SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5xks'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A8U_A_BEZA295_0
(CHLOROPEROXIDASE T)		 5xks THERMOSTABLE
MONOACYLGLYCEROL
LIPASE
(Geobacillus
sp.
12AMOR1) 		5 / 10 GLY A  28
PHE A  29
SER A  97
MET A  98
HIS A 226
 None
 0.73A 1a8uA-5xksA:
21.3		 1a8uA-5xksA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A8U_B_BEZB294_0
(CHLOROPEROXIDASE T)		 5xks THERMOSTABLE
MONOACYLGLYCEROL
LIPASE
(Geobacillus
sp.
12AMOR1) 		5 / 10 GLY A  28
PHE A  29
SER A  97
MET A  98
HIS A 226
 None
 0.72A 1a8uB-5xksA:
21.0		 1a8uB-5xksA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ8_A_CAMA503_0
(CYTOCHROME P450-CAM)		 5xks THERMOSTABLE
MONOACYLGLYCEROL
LIPASE
(Geobacillus
sp.
12AMOR1) 		5 / 9 PHE A 245
LEU A  39
VAL A  25
GLY A  95
THR A 103
 None
 1.25A 1dz8A-5xksA:
undetectable		 1dz8A-5xksA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ8_B_CAMB502_0
(CYTOCHROME P450-CAM)		 5xks THERMOSTABLE
MONOACYLGLYCEROL
LIPASE
(Geobacillus
sp.
12AMOR1) 		5 / 9 PHE A 245
LEU A  39
VAL A  25
GLY A  95
THR A 103
 None
 1.27A 1dz8B-5xksA:
undetectable		 1dz8B-5xksA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ9_A_CAMA503_0
(CYTOCHROME P450-CAM)		 5xks THERMOSTABLE
MONOACYLGLYCEROL
LIPASE
(Geobacillus
sp.
12AMOR1) 		4 / 8 PHE A 245
LEU A  39
VAL A  25
THR A 103
 None
 0.98A 1dz9A-5xksA:
undetectable		 1dz9A-5xksA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ9_B_CAMB502_0
(CYTOCHROME P450-CAM)		 5xks THERMOSTABLE
MONOACYLGLYCEROL
LIPASE
(Geobacillus
sp.
12AMOR1) 		5 / 9 PHE A 245
LEU A  39
VAL A  25
GLY A  95
THR A 103
 None
 1.26A 1dz9B-5xksA:
undetectable		 1dz9B-5xksA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O76_B_CAMB1420_0
(CYTOCHROME P450-CAM)		 5xks THERMOSTABLE
MONOACYLGLYCEROL
LIPASE
(Geobacillus
sp.
12AMOR1) 		4 / 8 PHE A 245
LEU A  39
VAL A  25
THR A 103
 None
 0.96A 1o76B-5xksA:
undetectable		 1o76B-5xksA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OQ5_A_CELA701_2
(CARBONIC ANHYDRASE
II)		 5xks THERMOSTABLE
MONOACYLGLYCEROL
LIPASE
(Geobacillus
sp.
12AMOR1) 		4 / 4 HIS A 226
VAL A 227
THR A  30
LEU A 157
 None
 1.06A 1oq5A-5xksA:
undetectable		 1oq5A-5xksA:
12.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UYU_A_CAMA1416_0
(CYTOCHROME P450-CAM)		 5xks THERMOSTABLE
MONOACYLGLYCEROL
LIPASE
(Geobacillus
sp.
12AMOR1) 		4 / 8 PHE A 245
LEU A  39
VAL A  25
THR A 103
 None
 1.14A 1uyuA-5xksA:
undetectable		 1uyuA-5xksA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1N_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 5xks THERMOSTABLE
MONOACYLGLYCEROL
LIPASE
(Geobacillus
sp.
12AMOR1) 		5 / 11 PHE A 245
LEU A  39
VAL A  25
GLY A  95
THR A 103
 None
 1.27A 2a1nA-5xksA:
undetectable		 2a1nA-5xksA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HW2_A_RFPA1200_1
(RIFAMPIN ADP-RIBOSYL
TRANSFERASE)		 5xks THERMOSTABLE
MONOACYLGLYCEROL
LIPASE
(Geobacillus
sp.
12AMOR1) 		5 / 12 ALA A 117
GLY A 115
SER A 241
GLY A  80
LEU A  84
 None
 0.97A 2hw2A-5xksA:
undetectable		 2hw2A-5xksA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IB2_A_IBPA3960_1
(LACTOTRANSFERRIN)		 5xks THERMOSTABLE
MONOACYLGLYCEROL
LIPASE
(Geobacillus
sp.
12AMOR1) 		4 / 4 GLY A  10
VAL A   8
GLY A  31
THR A  30
 None
 0.68A 3ib2A-5xksA:
undetectable		 3ib2A-5xksA:
11.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_C_PM6C1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 5xks THERMOSTABLE
MONOACYLGLYCEROL
LIPASE
(Geobacillus
sp.
12AMOR1) 		4 / 6 GLU A  66
PHE A 141
ALA A 165
ALA A 164
 None
 1.12A 3ns1C-5xksA:
undetectable		 3ns1C-5xksA:
6.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L7I_B_SAMB501_0
(S-ADENOSYLMETHIONINE
SYNTHASE)		 5xks THERMOSTABLE
MONOACYLGLYCEROL
LIPASE
(Geobacillus
sp.
12AMOR1) 		5 / 8 ARG A 220
ASP A 233
LEU A 221
ASN A 120
ILE A 119
 None
 1.46A 4l7iA-5xksA:
undetectable		 4l7iA-5xksA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1K_D_LOCD502_2
(TUBULIN BETA CHAIN)		 5xks THERMOSTABLE
MONOACYLGLYCEROL
LIPASE
(Geobacillus
sp.
12AMOR1) 		5 / 12 LEU A 221
LEU A 218
THR A 103
ALA A 121
ALA A 204
 None
 1.11A 4x1kD-5xksA:
undetectable		 4x1kD-5xksA:
11.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CP4_A_CAMA422_0
(CYTOCHROME P450CAM)		 5xks THERMOSTABLE
MONOACYLGLYCEROL
LIPASE
(Geobacillus
sp.
12AMOR1) 		5 / 9 PHE A 245
LEU A  39
VAL A  25
GLY A  95
THR A 103
 None
 1.36A 5cp4A-5xksA:
undetectable		 5cp4A-5xksA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NN4_A_SC2A1016_1
(LYSOSOMAL
ALPHA-GLUCOSIDASE)		 5xks THERMOSTABLE
MONOACYLGLYCEROL
LIPASE
(Geobacillus
sp.
12AMOR1) 		4 / 4 HIS A  27
GLY A  59
ARG A  54
THR A  60
 None
 1.46A 5nn4A-5xksA:
1.7		 5nn4A-5xksA:
7.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VW4_A_NCAA403_0
(FERREDOXIN--NADP
REDUCTASE)		 5xks THERMOSTABLE
MONOACYLGLYCEROL
LIPASE
(Geobacillus
sp.
12AMOR1) 		5 / 9 THR A  30
GLY A  31
ALA A 158
GLY A  28
SER A  97
 None
 0.67A 5vw4A-5xksA:
undetectable		 5vw4A-5xksA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YBB_A_SAMA601_0
(TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT)		 5xks THERMOSTABLE
MONOACYLGLYCEROL
LIPASE
(Geobacillus
sp.
12AMOR1) 		5 / 12 ALA A 122
GLY A 100
THR A 103
LEU A 128
ASN A 120
 None
 1.05A 5ybbA-5xksA:
undetectable		 5ybbA-5xksA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_2
(-)		 5xks THERMOSTABLE
MONOACYLGLYCEROL
LIPASE
(Geobacillus
sp.
12AMOR1) 		5 / 12 GLY A  99
GLY A  95
LEU A  96
GLY A  57
GLU A   3
 None
 0.97A 6gngB-5xksA:
6.0		 6gngB-5xksA:
8.42