SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5xjy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBM_B_RTLB951_1
(PROTEIN (CARTILAGE
OLIGOMERIC MATRIX
PROTEIN))		 5xjy ATP-BINDING CASSETTE
SUB-FAMILY A MEMBER
1
(Homo
sapiens) 		4 / 4 THR A  22
LEU A  26
VAL A  29
LEU A  33
 None
 0.91A 1fbmB-5xjyA:
undetectable		 1fbmB-5xjyA:
1.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM4_A_DXCA1001_0
(MAJOR POLLEN
ALLERGEN BET V 1-L)		 5xjy ATP-BINDING CASSETTE
SUB-FAMILY A MEMBER
1
(Homo
sapiens) 		5 / 12 THR A1401
ILE A1613
ALA A  64
SER A  63
MET A  61
 None
 1.09A 1fm4A-5xjyA:
undetectable		 1fm4A-5xjyA:
5.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GRM_A_DVAA6_0
(GRAMICIDIN A)		 5xjy ATP-BINDING CASSETTE
SUB-FAMILY A MEMBER
1
(Homo
sapiens) 		3 / 3 ALA A 594
VAL A 599
TRP A  69
 None
 0.93A 1grmA-5xjyA:
undetectable		 1grmA-5xjyA:
1.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GRM_B_DVAB6_0
(GRAMICIDIN A)		 5xjy ATP-BINDING CASSETTE
SUB-FAMILY A MEMBER
1
(Homo
sapiens) 		3 / 3 ALA A 594
VAL A 599
TRP A  69
 None
 0.93A 1grmB-5xjyA:
undetectable		 1grmB-5xjyA:
1.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M4G_A_RIOA500_0
(AMINOGLYCOSIDE
2'-N-ACETYLTRANSFERA
SE)		 5xjy ATP-BINDING CASSETTE
SUB-FAMILY A MEMBER
1
(Homo
sapiens) 		5 / 9 ASP A 571
GLU A1529
GLY A1598
ASP A 629
ASP A 575
 None
 1.47A 1m4gA-5xjyA:
undetectable		 1m4gA-5xjyA:
6.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M4G_B_RIOB501_0
(AMINOGLYCOSIDE
2'-N-ACETYLTRANSFERA
SE)		 5xjy ATP-BINDING CASSETTE
SUB-FAMILY A MEMBER
1
(Homo
sapiens) 		5 / 9 ASP A 571
GLU A1529
GLY A1598
ASP A 629
ASP A 575
 None
 1.44A 1m4gB-5xjyA:
undetectable		 1m4gB-5xjyA:
6.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2D55_C_DVAC8_0
(ACTINOMYCIN D)		 5xjy ATP-BINDING CASSETTE
SUB-FAMILY A MEMBER
1
(Homo
sapiens) 		3 / 3 PRO A  62
THR A  66
PRO A  68
 None
 0.81A 2d55C-5xjyA:
undetectable		 2d55C-5xjyA:
0.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_2
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 5xjy ATP-BINDING CASSETTE
SUB-FAMILY A MEMBER
1
(Homo
sapiens) 		4 / 6 PHE A1580
ARG A1579
ASN A1552
ASN A1588
 None
 1.27A 2nyrA-5xjyA:
undetectable		 2nyrA-5xjyA:
7.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VL2_B_BEZB1162_0
(PEROXIREDOXIN-5)		 5xjy ATP-BINDING CASSETTE
SUB-FAMILY A MEMBER
1
(Homo
sapiens) 		4 / 7 PRO A  57
THR A  86
PRO A  87
GLY A  88
 None
 0.96A 2vl2B-5xjyA:
undetectable		 2vl2B-5xjyA:
6.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_A_486A3_1
(GLUCOCORTICOID
RECEPTOR)		 5xjy ATP-BINDING CASSETTE
SUB-FAMILY A MEMBER
1
(Homo
sapiens) 		5 / 12 LEU A1614
ASN A1611
GLN A 602
VAL A 617
ARG A 606
 None
 1.30A 3h52A-5xjyA:
undetectable		 3h52A-5xjyA:
7.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PRS_A_RITA1001_2
(ENDOTHIAPEPSIN)		 5xjy ATP-BINDING CASSETTE
SUB-FAMILY A MEMBER
1
(Homo
sapiens) 		5 / 12 ASP A 571
GLY A1533
ASP A 585
PHE A1390
TYR A1513
 None
 1.15A 3prsA-5xjyA:
undetectable		 3prsA-5xjyA:
9.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_A_W9TA1012_1
(HEMOLYTIC LECTIN
CEL-III)		 5xjy ATP-BINDING CASSETTE
SUB-FAMILY A MEMBER
1
(Homo
sapiens) 		4 / 4 ASP A 575
GLY A 577
TRP A 574
ASP A 571
 None
 1.18A 3w9tA-5xjyA:
0.0		 3w9tA-5xjyA:
11.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB501_1
(HEMOLYTIC LECTIN
CEL-III)		 5xjy ATP-BINDING CASSETTE
SUB-FAMILY A MEMBER
1
(Homo
sapiens) 		4 / 5 ASP A 575
GLY A 577
TRP A 574
ASP A 571
 None
 1.19A 3w9tB-5xjyA:
undetectable		 3w9tB-5xjyA:
11.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_C_W9TC1003_1
(HEMOLYTIC LECTIN
CEL-III)		 5xjy ATP-BINDING CASSETTE
SUB-FAMILY A MEMBER
1
(Homo
sapiens) 		4 / 5 ASP A 575
GLY A 577
TRP A 574
ASP A 571
 None
 1.19A 3w9tC-5xjyA:
undetectable		 3w9tC-5xjyA:
11.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_D_W9TD501_1
(HEMOLYTIC LECTIN
CEL-III)		 5xjy ATP-BINDING CASSETTE
SUB-FAMILY A MEMBER
1
(Homo
sapiens) 		4 / 5 ASP A 575
GLY A 577
TRP A 574
ASP A 571
 None
 1.18A 3w9tD-5xjyA:
undetectable		 3w9tD-5xjyA:
11.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_E_W9TE501_1
(HEMOLYTIC LECTIN
CEL-III)		 5xjy ATP-BINDING CASSETTE
SUB-FAMILY A MEMBER
1
(Homo
sapiens) 		4 / 4 ASP A 575
GLY A 577
TRP A 574
ASP A 571
 None
 1.17A 3w9tE-5xjyA:
0.0		 3w9tE-5xjyA:
11.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_G_W9TG501_1
(HEMOLYTIC LECTIN
CEL-III)		 5xjy ATP-BINDING CASSETTE
SUB-FAMILY A MEMBER
1
(Homo
sapiens) 		4 / 4 ASP A 575
GLY A 577
TRP A 574
ASP A 571
 None
 1.19A 3w9tG-5xjyA:
0.0		 3w9tG-5xjyA:
11.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A83_A_DXCA1160_0
(MAJOR POLLEN
ALLERGEN BET V 1-A)		 5xjy ATP-BINDING CASSETTE
SUB-FAMILY A MEMBER
1
(Homo
sapiens) 		5 / 12 LEU A1404
ILE A1613
ALA A  64
SER A  63
MET A  61
 None
 1.30A 4a83A-5xjyA:
undetectable		 4a83A-5xjyA:
5.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_I_ZPCI1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5xjy ATP-BINDING CASSETTE
SUB-FAMILY A MEMBER
1
(Homo
sapiens) 		4 / 6 ILE A1677
PHE A1675
HIS A1686
VAL A1693
 None
 1.17A 4a97I-5xjyA:
3.0		 4a97I-5xjyA:
9.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DV1_A_SRYA1601_1
(16S RRNA
RIBOSOMAL PROTEIN
S12)		 5xjy ATP-BINDING CASSETTE
SUB-FAMILY A MEMBER
1
(Homo
sapiens) 		3 / 3 LYS A 373
LYS A 376
PRO A 377
 None
 1.25A 4dv1L-5xjyA:
undetectable		 4dv1L-5xjyA:
4.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEU_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 5xjy ATP-BINDING CASSETTE
SUB-FAMILY A MEMBER
1
(Homo
sapiens) 		4 / 8 ASP A 585
ASP A 575
ASP A 629
ASP A 571
 None
 1.12A 4feuD-5xjyA:
2.2		 4feuD-5xjyA:
7.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_A_ADNA402_1
(PROBABLE SUGAR
KINASE PROTEIN)		 5xjy ATP-BINDING CASSETTE
SUB-FAMILY A MEMBER
1
(Homo
sapiens) 		5 / 10 GLU A 662
ILE A 655
ALA A 746
ALA A 747
ILE A 656
 None
 0.96A 4lbgA-5xjyA:
undetectable		 4lbgA-5xjyA:
9.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M5M_A_DX4A401_0
(2-AMINO-4-HYDROXY-6-
HYDROXYMETHYLDIHYDRO
PTERIDINE
PYROPHOSPHOKINASE)		 5xjy ATP-BINDING CASSETTE
SUB-FAMILY A MEMBER
1
(Homo
sapiens) 		4 / 8 THR A 566
LEU A1377
ASN A1633
ARG A 557
 None
 1.18A 4m5mA-5xjyA:
undetectable		 4m5mA-5xjyA:
5.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGH_B_SAMB401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 5xjy ATP-BINDING CASSETTE
SUB-FAMILY A MEMBER
1
(Homo
sapiens) 		5 / 12 SER A1376
THR A 566
LEU A1606
ASP A 598
ILE A 556
 None
 1.35A 4pghB-5xjyA:
undetectable		 4pghB-5xjyA:
9.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_A_HFGA803_1
(PROLINE--TRNA LIGASE)		 5xjy ATP-BINDING CASSETTE
SUB-FAMILY A MEMBER
1
(Homo
sapiens) 		3 / 3 GLU A1420
THR A1630
HIS A 551
 None
 0.78A 4q15A-5xjyA:
undetectable		 4q15A-5xjyA:
12.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_B_HFGB803_1
(PROLINE--TRNA LIGASE)		 5xjy ATP-BINDING CASSETTE
SUB-FAMILY A MEMBER
1
(Homo
sapiens) 		3 / 3 GLU A1420
THR A1630
HIS A 551
 None
 0.77A 4q15B-5xjyA:
2.3		 4q15B-5xjyA:
12.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YDQ_B_HFGB802_1
(PROLINE--TRNA LIGASE)		 5xjy ATP-BINDING CASSETTE
SUB-FAMILY A MEMBER
1
(Homo
sapiens) 		3 / 3 GLU A1420
THR A1630
HIS A 551
 None
 0.76A 4ydqB-5xjyA:
2.2		 4ydqB-5xjyA:
11.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BPH_A_ACTA403_0
(D-ALANINE--D-ALANINE
LIGASE)		 5xjy ATP-BINDING CASSETTE
SUB-FAMILY A MEMBER
1
(Homo
sapiens) 		4 / 6 ARG A1503
GLY A1502
SER A1392
LEU A1500
 None
 1.29A 5bphA-5xjyA:
undetectable		 5bphA-5xjyA:
9.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWA_A_GCSA302_1
(CHITOSANASE)		 5xjy ATP-BINDING CASSETTE
SUB-FAMILY A MEMBER
1
(Homo
sapiens) 		4 / 7 ARG A 579
ASP A 575
TYR A 573
GLY A 572
 None
 1.06A 5hwaA-5xjyA:
undetectable		 5hwaA-5xjyA:
7.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5xjy ATP-BINDING CASSETTE
SUB-FAMILY A MEMBER
1
(Homo
sapiens) 		5 / 12 VAL A1769
VAL A1673
LEU A1676
TRP A1699
ALA A1756
 None
 1.19A 5iktB-5xjyA:
undetectable		 5iktB-5xjyA:
13.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0T_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 5xjy ATP-BINDING CASSETTE
SUB-FAMILY A MEMBER
1
(Homo
sapiens) 		4 / 5 TYR A 588
SER A1604
ALA A1601
GLN A 621
 None
 1.41A 5n0tA-5xjyA:
2.8		 5n0tA-5xjyA:
10.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWW_A_ACAA18_1
(SCRFP-TAG,GP41)		 5xjy ATP-BINDING CASSETTE
SUB-FAMILY A MEMBER
1
(Homo
sapiens) 		5 / 12 LYS A1410
LEU A1405
LEU A1404
GLU A1403
LEU A1402
 None
 1.25A 5nwwA-5xjyA:
undetectable		 5nwwA-5xjyA:
1.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRF_D_EVPD101_1
()		 5xjy ATP-BINDING CASSETTE
SUB-FAMILY A MEMBER
1
(Homo
sapiens) 		4 / 5 GLY A 592
ARG A 587
GLN A1380
MET A1383
 None
 1.05A 5zrfB-5xjyA:
undetectable		 5zrfB-5xjyA:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A7P_B_9SCB601_1
(SERUM ALBUMIN)		 5xjy ATP-BINDING CASSETTE
SUB-FAMILY A MEMBER
1
(Homo
sapiens) 		4 / 6 ASN A1709
CYH A1708
PHE A1672
SER A1343
 None
 1.27A 6a7pB-5xjyA:
undetectable		 6a7pB-5xjyA:
13.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_A_ZOTA3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 5xjy ATP-BINDING CASSETTE
SUB-FAMILY A MEMBER
1
(Homo
sapiens) 		5 / 12 LEU A 722
SER A 637
PHE A 632
PHE A  36
PHE A 643
 None
 1.44A 6a94A-5xjyA:
undetectable		 6a94A-5xjyA:
10.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CM4_A_8NUA2001_1
(D(2) DOPAMINE
RECEPTOR, ENDOLYSIN
CHIMERA)		 5xjy ATP-BINDING CASSETTE
SUB-FAMILY A MEMBER
1
(Homo
sapiens) 		4 / 4 ASP A1706
ALA A1766
SER A1757
PHE A1675
 None
 1.40A 6cm4A-5xjyA:
1.3		 6cm4A-5xjyA:
11.75