SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5xj1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C6Z_B_ROCB505_2
(PROTEIN (PROTEASE))		 5xj1 UNCHARACTERIZED RNA
METHYLTRANSFERASE
SP_1029
(Streptococcus
pneumoniae) 		5 / 12 GLY A 399
ALA A 400
ASP A 401
ILE A 373
ILE A 378
 None
 1.00A 1c6zB-5xj1A:
undetectable		 1c6zB-5xj1A:
13.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_B_PFLB4002_1
(SERUM ALBUMIN)		 5xj1 UNCHARACTERIZED RNA
METHYLTRANSFERASE
SP_1029
(Streptococcus
pneumoniae) 		4 / 6 LEU A 320
VAL A 339
SER A 342
GLN A 343
 None
 1.08A 1e7aB-5xj1A:
undetectable		 1e7aB-5xj1A:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FB7_A_ROCA100_1
(HIV-1 PROTEASE)		 5xj1 UNCHARACTERIZED RNA
METHYLTRANSFERASE
SP_1029
(Streptococcus
pneumoniae) 		5 / 12 GLY A 399
ALA A 400
ASP A 401
ILE A 373
ILE A 378
 None
 0.98A 1fb7A-5xj1A:
undetectable		 1fb7A-5xj1A:
14.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G5Y_C_9CRC502_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5xj1 UNCHARACTERIZED RNA
METHYLTRANSFERASE
SP_1029
(Streptococcus
pneumoniae) 		5 / 10 ALA A  74
LEU A  71
PHE A 160
PHE A 159
ILE A  80
 None
None
None
P6G  A 503 (-4.0A)
P6G  A 503 ( 4.7A)
 1.21A 1g5yC-5xj1A:
undetectable		 1g5yC-5xj1A:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXB_A_ROCA100_1
(HIV-1 PROTEASE)		 5xj1 UNCHARACTERIZED RNA
METHYLTRANSFERASE
SP_1029
(Streptococcus
pneumoniae) 		5 / 12 GLY A 399
ALA A 400
ASP A 401
ILE A 373
ILE A 378
 None
 0.83A 1hxbA-5xj1A:
undetectable		 1hxbA-5xj1A:
13.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AQU_B_DR7B300_1
(HIV-1 PROTEASE)		 5xj1 UNCHARACTERIZED RNA
METHYLTRANSFERASE
SP_1029
(Streptococcus
pneumoniae) 		5 / 10 GLY A 399
ALA A 400
ASP A 401
ILE A 373
ILE A 378
 None
 0.98A 2aquA-5xj1A:
undetectable		 2aquA-5xj1A:
14.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B60_B_RITB100_1
(GAG-POL POLYPROTEIN)		 5xj1 UNCHARACTERIZED RNA
METHYLTRANSFERASE
SP_1029
(Streptococcus
pneumoniae) 		6 / 12 GLY A 399
ALA A 400
ASP A 401
ILE A 373
ALA A 311
ILE A 378
 None
 0.95A 2b60A-5xj1A:
undetectable		 2b60A-5xj1A:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B60_B_RITB100_2
(GAG-POL POLYPROTEIN)		 5xj1 UNCHARACTERIZED RNA
METHYLTRANSFERASE
SP_1029
(Streptococcus
pneumoniae) 		6 / 11 GLY A 399
ALA A 400
ASP A 401
ILE A 373
ALA A 311
ILE A 378
 None
 0.94A 2b60B-5xj1A:
undetectable		 2b60B-5xj1A:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DCF_A_ACAA501_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 5xj1 UNCHARACTERIZED RNA
METHYLTRANSFERASE
SP_1029
(Streptococcus
pneumoniae) 		4 / 6 ALA A 400
TYR A 420
ILE A 309
ILE A 403
 None
 1.16A 2dcfA-5xj1A:
undetectable		 2dcfA-5xj1A:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F80_B_017B301_2
(POL POLYPROTEIN)		 5xj1 UNCHARACTERIZED RNA
METHYLTRANSFERASE
SP_1029
(Streptococcus
pneumoniae) 		5 / 12 GLY A 399
ALA A 400
ASP A 401
ILE A 373
ILE A 378
 None
 0.90A 2f80B-5xj1A:
undetectable		 2f80B-5xj1A:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F81_A_017A302_2
(POL POLYPROTEIN)		 5xj1 UNCHARACTERIZED RNA
METHYLTRANSFERASE
SP_1029
(Streptococcus
pneumoniae) 		5 / 12 GLY A 399
ALA A 400
ASP A 401
ILE A 373
ILE A 378
 None
 0.92A 2f81B-5xj1A:
undetectable		 2f81B-5xj1A:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS2_A_017A201_1
(PROTEASE)		 5xj1 UNCHARACTERIZED RNA
METHYLTRANSFERASE
SP_1029
(Streptococcus
pneumoniae) 		5 / 12 GLY A 399
ALA A 400
ASP A 401
ILE A 373
ILE A 378
 None
 1.01A 2hs2A-5xj1A:
undetectable		 2hs2A-5xj1A:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS2_A_017A201_2
(PROTEASE)		 5xj1 UNCHARACTERIZED RNA
METHYLTRANSFERASE
SP_1029
(Streptococcus
pneumoniae) 		5 / 12 GLY A 399
ALA A 400
ASP A 401
ILE A 373
ILE A 378
 None
 0.88A 2hs2B-5xj1A:
undetectable		 2hs2B-5xj1A:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IEN_B_017B402_2
(PROTEASE)		 5xj1 UNCHARACTERIZED RNA
METHYLTRANSFERASE
SP_1029
(Streptococcus
pneumoniae) 		5 / 12 GLY A 399
ALA A 400
ASP A 401
ILE A 373
ILE A 378
 None
 0.96A 2ienB-5xj1A:
undetectable		 2ienB-5xj1A:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NMY_A_ROCA401_2
(PROTEASE)		 5xj1 UNCHARACTERIZED RNA
METHYLTRANSFERASE
SP_1029
(Streptococcus
pneumoniae) 		5 / 12 GLY A 399
ALA A 400
ILE A 373
ALA A 311
ILE A 378
 None
 0.80A 2nmyB-5xj1A:
undetectable		 2nmyB-5xj1A:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4S_A_AB1A400_2
(PROTEASE)		 5xj1 UNCHARACTERIZED RNA
METHYLTRANSFERASE
SP_1029
(Streptococcus
pneumoniae) 		5 / 12 GLY A 399
ALA A 400
ASP A 401
ILE A 373
ILE A 378
 None
 0.86A 2o4sB-5xj1A:
undetectable		 2o4sB-5xj1A:
14.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_B_CHDB502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5xj1 UNCHARACTERIZED RNA
METHYLTRANSFERASE
SP_1029
(Streptococcus
pneumoniae) 		4 / 7 ILE A 161
ARG A 127
GLY A 144
MET A 154
 None
P6G  A 503 (-3.5A)
None
None
 1.10A 2pnjB-5xj1A:
3.7		 2pnjB-5xj1A:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYN_A_1UNA1001_1
(PROTEASE RETROPEPSIN)		 5xj1 UNCHARACTERIZED RNA
METHYLTRANSFERASE
SP_1029
(Streptococcus
pneumoniae) 		5 / 12 GLY A 399
ALA A 400
ASP A 401
ILE A 373
ILE A 378
 None
 0.93A 2pynA-5xj1A:
undetectable		 2pynA-5xj1A:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RKF_A_AB1A501_1
(PROTEASE RETROPEPSIN)		 5xj1 UNCHARACTERIZED RNA
METHYLTRANSFERASE
SP_1029
(Streptococcus
pneumoniae) 		6 / 12 GLY A 399
ALA A 400
ASP A 401
ILE A 373
ALA A 311
ILE A 378
 None
 0.97A 2rkfA-5xj1A:
undetectable		 2rkfA-5xj1A:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z54_A_AB1A200_1
(HIV-1 PROTEASE)		 5xj1 UNCHARACTERIZED RNA
METHYLTRANSFERASE
SP_1029
(Streptococcus
pneumoniae) 		5 / 12 GLY A 399
ALA A 400
ASP A 401
ILE A 373
ILE A 378
 None
 0.98A 2z54A-5xj1A:
undetectable		 2z54A-5xj1A:
13.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIF_A_SAMA298_0
(PUTATIVE
MODIFICATION
METHYLASE)		 5xj1 UNCHARACTERIZED RNA
METHYLTRANSFERASE
SP_1029
(Streptococcus
pneumoniae) 		5 / 12 ALA A 361
GLY A 314
THR A 317
GLU A 333
LEU A 334
 None
 0.76A 2zifA-5xj1A:
2.1		 2zifA-5xj1A:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZM7_A_ACAA501_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 5xj1 UNCHARACTERIZED RNA
METHYLTRANSFERASE
SP_1029
(Streptococcus
pneumoniae) 		4 / 7 ALA A 400
TYR A 420
ILE A 309
ILE A 403
 None
 1.16A 2zm7A-5xj1A:
undetectable		 2zm7A-5xj1A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_A_DGXA1_2
(NUCLEAR RECEPTOR
ROR-GAMMA)		 5xj1 UNCHARACTERIZED RNA
METHYLTRANSFERASE
SP_1029
(Streptococcus
pneumoniae) 		3 / 3 TRP A 256
VAL A 134
ARG A 136
 None
 0.86A 3b0wA-5xj1A:
undetectable		 3b0wA-5xj1A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYW_A_017A201_2
(HIV-1 PROTEASE)		 5xj1 UNCHARACTERIZED RNA
METHYLTRANSFERASE
SP_1029
(Streptococcus
pneumoniae) 		5 / 12 GLY A 399
ALA A 400
ASP A 401
ILE A 373
ILE A 378
 None
 0.91A 3cywB-5xj1A:
undetectable		 3cywB-5xj1A:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D1Z_B_017B201_2
(HIV-1 PROTEASE)		 5xj1 UNCHARACTERIZED RNA
METHYLTRANSFERASE
SP_1029
(Streptococcus
pneumoniae) 		5 / 12 GLY A 399
ALA A 400
ASP A 401
ILE A 373
ILE A 378
 None
 0.95A 3d1zB-5xj1A:
undetectable		 3d1zB-5xj1A:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D20_A_017A201_2
(HIV-1 PROTEASE)		 5xj1 UNCHARACTERIZED RNA
METHYLTRANSFERASE
SP_1029
(Streptococcus
pneumoniae) 		5 / 12 GLY A 399
ALA A 400
ASP A 401
ILE A 373
ILE A 378
 None
 0.92A 3d20B-5xj1A:
undetectable		 3d20B-5xj1A:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZY_D_BRLD478_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5xj1 UNCHARACTERIZED RNA
METHYLTRANSFERASE
SP_1029
(Streptococcus
pneumoniae) 		4 / 4 ILE A 226
GLN A 241
ILE A 236
LEU A 193
 GOL  A 502 (-3.9A)
None
None
None
 1.30A 3dzyD-5xj1A:
undetectable		 3dzyD-5xj1A:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKT_D_017D200_2
(PROTEASE)		 5xj1 UNCHARACTERIZED RNA
METHYLTRANSFERASE
SP_1029
(Streptococcus
pneumoniae) 		5 / 11 GLY A 399
ALA A 400
ASP A 401
ILE A 373
ILE A 378
 None
 0.95A 3ektD-5xj1A:
undetectable		 3ektD-5xj1A:
13.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKW_B_DR7B100_1
(PROTEASE)		 5xj1 UNCHARACTERIZED RNA
METHYLTRANSFERASE
SP_1029
(Streptococcus
pneumoniae) 		5 / 10 ALA A 400
ASP A 401
ILE A 373
ALA A 311
ILE A 378
 None
 1.03A 3ekwA-5xj1A:
undetectable		 3ekwA-5xj1A:
13.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKW_B_DR7B100_2
(PROTEASE)		 5xj1 UNCHARACTERIZED RNA
METHYLTRANSFERASE
SP_1029
(Streptococcus
pneumoniae) 		6 / 12 GLY A 399
ALA A 400
ASP A 401
ILE A 373
ALA A 311
ILE A 378
 None
 0.90A 3ekwB-5xj1A:
undetectable		 3ekwB-5xj1A:
13.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JVY_B_017B401_1
(GAG-POL POLYPROTEIN)		 5xj1 UNCHARACTERIZED RNA
METHYLTRANSFERASE
SP_1029
(Streptococcus
pneumoniae) 		5 / 12 GLY A 399
ALA A 400
ASP A 401
ILE A 373
ILE A 378
 None
 0.94A 3jvyA-5xj1A:
undetectable		 3jvyA-5xj1A:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JVY_B_017B401_2
(GAG-POL POLYPROTEIN)		 5xj1 UNCHARACTERIZED RNA
METHYLTRANSFERASE
SP_1029
(Streptococcus
pneumoniae) 		5 / 12 GLY A 399
ALA A 400
ASP A 401
ILE A 373
ILE A 378
 None
 0.87A 3jvyB-5xj1A:
undetectable		 3jvyB-5xj1A:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3007_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 5xj1 UNCHARACTERIZED RNA
METHYLTRANSFERASE
SP_1029
(Streptococcus
pneumoniae) 		5 / 9 ASN A 363
THR A 360
ALA A 361
ALA A 394
SER A 390
 None
 1.28A 3kp6B-5xj1A:
undetectable		 3kp6B-5xj1A:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LZS_A_017A200_1
(HIV-1 PROTEASE)		 5xj1 UNCHARACTERIZED RNA
METHYLTRANSFERASE
SP_1029
(Streptococcus
pneumoniae) 		5 / 12 GLY A 399
ALA A 400
ASP A 401
ILE A 373
ILE A 378
 None
 0.89A 3lzsA-5xj1A:
undetectable		 3lzsA-5xj1A:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LZS_A_017A200_2
(HIV-1 PROTEASE)		 5xj1 UNCHARACTERIZED RNA
METHYLTRANSFERASE
SP_1029
(Streptococcus
pneumoniae) 		5 / 12 GLY A 399
ALA A 400
ASP A 401
ILE A 373
ILE A 378
 None
 0.95A 3lzsB-5xj1A:
undetectable		 3lzsB-5xj1A:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LZU_A_017A200_1
(HIV-1 PROTEASE)		 5xj1 UNCHARACTERIZED RNA
METHYLTRANSFERASE
SP_1029
(Streptococcus
pneumoniae) 		5 / 12 GLY A 399
ALA A 400
ASP A 401
ILE A 373
ILE A 378
 None
 0.95A 3lzuA-5xj1A:
undetectable		 3lzuA-5xj1A:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MWS_B_017B201_1
(HIV-1 PROTEASE)		 5xj1 UNCHARACTERIZED RNA
METHYLTRANSFERASE
SP_1029
(Streptococcus
pneumoniae) 		5 / 12 GLY A 399
ALA A 400
ASP A 401
ILE A 373
ILE A 378
 None
 0.84A 3mwsA-5xj1A:
undetectable		 3mwsA-5xj1A:
13.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDU_A_ROCA101_1
(PROTEASE)		 5xj1 UNCHARACTERIZED RNA
METHYLTRANSFERASE
SP_1029
(Streptococcus
pneumoniae) 		5 / 12 GLY A 399
ALA A 400
ASP A 401
ILE A 373
ILE A 378
 None
 0.94A 3nduA-5xj1A:
undetectable		 3nduA-5xj1A:
13.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDW_A_RITA100_1
(PROTEASE)		 5xj1 UNCHARACTERIZED RNA
METHYLTRANSFERASE
SP_1029
(Streptococcus
pneumoniae) 		5 / 12 GLY A 399
ALA A 400
ASP A 401
ILE A 373
ILE A 378
 None
 0.88A 3ndwA-5xj1A:
undetectable		 3ndwA-5xj1A:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDX_A_RITA100_1
(PROTEASE)		 5xj1 UNCHARACTERIZED RNA
METHYLTRANSFERASE
SP_1029
(Streptococcus
pneumoniae) 		5 / 12 GLY A 399
ALA A 400
ASP A 401
ILE A 373
ILE A 378
 None
 0.89A 3ndxA-5xj1A:
undetectable		 3ndxA-5xj1A:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWM_B_017B402_2
(PROTEASE)		 5xj1 UNCHARACTERIZED RNA
METHYLTRANSFERASE
SP_1029
(Streptococcus
pneumoniae) 		5 / 12 GLY A 399
ALA A 400
ASP A 401
ILE A 373
ILE A 378
 None
 0.92A 3pwmB-5xj1A:
undetectable		 3pwmB-5xj1A:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKG_B_ROCB801_1
(PROTEASE)		 5xj1 UNCHARACTERIZED RNA
METHYLTRANSFERASE
SP_1029
(Streptococcus
pneumoniae) 		5 / 12 GLY A 399
ALA A 400
ASP A 401
ILE A 373
ILE A 378
 None
 0.92A 3tkgA-5xj1A:
undetectable		 3tkgA-5xj1A:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKW_B_017B401_1
(PROTEASE)		 5xj1 UNCHARACTERIZED RNA
METHYLTRANSFERASE
SP_1029
(Streptococcus
pneumoniae) 		5 / 12 GLY A 399
ALA A 400
ASP A 401
ILE A 373
ILE A 378
 None
 0.87A 3tkwA-5xj1A:
undetectable		 3tkwA-5xj1A:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TTP_A_017A201_1
(HIV-1 PROTEASE)		 5xj1 UNCHARACTERIZED RNA
METHYLTRANSFERASE
SP_1029
(Streptococcus
pneumoniae) 		5 / 10 GLY A 399
ALA A 400
ASP A 401
ILE A 373
ILE A 378
 None
 0.89A 3ttpA-5xj1A:
undetectable		 3ttpA-5xj1A:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TTP_A_017A201_2
(HIV-1 PROTEASE)		 5xj1 UNCHARACTERIZED RNA
METHYLTRANSFERASE
SP_1029
(Streptococcus
pneumoniae) 		5 / 10 GLY A 399
ALA A 400
ASP A 401
ILE A 373
ILE A 378
 None
 0.90A 3ttpB-5xj1A:
undetectable		 3ttpB-5xj1A:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZJQ_B_NCAB300_0
(PROTOGLOBIN)		 5xj1 UNCHARACTERIZED RNA
METHYLTRANSFERASE
SP_1029
(Streptococcus
pneumoniae) 		4 / 7 TYR A 312
VAL A 332
PHE A 391
ILE A 378
 EPE  A 504 (-4.7A)
None
None
None
 0.95A 3zjqB-5xj1A:
undetectable		 3zjqB-5xj1A:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HLA_A_017A200_1
(PROTEASE)		 5xj1 UNCHARACTERIZED RNA
METHYLTRANSFERASE
SP_1029
(Streptococcus
pneumoniae) 		5 / 12 GLY A 399
ALA A 400
ASP A 401
ILE A 373
ILE A 378
 None
 0.91A 4hlaA-5xj1A:
undetectable		 4hlaA-5xj1A:
14.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HLA_A_017A200_2
(PROTEASE)		 5xj1 UNCHARACTERIZED RNA
METHYLTRANSFERASE
SP_1029
(Streptococcus
pneumoniae) 		5 / 11 GLY A 399
ALA A 400
ASP A 401
ILE A 373
ILE A 378
 None
 0.89A 4hlaB-5xj1A:
undetectable		 4hlaB-5xj1A:
14.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HTF_A_ACTA303_0
(S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 5xj1 UNCHARACTERIZED RNA
METHYLTRANSFERASE
SP_1029
(Streptococcus
pneumoniae) 		3 / 3 TYR A  60
HIS A  85
ARG A  67
 None
 1.00A 4htfA-5xj1A:
15.1		 4htfA-5xj1A:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYT_A_OBNA1104_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 5xj1 UNCHARACTERIZED RNA
METHYLTRANSFERASE
SP_1029
(Streptococcus
pneumoniae) 		4 / 5 PRO A 382
ASP A 381
ILE A 378
VAL A 332
 None
EPE  A 504 (-3.8A)
None
None
 1.43A 4hytA-5xj1A:
2.7		 4hytA-5xj1A:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJV_A_RITA500_1
(PROTEASE)		 5xj1 UNCHARACTERIZED RNA
METHYLTRANSFERASE
SP_1029
(Streptococcus
pneumoniae) 		5 / 12 GLY A 399
ALA A 400
ASP A 401
ILE A 373
ILE A 378
 None
 0.91A 4njvA-5xj1A:
undetectable		 4njvA-5xj1A:
13.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T2Z_B_017B201_1
(PROTEASE)		 5xj1 UNCHARACTERIZED RNA
METHYLTRANSFERASE
SP_1029
(Streptococcus
pneumoniae) 		5 / 12 GLY A 399
ALA A 400
ASP A 401
ILE A 373
ILE A 378
 None
 0.85A 5t2zA-5xj1A:
undetectable		 5t2zA-5xj1A:
13.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UAH_C_RFPC3001_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 5xj1 UNCHARACTERIZED RNA
METHYLTRANSFERASE
SP_1029
(Streptococcus
pneumoniae) 		5 / 12 ARG A 127
LEU A 156
VAL A 199
LEU A 153
ARG A 135
 P6G  A 503 (-3.5A)
None
None
None
None
 1.50A 5uahC-5xj1A:
2.0		 5uahC-5xj1A:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UL4_A_SAMA803_0
(OXSB PROTEIN)		 5xj1 UNCHARACTERIZED RNA
METHYLTRANSFERASE
SP_1029
(Streptococcus
pneumoniae) 		5 / 12 ALA A 280
GLY A 314
GLY A 316
ILE A 318
LEU A 435
 None
 1.02A 5ul4A-5xj1A:
4.1		 5ul4A-5xj1A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXL_A_SAMA401_0
(2-(3-AMINO-3-CARBOXY
PROPYL)HISTIDINE
SYNTHASE)		 5xj1 UNCHARACTERIZED RNA
METHYLTRANSFERASE
SP_1029
(Streptococcus
pneumoniae) 		5 / 12 GLY A 261
SER A 205
GLN A 207
ASP A 273
ASP A 263
 None
 1.34A 6bxlA-5xj1A:
3.0		 6bxlA-5xj1A:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_C_AQ4C602_0
(CYTOCHROME P450 1A1)		 5xj1 UNCHARACTERIZED RNA
METHYLTRANSFERASE
SP_1029
(Streptococcus
pneumoniae) 		5 / 12 ILE A 403
LEU A 451
GLY A 399
ILE A 392
LEU A 423
 None
 1.15A 6dwnC-5xj1A:
undetectable		 6dwnC-5xj1A:
10.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_A_QPSA602_2
(-)		 5xj1 UNCHARACTERIZED RNA
METHYLTRANSFERASE
SP_1029
(Streptococcus
pneumoniae) 		5 / 9 THR A 317
GLY A 316
GLY A 314
TYR A 293
CYH A 358
 None
 1.44A 6gnfA-5xj1A:
2.2		 6gnfA-5xj1A:
23.06