SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5xj3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1H8S_A_AICA1000_1
(MUTANT AL2 6E7P9G)		 5xj3 IPILIMUMAB-VH
IPILIMUMAB-VL
(Homo
sapiens) 		6 / 12 TYR B  37
GLN B  90
PHE B  99
VAL A  37
ALA A  97
TRP A 108
 None
 0.59A 1h8sA-5xj3B:
21.3		 1h8sA-5xj3B:
30.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OLD_B_IPHB2001_0
(BENCE JONES KWR
PROTEIN -
IMMUNOGLOBULIN LIGHT
CHAIN)		 5xj3 IPILIMUMAB-VH
IPILIMUMAB-VL
(Homo
sapiens;
Homo
sapiens) 		4 / 7 TYR A  95
TYR B  37
PRO B  45
TYR B  88
 None
 0.73A 2oldA-5xj3A:
14.0
2oldB-5xj3A:
14.0		 2oldA-5xj3A:
undetectable
2oldB-5xj3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OLD_B_IPHB2001_0
(BENCE JONES KWR
PROTEIN -
IMMUNOGLOBULIN LIGHT
CHAIN)		 5xj3 IPILIMUMAB-VH
IPILIMUMAB-VL
(Homo
sapiens;
Homo
sapiens) 		4 / 7 TYR B  37
PRO B  45
TYR B  88
TYR A  95
 None
 0.67A 2oldA-5xj3B:
18.2
2oldB-5xj3B:
18.1		 2oldA-5xj3B:
undetectable
2oldB-5xj3B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_C_H3PC552_1
(GLUTAMATE
DEHYDROGENASE)		 5xj3 IPILIMUMAB-VH
IPILIMUMAB-VL
(Homo
sapiens) 		3 / 3 TYR B  88
TYR A  95
GLY A  44
 None
 0.75A 3eteB-5xj3B:
undetectable
3eteD-5xj3B:
undetectable
3eteF-5xj3B:
undetectable		 3eteB-5xj3B:
9.92
3eteD-5xj3B:
9.92
3eteF-5xj3B:
9.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_A_1GNA607_1
(PHIAB6 TAILSPIKE)		 5xj3 IPILIMUMAB-VH
(Homo
sapiens) 		3 / 3 THR A  28
SER A  31
TYR A  32
 None
 0.87A 5jsdA-5xj3A:
undetectable		 5jsdA-5xj3A:
8.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_B_1GNB618_1
(PHIAB6 TAILSPIKE)		 5xj3 IPILIMUMAB-VH
(Homo
sapiens) 		3 / 3 THR A  28
SER A  31
TYR A  32
 None
 0.87A 5jsdB-5xj3A:
undetectable		 5jsdB-5xj3A:
8.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_C_1GNC608_1
(PHIAB6 TAILSPIKE)		 5xj3 IPILIMUMAB-VH
(Homo
sapiens) 		3 / 3 THR A  28
SER A  31
TYR A  32
 None
 0.87A 5jsdC-5xj3A:
undetectable		 5jsdC-5xj3A:
8.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSE_A_1GNA608_1
(PHIAB6 TAILSPIKE)		 5xj3 IPILIMUMAB-VH
(Homo
sapiens) 		3 / 3 THR A  28
SER A  31
TYR A  32
 None
 0.89A 5jseA-5xj3A:
undetectable		 5jseA-5xj3A:
8.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSE_C_1GNC611_1
(PHIAB6 TAILSPIKE)		 5xj3 IPILIMUMAB-VH
(Homo
sapiens) 		3 / 3 THR A  28
SER A  31
TYR A  32
 None
 0.88A 5jseC-5xj3A:
3.0		 5jseC-5xj3A:
8.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4E_D_EDPD402_1
(PROTON-GATED ION
CHANNEL)		 5xj3 IPILIMUMAB-VL
(Homo
sapiens) 		4 / 8 THR B  75
SER B  64
THR B  73
SER B  66
 None
 0.96A 5l4eA-5xj3B:
undetectable
5l4eB-5xj3B:
undetectable
5l4eC-5xj3B:
undetectable
5l4eD-5xj3B:
undetectable
5l4eE-5xj3B:
undetectable		 5l4eA-5xj3B:
18.11
5l4eB-5xj3B:
18.11
5l4eC-5xj3B:
18.11
5l4eD-5xj3B:
18.11
5l4eE-5xj3B:
18.11