SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5xlm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GRM_A_DVAA6_0
(GRAMICIDIN A)		 5xlm SERINE/THREONINE-PRO
TEIN KINASE PKNI
(Mycobacterium
tuberculosis) 		3 / 3 ALA A 403
VAL A 405
TRP A 480
 None
 0.90A 1grmA-5xlmA:
undetectable		 1grmA-5xlmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GRM_B_DVAB6_0
(GRAMICIDIN A)		 5xlm SERINE/THREONINE-PRO
TEIN KINASE PKNI
(Mycobacterium
tuberculosis) 		3 / 3 ALA A 403
VAL A 405
TRP A 480
 None
 0.90A 1grmB-5xlmA:
undetectable		 1grmB-5xlmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB500_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 5xlm SERINE/THREONINE-PRO
TEIN KINASE PKNI
(Mycobacterium
tuberculosis) 		4 / 7 THR A 504
VAL A 522
THR A 524
VAL A 536
 None
 0.42A 3em0B-5xlmA:
5.9		 3em0B-5xlmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IK7_B_IMNB201_1
(TRANSTHYRETIN)		 5xlm SERINE/THREONINE-PRO
TEIN KINASE PKNI
(Mycobacterium
tuberculosis) 		4 / 8 THR A 503
LEU A 507
SER A 482
VAL A 487
 None
 0.83A 4ik7B-5xlmA:
undetectable		 4ik7B-5xlmA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDH_C_DAHC60_1
(PUTATIVE CYTOCHROME
C)		 5xlm SERINE/THREONINE-PRO
TEIN KINASE PKNI
(Mycobacterium
tuberculosis) 		4 / 6 GLN A 416
ASN A 434
VAL A 542
LEU A 517
 None
 1.30A 5xdhA-5xlmA:
undetectable
5xdhC-5xlmA:
undetectable		 5xdhA-5xlmA:
15.66
5xdhC-5xlmA:
15.66