SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5xkt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P91_B_SAMB2401_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE A)		 5xkt UREASE ACCESSORY
PROTEIN UREG
(Klebsiella
pneumoniae) 		5 / 12 LEU A 110
GLY A  19
GLY A  17
ILE A 126
THR A 122
 None
GNP  A 301 (-3.3A)
GNP  A 301 (-3.3A)
None
None
 1.13A 1p91B-5xktA:
undetectable		 1p91B-5xktA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_A_RALA600_1
(ESTROGEN RECEPTOR)		 5xkt UREASE ACCESSORY
PROTEIN UREG
(Klebsiella
pneumoniae) 		5 / 12 GLU A 104
LEU A  24
LEU A  23
ILE A 194
LEU A 100
 NI  A 302 ( 2.5A)
None
None
None
None
 1.09A 2jfaA-5xktA:
undetectable		 2jfaA-5xktA:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TGV_B_BEZB1_0
(HEME-BINDING PROTEIN
HUTZ)		 5xkt UREASE ACCESSORY
PROTEIN UREG
(Klebsiella
pneumoniae) 		4 / 6 ARG A  63
GLN A  36
PRO A   7
LEU A  91
 None
 1.19A 3tgvB-5xktA:
undetectable		 3tgvB-5xktA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TGV_D_BEZD1_0
(HEME-BINDING PROTEIN
HUTZ)		 5xkt UREASE ACCESSORY
PROTEIN UREG
(Klebsiella
pneumoniae) 		4 / 6 ARG A  63
GLN A  36
PRO A   7
LEU A  91
 None
 1.16A 3tgvD-5xktA:
undetectable		 3tgvD-5xktA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_A_ACTA502_0
(RNA POLYMERASE
3D-POL)		 5xkt UREASE ACCESSORY
PROTEIN UREG
(Klebsiella
pneumoniae) 		3 / 3 ARG A 136
LYS A 137
LYS A 133
 None
 1.39A 4k50A-5xktA:
undetectable		 4k50A-5xktA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_STRA301_2
(ANCESTRAL STEROID
RECEPTOR 2)		 5xkt UREASE ACCESSORY
PROTEIN UREG
(Klebsiella
pneumoniae) 		4 / 8 MET A  31
ALA A  30
THR A 180
PHE A 147
 None
 0.80A 4ltwA-5xktA:
undetectable		 4ltwA-5xktA:
13.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W7B_B_PA1B204_1
(ACYLOXYACYL
HYDROLASE SMALL
SUBUNIT
ACYLOXYACYL
HYDROLASE LARGE
SUBUNIT)		 5xkt UREASE ACCESSORY
PROTEIN UREG
(Klebsiella
pneumoniae) 		3 / 3 GLY A  96
ASN A  97
ARG A  63
 None
 0.77A 5w7bD-5xktA:
2.3		 5w7bD-5xktA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YNI_A_SAMA401_0
(NSP16 PROTEIN)		 5xkt UREASE ACCESSORY
PROTEIN UREG
(Klebsiella
pneumoniae) 		5 / 12 GLY A 107
ASN A 151
ASP A 127
LEU A 155
ASP A 154
 GNP  A 301 ( 3.8A)
GNP  A 301 (-3.2A)
None
GNP  A 301 ( 4.5A)
GNP  A 301 (-2.9A)
 1.21A 5yniA-5xktA:
undetectable		 5yniA-5xktA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC607_0
(ALPHA-AMYLASE)		 5xkt UREASE ACCESSORY
PROTEIN UREG
(Klebsiella
pneumoniae) 		4 / 6 GLY A  14
ASP A 127
GLY A 141
PRO A 140
 None
 0.62A 6ag0C-5xktA:
undetectable		 6ag0C-5xktA:
22.47