SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5xl2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMA_B_SAMB105_0
(PROTEIN (MET
REPRESSOR))		 5xl2 HEMAGGLUTININ
(Influenza
A
virus) 		5 / 11 GLU A  85
GLU A 394
ALA A 109
PHE A  83
GLY A 112
 None
 1.33A 1cmaA-5xl2A:
undetectable
1cmaB-5xl2A:
undetectable		 1cmaA-5xl2A:
12.74
1cmaB-5xl2A:
12.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMC_A_SAMA105_0
(MET REPRESSOR)		 5xl2 HEMAGGLUTININ
(Influenza
A
virus) 		5 / 10 ALA A 109
PHE A  83
GLY A 112
GLU A  85
GLU A 394
 None
 1.26A 1cmcA-5xl2A:
undetectable
1cmcB-5xl2A:
undetectable		 1cmcA-5xl2A:
12.74
1cmcB-5xl2A:
12.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMC_B_SAMB105_0
(MET REPRESSOR)		 5xl2 HEMAGGLUTININ
(Influenza
A
virus) 		5 / 10 GLU A  85
GLU A 394
ALA A 109
PHE A  83
GLY A 112
 None
 1.29A 1cmcA-5xl2A:
undetectable
1cmcB-5xl2A:
undetectable		 1cmcA-5xl2A:
12.74
1cmcB-5xl2A:
12.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_A_SAMA200_0
(METHIONINE REPRESSOR)		 5xl2 HEMAGGLUTININ
(Influenza
A
virus) 		5 / 11 GLU A  85
GLU A 394
ALA A 109
PHE A  83
GLY A 112
 None
 1.27A 1mjqA-5xl2A:
undetectable
1mjqB-5xl2A:
undetectable		 1mjqA-5xl2A:
12.74
1mjqB-5xl2A:
12.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_C_SAMC199_0
(METHIONINE REPRESSOR)		 5xl2 HEMAGGLUTININ
(Influenza
A
virus) 		5 / 10 GLU A  85
GLU A 394
ALA A 109
PHE A  83
GLY A 112
 None
 1.31A 1mjqC-5xl2A:
undetectable
1mjqD-5xl2A:
undetectable		 1mjqC-5xl2A:
12.74
1mjqD-5xl2A:
12.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_G_SAMG199_0
(METHIONINE REPRESSOR)		 5xl2 HEMAGGLUTININ
(Influenza
A
virus) 		5 / 10 GLU A  85
GLU A 394
ALA A 109
PHE A  83
GLY A 112
 None
 1.27A 1mjqG-5xl2A:
undetectable
1mjqH-5xl2A:
undetectable		 1mjqG-5xl2A:
12.74
1mjqH-5xl2A:
12.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_I_SAMI199_0
(METHIONINE REPRESSOR)		 5xl2 HEMAGGLUTININ
(Influenza
A
virus) 		5 / 11 GLU A  85
GLU A 394
ALA A 109
PHE A  83
GLY A 112
 None
 1.32A 1mjqI-5xl2A:
undetectable
1mjqJ-5xl2A:
undetectable		 1mjqI-5xl2A:
12.74
1mjqJ-5xl2A:
12.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXM_A_IMNA2002_1
(SERUM ALBUMIN)		 5xl2 HEMAGGLUTININ
(Influenza
A
virus) 		5 / 11 LEU A 104
ILE A 176
LEU A 147
TYR A 255
GLY A  68
 None
 1.35A 2bxmA-5xl2A:
undetectable		 2bxmA-5xl2A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8L_A_SAMA400_0
(HYPOTHETICAL PROTEIN
LMO1582)		 5xl2 HEMAGGLUTININ
(Influenza
A
virus) 		5 / 12 ALA A 109
GLY A 112
LEU A 257
VAL A  82
ASP A  81
 None
 1.14A 2f8lA-5xl2A:
undetectable		 2f8lA-5xl2A:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1499_1
(CYTOCHROME P450 3A4)		 5xl2 HEMAGGLUTININ
(Influenza
A
virus) 		4 / 7 PHE A 121
ILE A 233
ILE A 107
GLY A 253
 None
 0.97A 2v0mB-5xl2A:
undetectable		 2v0mB-5xl2A:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCT_B_ASDB1223_1
(GLUTATHIONE
S-TRANSFERASE A2)		 5xl2 HEMAGGLUTININ
(Influenza
A
virus) 		4 / 8 ILE A 227
GLY A 178
LEU A 248
LEU A 150
 None
 0.88A 2vctB-5xl2A:
undetectable		 2vctB-5xl2A:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WEO_A_ACRA1001_2
(ALPHA-GLUCOSIDASE)		 5xl2 HEMAGGLUTININ
(Influenza
A
virus) 		4 / 6 ILE A 372
TRP A 341
ILE A 321
MET A 318
 None
 1.43A 3weoA-5xl2A:
undetectable		 3weoA-5xl2A:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_H_ZPCH1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5xl2 HEMAGGLUTININ
(Influenza
A
virus) 		4 / 7 ILE A 176
HIS A 181
VAL A 220
PHE A 144
 None
 1.06A 4a97H-5xl2A:
undetectable		 4a97H-5xl2A:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L39_A_SALA602_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 5xl2 HEMAGGLUTININ
(Influenza
A
virus) 		4 / 6 LEU A 191
TYR A 192
ILE A 249
GLY A 130
 None
 0.97A 4l39A-5xl2A:
undetectable		 4l39A-5xl2A:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N6P_A_JMSA713_1
(LACTOTRANSFERRIN)		 5xl2 HEMAGGLUTININ
(Influenza
A
virus) 		4 / 4 HIS A  14
ALA A  15
VAL A  16
GLU A  31
 None
 1.31A 4n6pA-5xl2A:
undetectable		 4n6pA-5xl2A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_E_377E401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5xl2 HEMAGGLUTININ
(Influenza
A
virus) 		4 / 6 TYR A 171
GLU A 119
TYR A 175
LEU A 174
 None
 1.23A 4twdD-5xl2A:
undetectable
4twdE-5xl2A:
undetectable		 4twdD-5xl2A:
22.59
4twdE-5xl2A:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_B_URFB302_1
(URIDINE
PHOSPHORYLASE)		 5xl2 HEMAGGLUTININ
(Influenza
A
virus) 		4 / 7 THR A 264
GLY A 112
ALA A 109
ILE A  62
 None
 0.95A 4txnB-5xl2A:
undetectable		 4txnB-5xl2A:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U15_A_0HKA2001_1
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,LYSOZYME,MUSCARIN
IC ACETYLCHOLINE
RECEPTOR M3)		 5xl2 HEMAGGLUTININ
(Influenza
A
virus) 		5 / 12 SER A 311
THR A 316
ALA A 315
ALA A  35
ASN A 431
 None
 1.47A 4u15A-5xl2A:
undetectable		 4u15A-5xl2A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CHG_C_SAMC1101_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-4 SPECIFIC)		 5xl2 HEMAGGLUTININ
(Influenza
A
virus) 		5 / 12 ILE A 286
HIS A  43
HIS A 280
LEU A  44
LEU A  47
 None
 1.19A 6chgC-5xl2A:
undetectable		 6chgC-5xl2A:
15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GQI_A_ACTA604_0
(CYCLOHEXANONE
MONOOXYGENASE FROM
THERMOCRISPUM
MUNICIPALE)		 5xl2 HEMAGGLUTININ
(Influenza
A
virus) 		4 / 6 TRP A  80
ILE A  62
GLY A  57
GLU A  85
 None
 0.91A 6gqiA-5xl2A:
undetectable		 6gqiA-5xl2A:
22.39