SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5xjs'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_F_TFPF211_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 5xjs GEM-ASSOCIATED
PROTEIN 2
(Homo
sapiens) 		4 / 7 LEU 2 222
PHE 2 270
LEU 2 195
PHE 2 110
 None
 1.05A 1wrlE-5xjs2:
undetectable
1wrlF-5xjs2:
undetectable		 1wrlE-5xjs2:
22.34
1wrlF-5xjs2:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA509_0
(CHORISMATE SYNTHASE)		 5xjs GEM-ASSOCIATED
PROTEIN 2
(Homo
sapiens) 		3 / 3 ARG 2 245
GLN 2 103
PRO 2  98
 None
 0.98A 2qhfA-5xjs2:
undetectable		 2qhfA-5xjs2:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MI4_A_SPMA201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 5xjs GEM-ASSOCIATED
PROTEIN 2
(Homo
sapiens) 		4 / 6 ASN 2 200
GLU 2 204
GLU 2 141
GLU 2 142
 None
 1.14A 4mi4A-5xjs2:
undetectable		 4mi4A-5xjs2:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MI4_B_SPMB201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 5xjs GEM-ASSOCIATED
PROTEIN 2
(Homo
sapiens) 		4 / 7 ASN 2 200
GLU 2 204
GLU 2 141
GLU 2 142
 None
 1.14A 4mi4B-5xjs2:
undetectable
4mi4C-5xjs2:
undetectable		 4mi4B-5xjs2:
17.80
4mi4C-5xjs2:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MI4_C_SPMC201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 5xjs GEM-ASSOCIATED
PROTEIN 2
(Homo
sapiens) 		4 / 7 ASN 2 200
GLU 2 204
GLU 2 141
GLU 2 142
 None
 1.15A 4mi4A-5xjs2:
undetectable
4mi4C-5xjs2:
undetectable		 4mi4A-5xjs2:
17.80
4mi4C-5xjs2:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_A_SPMA201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 5xjs GEM-ASSOCIATED
PROTEIN 2
(Homo
sapiens) 		4 / 8 ASN 2 200
GLU 2 204
GLU 2 141
GLU 2 142
 None
 1.17A 4mj8A-5xjs2:
undetectable
4mj8C-5xjs2:
undetectable		 4mj8A-5xjs2:
18.24
4mj8C-5xjs2:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_B_SPMB201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 5xjs GEM-ASSOCIATED
PROTEIN 2
(Homo
sapiens) 		4 / 8 ASN 2 200
GLU 2 204
GLU 2 141
GLU 2 142
 None
 1.16A 4mj8B-5xjs2:
undetectable
4mj8C-5xjs2:
undetectable		 4mj8B-5xjs2:
18.24
4mj8C-5xjs2:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_C_SPMC201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 5xjs GEM-ASSOCIATED
PROTEIN 2
(Homo
sapiens) 		4 / 7 ASN 2 200
GLU 2 204
GLU 2 141
GLU 2 142
 None
 1.28A 4mj8C-5xjs2:
undetectable		 4mj8C-5xjs2:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_F_4LEF401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 5xjs GEM-ASSOCIATED
PROTEIN 2
(Homo
sapiens) 		4 / 8 LEU 2 233
LEU 2 219
THR 2 192
LEU 2 195
 None
 0.75A 4z90F-5xjs2:
2.5
4z90G-5xjs2:
2.5
4z90H-5xjs2:
2.5
4z90I-5xjs2:
2.4
4z90J-5xjs2:
2.4		 4z90F-5xjs2:
13.61
4z90G-5xjs2:
13.61
4z90H-5xjs2:
13.61
4z90I-5xjs2:
13.61
4z90J-5xjs2:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UAN_B_REAB503_1
(RETINOIC ACID
RECEPTOR BETA)		 5xjs GEM-ASSOCIATED
PROTEIN 2
(Homo
sapiens) 		5 / 12 CYH 2 241
LEU 2 233
LEU 2 237
ILE 2 234
LEU 2 222
 None
 1.43A 5uanB-5xjs2:
undetectable		 5uanB-5xjs2:
14.04