SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5xl6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HO5_A_ADNA1604_1
(5'-NUCLEOTIDASE)		 5xl6 HEMAGGLUTININ
(Influenza
A
virus) 		5 / 11 ILE A  63
SER A  69
GLY A  68
GLY A  65
PHE A  96
 None
 1.25A 1ho5A-5xl6A:
undetectable		 1ho5A-5xl6A:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_B_SAMB302_1
(HEMK PROTEIN)		 5xl6 HEMAGGLUTININ
(Influenza
A
virus) 		3 / 3 ASP A  73
PHE A 116
ASN A  64
 None
 0.71A 1sg9B-5xl6A:
undetectable		 1sg9B-5xl6A:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXM_A_IMNA2002_1
(SERUM ALBUMIN)		 5xl6 HEMAGGLUTININ
(Influenza
A
virus) 		5 / 11 LEU A 104
ILE A 176
LEU A 147
TYR A 255
GLY A  68
 None
 1.28A 2bxmA-5xl6A:
undetectable		 2bxmA-5xl6A:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8L_A_SAMA400_0
(HYPOTHETICAL PROTEIN
LMO1582)		 5xl6 HEMAGGLUTININ
(Influenza
A
virus) 		5 / 12 ALA A 109
GLY A 112
LEU A 257
VAL A  82
ASP A  81
 None
 1.12A 2f8lA-5xl6A:
undetectable		 2f8lA-5xl6A:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_B_SAMB301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 5xl6 HEMAGGLUTININ
(Influenza
A
virus) 		5 / 12 GLY A  68
PHE A 116
ILE A 176
LEU A 147
ARG A 252
 None
 1.19A 3iv6B-5xl6A:
undetectable		 3iv6B-5xl6A:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_D_SAMD301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 5xl6 HEMAGGLUTININ
(Influenza
A
virus) 		5 / 12 GLY A  68
PHE A 116
ILE A 176
LEU A 147
ARG A 252
 None
 1.18A 3iv6D-5xl6A:
undetectable		 3iv6D-5xl6A:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_H_ZPCH1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5xl6 HEMAGGLUTININ
(Influenza
A
virus) 		4 / 7 ILE A 176
HIS A 181
VAL A 220
PHE A 144
 None
 1.04A 4a97H-5xl6A:
undetectable		 4a97H-5xl6A:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DJF_A_C2FA300_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 5xl6 HEMAGGLUTININ
(Influenza
A
virus) 		5 / 12 ASP A 282
GLY A 284
ASN A  43
GLN A  42
ILE A 270
 None
 0.95A 4djfA-5xl6A:
undetectable		 4djfA-5xl6A:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQ4_A_SALA601_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 5xl6 HEMAGGLUTININ
(Influenza
A
virus) 		4 / 7 LEU A 191
TYR A 192
ILE A 249
GLY A 130
 SIA  A 603 (-4.7A)
None
None
SIA  A 603 ( 4.4A)
 0.93A 4eq4A-5xl6A:
undetectable		 4eq4A-5xl6A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQL_A_SALA602_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 5xl6 HEMAGGLUTININ
(Influenza
A
virus) 		4 / 7 LEU A 191
TYR A 192
ILE A 249
GLY A 130
 SIA  A 603 (-4.7A)
None
None
SIA  A 603 ( 4.4A)
 0.93A 4eqlA-5xl6A:
undetectable		 4eqlA-5xl6A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQL_B_SALB602_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 5xl6 HEMAGGLUTININ
(Influenza
A
virus) 		4 / 7 LEU A 191
TYR A 192
ILE A 249
GLY A 130
 SIA  A 603 (-4.7A)
None
None
SIA  A 603 ( 4.4A)
 0.95A 4eqlB-5xl6A:
undetectable		 4eqlB-5xl6A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_B_CQAB301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 5xl6 HEMAGGLUTININ
(Influenza
A
virus) 		4 / 8 GLY A 215
GLY A 225
GLU A 187
LEU A 223
 None
SIA  A 603 ( 4.4A)
SIA  A 603 (-3.1A)
SIA  A 603 (-4.3A)
 0.88A 4fgzB-5xl6A:
undetectable		 4fgzB-5xl6A:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L39_A_SALA602_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 5xl6 HEMAGGLUTININ
(Influenza
A
virus) 		4 / 6 LEU A 191
TYR A 192
ILE A 249
GLY A 130
 SIA  A 603 (-4.7A)
None
None
SIA  A 603 ( 4.4A)
 0.91A 4l39A-5xl6A:
undetectable		 4l39A-5xl6A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L39_B_SALB601_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 5xl6 HEMAGGLUTININ
(Influenza
A
virus) 		4 / 7 LEU A 191
TYR A 192
ILE A 249
GLY A 130
 SIA  A 603 (-4.7A)
None
None
SIA  A 603 ( 4.4A)
 0.90A 4l39B-5xl6A:
undetectable		 4l39B-5xl6A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_A_FOLA301_1
(FOLATE RECEPTOR
ALPHA)		 5xl6 HEMAGGLUTININ
(Influenza
A
virus) 		3 / 3 ASP A  61
TRP A 231
SER A  69
 None
 1.00A 4lrhA-5xl6A:
undetectable		 4lrhA-5xl6A:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N6P_A_JMSA713_1
(LACTOTRANSFERRIN)		 5xl6 HEMAGGLUTININ
(Influenza
A
virus) 		4 / 4 HIS A  14
ALA A  15
VAL A  16
GLU A  31
 None
 1.28A 4n6pA-5xl6A:
undetectable		 4n6pA-5xl6A:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GQI_A_ACTA604_0
(CYCLOHEXANONE
MONOOXYGENASE FROM
THERMOCRISPUM
MUNICIPALE)		 5xl6 HEMAGGLUTININ
(Influenza
A
virus) 		4 / 6 TRP A  80
ILE A  62
GLY A  57
GLU A  85
 None
 0.92A 6gqiA-5xl6A:
undetectable		 6gqiA-5xl6A:
20.48