SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5xj4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_B_ACHB301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 5xj4 PROGRAMMED CELL
DEATH 1 LIGAND 1
(Homo
sapiens) 		4 / 8 TYR A 112
THR A  37
TYR A  28
TRP A  57
 None
 1.22A 3wipB-5xj4A:
undetectable
3wipC-5xj4A:
undetectable		 3wipB-5xj4A:
undetectable
3wipC-5xj4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_C_ACHC301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 5xj4 PROGRAMMED CELL
DEATH 1 LIGAND 1
(Homo
sapiens) 		4 / 8 TYR A 112
THR A  37
TYR A  28
TRP A  57
 None
 1.26A 3wipC-5xj4A:
undetectable
3wipD-5xj4A:
undetectable		 3wipC-5xj4A:
undetectable
3wipD-5xj4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_E_ACHE301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 5xj4 PROGRAMMED CELL
DEATH 1 LIGAND 1
(Homo
sapiens) 		4 / 8 TRP A  57
TYR A 112
THR A  37
TYR A  28
 None
 1.30A 3wipA-5xj4A:
3.2
3wipE-5xj4A:
3.3		 3wipA-5xj4A:
undetectable
3wipE-5xj4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AT0_A_ACTA1490_0
(3-KETOSTEROID-DELTA4
-5ALPHA-DEHYDROGENAS
E)		 5xj4 PROGRAMMED CELL
DEATH 1 LIGAND 1
(Homo
sapiens) 		3 / 3 GLU A 223
TYR A 208
SER A 170
 None
 0.93A 4at0A-5xj4A:
undetectable		 4at0A-5xj4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D8P_A_ACTA810_0
(UNCHARACTERIZED
PROTEIN)		 5xj4 PROGRAMMED CELL
DEATH 1 LIGAND 1
(Homo
sapiens) 		4 / 6 TYR A  81
TYR A 112
GLU A  60
LYS A  62
 None
 1.18A 6d8pA-5xj4A:
undetectable		 6d8pA-5xj4A:
undetectable