SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5xj6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDV_E_SAME1287_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 5xj6 GLYCEROL-3-PHOSPHATE
ACYLTRANSFERASE
(Aquifex
aeolicus) 		5 / 12 GLY A  63
GLY A 111
ALA A  10
PHE A  57
ASP A  59
 None
None
None
None
PO4  A 306 ( 4.6A)
 1.27A 2vdvE-5xj6A:
undetectable		 2vdvE-5xj6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDV_F_SAMF1287_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 5xj6 GLYCEROL-3-PHOSPHATE
ACYLTRANSFERASE
(Aquifex
aeolicus) 		5 / 11 GLY A  63
GLY A 111
ALA A  10
PHE A  57
ASP A  59
 None
None
None
None
PO4  A 306 ( 4.6A)
 1.27A 2vdvF-5xj6A:
undetectable		 2vdvF-5xj6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IMA_D_ADND604_1
(PYRUVATE KINASE)		 5xj6 GLYCEROL-3-PHOSPHATE
ACYLTRANSFERASE
(Aquifex
aeolicus) 		3 / 3 ARG A 183
GLU A 179
ASN A 182
 None
 0.69A 4imaD-5xj6A:
undetectable		 4imaD-5xj6A:
10.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IP7_D_ADND604_1
(PYRUVATE KINASE
ISOZYMES L)		 5xj6 GLYCEROL-3-PHOSPHATE
ACYLTRANSFERASE
(Aquifex
aeolicus) 		3 / 3 ARG A 183
GLU A 179
ASN A 182
 None
 0.69A 4ip7D-5xj6A:
undetectable		 4ip7D-5xj6A:
10.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BYJ_A_OQRA302_0
(SULFOTRANSFERASE)		 5xj6 GLYCEROL-3-PHOSPHATE
ACYLTRANSFERASE
(Aquifex
aeolicus) 		5 / 12 VAL A 106
GLY A  85
THR A 146
MET A  93
LEU A  90
 PO4  A 306 (-4.0A)
None
OLC  A 302 ( 3.9A)
None
OLC  A 305 ( 4.9A)
 1.14A 5byjA-5xj6A:
undetectable		 5byjA-5xj6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IL1_A_SAMA601_0
(METTL3)		 5xj6 GLYCEROL-3-PHOSPHATE
ACYLTRANSFERASE
(Aquifex
aeolicus) 		5 / 12 ILE A 167
LEU A 163
SER A 124
PHE A 150
GLY A 170
 None
 1.37A 5il1A-5xj6A:
undetectable		 5il1A-5xj6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_E_CVIE301_0
(REGULATORY PROTEIN
TETR)		 5xj6 GLYCEROL-3-PHOSPHATE
ACYLTRANSFERASE
(Aquifex
aeolicus) 		5 / 12 MET A  93
ALA A  87
LEU A 172
ILE A 173
VAL A 112
 None
 1.24A 5vlmE-5xj6A:
2.3		 5vlmE-5xj6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_B_SAMB901_0
(MRNA CAPPING ENZYME
P5)		 5xj6 GLYCEROL-3-PHOSPHATE
ACYLTRANSFERASE
(Aquifex
aeolicus) 		5 / 10 VAL A  33
GLY A  34
ALA A  46
LEU A  30
ASN A  37
 None
None
None
None
PO4  A 306 (-3.2A)
 1.05A 5x6yB-5xj6A:
undetectable		 5x6yB-5xj6A:
undetectable