SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5xko'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4001_1
(SERUM ALBUMIN)		 5xko CYTIDINE/DEOXYCYTIDY
LATE DEAMINASE,
ZINC-BINDING REGION
(Mycolicibacteriu
m
smegmatis) 		4 / 5 ARG A  47
ALA A  21
ASP A  44
GLY A  30
 None
 1.21A 1e7cA-5xkoA:
undetectable		 1e7cA-5xkoA:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_A_AG2A7005_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 5xko CYTIDINE/DEOXYCYTIDY
LATE DEAMINASE,
ZINC-BINDING REGION
(Mycolicibacteriu
m
smegmatis) 		4 / 6 LEU A   8
ASP A   7
GLU A 144
ARG A 100
 None
 0.75A 1mt1A-5xkoA:
undetectable
1mt1F-5xkoA:
undetectable		 1mt1A-5xkoA:
13.55
1mt1F-5xkoA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_B_AG2B7001_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 5xko CYTIDINE/DEOXYCYTIDY
LATE DEAMINASE,
ZINC-BINDING REGION
(Mycolicibacteriu
m
smegmatis) 		4 / 6 GLU A 144
ARG A 100
LEU A   8
ASP A   7
 None
 0.91A 1mt1B-5xkoA:
undetectable
1mt1C-5xkoA:
undetectable		 1mt1B-5xkoA:
16.88
1mt1C-5xkoA:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_B_AG2B7011_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 5xko CYTIDINE/DEOXYCYTIDY
LATE DEAMINASE,
ZINC-BINDING REGION
(Mycolicibacteriu
m
smegmatis) 		4 / 5 GLU A 144
ARG A 100
LEU A   8
ASP A   7
 None
 0.85A 1n13B-5xkoA:
undetectable
1n13C-5xkoA:
undetectable		 1n13B-5xkoA:
16.88
1n13C-5xkoA:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_H_AG2H7012_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 5xko CYTIDINE/DEOXYCYTIDY
LATE DEAMINASE,
ZINC-BINDING REGION
(Mycolicibacteriu
m
smegmatis) 		4 / 6 GLU A 144
ARG A 100
LEU A   8
ASP A   7
 None
 0.79A 1n13H-5xkoA:
undetectable
1n13K-5xkoA:
undetectable		 1n13H-5xkoA:
16.88
1n13K-5xkoA:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_J_AG2J7013_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 5xko CYTIDINE/DEOXYCYTIDY
LATE DEAMINASE,
ZINC-BINDING REGION
(Mycolicibacteriu
m
smegmatis) 		4 / 7 LEU A   8
ASP A   7
GLU A 144
ARG A 100
 None
 0.85A 1n13G-5xkoA:
undetectable
1n13J-5xkoA:
undetectable		 1n13G-5xkoA:
13.55
1n13J-5xkoA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_L_AG2L7014_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 5xko CYTIDINE/DEOXYCYTIDY
LATE DEAMINASE,
ZINC-BINDING REGION
(Mycolicibacteriu
m
smegmatis) 		4 / 7 LEU A   8
ASP A   7
GLU A 144
ARG A 100
 None
 0.82A 1n13I-5xkoA:
undetectable
1n13L-5xkoA:
undetectable		 1n13I-5xkoA:
13.55
1n13L-5xkoA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQD_A_AG2A671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 5xko CYTIDINE/DEOXYCYTIDY
LATE DEAMINASE,
ZINC-BINDING REGION
(Mycolicibacteriu
m
smegmatis) 		4 / 7 LEU A   8
ASP A   7
GLU A 144
ARG A 100
 None
 0.76A 2qqdA-5xkoA:
undetectable
2qqdE-5xkoA:
undetectable		 2qqdA-5xkoA:
21.36
2qqdE-5xkoA:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQD_B_AG2B671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 5xko CYTIDINE/DEOXYCYTIDY
LATE DEAMINASE,
ZINC-BINDING REGION
(Mycolicibacteriu
m
smegmatis) 		4 / 8 GLU A 144
ARG A 100
LEU A   8
ASP A   7
 None
 0.92A 2qqdB-5xkoA:
undetectable
2qqdC-5xkoA:
undetectable		 2qqdB-5xkoA:
16.35
2qqdC-5xkoA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB200_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 5xko CYTIDINE/DEOXYCYTIDY
LATE DEAMINASE,
ZINC-BINDING REGION
(Mycolicibacteriu
m
smegmatis) 		4 / 5 PRO A 123
VAL A 124
THR A 105
GLY A  83
 None
None
None
CAC  A 201 (-4.1A)
 0.90A 3elzB-5xkoA:
undetectable		 3elzB-5xkoA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U52_A_CUA515_0
(PHENOL HYDROXYLASE
COMPONENT PHL
PHENOL HYDROXYLASE
COMPONENT PHN)		 5xko CYTIDINE/DEOXYCYTIDY
LATE DEAMINASE,
ZINC-BINDING REGION
(Mycolicibacteriu
m
smegmatis) 		3 / 3 HIS A  93
HIS A  85
ILE A 129
 None
 0.71A 3u52A-5xkoA:
undetectable
3u52C-5xkoA:
undetectable		 3u52A-5xkoA:
14.29
3u52C-5xkoA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_R_BEZR801_1
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 5xko CYTIDINE/DEOXYCYTIDY
LATE DEAMINASE,
ZINC-BINDING REGION
(Mycolicibacteriu
m
smegmatis) 		4 / 8 PHE A  29
ALA A  21
PRO A  57
LEU A  17
 CAC  A 201 (-3.8A)
None
CAC  A 201 (-4.5A)
None
 1.19A 5dzkd-5xkoA:
undetectable
5dzkr-5xkoA:
undetectable		 5dzkd-5xkoA:
26.18
5dzkr-5xkoA:
5.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YOD_B_BEZB201_0
(NS3 PROTEASE)		 5xko CYTIDINE/DEOXYCYTIDY
LATE DEAMINASE,
ZINC-BINDING REGION
(Mycolicibacteriu
m
smegmatis) 		4 / 5 ALA A  18
SER A  82
GLY A  83
TYR A 153
 None
None
CAC  A 201 (-4.1A)
None
 1.06A 5yodB-5xkoA:
undetectable		 5yodB-5xkoA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YOD_D_BEZD201_0
(NS3 PROTEASE)		 5xko CYTIDINE/DEOXYCYTIDY
LATE DEAMINASE,
ZINC-BINDING REGION
(Mycolicibacteriu
m
smegmatis) 		4 / 5 ALA A  18
SER A  82
GLY A  83
TYR A 153
 None
None
CAC  A 201 (-4.1A)
None
 0.99A 5yodD-5xkoA:
undetectable		 5yodD-5xkoA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AK3_A_P2EA1201_0
(PROSTAGLANDIN E2
RECEPTOR EP3
SUBTYPE,SOLUBLE
CYTOCHROME B562)		 5xko CYTIDINE/DEOXYCYTIDY
LATE DEAMINASE,
ZINC-BINDING REGION
(Mycolicibacteriu
m
smegmatis) 		5 / 12 THR A  39
THR A  40
VAL A  34
TYR A  80
THR A  78
 None
 1.47A 6ak3A-5xkoA:
undetectable		 6ak3A-5xkoA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_D_AM2D301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 5xko CYTIDINE/DEOXYCYTIDY
LATE DEAMINASE,
ZINC-BINDING REGION
(Mycolicibacteriu
m
smegmatis) 		4 / 8 ASP A  44
ARG A  45
GLU A  20
ASP A  24
 None
 1.17A 6mn4D-5xkoA:
undetectable		 6mn4D-5xkoA:
23.81