SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5xkl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXB_A_ROCA100_2
(HIV-1 PROTEASE)		 5xkl ESX-3
SECRETION-ASSOCIATED
PROTEIN ESPG3
(Mycobacterium
tuberculosis) 		3 / 3 ARG A  87
THR A 226
VAL A 214
 SO4  A 301 (-3.5A)
None
None
 0.89A 1hxbA-5xklA:
undetectable		 1hxbA-5xklA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N4F_A_ASRA141_0
(LYSOZYME C)		 5xkl ESX-3
SECRETION-ASSOCIATED
PROTEIN ESPG3
(Mycobacterium
tuberculosis) 		4 / 6 GLY A 170
THR A 167
PRO A 166
SER A 254
 None
 0.85A 1n4fA-5xklA:
undetectable		 1n4fA-5xklA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_D_FUAD705_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5xkl ESX-3
SECRETION-ASSOCIATED
PROTEIN ESPG3
(Mycobacterium
tuberculosis) 		5 / 12 SER A 231
PHE A 163
LEU A 165
VAL A 169
ALA A 171
 None
 1.42A 1q23D-5xklA:
undetectable
1q23E-5xklA:
undetectable		 1q23D-5xklA:
18.52
1q23E-5xklA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G70_A_SAMA2001_0
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 5xkl ESX-3
SECRETION-ASSOCIATED
PROTEIN ESPG3
(Mycobacterium
tuberculosis) 		5 / 12 TYR A  88
GLN A 279
LEU A 125
VAL A  30
ALA A 215
 None
 1.43A 2g70A-5xklA:
undetectable		 2g70A-5xklA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QAK_A_1UNA1001_2
(PROTEASE RETROPEPSIN)		 5xkl ESX-3
SECRETION-ASSOCIATED
PROTEIN ESPG3
(Mycobacterium
tuberculosis) 		3 / 3 ARG A  87
THR A 226
VAL A 214
 SO4  A 301 (-3.5A)
None
None
 0.82A 2qakA-5xklA:
undetectable		 2qakA-5xklA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V95_A_HCYA1375_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 5xkl ESX-3
SECRETION-ASSOCIATED
PROTEIN ESPG3
(Mycobacterium
tuberculosis) 		5 / 12 ALA A 106
ILE A  74
ASP A  72
PHE A 133
LYS A   6
 None
 1.26A 2v95A-5xklA:
undetectable		 2v95A-5xklA:
12.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V95_A_HCYA1375_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 5xkl ESX-3
SECRETION-ASSOCIATED
PROTEIN ESPG3
(Mycobacterium
tuberculosis) 		5 / 12 ALA A 106
VAL A  77
ASP A  72
PHE A 133
LYS A   6
 None
 1.30A 2v95A-5xklA:
undetectable		 2v95A-5xklA:
12.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNW_B_RTZB602_1
(CYTOCHROME P450 2D6)		 5xkl ESX-3
SECRETION-ASSOCIATED
PROTEIN ESPG3
(Mycobacterium
tuberculosis) 		5 / 12 GLY A 229
ALA A 171
ASP A 174
VAL A 242
VAL A  89
 None
 1.04A 4wnwB-5xklA:
undetectable		 4wnwB-5xklA:
11.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y8W_C_STRC603_1
(CYTOCHROME P450
21-HYDROXYLASE)		 5xkl ESX-3
SECRETION-ASSOCIATED
PROTEIN ESPG3
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 144
ILE A 104
GLY A 103
VAL A 211
LEU A 148
 None
 1.01A 4y8wC-5xklA:
undetectable		 4y8wC-5xklA:
10.92