SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5xix'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA205_1
(CARDIAC TROPONIN C)		 5xix ASPARAGINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		5 / 12 ILE A 472
PHE A 523
PHE A 256
PHE A 388
LEU A 436
 None
 1.20A 1dtlA-5xixA:
0.2		 1dtlA-5xixA:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_B_PFLB4002_1
(SERUM ALBUMIN)		 5xix ASPARAGINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		4 / 6 LEU A 160
VAL A 181
VAL A 148
GLN A 157
 None
 0.98A 1e7aB-5xixA:
undetectable		 1e7aB-5xixA:
7.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_G_ACTG306_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 5xix ASPARAGINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		3 / 3 ARG A 263
ARG A 386
ASP A 363
 None
 0.99A 3wipG-5xixA:
undetectable
3wipH-5xixA:
undetectable		 3wipG-5xixA:
undetectable
3wipH-5xixA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FU8_A_ACTA304_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 5xix ASPARAGINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		3 / 3 ARG A 506
HIS A 513
TYR A 502
 None
 1.08A 4fu8A-5xixA:
undetectable		 4fu8A-5xixA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FU9_A_ACTA312_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 5xix ASPARAGINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		3 / 3 ARG A 506
HIS A 513
TYR A 502
 None
 1.14A 4fu9A-5xixA:
undetectable		 4fu9A-5xixA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB0_B_ACTB401_0
(UNCHARACTERIZED
PROTEIN)		 5xix ASPARAGINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		4 / 5 VAL A 252
LEU A 520
VAL A 338
PHE A 256
 None
 0.94A 4lb0B-5xixA:
undetectable		 4lb0B-5xixA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PM5_A_CE3A301_2
(BETA-LACTAMASE
CTX-M-14)		 5xix ASPARAGINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		3 / 3 CYH A 342
PRO A 512
ASP A 349
 None
GOL  A 604 ( 4.3A)
None
 1.00A 4pm5A-5xixA:
undetectable		 4pm5A-5xixA:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J6H_A_NCAA402_0
(H-2 CLASS I
HISTOCOMPATIBILITY
ANTIGEN, Q10 ALPHA
CHAIN)		 5xix ASPARAGINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		3 / 3 PRO A 453
ARG A 451
GLU A 460
 None
 0.98A 5j6hA-5xixA:
undetectable		 5j6hA-5xixA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECE_C_DVAC3010_0
(VLM2
DODECADEPSIPEPTIDE)		 5xix ASPARAGINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		3 / 3 ALA A 161
PHE A 146
GLN A 140
 None
 0.68A 6eceA-5xixA:
undetectable		 6eceA-5xixA:
undetectable