SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5xjn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DSC_C_DVAC8_0
(ACTINOMYCIN D)		 5xjn CYTOCHROME P450
(Corynebacterium
glutamicum) 		3 / 3 THR A 170
THR A 172
PRO A 169
 None
 0.76A 1dscC-5xjnA:
undetectable		 1dscC-5xjnA:
2.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_1
(HMG-COA REDUCTASE)		 5xjn CYTOCHROME P450
(Corynebacterium
glutamicum) 		5 / 9 CYH A 376
HIS A 116
LEU A 108
LEU A 258
LEU A 262
 HEM  A 502 (-2.4A)
HEM  A 502 (-3.9A)
HEM  A 502 ( 3.7A)
None
HEM  A 502 ( 4.1A)
 1.38A 1hwiA-5xjnA:
undetectable		 1hwiA-5xjnA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_G_DVAG8_0
(ACTINOMYCIN D)		 5xjn CYTOCHROME P450
(Corynebacterium
glutamicum) 		3 / 3 THR A 170
THR A 172
PRO A 169
 None
 0.86A 1i3wG-5xjnA:
undetectable		 1i3wG-5xjnA:
2.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_H_DVAH8_0
(ACTINOMYCIN D)		 5xjn CYTOCHROME P450
(Corynebacterium
glutamicum) 		3 / 3 THR A 170
THR A 172
PRO A 169
 None
 0.87A 1i3wH-5xjnA:
undetectable		 1i3wH-5xjnA:
2.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_B_ACTB1868_0
(FPRA)		 5xjn CYTOCHROME P450
(Corynebacterium
glutamicum) 		3 / 3 ALA A 211
HIS A 212
VAL A 215
 None
 0.34A 1lqtB-5xjnA:
undetectable		 1lqtB-5xjnA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_B_ACTB1425_0
(FPRA)		 5xjn CYTOCHROME P450
(Corynebacterium
glutamicum) 		3 / 3 ALA A 211
HIS A 212
VAL A 215
 None
 0.34A 1lquB-5xjnA:
undetectable		 1lquB-5xjnA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_L_DVAL2_0
(7-AMINO-ACTINOMYCIN
D)		 5xjn CYTOCHROME P450
(Corynebacterium
glutamicum) 		3 / 3 THR A 172
PRO A 169
THR A 170
 None
 0.87A 1unjL-5xjnA:
undetectable		 1unjL-5xjnA:
2.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_L_DVAL8_0
(7-AMINO-ACTINOMYCIN
D)		 5xjn CYTOCHROME P450
(Corynebacterium
glutamicum) 		3 / 3 THR A 170
THR A 172
PRO A 169
 None
 0.84A 1unjL-5xjnA:
undetectable		 1unjL-5xjnA:
2.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_R_DVAR2_0
(7-AMINO-ACTINOMYCIN
D)		 5xjn CYTOCHROME P450
(Corynebacterium
glutamicum) 		3 / 3 THR A 172
PRO A 169
THR A 170
 None
 0.85A 1unjR-5xjnA:
undetectable		 1unjR-5xjnA:
2.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_R_DVAR8_0
(7-AMINO-ACTINOMYCIN
D)		 5xjn CYTOCHROME P450
(Corynebacterium
glutamicum) 		3 / 3 THR A 170
THR A 172
PRO A 169
 None
 0.84A 1unjR-5xjnA:
undetectable		 1unjR-5xjnA:
2.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_W_DVAW8_0
(7-AMINO-ACTINOMYCIN
D)		 5xjn CYTOCHROME P450
(Corynebacterium
glutamicum) 		3 / 3 THR A 170
THR A 172
PRO A 169
 None
 0.82A 1unjW-5xjnA:
undetectable		 1unjW-5xjnA:
2.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_X_DVAX2_0
(7-AMINO-ACTINOMYCIN
D)		 5xjn CYTOCHROME P450
(Corynebacterium
glutamicum) 		3 / 3 THR A 172
PRO A 169
THR A 170
 None
 0.83A 1unjX-5xjnA:
undetectable		 1unjX-5xjnA:
2.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_X_DVAX8_0
(7-AMINO-ACTINOMYCIN
D)		 5xjn CYTOCHROME P450
(Corynebacterium
glutamicum) 		3 / 3 THR A 170
THR A 172
PRO A 169
 None
 0.83A 1unjX-5xjnA:
undetectable		 1unjX-5xjnA:
2.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNM_E_DVAE2_0
(7-AMINOACTINOMYCIN D)		 5xjn CYTOCHROME P450
(Corynebacterium
glutamicum) 		3 / 3 THR A 172
PRO A 169
THR A 170
 None
 0.84A 1unmE-5xjnA:
undetectable		 1unmE-5xjnA:
2.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNM_E_DVAE8_0
(7-AMINOACTINOMYCIN D)		 5xjn CYTOCHROME P450
(Corynebacterium
glutamicum) 		3 / 3 THR A 170
THR A 172
PRO A 169
 None
 0.82A 1unmE-5xjnA:
undetectable		 1unmE-5xjnA:
2.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNM_F_DVAF2_0
(7-AMINOACTINOMYCIN D)		 5xjn CYTOCHROME P450
(Corynebacterium
glutamicum) 		3 / 3 THR A 172
PRO A 169
THR A 170
 None
 0.87A 1unmF-5xjnA:
undetectable		 1unmF-5xjnA:
2.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNM_F_DVAF8_0
(7-AMINOACTINOMYCIN D)		 5xjn CYTOCHROME P450
(Corynebacterium
glutamicum) 		3 / 3 THR A 170
THR A 172
PRO A 169
 None
 0.83A 1unmF-5xjnA:
undetectable		 1unmF-5xjnA:
2.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_A_AG2A672_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 5xjn CYTOCHROME P450
(Corynebacterium
glutamicum) 		4 / 7 LEU A  44
ILE A  56
MET A  51
ARG A  55
 None
 1.07A 2qqcA-5xjnA:
undetectable
2qqcF-5xjnA:
undetectable		 2qqcA-5xjnA:
9.07
2qqcF-5xjnA:
13.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_I_AG2I671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 5xjn CYTOCHROME P450
(Corynebacterium
glutamicum) 		4 / 7 LEU A  44
ILE A  56
MET A  51
ARG A  55
 None
 1.05A 2qqcG-5xjnA:
undetectable
2qqcJ-5xjnA:
undetectable		 2qqcG-5xjnA:
9.07
2qqcJ-5xjnA:
13.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_I_AG2I672_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 5xjn CYTOCHROME P450
(Corynebacterium
glutamicum) 		4 / 7 LEU A  44
ILE A  56
MET A  51
ARG A  55
 None
 1.08A 2qqcI-5xjnA:
undetectable
2qqcL-5xjnA:
undetectable		 2qqcI-5xjnA:
9.07
2qqcL-5xjnA:
13.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W1B_A_DXCA2034_0
(ACRIFLAVIN
RESISTANCE PROTEIN B)		 5xjn CYTOCHROME P450
(Corynebacterium
glutamicum) 		3 / 3 PHE A 127
SER A 261
LEU A 259
 HEM  A 502 (-3.7A)
88L  A 501 ( 2.7A)
None
 0.63A 2w1bA-5xjnA:
2.7		 2w1bA-5xjnA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E4E_A_4PZA501_1
(CYTOCHROME P450 2E1)		 5xjn CYTOCHROME P450
(Corynebacterium
glutamicum) 		3 / 3 ALA A 265
THR A 269
CYH A 376
 88L  A 501 ( 3.1A)
HEM  A 502 (-3.5A)
HEM  A 502 (-2.4A)
 0.47A 3e4eA-5xjnA:
31.9		 3e4eA-5xjnA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E4E_B_4PZB501_1
(CYTOCHROME P450 2E1)		 5xjn CYTOCHROME P450
(Corynebacterium
glutamicum) 		3 / 3 ALA A 265
THR A 269
CYH A 376
 88L  A 501 ( 3.1A)
HEM  A 502 (-3.5A)
HEM  A 502 (-2.4A)
 0.31A 3e4eB-5xjnA:
31.8		 3e4eB-5xjnA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_A_CHDA150_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 5xjn CYTOCHROME P450
(Corynebacterium
glutamicum) 		5 / 12 ASN A 413
THR A 198
VAL A 313
ILE A 312
THR A 272
 None
None
None
HEM  A 502 (-3.7A)
None
 1.04A 3elzA-5xjnA:
undetectable		 3elzA-5xjnA:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_C_CHDC150_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 5xjn CYTOCHROME P450
(Corynebacterium
glutamicum) 		5 / 12 ASN A 413
THR A 198
VAL A 313
ILE A 312
THR A 272
 None
None
None
HEM  A 502 (-3.7A)
None
 1.00A 3elzC-5xjnA:
undetectable		 3elzC-5xjnA:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GYQ_A_SAMA270_0
(RRNA
(ADENOSINE-2'-O-)-ME
THYLTRANSFERASE)		 5xjn CYTOCHROME P450
(Corynebacterium
glutamicum) 		5 / 12 LEU A 176
ALA A 179
GLY A 266
MET A 224
LEU A 259
 None
None
HEM  A 502 (-3.6A)
None
None
 1.28A 3gyqA-5xjnA:
undetectable
3gyqB-5xjnA:
undetectable		 3gyqA-5xjnA:
22.64
3gyqB-5xjnA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GYQ_B_SAMB270_0
(RRNA
(ADENOSINE-2'-O-)-ME
THYLTRANSFERASE)		 5xjn CYTOCHROME P450
(Corynebacterium
glutamicum) 		5 / 11 LEU A 176
ALA A 179
GLY A 266
MET A 224
LEU A 259
 None
None
HEM  A 502 (-3.6A)
None
None
 1.16A 3gyqB-5xjnA:
undetectable		 3gyqB-5xjnA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROZ_A_NCAA266_0
(APOLIPOPROTEIN
A-I-BINDING PROTEIN)		 5xjn CYTOCHROME P450
(Corynebacterium
glutamicum) 		4 / 6 LEU A 381
ALA A 386
LEU A 273
THR A 270
 HEM  A 502 ( 4.0A)
None
HEM  A 502 (-2.8A)
HEM  A 502 (-3.6A)
 1.10A 3rozA-5xjnA:
undetectable		 3rozA-5xjnA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UWL_D_FOZD316_0
(THYMIDYLATE SYNTHASE)		 5xjn CYTOCHROME P450
(Corynebacterium
glutamicum) 		5 / 12 HIS A 374
LEU A 367
GLY A 370
PHE A 371
ILE A  67
 HEM  A 502 (-3.7A)
None
HEM  A 502 (-2.9A)
None
None
 1.07A 3uwlD-5xjnA:
undetectable		 3uwlD-5xjnA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R3A_A_RBFA402_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 5xjn CYTOCHROME P450
(Corynebacterium
glutamicum) 		5 / 12 ALA A 126
GLN A 385
ILE A 177
ILE A 139
LEU A 135
 None
 1.15A 4r3aA-5xjnA:
undetectable		 4r3aA-5xjnA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4S0V_A_SUVA2001_2
(HUMAN OREXIN
RECEPTOR TYPE 2
FUSION PROTEIN TO P.
ABYSII GLYCOGEN
SYNTHASE)		 5xjn CYTOCHROME P450
(Corynebacterium
glutamicum) 		4 / 5 ILE A 298
PRO A 299
HIS A 366
VAL A 280
 None
 1.27A 4s0vA-5xjnA:
undetectable		 4s0vA-5xjnA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XJ7_A_ADNA303_1
(5'/3'-NUCLEOTIDASE
SURE)		 5xjn CYTOCHROME P450
(Corynebacterium
glutamicum) 		5 / 10 GLY A 314
ASN A 413
PRO A  31
LEU A 339
LEU A 337
 None
 1.16A 4xj7A-5xjnA:
undetectable
4xj7B-5xjnA:
undetectable		 4xj7A-5xjnA:
22.13
4xj7B-5xjnA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZPH_A_PRLA501_0
(ARYL HYDROCARBON
RECEPTOR NUCLEAR
TRANSLOCATOR
ENDOTHELIAL PAS
DOMAIN-CONTAINING
PROTEIN 1)		 5xjn CYTOCHROME P450
(Corynebacterium
glutamicum) 		4 / 7 VAL A 393
TRP A 426
LEU A 400
SER A 399
 None
 1.00A 4zphA-5xjnA:
undetectable
4zphB-5xjnA:
undetectable		 4zphA-5xjnA:
23.46
4zphB-5xjnA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWX_A_SAMA301_1
(GLYCINE SARCOSINE
N-METHYLTRANSFERASE)		 5xjn CYTOCHROME P450
(Corynebacterium
glutamicum) 		3 / 3 ARG A 345
ASN A  36
ASP A 405
 None
 0.90A 5gwxA-5xjnA:
undetectable		 5gwxA-5xjnA:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JGL_B_SAMB301_0
(UBIE/COQ5 FAMILY
METHYLTRANSFERASE,
PUTATIVE)		 5xjn CYTOCHROME P450
(Corynebacterium
glutamicum) 		5 / 12 ALA A 382
GLY A 378
LEU A 384
ALA A 386
PRO A 299
 HEM  A 502 (-2.9A)
HEM  A 502 (-3.7A)
None
None
None
 0.90A 5jglB-5xjnA:
undetectable		 5jglB-5xjnA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O4Y_A_CCSA14_0
(PHE-MAA-ASN-PRO-HIS-
LEU-SER-TRP-SER-TRP-
9KK-9KK-ARG-CCS-GLY-
NH2)		 5xjn CYTOCHROME P450
(Corynebacterium
glutamicum) 		4 / 6 PHE A 416
LEU A 414
ARG A 411
GLY A 200
 88L  A 501 ( 4.7A)
None
None
None
 1.12A 5o4yA-5xjnA:
undetectable		 5o4yA-5xjnA:
4.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_B_7V7B201_2
(ENDO-1,4-BETA-XYLANA
SE A)		 5xjn CYTOCHROME P450
(Corynebacterium
glutamicum) 		3 / 3 ARG A 417
PRO A 419
TYR A 308
 None
 1.06A 5tzoB-5xjnA:
undetectable		 5tzoB-5xjnA:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_H_RITH602_1
(CYTOCHROME P450 3A5)		 5xjn CYTOCHROME P450
(Corynebacterium
glutamicum) 		5 / 12 SER A 109
GLY A 200
PHE A 264
ALA A 265
THR A 269
 88L  A 501 ( 2.4A)
None
88L  A 501 (-4.2A)
88L  A 501 ( 3.1A)
HEM  A 502 (-3.5A)
 0.65A 5veuH-5xjnA:
30.1		 5veuH-5xjnA:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9Y_A_ACTA412_0
(UNCHARACTERIZED
PROTEIN KDOO)		 5xjn CYTOCHROME P450
(Corynebacterium
glutamicum) 		3 / 3 ARG A 279
PHE A  38
ARG A 417
 None
 0.78A 5y9yA-5xjnA:
undetectable		 5y9yA-5xjnA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YCP_A_BRLA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5xjn CYTOCHROME P450
(Corynebacterium
glutamicum) 		3 / 3 GLY A  28
VAL A  60
MET A  51
 None
 0.64A 5ycpA-5xjnA:
undetectable		 5ycpA-5xjnA:
9.89