SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5xjm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DSD_C_DVAC2_0
(ACTINOMYCIN D)		 5xjm FABH
(Mus
musculus) 		4 / 4 THR H 123
PRO H 125
THR H 124
PRO H 154
 None
 1.35A 1dsdC-5xjmH:
undetectable		 1dsdC-5xjmH:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DSD_C_DVAC2_0
(ACTINOMYCIN D)		 5xjm FABH
(Mus
musculus) 		4 / 4 THR H 124
PRO H 154
THR H 123
PRO H 125
 None
 1.26A 1dsdC-5xjmH:
undetectable		 1dsdC-5xjmH:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DSD_C_DVAC8_0
(ACTINOMYCIN D)		 5xjm FABH
(Mus
musculus) 		4 / 4 THR H 123
PRO H 125
THR H 124
PRO H 154
 None
 1.35A 1dsdC-5xjmH:
undetectable		 1dsdC-5xjmH:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DSD_C_DVAC8_0
(ACTINOMYCIN D)		 5xjm FABH
(Mus
musculus) 		4 / 4 THR H 124
PRO H 154
THR H 123
PRO H 125
 None
 1.26A 1dsdC-5xjmH:
undetectable		 1dsdC-5xjmH:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FZG_A_SAMA300_0
(16S RRNA METHYLASE)		 5xjm FABH
(Mus
musculus) 		5 / 12 THR H  28
GLY H  33
GLY H  31
ILE H  51
LEU H 100
 None
 1.30A 3fzgA-5xjmH:
undetectable		 3fzgA-5xjmH:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXT_B_MTXB2000_1
(ANTI-METHOTREXATE
CDR1-3 GRAFT VHH)		 5xjm FABH
(Mus
musculus) 		6 / 12 VAL H   2
LEU H   4
ALA H  24
MET H  34
ARG H  72
TYR H 109
 None
 0.86A 3qxtB-5xjmH:
21.4		 3qxtB-5xjmH:
59.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G10_A_ACTA301_0
(GLUTATHIONE
S-TRANSFERASE
HOMOLOG)		 5xjm TYPE-2 ANGIOTENSIN
II RECEPTOR,SOLUBLE
CYTOCHROME
B562,TYPE-2
ANGIOTENSIN II
RECEPTOR
(Escherichia
coli;
Homo
sapiens) 		4 / 6 PRO A 301
TYR A 108
TYR A 104
TYR A 103
 None
 1.21A 4g10A-5xjmA:
undetectable		 4g10A-5xjmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UY8_7_TRP71002_0
(TRYPTOPHANASE)		 5xjm TYPE-2 ANGIOTENSIN
II RECEPTOR,SOLUBLE
CYTOCHROME
B562,TYPE-2
ANGIOTENSIN II
RECEPTOR
(Escherichia
coli;
Homo
sapiens) 		4 / 4 ILE A  63
ASN A  62
ILE A  57
VAL A  56
 None
 1.18A 4uy87-5xjmA:
undetectable		 4uy87-5xjmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECM_D_LEUD602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 5xjm FABH
(Mus
musculus) 		4 / 7 ALA H  92
THR H  91
VAL H 116
GLU H  89
 None
 0.76A 5ecmD-5xjmH:
undetectable		 5ecmD-5xjmH:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECO_D_LEUD602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 5xjm FABH
(Mus
musculus) 		4 / 7 ALA H  92
THR H  91
VAL H 116
GLU H  89
 None
 0.84A 5ecoD-5xjmH:
undetectable		 5ecoD-5xjmH:
undetectable