SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5xjg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CQP_A_803A311_1
(ANTIGEN CD11A (P180))		 5xjg VACUOLAR PROTEIN 8
(Saccharomyces
cerevisiae) 		5 / 10 LEU A 491
VAL A 499
GLU A 415
LEU A 414
VAL A 448
 None
 1.11A 1cqpA-5xjgA:
undetectable
1cqpB-5xjgA:
undetectable		 1cqpA-5xjgA:
17.33
1cqpB-5xjgA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L2I_A_CCSA417_0
(ESTROGEN RECEPTOR)		 5xjg VACUOLAR PROTEIN 8
(Saccharomyces
cerevisiae) 		3 / 3 GLU A 287
LYS A 255
VAL A 253
 None
 0.89A 1l2iA-5xjgA:
undetectable		 1l2iA-5xjgA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OG5_A_SWFA502_1
(CYTOCHROME P450 2C9)		 5xjg VACUOLAR PROTEIN 8
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 109
ALA A 108
LEU A  94
THR A  53
LEU A  49
 None
 1.25A 1og5A-5xjgA:
undetectable		 1og5A-5xjgA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6K_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5xjg VACUOLAR PROTEIN 8
NUCLEUS-VACUOLE
JUNCTION PROTEIN 1
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		4 / 8 SER A 280
ARG A 242
ASN B 304
ASP B 306
 None
None
None
B3P  A 602 (-3.2A)
 1.27A 1p6kA-5xjgA:
undetectable		 1p6kA-5xjgA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6K_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5xjg VACUOLAR PROTEIN 8
NUCLEUS-VACUOLE
JUNCTION PROTEIN 1
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		4 / 8 SER A 280
ARG A 242
GLN B 308
ASN B 304
 None
 0.89A 1p6kA-5xjgA:
undetectable		 1p6kA-5xjgA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6K_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5xjg VACUOLAR PROTEIN 8
NUCLEUS-VACUOLE
JUNCTION PROTEIN 1
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		4 / 8 SER A 280
ARG A 242
GLN B 308
ASN B 304
 None
 0.83A 1p6kB-5xjgA:
undetectable		 1p6kB-5xjgA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS6_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5xjg VACUOLAR PROTEIN 8
NUCLEUS-VACUOLE
JUNCTION PROTEIN 1
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		4 / 8 SER A 280
ARG A 242
GLN B 308
ASN B 304
 None
 0.81A 1rs6A-5xjgA:
undetectable		 1rs6A-5xjgA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS6_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5xjg VACUOLAR PROTEIN 8
NUCLEUS-VACUOLE
JUNCTION PROTEIN 1
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		4 / 8 SER A 280
ARG A 242
GLN B 308
ASN B 304
 None
 0.76A 1rs6B-5xjgA:
undetectable		 1rs6B-5xjgA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS7_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5xjg VACUOLAR PROTEIN 8
NUCLEUS-VACUOLE
JUNCTION PROTEIN 1
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		4 / 8 SER A 280
ARG A 242
GLN B 308
ASN B 304
 None
 0.80A 1rs7B-5xjgA:
undetectable		 1rs7B-5xjgA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZQ_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5xjg VACUOLAR PROTEIN 8
NUCLEUS-VACUOLE
JUNCTION PROTEIN 1
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		4 / 8 SER A 280
ARG A 242
GLN B 308
ASN B 304
 None
 0.86A 1zzqA-5xjgA:
undetectable		 1zzqA-5xjgA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZQ_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5xjg VACUOLAR PROTEIN 8
NUCLEUS-VACUOLE
JUNCTION PROTEIN 1
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		4 / 8 SER A 280
ARG A 242
GLN B 308
ASN B 304
 None
 0.82A 1zzqB-5xjgA:
undetectable		 1zzqB-5xjgA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5xjg VACUOLAR PROTEIN 8
NUCLEUS-VACUOLE
JUNCTION PROTEIN 1
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		4 / 8 SER A 280
ARG A 242
GLN B 308
ASN B 304
 None
 0.91A 1zzuA-5xjgA:
undetectable		 1zzuA-5xjgA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5xjg VACUOLAR PROTEIN 8
NUCLEUS-VACUOLE
JUNCTION PROTEIN 1
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		4 / 8 SER A 280
ARG A 242
GLN B 308
ASN B 304
 None
 0.86A 1zzuB-5xjgA:
undetectable		 1zzuB-5xjgA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_B_2FAB500_2
(ADENOSYLHOMOCYSTEINA
SE)		 5xjg VACUOLAR PROTEIN 8
(Saccharomyces
cerevisiae) 		4 / 5 LEU A 259
GLN A 270
THR A 229
HIS A 296
 None
None
None
PE5  A 601 (-4.1A)
 1.23A 2zj0B-5xjgA:
undetectable		 2zj0B-5xjgA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_C_2FAC500_2
(ADENOSYLHOMOCYSTEINA
SE)		 5xjg VACUOLAR PROTEIN 8
(Saccharomyces
cerevisiae) 		4 / 5 LEU A 259
GLN A 270
THR A 229
HIS A 296
 None
None
None
PE5  A 601 (-4.1A)
 1.22A 2zj0C-5xjgA:
undetectable		 2zj0C-5xjgA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADS_A_IMNA2_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5xjg NUCLEUS-VACUOLE
JUNCTION PROTEIN 1
VACUOLAR PROTEIN 8
(Saccharomyces
cerevisiae) 		4 / 6 ILE B 295
ILE A 454
TYR A 451
LEU B 292
 None
 1.09A 3adsA-5xjgB:
undetectable		 3adsA-5xjgB:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_B_ADNB500_2
(ADENOSYLHOMOCYSTEINA
SE)		 5xjg VACUOLAR PROTEIN 8
(Saccharomyces
cerevisiae) 		4 / 5 LEU A 259
GLN A 270
THR A 229
HIS A 296
 None
None
None
PE5  A 601 (-4.1A)
 1.20A 3ce6B-5xjgA:
undetectable		 3ce6B-5xjgA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_D_ADND500_2
(ADENOSYLHOMOCYSTEINA
SE)		 5xjg VACUOLAR PROTEIN 8
(Saccharomyces
cerevisiae) 		4 / 5 LEU A 259
GLN A 270
THR A 229
HIS A 296
 None
None
None
PE5  A 601 (-4.1A)
 1.20A 3ce6D-5xjgA:
undetectable		 3ce6D-5xjgA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_D_ADND500_2
(ADENOSYLHOMOCYSTEINA
SE)		 5xjg VACUOLAR PROTEIN 8
(Saccharomyces
cerevisiae) 		4 / 5 LEU A 259
GLN A 270
THR A 229
LEU A 300
 None
 1.12A 3ce6D-5xjgA:
undetectable		 3ce6D-5xjgA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N58_C_ADNC500_2
(ADENOSYLHOMOCYSTEINA
SE)		 5xjg VACUOLAR PROTEIN 8
(Saccharomyces
cerevisiae) 		4 / 5 LEU A 259
GLN A 270
THR A 229
HIS A 296
 None
None
None
PE5  A 601 (-4.1A)
 1.20A 3n58C-5xjgA:
undetectable		 3n58C-5xjgA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N62_B_MTLB870_0
(NITRIC OXIDE
SYNTHASE)		 5xjg VACUOLAR PROTEIN 8
NUCLEUS-VACUOLE
JUNCTION PROTEIN 1
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		4 / 8 SER A 280
ARG A 242
GLN B 308
ASN B 304
 None
 0.87A 3n62B-5xjgA:
undetectable		 3n62B-5xjgA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N66_B_MTLB870_0
(NITRIC OXIDE
SYNTHASE)		 5xjg VACUOLAR PROTEIN 8
NUCLEUS-VACUOLE
JUNCTION PROTEIN 1
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		4 / 8 SER A 280
ARG A 242
GLN B 308
ASN B 304
 None
 0.79A 3n66B-5xjgA:
undetectable		 3n66B-5xjgA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZW_A_KKKA413_1
(FLAVOHEMOGLOBIN)		 5xjg VACUOLAR PROTEIN 8
(Saccharomyces
cerevisiae) 		4 / 8 ILE A 101
GLN A  64
ALA A  67
LEU A  94
 None
 0.84A 3ozwA-5xjgA:
undetectable		 3ozwA-5xjgA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M7T_A_SAMA503_0
(BTRN)		 5xjg VACUOLAR PROTEIN 8
(Saccharomyces
cerevisiae) 		5 / 11 TYR A  78
THR A  75
LEU A 112
LEU A  87
SER A  83
 None
 1.36A 4m7tA-5xjgA:
undetectable		 4m7tA-5xjgA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBS_A_DIFA503_1
(PENTALENIC ACID
SYNTHASE)		 5xjg VACUOLAR PROTEIN 8
(Saccharomyces
cerevisiae) 		4 / 7 LEU A 256
ALA A 231
LEU A 273
ILE A 235
 None
 0.76A 4ubsA-5xjgA:
undetectable		 4ubsA-5xjgA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDQ_A_BEZA306_0
(GLYCOSIDE HYDROLASE
FAMILY PROTEIN)		 5xjg VACUOLAR PROTEIN 8
(Saccharomyces
cerevisiae) 		3 / 3 ARG A 466
ASP A 459
TRP A 458
 None
 0.96A 4xdqA-5xjgA:
undetectable		 4xdqA-5xjgA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHZ_D_READ602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)		 5xjg VACUOLAR PROTEIN 8
(Saccharomyces
cerevisiae) 		5 / 12 GLU A 463
TRP A 458
CYH A 445
THR A 487
LEU A 469
 None
 1.43A 5fhzD-5xjgA:
undetectable		 5fhzD-5xjgA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHZ_D_READ602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)		 5xjg VACUOLAR PROTEIN 8
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 423
TRP A 458
CYH A 445
THR A 487
LEU A 469
 None
 1.37A 5fhzD-5xjgA:
undetectable		 5fhzD-5xjgA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K50_A_ACTA1403_0
(L-THREONINE
3-DEHYDROGENASE)		 5xjg VACUOLAR PROTEIN 8
(Saccharomyces
cerevisiae) 		4 / 5 SER A 254
VAL A 257
GLY A 292
ALA A 291
 None
None
PE5  A 601 (-3.9A)
None
 0.99A 5k50A-5xjgA:
undetectable		 5k50A-5xjgA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_A_6ZPA902_1
(GLUTAMATE RECEPTOR 2)		 5xjg NUCLEUS-VACUOLE
JUNCTION PROTEIN 1
VACUOLAR PROTEIN 8
(Saccharomyces
cerevisiae) 		4 / 8 PHE A 480
SER B 298
ASN A 436
SER A 475
 None
 1.05A 5l1fA-5xjgA:
undetectable
5l1fB-5xjgA:
undetectable		 5l1fA-5xjgA:
21.80
5l1fB-5xjgA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MSD_A_BEZA1202_0
(CARBOXYLIC ACID
REDUCTASE)		 5xjg VACUOLAR PROTEIN 8
(Saccharomyces
cerevisiae) 		4 / 5 ILE A 418
PHE A 373
SER A 409
ALA A 416
 None
 1.11A 5msdA-5xjgA:
undetectable		 5msdA-5xjgA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NU7_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 4)		 5xjg VACUOLAR PROTEIN 8
NUCLEUS-VACUOLE
JUNCTION PROTEIN 1
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		4 / 8 LEU A 213
ALA B 314
VAL A 212
HIS A 196
 None
 0.99A 5nu7A-5xjgA:
undetectable		 5nu7A-5xjgA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUN_A_MTLA805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5xjg VACUOLAR PROTEIN 8
NUCLEUS-VACUOLE
JUNCTION PROTEIN 1
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		4 / 8 SER A 280
ARG A 242
GLN B 308
ASN B 304
 None
 0.89A 5vunA-5xjgA:
undetectable		 5vunA-5xjgA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUN_B_MTLB805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5xjg VACUOLAR PROTEIN 8
NUCLEUS-VACUOLE
JUNCTION PROTEIN 1
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		4 / 8 SER A 280
ARG A 242
GLN B 308
ASN B 304
 None
 0.85A 5vunB-5xjgA:
undetectable		 5vunB-5xjgA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUO_B_MTLB805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5xjg VACUOLAR PROTEIN 8
NUCLEUS-VACUOLE
JUNCTION PROTEIN 1
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		4 / 8 SER A 280
ARG A 242
GLN B 308
ASN B 304
 None
 0.84A 5vuoB-5xjgA:
undetectable		 5vuoB-5xjgA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUU_B_MTLB805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5xjg VACUOLAR PROTEIN 8
NUCLEUS-VACUOLE
JUNCTION PROTEIN 1
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		4 / 8 SER A 280
ARG A 242
GLN B 308
ASN B 304
 None
 0.85A 6auuB-5xjgA:
undetectable		 6auuB-5xjgA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_G_ZOLG401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 5xjg VACUOLAR PROTEIN 8
NUCLEUS-VACUOLE
JUNCTION PROTEIN 1
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		4 / 7 ASP A 223
ASP A 221
ARG A 266
GLN B 317
 None
 1.17A 6g31G-5xjgA:
undetectable		 6g31G-5xjgA:
10.43