SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5xk2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GM7_B_PNNB1577_0
(PENICILLIN G ACYLASE
ALPHA SUBUNIT
PENICILLIN G ACYLASE
BETA SUBUNIT)		 5xk2 DIACYLGLYCEROL
LIPASE
(Aspergillus
oryzae) 		4 / 8 SER A  57
ALA A  76
PHE A  74
ILE A  84
 None
 1.16A 1gm7A-5xk2A:
undetectable
1gm7B-5xk2A:
undetectable		 1gm7A-5xk2A:
undetectable
1gm7B-5xk2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_B_CHDB2501_0
(FERROCHELATASE)		 5xk2 DIACYLGLYCEROL
LIPASE
(Aspergillus
oryzae) 		5 / 12 LEU A 211
PHE A 103
LEU A 213
MET A 216
ILE A  94
 None
 1.39A 1hrkB-5xk2A:
undetectable		 1hrkB-5xk2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_1
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 5xk2 DIACYLGLYCEROL
LIPASE
(Aspergillus
oryzae) 		5 / 12 ALA A 116
ALA A 180
ALA A 177
ILE A 192
LEU A 166
 None
 1.14A 2nyrA-5xk2A:
undetectable		 2nyrA-5xk2A:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VUF_B_FUAB2002_1
(SERUM ALBUMIN)		 5xk2 DIACYLGLYCEROL
LIPASE
(Aspergillus
oryzae) 		4 / 9 ILE A 192
ARG A 200
ALA A 157
VAL A 183
 None
 1.05A 2vufB-5xk2A:
undetectable		 2vufB-5xk2A:
10.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AVP_A_MV2A313_1
(PANTOTHENATE KINASE)		 5xk2 DIACYLGLYCEROL
LIPASE
(Aspergillus
oryzae) 		4 / 7 VAL A  77
ASP A  38
TYR A 145
ASN A  79
 None
 1.03A 3avpA-5xk2A:
undetectable		 3avpA-5xk2A:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB3_A_SAMA1102_1
(STRUCTURAL PROTEIN
VP3)		 5xk2 DIACYLGLYCEROL
LIPASE
(Aspergillus
oryzae) 		3 / 3 ARG A 128
ASP A 136
ASP A 129
 None
 0.92A 3jb3A-5xk2A:
undetectable		 3jb3A-5xk2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSF_H_PZIH800_0
(GLUTAMATE RECEPTOR 2)		 5xk2 DIACYLGLYCEROL
LIPASE
(Aspergillus
oryzae) 		4 / 8 TYR A 226
PRO A 207
SER A 267
SER A 256
 None
 1.07A 3lsfH-5xk2A:
undetectable		 3lsfH-5xk2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBR_A_ACTA608_0
(SERUM ALBUMIN)		 5xk2 DIACYLGLYCEROL
LIPASE
(Aspergillus
oryzae) 		3 / 3 LYS A 186
ARG A 182
HIS A 220
 None
 1.12A 4zbrA-5xk2A:
undetectable		 4zbrA-5xk2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JGL_B_SAMB301_0
(UBIE/COQ5 FAMILY
METHYLTRANSFERASE,
PUTATIVE)		 5xk2 DIACYLGLYCEROL
LIPASE
(Aspergillus
oryzae) 		5 / 12 TYR A  29
ALA A 159
LEU A 161
ALA A  87
GLY A 151
 None
 1.45A 5jglB-5xk2A:
undetectable		 5jglB-5xk2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_B_7V7B202_1
(ENDO-1,4-BETA-XYLANA
SE A)		 5xk2 DIACYLGLYCEROL
LIPASE
(Aspergillus
oryzae) 		4 / 8 TRP A 121
THR A 168
ARG A 167
GLN A 195
 None
 1.41A 5tzoB-5xk2A:
undetectable		 5tzoB-5xk2A:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6I_A_8PRA509_1
(ENVELOPE
GLYCOPROTEIN,GP,GP1
ENVELOPE
GLYCOPROTEIN)		 5xk2 DIACYLGLYCEROL
LIPASE
(Aspergillus
oryzae) 		5 / 12 VAL A  52
LEU A  42
ALA A  55
GLY A  56
THR A  80
 None
 1.16A 6f6iA-5xk2A:
undetectable
6f6iB-5xk2A:
undetectable		 6f6iA-5xk2A:
22.73
6f6iB-5xk2A:
23.96