 (-3.4A) HFG  A 801 (-3.0A) ANP  A 803 (-3.9A) HFG  A 801 (-4.2A)	0.53A	4ydqA-5xioA: 50.6	4ydqA-5xioA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4YDQ_B_HFGB802_0 (PROLINE--TRNA LIGASE)	5xio	PROLINE-TRNA SYNTHETASE CLASS II AARS (YBAK RNA BINDING DOMAIN PLUS TRNA SYNTHETASE) (Cryptosporidium parvum)	10 / 12	GLU A 310 VAL A 311 PRO A 330 THR A 331 ARG A 362 TRP A 379 HIS A 383 PHE A 426 SER A 480 GLY A 482	None HFG  A 801 (-4.3A) HFG  A 801 ( 4.8A) HFG  A 801 (-3.4A) ANP  A 803 ( 3.1A) None HFG  A 801 ( 4.7A) HFG  A 801 (-3.7A) HFG  A 801 ( 3.8A) HFG  A 801 (-3.9A)	0.73A	4ydqB-5xioA: 50.9	4ydqB-5xioA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4YDQ_B_HFGB802_0 (PROLINE--TRNA LIGASE)	5xio	PROLINE-TRNA SYNTHETASE CLASS II AARS (YBAK RNA BINDING DOMAIN PLUS TRNA SYNTHETASE) (Cryptosporidium parvum)	7 / 12	GLU A 364 THR A 331 ARG A 362 GLU A 381 HIS A 383 SER A 480 GLY A 482	ANP  A 803 (-3.7A) HFG  A 801 (-3.4A) ANP  A 803 ( 3.1A) HFG  A 801 ( 4.9A) HFG  A 801 ( 4.7A) HFG  A 801 ( 3.8A) HFG  A 801 (-3.9A)	1.45A	4ydqB-5xioA: 50.9	4ydqB-5xioA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4YDQ_B_HFGB802_0 (PROLINE--TRNA LIGASE)	5xio	PROLINE-TRNA SYNTHETASE CLASS II AARS (YBAK RNA BINDING DOMAIN PLUS TRNA SYNTHETASE) (Cryptosporidium parvum)	11 / 12	PHE A 307 GLU A 310 VAL A 311 PRO A 330 THR A 331 ARG A 362 GLU A 381 HIS A 383 PHE A 426 SER A 480 GLY A 482	HFG  A 801 (-3.7A) None HFG  A 801 (-4.3A) HFG  A 801 ( 4.8A) HFG  A 801 (-3.4A) ANP  A 803 ( 3.1A) HFG  A 801 ( 4.9A) HFG  A 801 ( 4.7A) HFG  A 801 (-3.7A) HFG  A 801 ( 3.8A) HFG  A 801 (-3.9A)	0.53A	4ydqB-5xioA: 50.9	4ydqB-5xioA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4YDQ_B_HFGB802_1 (PROLINE--TRNA LIGASE)	5xio	PROLINE-TRNA SYNTHETASE CLASS II AARS (YBAK RNA BINDING DOMAIN PLUS TRNA SYNTHETASE) (Cryptosporidium parvum)	3 / 3	GLU A 333 THR A 450 HIS A 452	HFG  A 801 (-3.0A) ANP  A 803 (-3.9A) HFG  A 801 (-4.2A)	0.52A	4ydqB-5xioA: 50.9	4ydqB-5xioA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5F9Z_A_HFGA702_0 (AMINOACYL-TRNA SYNTHETASE)	5xio	PROLINE-TRNA SYNTHETASE CLASS II AARS (YBAK RNA BINDING DOMAIN PLUS TRNA SYNTHETASE) (Cryptosporidium parvum)	6 / 12	GLU A 364 ARG A 362 TRP A 379 GLU A 381 SER A 480 GLY A 482	ANP  A 803 (-3.7A) ANP  A 803 ( 3.1A) None HFG  A 801 ( 4.9A) HFG  A 801 ( 3.8A) HFG  A 801 (-3.9A)	1.31A	5f9zA-5xioA: 50.9	5f9zA-5xioA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5F9Z_A_HFGA702_0 (AMINOACYL-TRNA SYNTHETASE)	5xio	PROLINE-TRNA SYNTHETASE CLASS II AARS (YBAK RNA BINDING DOMAIN PLUS TRNA SYNTHETASE) (Cryptosporidium parvum)	8 / 12	LEU A 297 GLU A 310 VAL A 311 PRO A 330 ARG A 362 GLU A 381 PHE A 426 GLY A 482	None None HFG  A 801 (-4.3A) HFG  A 801 ( 4.8A) ANP  A 803 ( 3.1A) HFG  A 801 ( 4.9A) HFG  A 801 (-3.7A) HFG  A 801 (-3.9A)	0.60A	5f9zA-5xioA: 50.9	5f9zA-5xioA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5F9Z_A_HFGA702_0 (AMINOACYL-TRNA SYNTHETASE)	5xio	PROLINE-TRNA SYNTHETASE CLASS II AARS (YBAK RNA BINDING DOMAIN PLUS TRNA SYNTHETASE) (Cryptosporidium parvum)	9 / 12	LEU A 297 VAL A 311 PRO A 330 ARG A 362 TRP A 379 GLU A 381 PHE A 426 SER A 480 GLY A 482	None HFG  A 801 (-4.3A) HFG  A 801 ( 4.8A) ANP  A 803 ( 3.1A) None HFG  A 801 ( 4.9A) HFG  A 801 (-3.7A) HFG  A 801 ( 3.8A) HFG  A 801 (-3.9A)	0.27A	5f9zA-5xioA: 50.9	5f9zA-5xioA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5F9Z_A_HFGA702_1 (AMINOACYL-TRNA SYNTHETASE)	5xio	PROLINE-TRNA SYNTHETASE CLASS II AARS (YBAK RNA BINDING DOMAIN PLUS TRNA SYNTHETASE) (Cryptosporidium parvum)	4 / 4	THR A 331 GLU A 333 THR A 450 HIS A 452	HFG  A 801 (-3.4A) HFG  A 801 (-3.0A) ANP  A 803 (-3.9A) HFG  A 801 (-4.2A)	0.53A	5f9zA-5xioA: 50.9	5f9zA-5xioA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5F9Z_B_HFGB703_0 (AMINOACYL-TRNA SYNTHETASE)	5xio	PROLINE-TRNA SYNTHETASE CLASS II AARS (YBAK RNA BINDING DOMAIN PLUS TRNA SYNTHETASE) (Cryptosporidium parvum)	6 / 12	GLU A 364 ARG A 362 TRP A 379 GLU A 381 SER A 480 GLY A 482	ANP  A 803 (-3.7A) ANP  A 803 ( 3.1A) None HFG  A 801 ( 4.9A) HFG  A 801 ( 3.8A) HFG  A 801 (-3.9A)	1.30A	5f9zB-5xioA: 51.6	5f9zB-5xioA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5F9Z_B_HFGB703_0 (AMINOACYL-TRNA SYNTHETASE)	5xio	PROLINE-TRNA SYNTHETASE CLASS II AARS (YBAK RNA BINDING DOMAIN PLUS TRNA SYNTHETASE) (Cryptosporidium parvum)	8 / 12	LEU A 297 GLU A 310 VAL A 311 PRO A 330 ARG A 362 PHE A 426 SER A 480 GLY A 482	None None HFG  A 801 (-4.3A) HFG  A 801 ( 4.8A) ANP  A 803 ( 3.1A) HFG  A 801 (-3.7A) HFG  A 801 ( 3.8A) HFG  A 801 (-3.9A)	0.64A	5f9zB-5xioA: 51.6	5f9zB-5xioA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5F9Z_B_HFGB703_0 (AMINOACYL-TRNA SYNTHETASE)	5xio	PROLINE-TRNA SYNTHETASE CLASS II AARS (YBAK RNA BINDING DOMAIN PLUS TRNA SYNTHETASE) (Cryptosporidium parvum)	9 / 12	LEU A 297 VAL A 311 PRO A 330 ARG A 362 TRP A 379 GLU A 381 PHE A 426 SER A 480 GLY A 482	None HFG  A 801 (-4.3A) HFG  A 801 ( 4.8A) ANP  A 803 ( 3.1A) None HFG  A 801 ( 4.9A) HFG  A 801 (-3.7A) HFG  A 801 ( 3.8A) HFG  A 801 (-3.9A)	0.30A	5f9zB-5xioA: 51.6	5f9zB-5xioA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5F9Z_B_HFGB703_1 (AMINOACYL-TRNA SYNTHETASE)	5xio	PROLINE-TRNA SYNTHETASE CLASS II AARS (YBAK RNA BINDING DOMAIN PLUS TRNA SYNTHETASE) (Cryptosporidium parvum)	4 / 4	THR A 331 GLU A 333 THR A 450 HIS A 452	HFG  A 801 (-3.4A) HFG  A 801 (-3.0A) ANP  A 803 (-3.9A) HFG  A 801 (-4.2A)	0.52A	5f9zB-5xioA: 51.6	5f9zB-5xioA: undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5IFU_A_GBMA801_1 (PROLINE--TRNA LIGASE)	5xio	PROLINE-TRNA SYNTHETASE CLASS II AARS (YBAK RNA BINDING DOMAIN PLUS TRNA SYNTHETASE) (Cryptosporidium parvum)	10 / 12	PHE A 234 TYR A 238 LEU A 259 THR A 485 ARG A 486 ILE A 488 GLY A 489 ILE A 492 MET A 493 TYR A 719	None None None None ANP  A 803 (-3.5A) None None None None None	0.70A	5ifuA-5xioA: 45.9	5ifuA-5xioA: 58.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5IFU_A_GBMA801_1 (PROLINE--TRNA LIGASE)	5xio	PROLINE-TRNA SYNTHETASE CLASS II AARS (YBAK RNA BINDING DOMAIN PLUS TRNA SYNTHETASE) (Cryptosporidium parvum)	6 / 12	PHE A 234 TYR A 238 TYR A 257 ARG A 486 ILE A 492 MET A 493	None None None ANP  A 803 (-3.5A) None None	1.26A	5ifuA-5xioA: 45.9	5ifuA-5xioA: 58.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5IFU_B_GBMB801_1 (PROLINE--TRNA LIGASE)	5xio	PROLINE-TRNA SYNTHETASE CLASS II AARS (YBAK RNA BINDING DOMAIN PLUS TRNA SYNTHETASE) (Cryptosporidium parvum)	7 / 9	TYR A 238 ILE A 248 LEU A 259 THR A 485 ARG A 486 ILE A 488 GLY A 489	None None None None ANP  A 803 (-3.5A) None None	0.42A	5ifuB-5xioA: 45.2	5ifuB-5xioA: 58.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5XIO_A_HFGA801_0 (PROLINE-TRNA SYNTHETASE CLASS II AARS (YBAK RNA BINDING DOMAIN PLUS TRNA SYNTHETASE))	5xio	PROLINE-TRNA SYNTHETASE CLASS II AARS (YBAK RNA BINDING DOMAIN PLUS TRNA SYNTHETASE) (Cryptosporidium parvum)	5 / 12	PHE A 307 GLU A 310 HIS A 383 THR A 432 SER A 480	HFG  A 801 (-3.7A) None HFG  A 801 ( 4.7A) None HFG  A 801 ( 3.8A)	1.38A	5xioA-5xioA: 60.2	5xioA-5xioA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5XIO_A_HFGA801_0 (PROLINE-TRNA SYNTHETASE CLASS II AARS (YBAK RNA BINDING DOMAIN PLUS TRNA SYNTHETASE))	5xio	PROLINE-TRNA SYNTHETASE CLASS II AARS (YBAK RNA BINDING DOMAIN PLUS TRNA SYNTHETASE) (Cryptosporidium parvum)	12 / 12	PHE A 307 GLU A 310 VAL A 311 PRO A 330 ARG A 362 TRP A 379 GLU A 381 HIS A 383 PHE A 426 THR A 450 SER A 480 GLY A 482	HFG  A 801 (-3.7A) None HFG  A 801 (-4.3A) HFG  A 801 ( 4.8A) ANP  A 803 ( 3.1A) None HFG  A 801 ( 4.9A) HFG  A 801 ( 4.7A) HFG  A 801 (-3.7A) ANP  A 803 (-3.9A) HFG  A 801 ( 3.8A) HFG  A 801 (-3.9A)	0.00A	5xioA-5xioA: 60.2	5xioA-5xioA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5XIO_A_HFGA801_1 (PROLINE-TRNA SYNTHETASE CLASS II AARS (YBAK RNA BINDING DOMAIN PLUS TRNA SYNTHETASE))	5xio	PROLINE-TRNA SYNTHETASE CLASS II AARS (YBAK RNA BINDING DOMAIN PLUS TRNA SYNTHETASE) (Cryptosporidium parvum)	3 / 3	THR A 331 GLU A 333 HIS A 452	HFG  A 801 (-3.4A) HFG  A 801 (-3.0A) HFG  A 801 (-4.2A)	0.01A	5xioA-5xioA: 60.2	5xioA-5xioA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5XIO_B_HFGB802_0 (PROLINE-TRNA SYNTHETASE CLASS II AARS (YBAK RNA BINDING DOMAIN PLUS TRNA SYNTHETASE))	5xio	PROLINE-TRNA SYNTHETASE CLASS II AARS (YBAK RNA BINDING DOMAIN PLUS TRNA SYNTHETASE) (Cryptosporidium parvum)	9 / 12	GLU A 364 THR A 331 ARG A 362 TRP A 379 GLU A 381 HIS A 383 PHE A 426 THR A 450 HIS A 452	ANP  A 803 (-3.7A) HFG  A 801 (-3.4A) ANP  A 803 ( 3.1A) None HFG  A 801 ( 4.9A) HFG  A 801 ( 4.7A) HFG  A 801 (-3.7A) ANP  A 803 (-3.9A) HFG  A 801 (-4.2A)	1.23A	5xioB-5xioA: 56.6	5xioB-5xioA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5XIO_B_HFGB802_0 (PROLINE-TRNA SYNTHETASE CLASS II AARS (YBAK RNA BINDING DOMAIN PLUS TRNA SYNTHETASE))	5xio	PROLINE-TRNA SYNTHETASE CLASS II AARS (YBAK RNA BINDING DOMAIN PLUS TRNA SYNTHETASE) (Cryptosporidium parvum)	12 / 12	PHE A 307 GLU A 310 VAL A 311 PRO A 330 THR A 331 ARG A 362 TRP A 379 GLU A 381 HIS A 383 PHE A 426 THR A 450 HIS A 452	HFG  A 801 (-3.7A) None HFG  A 801 (-4.3A) HFG  A 801 ( 4.8A) HFG  A 801 (-3.4A) ANP  A 803 ( 3.1A) None HFG  A 801 ( 4.9A) HFG  A 801 ( 4.7A) HFG  A 801 (-3.7A) ANP  A 803 (-3.9A) HFG  A 801 (-4.2A)	0.34A	5xioB-5xioA: 56.6	5xioB-5xioA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5XIP_A_HFGA1003_0 (PROLYL-TRNA SYNTHETASE, PUTATIVE)	5xio	PROLINE-TRNA SYNTHETASE CLASS II AARS (YBAK RNA BINDING DOMAIN PLUS TRNA SYNTHETASE) (Cryptosporidium parvum)	6 / 12	GLU A 364 ARG A 362 HIS A 383 THR A 450 SER A 480 GLY A 482	ANP  A 803 (-3.7A) ANP  A 803 ( 3.1A) HFG  A 801 ( 4.7A) ANP  A 803 (-3.9A) HFG  A 801 ( 3.8A) HFG  A 801 (-3.9A)	1.49A	5xipA-5xioA: 50.3	5xipA-5xioA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5XIP_A_HFGA1003_0 (PROLYL-TRNA SYNTHETASE, PUTATIVE)	5xio	PROLINE-TRNA SYNTHETASE CLASS II AARS (YBAK RNA BINDING DOMAIN PLUS TRNA SYNTHETASE) (Cryptosporidium parvum)	11 / 12	LEU A 297 GLU A 310 VAL A 311 PRO A 330 THR A 331 ARG A 362 HIS A 383 PHE A 426 THR A 450 SER A 480 GLY A 482	None None HFG  A 801 (-4.3A) HFG  A 801 ( 4.8A) HFG  A 801 (-3.4A) ANP  A 803 ( 3.1A) HFG  A 801 ( 4.7A) HFG  A 801 (-3.7A) ANP  A 803 (-3.9A) HFG  A 801 ( 3.8A) HFG  A 801 (-3.9A)	0.57A	5xipA-5xioA: 50.3	5xipA-5xioA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5XIP_A_HFGA1003_0 (PROLYL-TRNA SYNTHETASE, PUTATIVE)	5xio	PROLINE-TRNA SYNTHETASE CLASS II AARS (YBAK RNA BINDING DOMAIN PLUS TRNA SYNTHETASE) (Cryptosporidium parvum)	11 / 12	LEU A 297 PHE A 307 GLU A 310 VAL A 311 PRO A 330 THR A 331 ARG A 362 HIS A 383 THR A 450 SER A 480 GLY A 482	None HFG  A 801 (-3.7A) None HFG  A 801 (-4.3A) HFG  A 801 ( 4.8A) HFG  A 801 (-3.4A) ANP  A 803 ( 3.1A) HFG  A 801 ( 4.7A) ANP  A 803 (-3.9A) HFG  A 801 ( 3.8A) HFG  A 801 (-3.9A)	0.80A	5xipA-5xioA: 50.3	5xipA-5xioA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5XIP_A_HFGA1003_1 (PROLYL-TRNA SYNTHETASE, PUTATIVE)	5xio	PROLINE-TRNA SYNTHETASE CLASS II AARS (YBAK RNA BINDING DOMAIN PLUS TRNA SYNTHETASE) (Cryptosporidium parvum)	3 / 3	GLU A 333 TRP A 379 HIS A 452	HFG  A 801 (-3.0A) None HFG  A 801 (-4.2A)	0.27A	5xipA-5xioA: 50.3	5xipA-5xioA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5XIP_B_HFGB1003_0 (PROLYL-TRNA SYNTHETASE, PUTATIVE)	5xio	PROLINE-TRNA SYNTHETASE CLASS II AARS (YBAK RNA BINDING DOMAIN PLUS TRNA SYNTHETASE) (Cryptosporidium parvum)	10 / 12	GLU A 310 VAL A 311 PRO A 330 THR A 331 GLU A 333 ARG A 362 HIS A 383 PHE A 426 THR A 450 HIS A 452	None HFG  A 801 (-4.3A) HFG  A 801 ( 4.8A) HFG  A 801 (-3.4A) HFG  A 801 (-3.0A) ANP  A 803 ( 3.1A) HFG  A 801 ( 4.7A) HFG  A 801 (-3.7A) ANP  A 803 (-3.9A) HFG  A 801 (-4.2A)	0.61A	5xipB-5xioA: 50.9	5xipB-5xioA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5XIP_B_HFGB1003_0 (PROLYL-TRNA SYNTHETASE, PUTATIVE)	5xio	PROLINE-TRNA SYNTHETASE CLASS II AARS (YBAK RNA BINDING DOMAIN PLUS TRNA SYNTHETASE) (Cryptosporidium parvum)	6 / 12	GLU A 364 ARG A 362 TRP A 379 HIS A 383 THR A 450 HIS A 452	ANP  A 803 (-3.7A) ANP  A 803 ( 3.1A) None HFG  A 801 ( 4.7A) ANP  A 803 (-3.9A) HFG  A 801 (-4.2A)	1.37A	5xipB-5xioA: 50.9	5xipB-5xioA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5XIP_B_HFGB1003_0 (PROLYL-TRNA SYNTHETASE, PUTATIVE)	5xio	PROLINE-TRNA SYNTHETASE CLASS II AARS (YBAK RNA BINDING DOMAIN PLUS TRNA SYNTHETASE) (Cryptosporidium parvum)	10 / 12	PHE A 307 GLU A 310 VAL A 311 PRO A 330 THR A 331 GLU A 333 ARG A 362 HIS A 383 THR A 450 HIS A 452	HFG  A 801 (-3.7A) None HFG  A 801 (-4.3A) HFG  A 801 ( 4.8A) HFG  A 801 (-3.4A) HFG  A 801 (-3.0A) ANP  A 803 ( 3.1A) HFG  A 801 ( 4.7A) ANP  A 803 (-3.9A) HFG  A 801 (-4.2A)	0.75A	5xipB-5xioA: 50.9	5xipB-5xioA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5XIP_B_HFGB1003_0 (PROLYL-TRNA SYNTHETASE, PUTATIVE)	5xio	PROLINE-TRNA SYNTHETASE CLASS II AARS (YBAK RNA BINDING DOMAIN PLUS TRNA SYNTHETASE) (Cryptosporidium parvum)	10 / 12	PHE A 307 VAL A 311 PRO A 330 THR A 331 GLU A 333 ARG A 362 TRP A 379 HIS A 383 THR A 450 HIS A 452	HFG  A 801 (-3.7A) HFG  A 801 (-4.3A) HFG  A 801 ( 4.8A) HFG  A 801 (-3.4A) HFG  A 801 (-3.0A) ANP  A 803 ( 3.1A) None HFG  A 801 ( 4.7A) ANP  A 803 (-3.9A) HFG  A 801 (-4.2A)	0.60A	5xipB-5xioA: 50.9	5xipB-5xioA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5XIP_B_HFGB1003_0 (PROLYL-TRNA SYNTHETASE, PUTATIVE)	5xio	PROLINE-TRNA SYNTHETASE CLASS II AARS (YBAK RNA BINDING DOMAIN PLUS TRNA SYNTHETASE) (Cryptosporidium parvum)	10 / 12	VAL A 311 PRO A 330 THR A 331 GLU A 333 ARG A 362 TRP A 379 HIS A 383 PHE A 426 THR A 450 HIS A 452	HFG  A 801 (-4.3A) HFG  A 801 ( 4.8A) HFG  A 801 (-3.4A) HFG  A 801 (-3.0A) ANP  A 803 ( 3.1A) None HFG  A 801 ( 4.7A) HFG  A 801 (-3.7A) ANP  A 803 (-3.9A) HFG  A 801 (-4.2A)	0.42A	5xipB-5xioA: 50.9	5xipB-5xioA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5XIP_B_HFGB1003_0 (PROLYL-TRNA SYNTHETASE, PUTATIVE)	5xio	PROLINE-TRNA SYNTHETASE CLASS II AARS (YBAK RNA BINDING DOMAIN PLUS TRNA SYNTHETASE) (Cryptosporidium parvum)	5 / 12	VAL A 311 PRO A 330 THR A 331 HIS A 383 PHE A 458	HFG  A 801 (-4.3A) HFG  A 801 ( 4.8A) HFG  A 801 (-3.4A) HFG  A 801 ( 4.7A) None	1.28A	5xipB-5xioA: 50.9	5xipB-5xioA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5XIP_C_HFGC1003_0 (PROLYL-TRNA SYNTHETASE, PUTATIVE)	5xio	PROLINE-TRNA SYNTHETASE CLASS II AARS (YBAK RNA BINDING DOMAIN PLUS TRNA SYNTHETASE) (Cryptosporidium parvum)	6 / 12	GLU A 364 TRP A 379 GLU A 381 HIS A 383 THR A 450 GLY A 482	ANP  A 803 (-3.7A) None HFG  A 801 ( 4.9A) HFG  A 801 ( 4.7A) ANP  A 803 (-3.9A) HFG  A 801 (-3.9A)	1.11A	5xipC-5xioA: 50.6	5xipC-5xioA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5XIP_C_HFGC1003_0 (PROLYL-TRNA SYNTHETASE, PUTATIVE)	5xio	PROLINE-TRNA SYNTHETASE CLASS II AARS (YBAK RNA BINDING DOMAIN PLUS TRNA SYNTHETASE) (Cryptosporidium parvum)	7 / 12	LEU A 297 GLU A 310 VAL A 311 THR A 331 PHE A 426 THR A 450 GLY A 482	None None HFG  A 801 (-4.3A) HFG  A 801 (-3.4A) HFG  A 801 (-3.7A) ANP  A 803 (-3.9A) HFG  A 801 (-3.9A)	0.67A	5xipC-5xioA: 50.6	5xipC-5xioA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5XIP_C_HFGC1003_0 (PROLYL-TRNA SYNTHETASE, PUTATIVE)	5xio	PROLINE-TRNA SYNTHETASE CLASS II AARS (YBAK RNA BINDING DOMAIN PLUS TRNA SYNTHETASE) (Cryptosporidium parvum)	11 / 12	LEU A 297 VAL A 311 PRO A 330 THR A 331 GLU A 333 TRP A 379 GLU A 381 HIS A 383 PHE A 426 THR A 450 GLY A 482	None HFG  A 801 (-4.3A) HFG  A 801 ( 4.8A) HFG  A 801 (-3.4A) HFG  A 801 (-3.0A) None HFG  A 801 ( 4.9A) HFG  A 801 ( 4.7A) HFG  A 801 (-3.7A) ANP  A 803 (-3.9A) HFG  A 801 (-3.9A)	0.31A	5xipC-5xioA: 50.6	5xipC-5xioA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5XIP_C_HFGC1003_0 (PROLYL-TRNA SYNTHETASE, PUTATIVE)	5xio	PROLINE-TRNA SYNTHETASE CLASS II AARS (YBAK RNA BINDING DOMAIN PLUS TRNA SYNTHETASE) (Cryptosporidium parvum)	5 / 12	VAL A 311 PRO A 330 THR A 331 GLU A 381 PHE A 458	HFG  A 801 (-4.3A) HFG  A 801 ( 4.8A) HFG  A 801 (-3.4A) HFG  A 801 ( 4.9A) None	1.19A	5xipC-5xioA: 50.6	5xipC-5xioA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5XIP_D_HFGD1003_0 (PROLYL-TRNA SYNTHETASE, PUTATIVE)	5xio	PROLINE-TRNA SYNTHETASE CLASS II AARS (YBAK RNA BINDING DOMAIN PLUS TRNA SYNTHETASE) (Cryptosporidium parvum)	7 / 12	GLU A 364 THR A 331 ARG A 362 TRP A 379 GLU A 381 THR A 450 TRP A 481	ANP  A 803 (-3.7A) HFG  A 801 (-3.4A) ANP  A 803 ( 3.1A) None HFG  A 801 ( 4.9A) ANP  A 803 (-3.9A) None	1.43A	5xipD-5xioA: 50.6	5xipD-5xioA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5XIP_D_HFGD1003_0 (PROLYL-TRNA SYNTHETASE, PUTATIVE)	5xio	PROLINE-TRNA SYNTHETASE CLASS II AARS (YBAK RNA BINDING DOMAIN PLUS TRNA SYNTHETASE) (Cryptosporidium parvum)	9 / 12	LEU A 297 GLU A 310 VAL A 311 THR A 331 GLU A 333 ARG A 362 TRP A 379 PHE A 426 THR A 450	None None HFG  A 801 (-4.3A) HFG  A 801 (-3.4A) HFG  A 801 (-3.0A) ANP  A 803 ( 3.1A) None HFG  A 801 (-3.7A) ANP  A 803 (-3.9A)	0.65A	5xipD-5xioA: 50.6	5xipD-5xioA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5XIP_D_HFGD1003_0 (PROLYL-TRNA SYNTHETASE, PUTATIVE)	5xio	PROLINE-TRNA SYNTHETASE CLASS II AARS (YBAK RNA BINDING DOMAIN PLUS TRNA SYNTHETASE) (Cryptosporidium parvum)	11 / 12	LEU A 297 VAL A 311 PRO A 330 THR A 331 GLU A 333 ARG A 362 TRP A 379 GLU A 381 PHE A 426 THR A 450 TRP A 481	None HFG  A 801 (-4.3A) HFG  A 801 ( 4.8A) HFG  A 801 (-3.4A) HFG  A 801 (-3.0A) ANP  A 803 ( 3.1A) None HFG  A 801 ( 4.9A) HFG  A 801 (-3.7A) ANP  A 803 (-3.9A) None	0.39A	5xipD-5xioA: 50.6	5xipD-5xioA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5XIP_D_HFGD1003_0 (PROLYL-TRNA SYNTHETASE, PUTATIVE)	5xio	PROLINE-TRNA SYNTHETASE CLASS II AARS (YBAK RNA BINDING DOMAIN PLUS TRNA SYNTHETASE) (Cryptosporidium parvum)	6 / 12	VAL A 311 PRO A 330 THR A 331 GLU A 381 PHE A 458 TRP A 481	HFG  A 801 (-4.3A) HFG  A 801 ( 4.8A) HFG  A 801 (-3.4A) HFG  A 801 ( 4.9A) None None	1.42A	5xipD-5xioA: 50.6	5xipD-5xioA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5XIQ_A_HFGA1002_0 (PROLYL-TRNA SYNTHETASE (PRORS))	5xio	PROLINE-TRNA SYNTHETASE CLASS II AARS (YBAK RNA BINDING DOMAIN PLUS TRNA SYNTHETASE) (Cryptosporidium parvum)	7 / 12	GLU A 364 TRP A 379 GLU A 381 HIS A 383 THR A 450 SER A 480 GLY A 482	ANP  A 803 (-3.7A) None HFG  A 801 ( 4.9A) HFG  A 801 ( 4.7A) ANP  A 803 (-3.9A) HFG  A 801 ( 3.8A) HFG  A 801 (-3.9A)	1.09A	5xiqA-5xioA: 51.7	5xiqA-5xioA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5XIQ_A_HFGA1002_0 (PROLYL-TRNA SYNTHETASE (PRORS))	5xio	PROLINE-TRNA SYNTHETASE CLASS II AARS (YBAK RNA BINDING DOMAIN PLUS TRNA SYNTHETASE) (Cryptosporidium parvum)	11 / 12	LEU A 297 PHE A 307 GLU A 310 VAL A 311 PRO A 330 TRP A 379 GLU A 381 PHE A 426 THR A 450 SER A 480 GLY A 482	None HFG  A 801 (-3.7A) None HFG  A 801 (-4.3A) HFG  A 801 ( 4.8A) None HFG  A 801 ( 4.9A) HFG  A 801 (-3.7A) ANP  A 803 (-3.9A) HFG  A 801 ( 3.8A) HFG  A 801 (-3.9A)	0.59A	5xiqA-5xioA: 51.7	5xiqA-5xioA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5XIQ_A_HFGA1002_0 (PROLYL-TRNA SYNTHETASE (PRORS))	5xio	PROLINE-TRNA SYNTHETASE CLASS II AARS (YBAK RNA BINDING DOMAIN PLUS TRNA SYNTHETASE) (Cryptosporidium parvum)	11 / 12	LEU A 297 PHE A 307 VAL A 311 PRO A 330 TRP A 379 GLU A 381 HIS A 383 PHE A 426 THR A 450 SER A 480 GLY A 482	None HFG  A 801 (-3.7A) HFG  A 801 (-4.3A) HFG  A 801 ( 4.8A) None HFG  A 801 ( 4.9A) HFG  A 801 ( 4.7A) HFG  A 801 (-3.7A) ANP  A 803 (-3.9A) HFG  A 801 ( 3.8A) HFG  A 801 (-3.9A)	0.41A	5xiqA-5xioA: 51.7	5xiqA-5xioA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5XIQ_A_HFGA1002_1 (PROLYL-TRNA SYNTHETASE (PRORS))	5xio	PROLINE-TRNA SYNTHETASE CLASS II AARS (YBAK RNA BINDING DOMAIN PLUS TRNA SYNTHETASE) (Cryptosporidium parvum)	4 / 4	THR A 331 GLU A 333 ARG A 362 HIS A 452	HFG  A 801 (-3.4A) HFG  A 801 (-3.0A) ANP  A 803 ( 3.1A) HFG  A 801 (-4.2A)	0.23A	5xiqA-5xioA: 51.7	5xiqA-5xioA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5XIQ_B_HFGB1002_0 (PROLYL-TRNA SYNTHETASE (PRORS))	5xio	PROLINE-TRNA SYNTHETASE CLASS II AARS (YBAK RNA BINDING DOMAIN PLUS TRNA SYNTHETASE) (Cryptosporidium parvum)	7 / 12	GLU A 364 ARG A 362 TRP A 379 GLU A 381 HIS A 383 THR A 450 SER A 480	ANP  A 803 (-3.7A) ANP  A 803 ( 3.1A) None HFG  A 801 ( 4.9A) HFG  A 801 ( 4.7A) ANP  A 803 (-3.9A) HFG  A 801 ( 3.8A)	1.33A	5xiqB-5xioA: 51.2	5xiqB-5xioA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5XIQ_B_HFGB1002_0 (PROLYL-TRNA SYNTHETASE (PRORS))	5xio	PROLINE-TRNA SYNTHETASE CLASS II AARS (YBAK RNA BINDING DOMAIN PLUS TRNA SYNTHETASE) (Cryptosporidium parvum)	11 / 12	LEU A 297 PHE A 307 GLU A 310 VAL A 311 PRO A 330 ARG A 362 TRP A 379 GLU A 381 PHE A 426 THR A 450 SER A 480	None HFG  A 801 (-3.7A) None HFG  A 801 (-4.3A) HFG  A 801 ( 4.8A) ANP  A 803 ( 3.1A) None HFG  A 801 ( 4.9A) HFG  A 801 (-3.7A) ANP  A 803 (-3.9A) HFG  A 801 ( 3.8A)	0.55A	5xiqB-5xioA: 51.2	5xiqB-5xioA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5XIQ_B_HFGB1002_0 (PROLYL-TRNA SYNTHETASE (PRORS))	5xio	PROLINE-TRNA SYNTHETASE CLASS II AARS (YBAK RNA BINDING DOMAIN PLUS TRNA SYNTHETASE) (Cryptosporidium parvum)	11 / 12	LEU A 297 PHE A 307 VAL A 311 PRO A 330 ARG A 362 TRP A 379 GLU A 381 HIS A 383 PHE A 426 THR A 450 SER A 480	None HFG  A 801 (-3.7A) HFG  A 801 (-4.3A) HFG  A 801 ( 4.8A) ANP  A 803 ( 3.1A) None HFG  A 801 ( 4.9A) HFG  A 801 ( 4.7A) HFG  A 801 (-3.7A) ANP  A 803 (-3.9A) HFG  A 801 ( 3.8A)	0.37A	5xiqB-5xioA: 51.2	5xiqB-5xioA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5XIQ_B_HFGB1002_1 (PROLYL-TRNA SYNTHETASE (PRORS))	5xio	PROLINE-TRNA SYNTHETASE CLASS II AARS (YBAK RNA BINDING DOMAIN PLUS TRNA SYNTHETASE) (Cryptosporidium parvum)	3 / 3	THR A 331 GLU A 333 HIS A 452	HFG  A 801 (-3.4A) HFG  A 801 (-3.0A) HFG  A 801 (-4.2A)	0.11A	5xiqB-5xioA: 51.2	5xiqB-5xioA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5XIQ_C_HFGC1002_0 (PROLYL-TRNA SYNTHETASE (PRORS))	5xio	PROLINE-TRNA SYNTHETASE CLASS II AARS (YBAK RNA BINDING DOMAIN PLUS TRNA SYNTHETASE) (Cryptosporidium parvum)	7 / 12	GLU A 364 ARG A 362 TRP A 379 GLU A 381 HIS A 383 THR A 450 SER A 480	ANP  A 803 (-3.7A) ANP  A 803 ( 3.1A) None HFG  A 801 ( 4.9A) HFG  A 801 ( 4.7A) ANP  A 803 (-3.9A) HFG  A 801 ( 3.8A)	1.42A	5xiqC-5xioA: 51.3	5xiqC-5xioA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5XIQ_C_HFGC1002_0 (PROLYL-TRNA SYNTHETASE (PRORS))	5xio	PROLINE-TRNA SYNTHETASE CLASS II AARS (YBAK RNA BINDING DOMAIN PLUS TRNA SYNTHETASE) (Cryptosporidium parvum)	9 / 12	PHE A 307 GLU A 310 VAL A 311 PRO A 330 ARG A 362 TRP A 379 GLU A 381 PHE A 426 THR A 450	HFG  A 801 (-3.7A) None HFG  A 801 (-4.3A) HFG  A 801 ( 4.8A) ANP  A 803 ( 3.1A) None HFG  A 801 ( 4.9A) HFG  A 801 (-3.7A) ANP  A 803 (-3.9A)	0.59A	5xiqC-5xioA: 51.3	5xiqC-5xioA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5XIQ_C_HFGC1002_0 (PROLYL-TRNA SYNTHETASE (PRORS))	5xio	PROLINE-TRNA SYNTHETASE CLASS II AARS (YBAK RNA BINDING DOMAIN PLUS TRNA SYNTHETASE) (Cryptosporidium parvum)	11 / 12	PHE A 307 VAL A 311 PRO A 330 THR A 331 ARG A 362 TRP A 379 GLU A 381 HIS A 383 PHE A 426 THR A 450 SER A 480	HFG  A 801 (-3.7A) HFG  A 801 (-4.3A) HFG  A 801 ( 4.8A) HFG  A 801 (-3.4A) ANP  A 803 ( 3.1A) None HFG  A 801 ( 4.9A) HFG  A 801 ( 4.7A) HFG  A 801 (-3.7A) ANP  A 803 (-3.9A) HFG  A 801 ( 3.8A)	0.39A	5xiqC-5xioA: 51.3	5xiqC-5xioA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5XIQ_D_HFGD1002_0 (PROLYL-TRNA SYNTHETASE (PRORS))	5xio	PROLINE-TRNA SYNTHETASE CLASS II AARS (YBAK RNA BINDING DOMAIN PLUS TRNA SYNTHETASE) (Cryptosporidium parvum)	7 / 12	GLU A 364 ARG A 362 TRP A 379 GLU A 381 HIS A 383 THR A 450 GLY A 482	ANP  A 803 (-3.7A) ANP  A 803 ( 3.1A) None HFG  A 801 ( 4.9A) HFG  A 801 ( 4.7A) ANP  A 803 (-3.9A) HFG  A 801 (-3.9A)	1.35A	5xiqD-5xioA: 51.5	5xiqD-5xioA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5XIQ_D_HFGD1002_0 (PROLYL-TRNA SYNTHETASE (PRORS))	5xio	PROLINE-TRNA SYNTHETASE CLASS II AARS (YBAK RNA BINDING DOMAIN PLUS TRNA SYNTHETASE) (Cryptosporidium parvum)	12 / 12	LEU A 297 PHE A 307 GLU A 310 VAL A 311 PRO A 330 ARG A 362 TRP A 379 GLU A 381 HIS A 383 PHE A 426 THR A 450 GLY A 482	None HFG  A 801 (-3.7A) None HFG  A 801 (-4.3A) HFG  A 801 ( 4.8A) ANP  A 803 ( 3.1A) None HFG  A 801 ( 4.9A) HFG  A 801 ( 4.7A) HFG  A 801 (-3.7A) ANP  A 803 (-3.9A) HFG  A 801 (-3.9A)	0.59A	5xiqD-5xioA: 51.5	5xiqD-5xioA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5XIQ_D_HFGD1002_1 (PROLYL-TRNA SYNTHETASE (PRORS))	5xio	PROLINE-TRNA SYNTHETASE CLASS II AARS (YBAK RNA BINDING DOMAIN PLUS TRNA SYNTHETASE) (Cryptosporidium parvum)	3 / 3	THR A 331 GLU A 333 HIS A 452	HFG  A 801 (-3.4A) HFG  A 801 (-3.0A) HFG  A 801 (-4.2A)	0.11A	5xiqD-5xioA: 51.5	5xiqD-5xioA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6MN8_A_HFGA603_0 (UNCHARACTERIZED PROTEIN)	5xio	PROLINE-TRNA SYNTHETASE CLASS II AARS (YBAK RNA BINDING DOMAIN PLUS TRNA SYNTHETASE) (Cryptosporidium parvum)	8 / 12	GLU A 364 TRP A 379 GLU A 381 HIS A 383 THR A 450 SER A 480 TRP A 481 GLY A 482	ANP  A 803 (-3.7A) None HFG  A 801 ( 4.9A) HFG  A 801 ( 4.7A) ANP  A 803 (-3.9A) HFG  A 801 ( 3.8A) None HFG  A 801 (-3.9A)	1.10A	6mn8A-5xioA: 43.8	6mn8A-5xioA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6MN8_A_HFGA603_0 (UNCHARACTERIZED PROTEIN)	5xio	PROLINE-TRNA SYNTHETASE CLASS II AARS (YBAK RNA BINDING DOMAIN PLUS TRNA SYNTHETASE) (Cryptosporidium parvum)	10 / 12	LEU A 297 PHE A 307 GLU A 310 VAL A 311 PRO A 330 TRP A 379 GLU A 381 HIS A 383 TRP A 481 GLY A 482	None HFG  A 801 (-3.7A) None HFG  A 801 (-4.3A) HFG  A 801 ( 4.8A) None HFG  A 801 ( 4.9A) HFG  A 801 ( 4.7A) None HFG  A 801 (-3.9A)	0.52A	6mn8A-5xioA: 43.8	6mn8A-5xioA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6MN8_A_HFGA603_0 (UNCHARACTERIZED PROTEIN)	5xio	PROLINE-TRNA SYNTHETASE CLASS II AARS (YBAK RNA BINDING DOMAIN PLUS TRNA SYNTHETASE) (Cryptosporidium parvum)	11 / 12	LEU A 297 PHE A 307 VAL A 311 PRO A 330 TRP A 379 GLU A 381 HIS A 383 THR A 450 SER A 480 TRP A 481 GLY A 482	None HFG  A 801 (-3.7A) HFG  A 801 (-4.3A) HFG  A 801 ( 4.8A) None HFG  A 801 ( 4.9A) HFG  A 801 ( 4.7A) ANP  A 803 (-3.9A) HFG  A 801 ( 3.8A) None HFG  A 801 (-3.9A)	0.44A	6mn8A-5xioA: 43.8	6mn8A-5xioA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6MN8_A_HFGA603_1 (UNCHARACTERIZED PROTEIN)	5xio	PROLINE-TRNA SYNTHETASE CLASS II AARS (YBAK RNA BINDING DOMAIN PLUS TRNA SYNTHETASE) (Cryptosporidium parvum)	4 / 4	THR A 331 GLU A 333 ARG A 362 HIS A 452	HFG  A 801 (-3.4A) HFG  A 801 (-3.0A) ANP  A 803 ( 3.1A) HFG  A 801 (-4.2A)	0.45A	6mn8A-5xioA: 43.8	6mn8A-5xioA: undetectable