SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5xjh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L2I_B_CCSB417_0
(ESTROGEN RECEPTOR)		 5xjh POLY(ETHYLENE
TEREPHTHALATE)
HYDROLASE
(Ideonella
sakaiensis) 		4 / 6 PRO A 181
PHE A 201
GLU A 231
GLN A 182
 None
 0.97A 1l2iB-5xjhA:
undetectable		 1l2iB-5xjhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS7_A_ACTA860_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5xjh POLY(ETHYLENE
TEREPHTHALATE)
HYDROLASE
(Ideonella
sakaiensis) 		4 / 5 GLY A 164
ILE A 168
VAL A 156
SER A 124
 None
 1.09A 1rs7A-5xjhA:
undetectable		 1rs7A-5xjhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS7_B_ACTB861_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5xjh POLY(ETHYLENE
TEREPHTHALATE)
HYDROLASE
(Ideonella
sakaiensis) 		4 / 6 GLY A 164
ILE A 168
VAL A 156
SER A 124
 None
 1.10A 1rs7B-5xjhA:
undetectable		 1rs7B-5xjhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_A_ROFA502_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 5xjh POLY(ETHYLENE
TEREPHTHALATE)
HYDROLASE
(Ideonella
sakaiensis) 		5 / 12 PRO A  99
TYR A  69
THR A 110
ILE A  83
SER A  92
 None
 1.07A 1xoqA-5xjhA:
undetectable		 1xoqA-5xjhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_A_ROFA502_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 5xjh POLY(ETHYLENE
TEREPHTHALATE)
HYDROLASE
(Ideonella
sakaiensis) 		5 / 12 PRO A  99
TYR A  69
THR A 110
ILE A  83
SER A  93
 None
 1.33A 1xoqA-5xjhA:
undetectable		 1xoqA-5xjhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_B_ROFB501_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 5xjh POLY(ETHYLENE
TEREPHTHALATE)
HYDROLASE
(Ideonella
sakaiensis) 		5 / 12 PRO A  99
TYR A  69
THR A 110
ILE A  83
SER A  92
 None
 1.08A 1xoqB-5xjhA:
undetectable		 1xoqB-5xjhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_B_ROFB501_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 5xjh POLY(ETHYLENE
TEREPHTHALATE)
HYDROLASE
(Ideonella
sakaiensis) 		5 / 12 PRO A  99
TYR A  69
THR A 110
ILE A  83
SER A  93
 None
 1.33A 1xoqB-5xjhA:
undetectable		 1xoqB-5xjhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_J_BEZJ5041_0
(CES1 PROTEIN)		 5xjh POLY(ETHYLENE
TEREPHTHALATE)
HYDROLASE
(Ideonella
sakaiensis) 		4 / 4 GLY A  86
SER A 160
ILE A 208
HIS A 237
 None
 1.23A 1yajJ-5xjhA:
13.8		 1yajJ-5xjhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A302_1
(THIOPURINE
S-METHYLTRANSFERASE)		 5xjh POLY(ETHYLENE
TEREPHTHALATE)
HYDROLASE
(Ideonella
sakaiensis) 		4 / 6 THR A 286
PHE A 229
LEU A 199
LEU A 230
 None
 1.20A 3bgdA-5xjhA:
undetectable		 3bgdA-5xjhA:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_A_ROFA901_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 5xjh POLY(ETHYLENE
TEREPHTHALATE)
HYDROLASE
(Ideonella
sakaiensis) 		5 / 12 PRO A  99
TYR A  69
THR A 110
ILE A  83
SER A  92
 None
 1.08A 3g4lA-5xjhA:
undetectable		 3g4lA-5xjhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_A_ROFA901_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 5xjh POLY(ETHYLENE
TEREPHTHALATE)
HYDROLASE
(Ideonella
sakaiensis) 		5 / 12 PRO A  99
TYR A  69
THR A 110
ILE A  83
SER A  93
 None
 1.30A 3g4lA-5xjhA:
undetectable		 3g4lA-5xjhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB1_A_SAMA1101_0
(STRUCTURAL PROTEIN
VP3)		 5xjh POLY(ETHYLENE
TEREPHTHALATE)
HYDROLASE
(Ideonella
sakaiensis) 		5 / 12 GLY A 162
ALA A  89
PRO A 184
ALA A 183
PRO A 181
 None
 1.01A 3jb1A-5xjhA:
undetectable		 3jb1A-5xjhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LD6_A_KKKA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5xjh POLY(ETHYLENE
TEREPHTHALATE)
HYDROLASE
(Ideonella
sakaiensis) 		5 / 12 TRP A  97
ALA A  65
ILE A 109
ILE A  81
MET A 157
 None
 1.05A 3ld6A-5xjhA:
undetectable		 3ld6A-5xjhA:
10.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_A_ACTA860_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5xjh POLY(ETHYLENE
TEREPHTHALATE)
HYDROLASE
(Ideonella
sakaiensis) 		4 / 5 GLY A 164
ILE A 168
VAL A 156
SER A 124
 None
 1.24A 4d33A-5xjhA:
undetectable		 4d33A-5xjhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5xjh POLY(ETHYLENE
TEREPHTHALATE)
HYDROLASE
(Ideonella
sakaiensis) 		4 / 5 GLY A 164
ILE A 168
VAL A 156
SER A 124
 None
 1.25A 4d33B-5xjhA:
undetectable		 4d33B-5xjhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCK_B_SAMB2409_0
(RNA-DIRECTED RNA
POLYMERASE L)		 5xjh POLY(ETHYLENE
TEREPHTHALATE)
HYDROLASE
(Ideonella
sakaiensis) 		5 / 12 GLY A 158
SER A 166
LEU A 167
ALA A 170
ALA A 179
 None
 1.10A 4uckB-5xjhA:
undetectable		 4uckB-5xjhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW4_A_SAMA801_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE I)		 5xjh POLY(ETHYLENE
TEREPHTHALATE)
HYDROLASE
(Ideonella
sakaiensis) 		5 / 12 ILE A 109
GLY A  66
ASP A 112
ALA A 130
LEU A 131
 None
 1.23A 5hw4A-5xjhA:
undetectable		 5hw4A-5xjhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW4_B_SAMB801_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE I)		 5xjh POLY(ETHYLENE
TEREPHTHALATE)
HYDROLASE
(Ideonella
sakaiensis) 		5 / 11 ILE A 109
GLY A  66
ASP A 112
ALA A 130
LEU A 131
 None
 1.21A 5hw4B-5xjhA:
undetectable		 5hw4B-5xjhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW4_C_SAMC801_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE I)		 5xjh POLY(ETHYLENE
TEREPHTHALATE)
HYDROLASE
(Ideonella
sakaiensis) 		5 / 12 ILE A 109
GLY A  66
ASP A 112
ALA A 130
LEU A 131
 None
 1.20A 5hw4C-5xjhA:
undetectable		 5hw4C-5xjhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IMS_A_ACTA708_0
(ACETOLACTATE
SYNTHASE CATALYTIC
SUBUNIT,
MITOCHONDRIAL)		 5xjh POLY(ETHYLENE
TEREPHTHALATE)
HYDROLASE
(Ideonella
sakaiensis) 		3 / 3 GLY A 163
GLY A 162
GLN A 127
 None
 0.47A 5imsA-5xjhA:
2.7		 5imsA-5xjhA:
undetectable